amphotericin-b and Erythema

Topics: Amphotericin B; Arthritis, Infectious; Coccidioidomycosis; Eosinophilia; Erythema; Erythema Multiforme; Erythema Nodosum; Ethnicity; Female; Humans; Liver Diseases; Lung Diseases, Fungal; Meningitis; Miconazole; Osteomyelitis; Pregnancy; Pregnancy Complications, Infectious; Skin Diseases, Infectious; Tenosynovitis; Transfer Factor; United States

The efficacy of fluconazole and amphotericin in the management of denture stomatitis was investigated in a comparative trial. Patients were assessed clinically, hematologically, and mycologically at the time of entry into the study and at 1, 4, and 12 weeks thereafter. A total of 29 patients were selected at random to receive 50 mg of fluconazole daily for 14 days; 30 patients were selected to receive amphotericin lozenges and cream for 28 days. Clinical response rates were similar in both treatment groups throughout the study. The best mycologic response was noted after 1 week whereas the best clinical response was observed after 4 weeks. Clinical evidence of relapse and recurrence at 12 weeks was a common finding irrespective of treatment. Side effects were uncommon in both groups.

Topics: Adult; Aged; Aged, 80 and over; Amphotericin B; Candidiasis, Oral; Erythema; Female; Fluconazole; Humans; Male; Middle Aged; Random Allocation; Stomatitis, Denture

The clinical effects of an antibacterial substance with antifungal activity (chlorhexidine) and specific antimycotic (amphotericin B) in denture stomatitis were studied in 100 patients. Five 14-day regimens of chlorhexidine, amphotericin B or placebo lozenges combined with denture immersion in 0.2% chlorhexidine or water were tested. The efficiency of amphotericin B and chlorhexidine was comparable. This indicates that chlorhexidine has a considerable antifungal effect in the oral cavity and, further, that fungi are the responsible micro-organism in denture stomatitis rather than bacteria. Chlorhexidine frequently discloured the dentures. A high incidence of local and general predisposing factors to denture stomatitis, as well as of relapse 14 days after treatment, was observed.

Topics: Amphotericin B; Biguanides; Chlorhexidine; Clinical Trials as Topic; Drug Therapy, Combination; Erythema; Humans; Maxillary Diseases; Mycoses; Stomatitis; Stomatitis, Denture

Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Dermatomycoses; Edema; Erythema; Humans; Infant, Extremely Premature; Infant, Newborn; Infant, Premature, Diseases; Male; Twins

Topics: Aged; Amphotericin B; Antifungal Agents; Aspergillus fumigatus; Blister; Bronchoalveolar Lavage; Disseminated Intravascular Coagulation; Erythema; Fatal Outcome; Humans; Invasive Pulmonary Aspergillosis; Male; Pemphigoid, Bullous; Tomography, X-Ray Computed

Topics: Aged; Amphotericin B; Antifungal Agents; Edema; Erythema; Female; Forearm; Hand; Histoplasmosis; Humans; Itraconazole; Kansas; Pain; Treatment Outcome

Mucormycosis is a rare opportunistic fungal infection with clinical polymorphism and is rapidly extensive and destructive. It is caused by fungi of the mucorales group in the environment and generally arises in the context of immunosuppression. Often difficult and late, diagnosis is based on mycological and histological examination. We report the case of a 10-year-old patient admitted for a pruritic erythematous scaly eruption located in the right inguinal area associated with satellite lymphadenopathy and lymphedema of the right lower limb. The histological study of the cutaneous biopsy revealed a granulomatous reaction with filaments. The mycological examination of the collection of the cutaneous lesion showed mucorales filaments and a stump of Absidia corymbifera was isolated. Abdomino-pelvic CT showed muscular extension with vascular and ureteral englobement. The diagnosis of cutaneous mucormycosis was made. Immunological investigations were normal. Treatment included itraconazole for 3months followed by IV amphotericin B for 1month, with favorable clinical and radiological progression. Mucormycosis is an uncommon fungal infection whose cutaneous localization is rare. It occurs exceptionally in immunocompetent patients and is clinically manifested by a vesicular and pustular rash progressing to ulceration. The diagnosis is confirmed by mycological and histological studies. Treatment consists of antifungal therapy associated with surgical excision of necrotic and infected tissue.

