amphotericin-b and Brain-Injuries

Mucormycosis are opportunist infections occurring usually among predisposed patients. We report a case of an 18-year-old male with a severe thoracic trauma who developed an Absidia infection on his contused pulmonary parenchyma, without presenting the usual risk factors (diabetes mellitus, immunodeficiency). The early diagnosis using bronchoscopy has probably improved the outcome by allowing a faster treatment. After 18-months, the infectious process resolved thanks to a combination of a medical treatment composed of high-dose amphotericin B lipid formulation, itraconazole and a complementary surgical treatment.

Topics: Absidia; Adolescent; Amphotericin B; Antifungal Agents; Bicycling; Brain Damage, Chronic; Brain Injuries; Brain Stem; Cerebral Hemorrhage; Combined Modality Therapy; Drug Therapy, Combination; Humans; Itraconazole; Lung Abscess; Lung Diseases, Fungal; Male; Mucormycosis; Multiple Trauma; Pneumonectomy; Thoracic Injuries; Vancomycin

Topics: Accidents, Traffic; Amphotericin B; Antibodies, Fungal; Blood; Brain Injuries; Candida albicans; Candidiasis; Child; Flucytosine; Humans; Male; Miconazole; Prednisolone

A previously healthy youth who had sustained severe head trauma and had received steroids and broad-spectrum antimicrobial agents developed a cranial zygomycotic infection with Saksenaea vasiformis. This is the first time this zygomycete has been implicated as a disease agent. Early identification of the fungal infection and subsequent vigorous medical and surgical therapy led to recovery.

Topics: Adult; Amphotericin B; Brain Diseases; Brain Injuries; Fungi; Humans; Male; Mycoses