amphotericin-b and Bronchial-Diseases

Tracheobronchial mucormycosis is a rare and invasive pulmonary mucormycosis involving the tracheobronchial tree.. At a 3500-bed tertiary care center.. This was a retroactive study of 12 cases of tracheobronchial mucormycosis diagnosed in our hospital, and 48 cases that were previously reported in the English literature.. Rhizopus was the predominant species of pathogen (66.7%). Primary bronchus was the most frequently involved location (38.2%), and upper lobes (51% of cases) were a predilection. Obstructive necrosis and mucosal necrosis were the most common pathological forms (40% and 34.5%, respectively). Fever (59.3%), cough (59.3%), dyspnea (40.7%) and hemoptysis (30.5%) were the most common symptoms. 51.4% patients had rales, 40% had moist rales and 28.6% had negative physical findings. Ninety-five percent patients had immunosuppressive diseases. Diabetes mellitus (66.7%), diabetes ketoacidosis (21.7%), corticosteroid therapy (20%) and kidney insufficiency (18.3%) were the most common predisposing factors. 13.2% had neutropenia which was mostly among the non-diabetic patients (P = .006). Endobronchial lesion of 23.2% had imaging reports with 33.9% exhibiting single mass. Pathological diagnosis of 76.7% used the transbronchial biopsy. The most frequent antifungal therapies were intravenous amphotericin B (79.7%), surgery (33.3%) and surgery combined with amphotericin B therapy (28.3%). Overall in-hospital mortality was 52.5%, with hemoptysis (P = .017), dyspnea at presentation (P = .022) and angioinvasion (P = .03) as independent risk prognostic factors. In contrast, surgery (P = .003) was an independent protection prognostic factor.. Tracheobronchial mucormycosis is a rare but severe disease with high mortality because of its nonspecific clinical presentations and variable predisposing factors.

Topics: Amphotericin B; Antifungal Agents; Bronchial Diseases; Bronchoscopy; Female; Humans; Lung; Male; Middle Aged; Mucorales; Mucormycosis; Tomography, X-Ray Computed; Tracheal Diseases

This case report describes a patient with acute myelocytic leukaemia, who developed a necrotizing bronchial aspergillosis. This is an uncommon, new form of invasive aspergillosis, which is mainly seen in the heart-lung transplantation setting and has only been reported once in another patient with leukaemia. Neither amphotericin B nor liposomal amphotericin (AmBisome) was effective. Only after the immune system had recovered did the infection disappear.

Topics: Amphotericin B; Aspergillosis; Bronchial Diseases; Bronchoscopy; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Necrosis; Radiography

Lung mucormycosis is a rare fungal infection that has been described mainly in oncologic and diabetic patients. We here report the case of an endobronchial lesion caused by this fungus in an immunocompetent person. Prompt diagnosis, and therapy with Amphotericin B and surgery, permitted the complete resolution.

Topics: Aged; Amphotericin B; Antifungal Agents; Biopsy; Bronchial Diseases; Bronchoscopy; Combined Modality Therapy; Diabetes Mellitus, Type 2; Diagnosis, Differential; Humans; Immunocompromised Host; Male; Mucormycosis; Pneumonectomy; Pulmonary Atelectasis; Tomography, X-Ray Computed

Ulcerative tracheobronchial aspergillosis after lung transplantation (ltx) may lead to bronchial-pulmonary artery fistula that results in fatal bleeding. We report our early experience with combined systemic, aerolized and topical application of amphotericin B in 3 cases of bronchial aspergillosis after ltx. Two patients are still alive, but 1 died of bleeding from a fistula between the left upper lobe bronchus and the pulmonary artery. Aspergillosis in the second patient resolved with minimal stenosis of the left main and the left upper lobe bronchus, and the third patient developed an anastomotic stenosis that was successfully dilated.

Topics: Administration, Inhalation; Administration, Topical; Adult; Aerosols; Amphotericin B; Anastomosis, Surgical; Antifungal Agents; Aspergillosis; Bronchi; Bronchial Diseases; Bronchial Fistula; Constriction, Pathologic; Fatal Outcome; Female; Hemorrhage; Humans; Lung Diseases, Fungal; Lung Transplantation; Male; Middle Aged; Pulmonary Artery; Vascular Fistula

This is the first report of bronchocentric granulomatosis due to Aspergillus terreus in a healthy and non-asthmatic 74-year-old Japanese woman. Following identification of the fungus, oral itraconazole therapy was begun after intrabronchial infusion of amphotericin B. No recurrence has occurred after treatment for 24 months. We should consider the possibility of bronchocentric granulomatosis including Aspergillus terreus, when an intrabronchial lesion is found even in a healthy and non-asthmatic person. Oral itraconazole after intrabronchial infusion of amphotericin B seems to be effective in such cases.

Topics: Aged; Amphotericin B; Antifungal Agents; Aspergillosis; Bronchial Diseases; Female; Granuloma, Respiratory Tract; Humans; Immunocompetence; Tomography, X-Ray Computed

We report the case of a 43 year old male patient, with normal immune function, who presented with right middle and lower lobe collapse. At bronchoscopy, a white lobulated lesion was seen, completely obstructing the origin of bronchus intermedius. Bronchial washings and biopsy of the lesion demonstrated cryptococcal organisms. The patient responded clinically and radiologically to amphotericin B and flucytosine; however, repeat bronchoscopy revealed only partial resolution of the endobronchial lesion.

