amphotericin-b has been researched along with Carcinoma-256--Walker* in 3 studies
3 other study(ies) available for amphotericin-b and Carcinoma-256--Walker
| Article | Year |
|---|---|
Synthesis of (1,4)-naphthoquinono-[3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives as antifungal, antibacterial, and anticancer agents.
A series of (1,4)-naphthoquinono [3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives 2-7 were synthesized and evaluated for antifungal, antibacterial, and anticancer activities. The structure-activity relationship of these compounds was studied and the results show that the compound 2b exhibited in vitro antifungal activity against Candida albicans and Cryptococcus neoformans, and also possessed antibacterial profile against Klebsiella pneumoniae and Escherichia coli whereas 1c showed anticancer activity against Walker 256 Carcinosarcoma in rats. Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Agents; Candida albicans; Carcinoma 256, Walker; Cryptococcus neoformans; Escherichia coli; Klebsiella pneumoniae; Microbial Sensitivity Tests; Naphthoquinones; Pyrazoles; Rats; Structure-Activity Relationship | 2005 |
Design, synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antifungal and anticancer agents.
A series of 1,4-naphthoquinone derivatives were synthesized and tested for antifungal and antitumor activity against a number of fungal disease causative species and Walker 256 carcinoma cell lines. The results show that the compounds 8a,e and 11b possess pronounced antifungal profile where as 7b and f were found to be active against Walker 256 carcinoma cell lines. Moreover 7c and 11a showed inhibitory effect against reverse transcriptase enzyme from Rauscher Murine Leukemia Virus. Topics: Animals; Antifungal Agents; Antineoplastic Agents; Carcinoma 256, Walker; Drug Design; Drug Evaluation, Preclinical; Microbial Sensitivity Tests; Naphthoquinones | 2004 |
[Effect of amphotericin B on the diuretic action of diacarb and various indicators of water-salt metabolism in healthy and tumor-bearing animals].
The experiments with albino rats, Wistar rats and SHK mice showed that the combined use of amphotericin B and diacarb markedly potentiated the effect of the latter: the amount of the urine excreted within 6 h and the renal excretion of sodium ions increased 1.8 and 1.5 times, respectively. Analogous trends were observed in the experiments with stabilization of the animal water balance by 2 per cent water loading. The studies on rats with Pliss lymphosarcoma showed that the diuresis level in the tumor-bearing animals was 3 times lower than that in healthy rats. The treatment with 5-fluorouracil lowered this index more significantly. With the use of amphotericin B, diacarb and their combination the urination level came to normal. The cyclophosphamide therapy of mice with sarcoma 180 was accompanied by accumulation of water in the tumor tissue. The combined use of the cytostatic with the polyenic antibiotic and diuretic resulted in a significant lowering of this index. In rats with Walker-256 carcinosarcoma, the treatment with the above three drugs lowered the sodium ion concentration and increased the calcium ion concentration in the tumor tissue. At the same time the electrolyte level in some organs not affected with malignant tumor (spleen, thymus, liver and adrenal glands) returned to normal. Topics: Acetazolamide; Amphotericin B; Animals; Carcinoma 256, Walker; Diuresis; Diuretics; Drug Synergism; Female; Lymphoma, Non-Hodgkin; Male; Mice; Potassium; Rats; Rats, Inbred Strains; Sarcoma, Experimental; Sodium; Water-Electrolyte Balance | 1984 |