amphotericin-b and Colitis--Ulcerative

Non-alcoholic fatty liver disease (NAFLD), defined as excessive fat accumulation in hepatocytes when no other pathologic causes are present, is an increasingly common obesity-related disorder. We sought to describe the prevalence of elevated liver enzymes, a marker of liver damage, among New Zealand adults, and high-risk subgroups including those with an elevated body mass index and those with pre-diabetes or diabetes, to gain a better understanding of the burden of liver disease.. A total of 4,721 New Zealanders aged 15+ years participated in a nationally representative nutrition survey. Liver enzymes, alanine transaminase (ALT) and gamma glutamyl transpeptidase (GGT) were measured in serum. Results were available for 3,035 participants, of whom 10.8% were Māori and 4.5% Pacific.. Obesity-related liver disease is likely to increasingly burden the New Zealand health sector and contribute to health disparities unless effective obesity treatment and prevention measures are given high priority. © 2015 The Authors. Obesity Science & Practice published by John Wiley & Sons Ltd, World Obesity and The Obesity Society.. LVADs are an important therapeutic alternative to heart transplantation in the context of a developing heart transplant programme with outcomes that are comparable to those reported by other centres.. 3D graphene-nanowall-decorated carbon felts (CF) are synthesized via an in situ microwave plasma enhanced chemical vapor deposition method and used as positive electrode for vanadium redox flow battery (VRFB). The carbon fibers in CF are successfully wrapped by vertically grown graphene nanowalls, which not only increase the electrode specific area, but also expose a high density of sharp graphene edges with good catalytic activities to the vanadium ions. As a result, the VRFB with this novel electrode shows three times higher reaction rate toward VO

Topics: Acetylglucosaminidase; Adolescent; Adult; Aged; Aged, 80 and over; Amphotericin B; Anemia; Animals; Antifungal Agents; Area Under Curve; Biomarkers; Blotting, Western; Body Mass Index; C-Reactive Protein; Cardiovascular Diseases; Carotenoids; Cell Line; Chemistry, Pharmaceutical; Child; Child Health Services; Child, Preschool; Clinical Decision-Making; Colitis, Ulcerative; Colonoscopy; Conjugation, Genetic; Crohn Disease; Cross-Sectional Studies; Cytokines; Diet Records; Drug Administration Schedule; Drug Carriers; Drug Resistance, Bacterial; Epithelial Cells; Escherichia coli; Feces; Female; Gene Transfer, Horizontal; Genetic Loci; Hemoglobins; Host-Pathogen Interactions; Humans; Interspersed Repetitive Sequences; Kidney; Leukocyte L1 Antigen Complex; Magnetic Resonance Imaging; Male; Micelles; Microscopy, Confocal; Middle Aged; Models, Biological; Nutrition Surveys; Pediatric Obesity; Physical Fitness; Polyesters; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Recombination, Genetic; Sedentary Behavior; Sequence Analysis, DNA; Serum Albumin; Signal Transduction; Streptococcus; Surveys and Questionnaires; Tissue Distribution; Tomography, X-Ray Computed; United States; Young Adult

We present a case of cerebral Scedosporium apiospermum infection presenting with intestinal manifestations in a 64-year-old male patient on immunosuppression for orthotopic liver transplantation. At admission, the patient's chief complaint was chronic watery diarrhea and he was found to have colonic ulcers on endoscopy. His hospital course was complicated by a tonic-clonic seizure caused by a left frontal brain abscess, with the causative agent being identified by culture. He was treated with lobectomy, high-dose intravenous voriconazole, and liposomal amphotericin with clinical, endoscopic, and histologic improvement. To our knowledge, S. apiospermum has not been previously described as a cause of colitis. The septate branching appearance of the Scedosporium species is similar to the more common Aspergillus species. This case of gastrointestinal Scedosporium brings into question previously reported cases of isolated gastrointestinal aspergillosis diagnosed by histopathology. Clinical suspicion for S. apiospermum must be maintained in immunosuppressed patients presenting with neurologic and gastrointestinal symptoms.

Topics: Amphotericin B; Antifungal Agents; Brain Abscess; Central Nervous System Fungal Infections; Colitis, Ulcerative; Histocytochemistry; Humans; Male; Microscopy; Middle Aged; Psychosurgery; Pyrimidines; Scedosporium; Triazoles; Voriconazole

Topics: Adrenal Cortex Hormones; Aged; Amphotericin B; Antiprotozoal Agents; Azathioprine; Biopsy; Colitis, Ulcerative; Colon; Colonic Polyps; Diagnosis, Differential; Female; Fever; Humans; Immunocompromised Host; Immunosuppressive Agents; Leishmaniasis, Visceral; Pancytopenia