Topics: Adult; Amphotericin B; Antifungal Agents; Bronchial Diseases; Bronchoscopy; Cryptococcosis; Flucytosine; Humans; Lung Diseases, Obstructive; Male; Radiography

The case of a 70-year-old male with lymphoblastic leukemia is reviewed, who presented the rare and almost always fatal complication of pulmonary mucormycosis, but who was treated satisfactorily with amphotericin B and surgery. The risk of massive hemoptysis in the course of mucormycosis that invades the lung vessels, makes us believe that surgery is an essential part of the management of this disease. It is suggested that the patient be operated as soon as the diagnosis is obtained, as we did in our case, to avoid other risks in combined management with amphotericin B.

Topics: Aged; Amphotericin B; Bronchial Diseases; Combined Modality Therapy; Humans; Immunocompromised Host; Lung; Lung Diseases, Fungal; Male; Mucormycosis

Topics: Amphotericin B; Bronchial Diseases; Candidiasis; Humans

When clinically apparent, coccidioidomycosis usually presents either as an interstitial pulmonary infiltrate or, later in its course, a parenchymal nodule often with cavitation. The present report concerns a young adult woman whose presentation was one of shortness of breath with wheezing and stridor, secondary to a localized endobronchial coccidiodal granuloma producing nearly complete obstruction of the right mainstem bronchus. Such a presentation has not been reported previously in an adult. The possible association of serious fungal disease with previous jejunoileal bypass surgery is discussed.

Topics: Adult; Airway Obstruction; Amphotericin B; Biopsy; Bronchial Diseases; Bronchoscopy; Coccidioidomycosis; Female; Humans; Tomography, X-Ray

Topics: Aerosols; Amphotericin B; Bronchial Diseases; Candidiasis; Humans; Lung Diseases, Fungal; Nystatin; Physical Education and Training

Topics: Aged; Amphotericin B; Bronchial Diseases; Colistin; Flucytosine; Geotrichosis; Humans; Lung Diseases, Fungal; Male; Microbial Sensitivity Tests; Middle Aged; Mitosporic Fungi; Mycoses; Neomycin; Potassium Iodide; Sulfadiazine

Topics: Adolescent; Adult; Aged; Amphotericin B; Antifungal Agents; Aspergillosis; Bronchial Diseases; Child; Female; Humans; Lung Diseases, Fungal; Male; Middle Aged; Nystatin

Topics: Adult; Aged; Amphotericin B; Antibodies; Aspergillosis; Aspergillus; Bronchial Diseases; Cromolyn Sodium; Female; Histamine Release; Humans; Immunoglobulin E; Lung Diseases, Fungal; Male; Middle Aged; Natamycin; Precipitin Tests; Respiratory Hypersensitivity; Skin Tests; Sputum

Topics: Amphotericin B; Anti-Bacterial Agents; Antifungal Agents; Bronchial Diseases; Candida; Candidiasis; Humans; Lung Diseases, Fungal

Topics: Amphotericin B; Animals; Antibodies; Aspergillosis; Aspergillus; Bronchial Diseases; Chemical Precipitation; Child; Eosinophilia; Female; Guinea Pigs; Haplorhini; Humans; Immunity, Maternally-Acquired; Immunodiffusion; Lung Diseases, Fungal; Prednisone; Radiography, Thoracic; Respiratory Hypersensitivity; Skin Tests; Sputum

Topics: Aerosols; Amphotericin B; Animals; Antibodies; Aspergillosis; Aspergillus; Bronchial Diseases; Child; Female; Haplorhini; Humans; Immunization, Passive; Immunodiffusion; Immunoglobulin G; Injections, Intravenous; Lung Diseases, Fungal; Prednisone

Topics: Adult; Amphotericin B; Aspergillosis; Bronchial Diseases; Humans; Male

Topics: Adult; Amphotericin B; Aspergillosis; Aspergillus; Bronchial Diseases; Humans; Iodine; Lung Diseases; Lung Diseases, Fungal; Male; Precipitin Tests; Prednisone; Respiratory Hypersensitivity; Skin Tests; Sodium; United States

Topics: Aerosols; Amphotericin B; Asthma; Bronchial Diseases; Bronchodilator Agents; Cystic Fibrosis; Eosinophilia; Isotonic Solutions; Lung Diseases; Mucus; Polymyxins; Radiography; Sodium Chloride; Spirometry; Sputum; Ultrasonics; Ventilators, Mechanical

Topics: Adult; Amphotericin B; Blastomyces; Blastomycosis; Bone Diseases; Bronchial Diseases; Fluorescent Antibody Technique; France; Humans; Immunodiffusion; Kidney Diseases; Lung Diseases; Male; Tunisia

Topics: Amphotericin B; Ampicillin; Anti-Bacterial Agents; Bronchial Diseases; Humans; Influenza, Human; Kanamycin; Lung Diseases; Methicillin; Novobiocin; Oleandomycin; Tetracycline

Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Bronchial Diseases; Bronchial Fistula; Drug Therapy; Fistula; Humans; Lung Diseases, Fungal; Pleura; Pneumonectomy; Pulmonary Aspergillosis; Radiography, Thoracic; Tuberculosis, Pulmonary