amphotericin-b and Alcoholism

Sporotrichosis is an implantation mycosis highly prevalent in Brazil, associated with soil activities and contact with infected animals. It has numerous clinical manifestations and its disseminated cutaneous form is uncommon, found in approximately 4% of cases and usually related to immunosuppressive conditions. We report an alcoholic 56-year-old male patient with no other comorbidities, presenting with multiple cutaneous nodules and ulcers. The patient was diagnosed with disseminated cutaneous sporotrichosis based on the isolation and identification of Sporothrix spp. The patient was initially treated with amphotericin B with satisfactory results and then with itraconazole.

Topics: Alcoholism; Amphotericin B; Animals; Antifungal Agents; Brazil; Humans; Itraconazole; Male; Middle Aged; Sporothrix; Sporotrichosis; Treatment Outcome; Ulcer

Topics: Alcoholism; Amphotericin B; Antifungal Agents; Candida; Candidiasis; Cross Infection; Fatal Outcome; Fluconazole; Humans; Infection Control; Intubation, Intratracheal; Male; Maxillary Sinusitis; Middle Aged; Respiratory Distress Syndrome; Risk Factors; Serotyping

A 34-year-old alcoholic and drug addict developed cavitary pulmonary sporotrichosis that progressed slowly during 6 years. Pulmonary resection and pre- and postoperative therapy with amphotericin B were associated with prompt clinical improvement with no evidence of relapse during a 2-year follow-up. Histologic examination of lung revealed granulomatous inflammation with organisms consistent with Sporothrix schenckii, and interstitial talc (magnesium silicate) granulomas. The latter finding was consistent with the history of intravenous drug abuse. Although the presence of silicates in lung enhances the pathogenicity of some microorganisms, the relation of these findings to the pathogenesis of sporotrichosis in our patient is unclear.

Topics: Adult; Alcoholism; Amphotericin B; Humans; Lung; Lung Diseases, Fungal; Male; Sporotrichosis; Substance-Related Disorders

The first case of Allescheria (Petriellidium) boydii sinusitis is reported. The organism was isolated from the maxillary sinus in an elderly, diabetic, chronic alcoholic man on maintenance hemodialysis who developed a syndrome resembling mucormycosis. Infections with A. boydii are infrequent and are most commonly limited to Madura foot. In addition, several cases of pulmonary and central nervous system involvement have been described. There is no established therapy for A. boydii, since the published data on antimicrobial sensitivity are limited. Our organism was inhibited by 1.25 mg of amphotericin B per ml and 0.15 mg of miconazide per ml.

Topics: Alcoholism; Amphotericin B; Ascomycota; Diabetes Complications; Humans; Male; Maxillary Sinus; Miconazole; Middle Aged; Mycoses; Sinusitis

Topics: Alcoholism; Amphotericin B; Candida albicans; Candidiasis; Female; Hepatic Encephalopathy; Humans; Middle Aged; Pseudomonas Infections; Sepsis