Topics: Amphotericin B; Antifungal Agents; Child; Dermatomycoses; Erythema; Granuloma; Groin; Humans; Immunocompetence; Itraconazole; Lymphedema; Male; Mucormycosis; Pruritus

Zygomycosis is an opportunistic fungal infection mainly affecting patients with diabetes mellitus, immunodeficiency, and malignancies. The majority of cases in which it has been reported as a posttransplantation complication have been after renal or liver transplantation. There are few instances of rhino-sinusitis and orbital mucormycosis complicating heart transplantation.. A 38-year-old diabetic man who had undergone heart transplantation returned to the transplantation follow-up clinic 20 days after a successful operation with unilateral periorbital swelling, nasal discharge, and multiple cranial nerve dysfunctions. Multidisciplinary investigations resulted in detection of mucormycosis in the paranasal sinuses and the orbital space, as well as a thrombosis of the cavernous sinus. Surgical ablation of the infected parts, along with antifungal treatment and adjustment of immunosuppressive maintenance, restricted extension of the craniofacial involvement. Allograft function remained undisturbed.. Early detection of opportunistic infections in transplant recipients plays a big role in preventing dissemination. Fungal infections, including zygomycosis, should be considered for recipients, especially those with risk factors, such as diabetes, who present with local unusual manifestations. Sinonasal and orbital mucormycosis, if diagnosed in timely fashion, can be managed to reduce mortality. Although devastation of one-side facial and ophthalmic structures was inevitable in this case, the overall outcome was acceptable.

Topics: Adult; Amphotericin B; Antifungal Agents; Blood Transfusion; Brain; Cardiomyopathy, Dilated; Diabetes Mellitus, Type 2; Erythema; Female; Heart Transplantation; Humans; Magnetic Resonance Imaging; Male; Mucormycosis; Rhinitis; Risk Factors; Tissue Donors; Tomography, X-Ray Computed; Treatment Outcome; Zygomycosis

Topics: Aged; Amphotericin B; Antifungal Agents; Debridement; Erythema; Fatal Outcome; Female; Humans; Leg Ulcer; Mucormycosis

We report a case of persistent annular erythema of infancy in a 4-month-old boy. Physical and laboratory parameters showed no sign of internal disease or specific infection except a massive Candida albicans colonization (> 103 organisms/mm3) of the lower gastrointestinal tract. Oral treatment with amphotericin B for 2 weeks resulted in a complete remission of the skin lesions indicating Candida colonization as a trigger.

Topics: Amphotericin B; Anti-Bacterial Agents; Candidiasis; Erythema; Facial Dermatoses; Humans; Infant; Intestinal Diseases; Intestine, Large; Male; Treatment Outcome

Topics: Amphotericin B; Antifungal Agents; Candidiasis; Erythema; Female; Humans; Intestinal Diseases; Male; Middle Aged; Nystatin

A 12-year-old girl had been presenting a woody infiltration and erythema in the frontal region and on the entire left half of the face, leading to deformity of the nose and buccal fissure, and adenomegaly in a posterior cervical chain, for the last 18 months. Sinusitis was diagnosed and treated with antibiotics, and submitted to ethmoid sinusotomy, with no improvement. Several laboratory tests were made to find the correct diagnosis. An intradermal test for delayed hypersensitivity showed a positive reaction (5 mm) with necrosis for metabolic antigens for Conidiobolus. An oral mucosa biopsy showed a dense lymphohistiocytic infiltrate and focal points of necrosis. Gomori staining for fungi revealed countless wide, nonseptate hyphae. Amphotericin B was prescribed during 35 days, with no improvement. Terbinafine given orally was started in association with amphotericin B. Reduction of the lesions was observed 2 months later. No side effects were seen during 4 months of treatment.

Topics: Amphotericin B; Antifungal Agents; Antigens, Fungal; Child; Dermatomycoses; Drug Combinations; Entomophthora; Erythema; Ethmoid Sinusitis; Facial Dermatoses; Female; Humans; Lymphatic Diseases; Mouth Diseases; Naphthalenes; Nose Diseases; Terbinafine

Topics: Adolescent; Amphotericin B; Edema; Erythema; Humans; Male

Acute respiratory failure caused by infection with Coccidioides immitis is a rare, usually fatal, event. We report 2 patients who survived acute respiratory failure caused by primary pulmonary coccidioidomycosis. We attribute the severity of illness to a large inoculum of organisms. Their treatment included antifungal therapy with amphotericin B and diuresis to decrease noncardiogenic pulmonary edema. Coccidioidomycosis causing respiratory failure may be more frequent than currently clinically appreciated and may result from primary pulmonary coccidioidomycosis, miliary pulmonary disease, or as part of the multisystem organ failure seen in fungemic patients.

Topics: Adult; Amphotericin B; Antibodies, Fungal; Coccidioidomycosis; Complement Fixation Tests; Erythema; Furosemide; Humans; Ketoconazole; Lung Diseases, Fungal; Male; Pulmonary Edema; Respiratory Insufficiency

Topics: Amphotericin B; Blastomyces; Blastomycosis; Cytosine; Erythema; Facial Dermatoses; Flour; Humans; Leg Dermatoses; Male; Microscopy, Electron; Middle Aged; Spain; Spores, Fungal