amphotericin-b and Eyelid-Diseases

Topics: Aged, 80 and over; Amphotericin B; Biopsy; Diagnosis, Differential; Eyelid Diseases; Female; Humans; Leishmaniasis, Cutaneous; Nasal Septum; Orbital Cellulitis; Rare Diseases

Fungal orbital infections are rare among children, especially in immunocompetent infants. Two infants presented to us with unilateral proptosis and swelling of the eyelids and periorbital area. Imaging showed an intraorbital mass causing proptosis and bony orbital expansion. There was no sinus, nasal, or intracranial involvement. Systemic evaluation did not reveal any evidence of a compromised immune system. A biopsy from the mass showed the presence of fungal infection. Both infants responded well to medical therapy with intravenous amphotericin B.

Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Edema; Exophthalmos; Eye Infections, Fungal; Eyelid Diseases; Humans; Immunocompetence; Infant; Infusions, Intravenous; Magnetic Resonance Imaging; Male; Mucormycosis; Orbital Diseases; Tomography, X-Ray Computed

Necrotising fasciitis (NF) is an extremely rare skin and soft tissue infection with extensive necrosis of the subcutaneous tissue and underlying fascia, which usually affects the limbs and trunk. It rarely affects the head and neck region because of the excellent blood supply in this region. We report a case of NF initially misdiagnosed as a traumatic pre-septal cellulitis following self-puncture of a hordeolum externum (stye) and its resistance to aggressive antibiotic therapy resulting in the loss of the lower eyelid.

Topics: Adult; Amphotericin B; Antitubercular Agents; Blepharoplasty; Combined Modality Therapy; Debridement; Drug Therapy, Combination; Early Diagnosis; Eyelid Diseases; Eyelids; Fasciitis, Necrotizing; Humans; Male; Orbital Diseases

Topics: Adult; AIDS-Related Opportunistic Infections; Amphotericin B; Antifungal Agents; Cryptococcosis; Cryptococcus neoformans; Eye Infections, Fungal; Eyelid Diseases; Flucytosine; Humans; Male; Skin Diseases, Bacterial

To report a case of ocular neuromyotonia occurring after cavernous sinus thrombosis secondary to mucormycosis.. Case report. We performed serial comprehensive neuro-ophthalmologic examinations.. Fifteen months after initial total ophthalmoplegia of the right eye and complete right upper eyelid ptosis, isolated ocular neuromyotonia, characterized by episodic upward jerking movements of the right upper eyelid, was noted.. Ocular neuromyotonia, which usually manifests in patients with a history of intracranial tumors and cranial radiation, may also be secondary to infectious cavernous sinus thrombosis.

Topics: Adult; Amphotericin B; Antifungal Agents; Cavernous Sinus; Eye Infections, Fungal; Eyelid Diseases; Follow-Up Studies; Humans; Male; Mucormycosis; Myotonia; Oculomotor Muscles; Ophthalmoplegia; Sinus Thrombosis, Intracranial

A twelve year old boy with acute lymphoblastic leukemia was treated with combination chemotherapy. Two weeks later a cellulitis of the left upper and lower eyelid appeared, followed by a rapidly increasing, deep necrotic inflammation of the periorbital area leading to proptosis. Mucormycosis was identified by histology and microbiology. The spreading inflammatory process was arrested by amphotericin B in a total dose of 1.2 g combined with a drainage of the necrotic tissue of the paranasal sinus, left orbit and bifrontal cerebral abscess. The patient is still in complete continuous remission four years later but a large defect of the nasal, maxillary and orbital area remains. This case demonstrates that the usual fatal outcome of mucormycosis in leukemia is curable with amphotericin B and aggressive surgery.

Topics: Amphotericin B; Antineoplastic Combined Chemotherapy Protocols; Child; Combined Modality Therapy; Eyelid Diseases; Humans; Leukemia, Lymphoid; Male; Meningoencephalitis; Mucormycosis; Nose Diseases; Orbital Diseases

An 84-year-old man had a verrucous lesion of the left lower eyelid that caused progressive ectropion. Cultures of the lesion taken at the time of surgical excision demonstrated Blastomyces dermatitidis. Histologically, the excised tissue demonstrated pseudoepitheliomatous hyperplasia, a characteristic change of cutaneous blastomycosis.

Topics: Aged; Amphotericin B; Blastomycosis; Eyelid Diseases; Hospitalization; Humans; Male; Potassium Iodide