amphidinolide-h and Leukemia

amphidinolide-h has been researched along with Leukemia* in 1 studies

Other Studies

1 other study(ies) available for amphidinolide-h and Leukemia

Article	Year
Amphidinolides H2-H5, G2, and G3, new cytotoxic 26- and 27-membered macrolides from dinoflagellate Amphidinium sp. The Journal of organic chemistry, 2002, Sep-20, Volume: 67, Issue:19 Six new macrolides, amphidinolides H2 (5), H3 (6), H4 (7), H5 (8), G2 (9), and G3 (10), have been isolated from a marine dinoflagellate Amphidinium sp. (strain Y-42). Cytotoxicity of five derivatives (11-15) of amphidinolide H (1) in addition to 10 amphidinolides (1-10) containing amphidinolides H (1), G (2), B (3), and D (4) was examined, and it was found that the presence of an allyl epoxide, an S-cis-diene moiety, and the ketone at C-20 was important for the cytotoxicity of amphidinolide H (1)-type macrolides. Topics: Animals; Cell Survival; Dinoflagellida; Drug Screening Assays, Antitumor; Humans; Japan; KB Cells; Leukemia; Macrolides; Marine Toxins; Mice; Molecular Conformation; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured	2002

Article

Year

Amphidinolides H2-H5, G2, and G3, new cytotoxic 26- and 27-membered macrolides from dinoflagellate Amphidinium sp.

The Journal of organic chemistry, 2002, Sep-20, Volume: 67, Issue:19

Six new macrolides, amphidinolides H2 (5), H3 (6), H4 (7), H5 (8), G2 (9), and G3 (10), have been isolated from a marine dinoflagellate Amphidinium sp. (strain Y-42). Cytotoxicity of five derivatives (11-15) of amphidinolide H (1) in addition to 10 amphidinolides (1-10) containing amphidinolides H (1), G (2), B (3), and D (4) was examined, and it was found that the presence of an allyl epoxide, an S-cis-diene moiety, and the ketone at C-20 was important for the cytotoxicity of amphidinolide H (1)-type macrolides.

Topics: Animals; Cell Survival; Dinoflagellida; Drug Screening Assays, Antitumor; Humans; Japan; KB Cells; Leukemia; Macrolides; Marine Toxins; Mice; Molecular Conformation; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured

2002