amphoglucamine and Candidiasis

It was shown that combined use of the polyene antibiotic amphoglucamine (AMG) and 5-fluorocytosine (5-FC), rifampicin, or methacycline was much more efficient in therapy of experimental generalized candidiasis. Combination of AMG with 5-FC or rifampicin proved to be the most favourable. The use of these combinations resulted in a 7-8-fold increase in the average lifespan of experimental animals, markedly increased their survival and lowered contamination of the internal organs with the fungus. Combination of AMG with 5-FC resulted in complete healing of experimental mice by the end of the treatment. Summation of the antifungal action of the drugs provided the required effect with the polyene dose 2 times lower than the therapeutic one.

Topics: Amphotericin B; Animals; Candidiasis; Drug Evaluation, Preclinical; Drug Therapy, Combination; Flucytosine; Methacycline; Mice; Rifampin

The efficacy of amphoglucamine was tested on male and female albino mice infected intravenously with Candida albicans and treated with testosterone and folliculin in doses of 1 mg and 10 units per mouse respectively. It was shown that 0.25 per cent of the experimental mice treated with testosterone alone survived, while the use of amphoglucamine alone in a dose of 1 mg/kg per os provided the survival of 0.5 per cent of the animals. With the use of the both drugs in combination almost all animals survived. Combined treatment with amphoglucamine and folliculin was not effective: isolation of Candida from all organs persisted, the spleen index changed insignificantly. Under the effect of testosterone the level of the spleen contamination was lower as compared to the control. The use of testosterone for a definite period of time promoted elimination of Candida from the internal organs. No significant difference in the titers of the complement-binding antibodies in the group of the mice treated with both the drugs was observed. It is suggested that the effect of the sex hormones on the fungus infection is associated with changing of the cell protective mechanisms.

Topics: Amphotericin B; Animals; Antifungal Agents; Candidiasis; Drug Evaluation, Preclinical; Drug Therapy, Combination; Estrone; Female; Male; Mice; Testosterone; Time Factors

Topics: Adult; Aged; Amphotericin B; Candidiasis; Drug Resistance, Microbial; Female; Glucosamine; Humans; Intestinal Diseases; Male; Middle Aged