amphotericin-b and Cytomegalovirus-Retinitis

Topics: Adult; Amphotericin B; Anti-HIV Agents; Antiprotozoal Agents; Cytomegalovirus Retinitis; Drug Resistance, Viral; HIV; HIV Infections; Honduras; Humans; Leishmania infantum; Leishmaniasis, Visceral; Male; Toxoplasmosis, Cerebral

Topics: AIDS-Related Opportunistic Infections; Amphotericin B; Anti-Bacterial Agents; Antiviral Agents; Cidofovir; Clinical Trials as Topic; Cytomegalovirus Retinitis; Cytosine; HIV Infections; Humans; Isoquinolines; Nelfinavir; Nevirapine; Organophosphonates; Organophosphorus Compounds; Protease Inhibitors; Pyridines; Ritonavir; Sulfonic Acids

A 51-year-old man with acquired immunodeficiency syndrome and cytomegalovirus retinitis had bilateral endogenous fungal endophthalmitis. Cultures yielded Fusarium species. Histopathologic examination showed a severe necrotizing acute and granulomatous reaction, with numerous fungal elements in the retina and uveal tract. Fungal elements were seen in the lens, sclera, and emissarial vessels. Angiopathic infiltration by fungus and widespread thrombosis produced retinal and choroidal infarction. In some areas, fungal infection coexisted with cytomegalovirus retinitis. The bilateral distribution suggests hematogenous seeding of the eyes. The eye findings were the first clinically apparent manifestations of fungal disease in this patient.

Topics: AIDS-Related Opportunistic Infections; Amphotericin B; Antifungal Agents; Cytomegalovirus Retinitis; Endophthalmitis; Eye; Eye Infections, Fungal; Fluconazole; Fungemia; Fusarium; Humans; Male; Middle Aged; Mycoses

Topics: Adult; AIDS-Related Opportunistic Infections; Amphotericin B; Antifungal Agents; Antiviral Agents; Candidiasis; Contraindications; Cytomegalovirus Retinitis; Drug Therapy, Combination; Foscarnet; Humans; Male; Renal Insufficiency