amphotericin-b and Bronchial-Fistula

Topics: Administration, Inhalation; Amphotericin B; Antifungal Agents; Aspergillus fumigatus; Bronchial Fistula; Empyema; Humans; Male; Middle Aged; Pleural Diseases; Pulmonary Aspergillosis

We report a case of bronchopleural fistula in a patient with allergic bronchopulmonary aspergillosis. A 25-year-old man was admitted with high fever and chest pain. Although his chest CT in a previous hospital showed pulmonary infiltrate suggesting the existence of a mucous plug, a mass shadow in the right upper lobe was recognized on admission to our hospital. Based on the presence of eosinophilia, elevated levels of total IgE and Aspergillus-specific IgE, positive precipitating antibody to Aspergillus, and detection of A. fumigatus in bronchial washing fluid, we diagnosed this case as ABPA complicated with lung abscess. Although we treated by antibiotics and antifungal drugs, the lung abscess did not improve and led to bronchopleural fistula. After addition of nebulised liposomal amphotericin B, his symptoms improved and treatment was successful.

Topics: Administration, Inhalation; Adult; Amphotericin B; Antifungal Agents; Aspergillosis, Allergic Bronchopulmonary; Bronchial Fistula; Fistula; Humans; Liposomes; Lung Abscess; Male; Pleural Diseases; Treatment Outcome

Ulcerative tracheobronchial aspergillosis after lung transplantation (ltx) may lead to bronchial-pulmonary artery fistula that results in fatal bleeding. We report our early experience with combined systemic, aerolized and topical application of amphotericin B in 3 cases of bronchial aspergillosis after ltx. Two patients are still alive, but 1 died of bleeding from a fistula between the left upper lobe bronchus and the pulmonary artery. Aspergillosis in the second patient resolved with minimal stenosis of the left main and the left upper lobe bronchus, and the third patient developed an anastomotic stenosis that was successfully dilated.

Topics: Administration, Inhalation; Administration, Topical; Adult; Aerosols; Amphotericin B; Anastomosis, Surgical; Antifungal Agents; Aspergillosis; Bronchi; Bronchial Diseases; Bronchial Fistula; Constriction, Pathologic; Fatal Outcome; Female; Hemorrhage; Humans; Lung Diseases, Fungal; Lung Transplantation; Male; Middle Aged; Pulmonary Artery; Vascular Fistula

Topics: Adolescent; Amphotericin B; Aspergillosis; Bronchial Fistula; Fistula; Humans; Lung Diseases, Fungal; Male; Pericardium; Pneumopericardium; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiography

Topics: Amphotericin B; Antitubercular Agents; Aspergillosis; Aspergillus flavus; Aspergillus fumigatus; Bronchial Fistula; Empyema; Empyema, Tuberculous; Fistula; Humans; Male; Middle Aged; Pleural Diseases; Radionuclide Imaging; Xenon Radioisotopes

We report the successful treatment of a patient with a bronchopleural fistual and pleural aspergilloma. Treatment consisted of intrapleural instillation of amphotericin B and nystatin followed by creation of an Eloesser flap.

Topics: Amphotericin B; Aspergillosis; Bronchial Fistula; Drainage; Female; Fistula; Humans; Middle Aged; Nystatin; Pleural Diseases; Radiography

Topics: Amphotericin B; Bronchial Fistula; Fistula; Histoplasma; Histoplasmosis; Humans; Male; Middle Aged; Pleural Diseases; Skin Diseases

Topics: Adult; Amphotericin B; Aspergillosis; Bronchial Fistula; Empyema; Humans; Lung Diseases, Fungal; Male; Precipitin Tests; Prednisone; Radioimmunoassay; Skin Tests

Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Bronchial Diseases; Bronchial Fistula; Drug Therapy; Fistula; Humans; Lung Diseases, Fungal; Pleura; Pneumonectomy; Pulmonary Aspergillosis; Radiography, Thoracic; Tuberculosis, Pulmonary