amphotericin-b and Chorioretinitis

Topics: Amphotericin B; Animals; Chorioretinitis; Diagnosis, Differential; Eye Diseases; Fundus Oculi; Histoplasma; Histoplasmosis; Humans; Light Coagulation; Toxoplasmosis, Ocular

Topics: Amphotericin B; Animals; Birds; Chorioretinitis; Europe; Eye Diseases; Haplorhini; Histoplasma; Histoplasmin; Histoplasmosis; History of Medicine; Humans; Rabbits; Rats; United States

To determine the incidence of hematogenous candida endophthalmitis in seriously ill patients given parenteral hyperalimentation fluids, 131 hyperalimented postoperative patients were prospectively evaluated. All patients were screened weekly for the development of chorioretinal lesions, blood cultures positive for Candida albicans, and signs and symptoms of candida infection. Thirteen (9.9%) of 131 patients developed chorioretinal lesions compatible with hematogenous candida endophthalmitis. Seven of the 13 patients with eye lesions had blood cultures positive for yeast, whereas only two of 118 without eye lesions had blood cultures positive for yeast (P less than 0.0005). Thus, the occurrence of eye lesions consistent with hematogenous candida endophthalmitis correlated with positive blood cultures for yeast and strongly suggested invasive candidiasis.

Topics: Amphotericin B; Candidiasis; Candidiasis, Oral; Chorioretinitis; Culture Media; Endophthalmitis; Gastrointestinal Hemorrhage; Humans; Intertrigo; Parenteral Nutrition; Parenteral Nutrition, Total; Urinary Tract Infections; Wound Infection

Topics: Adrenocorticotropic Hormone; Adult; Amphotericin B; Chorioretinitis; Clinical Trials as Topic; Female; Glucocorticoids; Histoplasmosis; Humans; Injections, Intravenous; Kidney Diseases; Kidney Function Tests; Male; Sulfonamides; Vision Tests; Visual Perception

To describe the management of bilateral chorioretinitis with. A retrospective case report.. This is the first report of chorioretinitis with

Topics: Amphotericin B; Antifungal Agents; Child; Chorioretinitis; Humans; Male; Retrospective Studies; Voriconazole

Topics: Aged, 80 and over; Amphotericin B; Angiogenesis Inhibitors; Antifungal Agents; Bevacizumab; Candidiasis; Chorioretinitis; Choroidal Neovascularization; Coloring Agents; Drug Therapy, Combination; Eye Infections, Fungal; Fluorescein Angiography; Humans; Indocyanine Green; Intravitreal Injections; Male; Subretinal Fluid; Tomography, Optical Coherence; Vascular Endothelial Growth Factor A; Visual Acuity

To report on a case of Histoplasma capsulatum endogenous endophthalmitis in an immunocompetent patient.. A 30-year-old patient was admitted with floaters and vision impairment of 1 month's duration. He had a history of adrenal insufficiency, together with nasal, septum, and soft palate lesions of 3 months; duration. Culture results from specimens of these lesions were positive for H capsulatum. He was human immunodeficiency virus negative and there was no evidence of immunodepression or history of immunosuppression. Fundus examination revealed multiple fluffy balls with a string of pearls appearance, 2+ vitreous haze, multiple foci of retinochoroiditis inferiorly in the peripheral retina, and a 6-disk area lesion of retinochoroiditis at the superotemporal periphery. Due to poor response to oral itraconazole, a vitrectomy was performed with an intraocular injection of amphotericin B 5 μg/0.1 mL and removal for a vitreous specimen for culture of bacteria and fungi.. Vitreous specimen culture of the yeast at 28°C grew a white filamentous fungus colony, which was again cultured in a brain heart infusion agar medium, where it developed hyaline septate hyphae with microconidia and circular macroconidia with double wall, which was stained with a lactophenol dye at microscopic examination. The macroscopic morphology was consistent with H capsulatum.. Although endogenous H capsulatum endophthalmitis is a rare entity, it should be considered as a possible etiology even in apparently immunocompetent hosts, especially in patients with history of disseminated disease.

Topics: Adult; Amphotericin B; Antifungal Agents; Chorioretinitis; Combined Modality Therapy; Endophthalmitis; Eye Infections, Fungal; Histoplasma; Histoplasmosis; Humans; Immunocompetence; Immunocompromised Host; Injections, Intraocular; Male; Vitrectomy; Vitreous Body

Topics: Adult; Amphotericin B; Antifungal Agents; Candidiasis; Chorioretinitis; Eye Infections, Fungal; Fluconazole; Fluorescein Angiography; Humans; Male; Visual Acuity

Topics: Aged; Amphotericin B; Antifungal Agents; Chorioretinitis; DNA, Fungal; Drug Therapy, Combination; Drugs, Chinese Herbal; Eye Infections, Fungal; Female; Fluconazole; Fluorescein Angiography; Humans; Immunocompromised Host; Medicine, Chinese Traditional; Opportunistic Infections; Polymerase Chain Reaction; Prednisolone; Vitreous Body