Ulcerative colitis is a chronically recurrent inflammatory bowel disease of unknown origin. The present work describes design and synthesis of 3-aminofurosalicylic acid 4, azo-conjugates with aniline 2a, 4-ASA 2b or sulphapyridine 2c as well as N-arylsulphonamido 5, chlorosulphonyl 6, aminosulphonyl 7 and N-arylaminosulphonyl derivatives 8 (positional isosters of 5). All the synthesized compounds were evaluated for their anti-ulcerogenic effect on acetic acid-induced ulcerative colitis in rats. It was noticed that oral treatment with sulphasalazine (a reference drug) and the tested compounds 2a, 2c, 4 and 5c in equimolar doses significantly reduced the intensity of lesion score, ulcer area, ulcer index and wet weight/length ratio compared to the control group. On the other hand, compounds 2b, 5a, 5b and 7 had a lower anti-ulcerogenic efficacy. Also, the antimicrobial activity of the synthesized compounds was screened in vitro using the agar diffusion assay technique. In addition, docking of the tested compounds into cycloxygenase II using molecular operating environment (MOE) was performed in order to rationalize the obtained biological results and their mechanism of action.

Topics: Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Bacteria; Benzofurans; Colitis, Ulcerative; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Design; Hydrophobic and Hydrophilic Interactions; Lethal Dose 50; Lipoxygenase Inhibitors; Male; Mice; Models, Molecular; Protein Conformation; Rats; Salicylic Acid; Stomach

Topics: Acinetobacter baumannii; Acinetobacter Infections; Adult; Amphotericin B; Anti-Bacterial Agents; Antifungal Agents; Arthritis, Rheumatoid; Colitis, Ulcerative; Combined Modality Therapy; Drainage; Fatal Outcome; Gastrointestinal Diseases; Humans; Ileal Diseases; Intestinal Perforation; Intraoperative Complications; Jejunal Diseases; Liposomes; Male; Mucormycosis; Peritonitis; Postoperative Complications; Shock, Septic; Triazoles

Cardiac mucormycosis is an exceedingly rare condition. This case report describes mucormycosis endocarditis in an immunocompromised patient with ulcerative colitis. His condition was further complicated by multiple septic emboli to the lungs. His management included surgical excision of the right atrial endocarditic vegetation and antifungal treatment with high-dose liposomal amphotericin B.

Topics: Adult; Amphotericin B; Antifungal Agents; Colitis, Ulcerative; Combined Modality Therapy; Endocarditis; Enterococcus faecium; Humans; Immunocompromised Host; Lung Diseases, Fungal; Male; Mucor; Mucormycosis; Ultrasonography

Sensitivity of 50 Candida fungus strains isolated from patients with chronic intestine diseases was studied with respect to amphotericin B, levorin, enteroseptol, intestopan and decamethoxin. The rate of forming resistant variants of the strains with respect to decamethoxin and development of their cross resistance to levorin was estimated. It was shown that decamethoxin was the most active antifungal drug among the drugs tested. Estimation of sensitivity of the Candida strains to enteroseptol and intestopan revealed that the fungicidal concentration of enteroseptol for 78 per cent of the strains ranged within 3.9-7.8 micrograms/ml. It was demonstrated that development of resistance to decamethoxin in the strains of Candida albicans was slow and did not reach high levels. No cross resistance between decamethoxin and levorin was detected.

Topics: Amphotericin B; Antifungal Agents; Candicidin; Candida; Clioquinol; Colitis; Colitis, Ulcerative; Decamethonium Compounds; Drug Combinations; Drug Resistance, Microbial; Feces; Humans; Microbial Sensitivity Tests; Oxyquinoline; Quinaldines

Topics: Adenocarcinoma; Adult; Amphotericin B; Aspergillosis; Colectomy; Colitis, Ulcerative; Colonic Neoplasms; Humans; Lung Diseases, Fungal; Male; Postoperative Complications; Splenectomy

Topics: Amphotericin B; Animals; Anti-Bacterial Agents; Antitoxins; Cells, Cultured; Clostridium; Colitis, Ulcerative; Cricetinae; Cytotoxicity, Immunologic; Diarrhea; Enterocolitis, Pseudomembranous; Haplorhini; Humans; Infant, Newborn; Mice; Neomycin; Penicillins; Polymyxins; Rabbits; Streptomycin; Toxins, Biological

At the present time most authors do not believe, that allergic processes do play a role in the etiology of Crohn's disease or of ulcerative colitis. Data are presented however demonstrating a pathogenic role of mould fungus allergens in these diseases. Diagnostic and therapeutic implications of these results are discussed.

Topics: Adolescent; Adult; Amphotericin B; Child; Colitis, Ulcerative; Crohn Disease; Desensitization, Immunologic; Humans; Intestinal Mucosa; Middle Aged; Nystatin

Topics: Adult; Amphotericin B; Candidiasis; Colitis, Ulcerative; Cytosine; Female; Fluorescein Angiography; Fundus Oculi; Humans; Retinal Diseases

Topics: Administration, Oral; Amphotericin B; Antifungal Agents; Colitis, Ulcerative; Creatinine; Enteritis; Humans; Kidney Function Tests; Proteinuria

Topics: Amphotericin B; Anti-Bacterial Agents; Candidiasis; Colitis; Colitis, Ulcerative; Dermatologic Agents; Humans; Prednisolone; Vitamin K