amphotericin-b and Endocrine-System-Diseases

Topics: Adolescent; Adult; Amphotericin B; Animals; Autoantibodies; Blood Transfusion; Candidiasis; Candidiasis, Cutaneous; Child; Endocrine System Diseases; Female; Foot Dermatoses; Hand Dermatoses; Humans; Immunity; Immunity, Cellular; Lymphocyte Activation; Macrophages; Male; Mucous Membrane; Nails; Skin

We reviewed the clinical course in 43 patients from eight medical centers who were given the diagnosis of chronic mucocutaneous candidiasis, a rare disorder of unknown cause that may occur in childhood. Recurrent or severe infections with organisms other than Candida were seen in 80% of the patients. There were nine cases of septicemia. Seven patients have died; six of these deaths were directly related to non-Candida infectious complications. Endocrine dysfunction, including Addison disease (11 patients) and hypothyroidism (9 patients), was seen in 19 of 43 patients. Immunologic studies failed to reveal a consistent abnormality, although two of five patients with reversed T4/T8 ratios are among those who have died. Ketoconazole was effective in controlling symptoms of candidiasis in most patients. The findings from this study indicate that non-Candida infections cause serious morbidity and may result in death in patients with chronic mucocutaneous candidiasis.

Topics: Adolescent; Amphotericin B; Autoimmune Diseases; Candidiasis; Candidiasis, Chronic Mucocutaneous; Child; Child, Preschool; Endocrine System Diseases; Family; Female; Flucytosine; Humans; Immunoglobulin A; Immunoglobulin G; Incidence; Infant; Infections; Ketoconazole; Lung Diseases; Male; Survival Rate

Topics: Amphotericin B; Biopsy; Candida albicans; Candidiasis, Oral; Cheilitis; Diabetes Complications; Endocrine System Diseases; Fluorescent Antibody Technique; Humans; Immunity, Cellular; Immunologic Deficiency Syndromes; Leukoplakia, Oral; Metabolic Diseases; Nutrition Disorders; Nystatin; Sjogren's Syndrome; Stomatitis, Denture