Topics: Adult; AIDS-Related Opportunistic Infections; Amphotericin B; Antifungal Agents; Chorioretinitis; Cryptococcosis; Cryptococcus neoformans; Drug Resistance, Multiple, Fungal; Fluconazole; Flucytosine; Humans; Itraconazole; Meningitis, Cryptococcal; Pneumonia; Prednisolone; Pyrimidines; Triazoles; Voriconazole

We report a case of endogenous aspergillus endophthalmitis. This infection occurred in a young immunocompromised boy of 6 years old. The localisation of the chorioretinitis was unusual because out of the posterior area. The evolution was favorable with recovering of the visual acuity under general treatment and intravitreous injections.

Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Child; Chorioretinitis; Diagnosis, Differential; Endophthalmitis; Humans; Injections; Male; Opportunistic Infections; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vitreous Body

To describe ocular findings in 2 patients with disseminated coccidioidomycosis diagnosed by skin biopsy.. The clinical and histopathologic findings of the 2 patients were reviewed retrospectively.. One patient had a unilateral, granulomatous iridocyclitis with multiple iris nodules and a large vascularized anterior chamber mass, in the setting of pulmonary, cutaneous, and skeletal infection by Coccidioides immitis. The second patient developed papilledema and multifocal chorioretinitis accompanied by pulmonary, cutaneous, and meningeal C immitis infection. In each case, examination of the skin biopsy specimen revealed C immitis spherules. Treatments included local and systemic amphotericin B and oral fluconazole.. Although rare, intraocular involvement can occur in the setting of disseminated coccidioidomycosis. A thorough systemic evaluation and biopsy of suspicious skin lesions can aid in the diagnosis.

Topics: Adult; Amphotericin B; Biopsy; Bone Diseases; Brain Diseases; Chorioretinitis; Coccidioidomycosis; Dermatomycoses; Eye Infections, Fungal; Female; Fluconazole; Humans; Iridocyclitis; Lung Diseases, Fungal; Male; Radiography; Radionuclide Imaging; Retrospective Studies; Skin; Technetium Tc 99m Pyrophosphate

We report two cases of candidal chorioretinitis occurring to two friends who abused of intravenous crack using the same syringe . An endophthalmitis "a minima" due to a therapeutic delay arose in one patient, when a rare spontaneous healing happened to the second patient. In both cases, an epiretinal membrane is noted after the lesions scarred. Ocular candidal infection is a typical complication occurring to intravenous drug addicts. The visual prognosis depends not only on early diagnosis and treatment, but also on a strict follow-up because late complications are frequent in spite of the healing of initial lesions.

Topics: Adult; Amphotericin B; Antifungal Agents; Candidiasis; Chorioretinitis; Cocaine-Related Disorders; Crack Cocaine; Endophthalmitis; Epiretinal Membrane; Eye Infections, Fungal; Flucytosine; Humans; Male; Needle Sharing; Substance Abuse, Intravenous

Topics: Adult; Amphotericin B; Antifungal Agents; Candida albicans; Candidiasis; Chorioretinitis; Drug Therapy, Combination; Endophthalmitis; Eye Infections, Fungal; Female; Fluconazole; Fundus Oculi; Humans; Job Syndrome; Vitreous Body

To study the clinical histories and courses of six patients with choroidal neovascularization secondary to endogenous Candida albicans chorioretinitis.. The medical records, fundus photographs, and fluorescein angiograms of six patients who developed C. albicans chorioretinitis secondary to candidemia and who subsequently developed choroidal neovascularization in one or both eyes were reviewed.. The six patients ranged in age from 18 to 79 years. Four were women and two men; all but one showed evidence of bilateral chorioretinal scarring secondary to C. albicans chorioretinitis. All patients had been treated successfully with systemic antifungal therapy (amphotericin B). Two weeks to two years after the chorioretinitis, choroidal neovascularization developed in one eye (four cases) or both eyes (two cases). The neovascularization on initial examination was subfoveal in four eyes, extrafoveal in three eyes, and juxtafoveal in one eye. Laser photocoagulation was used in four of the eight involved eyes. In these cases, the active choroidal neovascularization was brought under control. In one eye, the patient had submacular surgery for excision of the choroidal neovascular membrane. Final visual acuities ranged from 20/20 to 20/200 in treated eyes and from 20/50 to 20/400 in untreated eyes.. Choroidal neovascularization is a potential cause of late visual loss in patients who have had C. albicans sepsis and endogenous C. albicans chorioretinitis. Eyes that have chorioretinal scarring from C. albicans chorioretinitis should be watched for the development of choroidal neovascularization. Laser photocoagulation or perhaps surgical excision of the neovascular complex may be of benefit in selected cases.

