amphotericin-b and Foot-Ulcer

Cutaneous cryptococcosis, caused by an encapsulated yeast, Cryptococcus neoformans, is generally associated with concomitant systemic infection. Here we report a case of primary cutaneous cryptococcosis with spread to central nervous system in an HIV seronegative young boy. In the present case, a 17-year-old boy who was suffering from a non-healing ulcer on his right great toe for 5 months, presented with the signs and symptoms of meningitis. Cryptococcus neoformans var. gattii was isolated from the CSF of the patient. Amphotericin B administration produced recovery from the meningitis as well as from the ulcer. This case study suggests that primary cutaneous cryptococcosis can be diagnosed provisionally by a simple Gram stained smear and India ink examination in order to avoid occurrence of disseminated cryptococcosis, including meningial involvement, which may have a fatal outcome.

Topics: Adolescent; Amphotericin B; Antifungal Agents; Carbon; Coloring Agents; Cryptococcosis; Cryptococcus gattii; Dermatomycoses; Fluconazole; Foot Ulcer; Fungemia; Gentian Violet; HIV Seronegativity; Humans; Male; Meningitis, Cryptococcal; Phenazines; Staining and Labeling; Toes

Topics: Adult; Amphotericin B; Antifungal Agents; Blastomyces; Blastomycosis; Foot Ulcer; Humans; Itraconazole; Male; Necrosis; Osteomyelitis; Pain; Wound Healing

Topics: Alternaria; Amphotericin B; Antifungal Agents; Combined Modality Therapy; Dermatomycoses; Female; Foot Ulcer; Humans; Immunocompromised Host; Immunosuppression Therapy; Kidney Transplantation; Leg Ulcer; Middle Aged; Postoperative Complications

Coccidioidal osteomyelitis is difficult to diagnose. Confirmation depends on culture and histopathological examination. This rare type of fungal osteomyelitis is to be considered in the differential diagnosis of a chronic infection in some areas of the world. Specific treatment with excision and amphotericin-B can be effective.

Topics: Amphotericin B; Coccidioides; Coccidioidomycosis; Debridement; Foot Ulcer; Humans; Male; Metatarsus; Middle Aged; Osteomyelitis