amphotericin-b has been researched along with Eye-Diseases--Hereditary* in 1 studies
1 other study(ies) available for amphotericin-b and Eye-Diseases--Hereditary
| Article | Year |
|---|---|
A critical role of calcineurin in stress responses, hyphal formation, and virulence of the pathogenic fungus Trichosporon asahii.
Trichosporon asahii is a conditional pathogenic fungus that causes severe and sometimes fatal infections in immunocompromised patients. While calcineurin, an essential component of a calcium-dependent signaling pathway, is known to regulate stress resistance and virulence of some pathogenic fungi, its role in T. asahii has not been investigated. Here, we demonstrated that calcineurin gene-deficient T. asahii mutants are sensitive to high temperature as well as cell-membrane and cell-wall stress, and exhibit decreased hyphal formation and virulence against silkworms. Growth of T. asahii mutants deficient in genes encoding subunits of calcineurin, cna1 and cnb1, was delayed at 40 °C. The cna1 and cnb1 gene-deficient mutants also showed sensitivity to sodium dodecyl sulfate, Congo red, dithiothreitol, and tunicamycin. On the other hand, these mutants exhibited no sensitivity to caffeine, sorbitol, monensin, CaCl Topics: Amphotericin B; Antifungal Agents; Basidiomycota; Caffeine; Calcineurin; Calcium; Calcium Chloride; Congo Red; Cornea; Corneal Diseases; Dithiothreitol; Eye Diseases, Hereditary; Fluconazole; Monensin; Sodium Chloride; Sodium Dodecyl Sulfate; Sorbitol; Trichosporon; Tunicamycin; Virulence; Voriconazole | 2022 |