amphotericin-b and Calcinosis

A 4-year-old spayed female mixed breed dog was referred to the Michigan State University, Veterinary Teaching Hospital (MSU-VTH) with vomiting, lethargy and anorexia of 2 weeks duration. Abdominal radiographs and ultrasonography showed hepatosplenomegaly. Cytological evaluation of ultrasound-guided fine needle aspirates of the liver and spleen revealed fungal organisms and pyogranulomatous inflammation; fungal culture documented Paecilomyces variotii infection. The dog received antifungal therapy and supportive care. Multiple firm plaque-like skin lesions, predominantly involving the inguinal region, developed 18 days after initial presentation and were diagnosed histopathologically as calcinosis cutis. While generalized calcinosis cutis has been reported in three dogs with blastomycosis and one dog with leptospirosis, the association with disseminated Paecilomyces spp. infection is novel.

Topics: Amphotericin B; Animals; Antifungal Agents; Calcinosis; Dog Diseases; Dogs; Female; Mycoses; Paecilomyces; Skin Diseases

Topics: Adult; Amphotericin B; Antifungal Agents; Calcinosis; Fluconazole; Hearing Loss; Humans; Hydrocephalus; Magnetic Resonance Imaging; Male; Meningitis, Cryptococcal; Pulvinar; Tomography, X-Ray Computed

Invasion of the major airways is a rare manifestation of respiratory tract involvement by Aspergillus sp. and is seen almost exclusively in immunocompromised patients. We present calcification as a new feature of this condition and its demonstration by ultrasound in a 15-year-old boy with severe neutropenia secondary to aplastic anaemia.

Topics: Adolescent; Amphotericin B; Anemia, Aplastic; Antifungal Agents; Aspergillosis; Calcinosis; Humans; Immunocompromised Host; Male; Neutropenia; Trachea; Tracheal Diseases; Ultrasonography

In an 11-year-old immunocompetent girl with protracted cryptococcal infection of the central nervous system, CT showed multiple areas of parenchymal calcification. MR imaging showed large gelatinous pseudocysts around the brain stem. These imaging features and the child's age are unusual for intracranial cryptococcosis.

Topics: Amphotericin B; Antifungal Agents; Brain; Brain Stem; Calcinosis; Child; Combined Modality Therapy; Craniotomy; Cysts; Diagnosis, Differential; Female; Humans; Magnetic Resonance Imaging; Meninges; Meningitis, Cryptococcal; Tomography, X-Ray Computed

Sixteen patients with pericarditis caused by Histoplasma capsulatum were studied. Fourteen were less than 30 years old, and no patient had an underlying illness or was receiving immunosuppressive therapy. All patients experienced a flu-like prodromal illness lasting from 2 weeks to 4 months. Pneumonitis or hilar adenopathy, or both, was found in 12; pleural effusion, uncommon in primary pulmonary histoplasmosis, was found in seven patients. Pericardial fluid, pleural fluid and bone marrow cultures yielded no growth. All patients demonstrated a fourfold or greater change in complement-fixing antibody titers. No patient had disseminated disease, and only one required treatment with ampholericin B. The illness ran a protracted course, and in six patients symptomatic pericarditis recurred. Ultimately all recovered. Ten patients were restudied 6 months to 12 years after recover. Only one patient had pericardial calcification, and none had constrictive pericarditis. This form of granulomatous pericarditis, unlike that caused by Mycobacterium tuberculosis, appears to carry a good prognosis.

Topics: Adolescent; Adult; Amphotericin B; Calcinosis; Diagnosis, Differential; Female; Follow-Up Studies; Histoplasmosis; Humans; Male; Middle Aged; Pericarditis; Prognosis

Topics: Adolescent; Amphotericin B; Calcinosis; Child; Female; Histoplasmosis; Humans; Pericarditis, Constrictive; Radiography

Topics: Amphotericin B; Calcinosis; Candidiasis; Child; Female; Humans; Kidney; Skull; Urography

Topics: Amphotericin B; Calcinosis; Calcium; Dogs; Kidney Diseases; Kidney Tubules; Research; Toxicology