amphotericin-b and Eye-Foreign-Bodies

Topics: Adolescent; Adult; Amphotericin B; Animals; Cataract Extraction; Child; Child, Preschool; Electrocoagulation; Eye Diseases; Eye Foreign Bodies; Female; Hemorrhage; Humans; Infant, Newborn; Male; Methicillin; Methods; Middle Aged; Postoperative Complications; Prostheses and Implants; Rabbits; Retina; Retinal Detachment; Retinal Diseases; Urokinase-Type Plasminogen Activator; Uvea; Vitreous Body

A 42-year-old woman presented with fever, left ear pain, restricted mouth opening, difficulty in swallowing and inability to open her left eyelid for a period of 10 days. She was treated with antibiotics for the same at a local medical facility; however, a sudden decrease in her left eye vision prompted her to visit our tertiary centre. Her history was insignificant except for having multiple left ear syringing for an insect removal 10 days before onset of her current symptoms. On examination, she had ptosis of the left eye with chemosis, dilated pupil with only perception of light and restricted ocular mobility. Oral examination revealed trismus and bulge in the left peritonsillar region. Left ear examination revealed a large central perforation with mucopurulent discharge. CT of the neck with contrast demonstrated a collection in the left peritonsillar space with left internal carotid artery thrombosis. MRI of the brain with gadolinium revealed left cavernous sinus thrombosis with acute infarcts in the left frontal lobe. An emergency incision and drainage of the left peritonsillar abscess was performed. Culture grew broad aseptate fungal hyphae. Despite starting on antifungal therapy, she succumbed to her illness.

Topics: Adult; Amphotericin B; Animals; Cavernous Sinus; Cavernous Sinus Thrombosis; Coleoptera; Drainage; Drug Therapy, Combination; Enoxaparin; Eye Foreign Bodies; Fatal Outcome; Female; Humans; Hyphae; Magnetic Resonance Imaging; Meropenem; Mucorales; Mucormycosis; Osteomyelitis; Skull Base; Vancomycin

Topics: Amphotericin B; Antifungal Agents; Ascomycota; Cornea; Corneal Injuries; Endophthalmitis; Eye Foreign Bodies; Eye Infections, Fungal; Eye Injuries, Penetrating; Humans; Keratoplasty, Penetrating; Male; Middle Aged; Mycoses; Sclera; Ultrasonography; Visual Acuity; Vitreous Body; Young Adult

Topics: Absidia; Accidents, Occupational; Adult; Amphotericin B; Antifungal Agents; Corneal Ulcer; Eye Foreign Bodies; Eye Injuries, Penetrating; Humans; Male; Mucormycosis

To report a case of recurrent fungal sclerokeratitis and endophthalmitis with a very successful outcome due to aggressive combined surgical and medical therapy. To discuss the management of this potentially devastating infection.. A 65-year-old man presented with 6 months of left eye redness and irritation after injury from organic matter propelled from an airboat. Initially, he had been treated with foreign body removal, antibiotics, and steroids. He was diagnosed with reactive sclerokeratitis at presentation and was treated with steroids. However, when he did not improve, cultures were obtained and Acremonium species filamentous fungi was identified. Despite treatment with appropriate topical and systemic antifungals, his fungal sclerokeratitis progressed to endophthalmitis. Two therapeutic penetrating keratoplasties (PKs) with iridectomy and intraocular amphotericin B were necessary to eradicate the fungal infection.. Visual acuity was restored to 20/25-3 with correction 9 months after initial presentation. There was no recurrence of fungal infection after the second therapeutic PK.. The possible reasons for recurrence of fungal infection are discussed. The role of timely and aggressive medical and surgical intervention for fungal sclerokeratitis and endophthalmitis in restoring excellent vision is emphasized.

Topics: Acremonium; Aged; Amphotericin B; Antifungal Agents; Endophthalmitis; Eye Foreign Bodies; Eye Infections, Fungal; Eye Injuries, Penetrating; Humans; Keratitis; Keratoplasty, Penetrating; Male; Secondary Prevention; Visual Acuity

To report two patients with severe fungal corneal ulcers who were treated successfully with topical amphotericin B ointment.. Two eyes of two patients developed corneal ulcers and hypopyon after corneal foreign body removal. Aspergillus fumigatus and Fusarium solani were isolated in Patients 1 and 2, respectively. By antifungal susceptibility testing, amphotericin B was shown to have the lowest minimal inhibitory concentration.. Topical administration of amphotericin B ointment resulted in dramatic improvement in fungal corneal ulcers.. Antifungal susceptibility tests may aid with selection of antifungal agents. Amphotericin B ointment is one of the promising therapies for keratomycosis caused by antimycotic-resistant fungi.

Topics: Administration, Topical; Aged; Amphotericin B; Antifungal Agents; Aspergillus fumigatus; Cornea; Corneal Injuries; Corneal Ulcer; Eye Foreign Bodies; Eye Infections, Fungal; Female; Follow-Up Studies; Fusarium; Humans; Male; Middle Aged; Mycoses; Ointments

Topics: Acremonium; Alternaria; Amphotericin B; Aspergillosis; Aspergillus; Candida albicans; Candidiasis; Corneal Ulcer; Drug Resistance, Microbial; Exophiala; Eye Foreign Bodies; Eye Injuries; Fusarium; Humans; Mycoses

Topics: Adult; Amphotericin B; Corneal Diseases; Eye Foreign Bodies; Eye Injuries; Humans; Male; Natamycin; Penicillium; Penicillium chrysogenum