Topics: Adolescent; Adult; Aged; Amphotericin B; Antifungal Agents; Candida albicans; Candidiasis; Chorioretinitis; Choroid; Eye Infections, Fungal; Female; Fluorescein Angiography; Fundus Oculi; Fungemia; Humans; Laser Coagulation; Male; Middle Aged; Neovascularization, Pathologic; Visual Acuity

Candida endophthalmitis may occur either during systemic Candida infection (candidemia), particularly in immunocompromised hosts or as a single manifestation in drug abusers.. One case of endogenous candida endophthalmitis (ECE) in a patient with systemic candidiasis and four cases of drug abusers are presented. Well confined inflammatory lesions in retina and choroid were adequately treated with systemic Amphotericin B administration, whereas lesion extension beyond the internal limiting membrane towards the vitreous required surgical management, to remove epiretinal fibrovascular tissue, and intravitreal Amphotericin B injection.. In all cases, treatment resulted to regression of the lesions, however visual function recovery depends on location of chorioretinal lesions.

Topics: Adult; Amphotericin B; Candidiasis; Chorioretinitis; Combined Modality Therapy; Dose-Response Relationship, Drug; Endophthalmitis; Female; Humans; Injections, Intravenous; Male; Middle Aged; Opportunistic Infections; Vitrectomy

Topics: Amphotericin B; Candidiasis; Chorioretinitis; Eye Infections, Fungal; Humans; Retinal Detachment; Visual Acuity

Topics: Adult; Amphotericin B; Candidiasis; Chorioretinitis; Female; Humans; Remission Induction; Retina

Topics: Administration, Oral; Amphotericin B; Arthritis, Infectious; Candidiasis; Chorioretinitis; Humans; Imidazoles; Infant; Injections, Intra-Articular; Male; Miconazole; Osteomyelitis; Sepsis

We acknowledge that for most patients with istoplasmic chorioretinitis, the only treatment available is steroids. We agree with Schlaegel that steroids have to be used in adequate doses and for long periods of time. Alternate-day treatment should be instituted as soon as possible. Because it takes the adrenals 10 days to to weeks to be suppressed by sterid therapy, we treat our patients with daily doses for as short a time as possible and then witch over o alernate-day treatment. A short-acting steroid such as prednisone, prednisolone, or methylprednisolone should be used at the outset if long-term therapy is necessary and one anticipates using alternate-day therapy...

Topics: Adrenal Cortex Hormones; Amphotericin B; Chorioretinitis; Desensitization, Immunologic; Histoplasmin; Histoplasmosis; Humans; Light Coagulation; Xenon

Topics: Adolescent; Adult; Amphotericin B; Candidiasis; Catheterization; Chorioretinitis; Choroiditis; Female; Flucytosine; Humans; Macula Lutea; Male; Middle Aged; Ophthalmoscopy; Postoperative Complications; Retinitis; Sepsis

Topics: Adult; Amphotericin B; Australia; Chorioretinitis; Eye Diseases; Eye Manifestations; Hemorrhage; Histoplasmosis; Humans; Male; Prednisone; Retinal Vessels; Visual Acuity

Topics: Actinomycosis; Amphotericin B; Animals; Antifungal Agents; Atropine; Chorioretinitis; Conjunctivitis; Eye Diseases; Hot Temperature; Humans; Laser Therapy; Light Coagulation; Mycoses; Natamycin; Nocardia Infections; Nystatin; Penicillins; Rabbits; Sporotrichosis; Streptomycin; Sulfacetamide; Sulfadiazine; Vitreous Body

Topics: Adult; Amphotericin B; Chorioretinitis; Female; Histoplasmosis; Humans; Male; Middle Aged; Uveitis

Case reports of three residents of Ontario with clinical histoplasmic chorioretinitis are presented. The diagnosis was made on the basis of the clinical appearance, the presence of calcified lesions in the chest, a negative skin test to tuberculin, and a positive skin test to toxoplasmin. All patients were treated with intravenous amphotericin B. Except for transitory elevation of blood urea nitrogen, there were no serious complications from the drug and in all cases the lesions in the eyes were improved. Histologic or cultural proof of the presence of fungus in the eye is not available, but clinical and laboratory findings can combine to point to the diagnosis of histoplasmosis. In such cases, since vision is at stake, treatment with amphotericin B should be considered.

Topics: Amphotericin B; Blood Chemical Analysis; Blood Urea Nitrogen; Canada; Chorioretinitis; Histoplasmin; Histoplasmosis; Humans; Hydrocortisone; Kidney Diseases; Leukocyte Count; Nitrogen; Ontario; Prednisone; Toxicology; Tuberculin Test; Urea

Topics: Amphotericin B; Chorioretinitis; Diagnosis; Drug Therapy; Eye Diseases; Histoplasmosis; Humans

Topics: Amphotericin B; Antifungal Agents; Chorioretinitis; Histoplasmosis; Retinitis; Uveitis