Page last updated: 2024-10-25

amphetamine and Neuroblastoma

amphetamine has been researched along with Neuroblastoma in 9 studies

Amphetamine: A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.
1-phenylpropan-2-amine : A primary amine that is isopropylamine in which a hydrogen attached to one of the methyl groups has been replaced by a phenyl group.
amphetamine : A racemate comprising equimolar amounts of (R)-amphetamine (also known as levamphetamine or levoamphetamine) and (S)-amphetamine (also known as dexamfetamine or dextroamphetamine.

Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)

Research Excerpts

ExcerptRelevanceReference
" The aim of the present study was to examine the effects of drugs (amphetamine, methylphenidate and atomoxetine) used in the treatment of attention deficit-hyperactivity disorder on the expression of this enzyme via reverse transcriptase-polymerase chain reaction in human neuroblastoma SH-SY5Y and human monocytic U-937 cells at concentrations of 50, 500 and 5,000 ng/ml."3.76Impact of psychostimulants and atomoxetine on the expression of 8-hydroxyguanine glycosylase 1 in human cells. ( Clement, HW; Gebhardt, S; Heiser, P; Hemmeter, UM; Kircher, T; Krieg, JC; Schmidt, AJ; Schulz, E, 2010)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19901 (11.11)18.7374
1990's0 (0.00)18.2507
2000's3 (33.33)29.6817
2010's4 (44.44)24.3611
2020's1 (11.11)2.80

Authors

AuthorsStudies
Zhou, X1
Bouitbir, J1
Liechti, ME1
Krähenbühl, S1
Mancuso, RV1
Xilouri, M1
Brekk, OR1
Landeck, N1
Pitychoutis, PM1
Papasilekas, T1
Papadopoulou-Daifoti, Z1
Kirik, D1
Stefanis, L1
Hao, F1
Yang, C1
Chen, SS1
Wang, YY1
Zhou, W1
Hao, Q1
Lu, T1
Hoffer, B1
Zhao, LR1
Duan, WM1
Xu, QY1
Schmidt, AJ2
Krieg, JC2
Clement, HW2
Gebhardt, S2
Schulz, E2
Heiser, P2
Hemmeter, UM1
Kircher, T1
Mazei-Robison, MS1
Blakely, RD1
Kääriäinen, TM1
Piltonen, M1
Ossola, B1
Kekki, H1
Lehtonen, S1
Nenonen, T1
Lecklin, A1
Raasmaja, A1
Männistö, PT1
Klongpanichapak, S1
Phansuwan-Pujito, P1
Ebadi, M1
Govitrapong, P1
Zwiller, J1
Treska-Ciesielski, J1
Mack, G1
Mandel, P1

Other Studies

9 other studies available for amphetamine and Neuroblastoma

ArticleYear
    International journal of molecular sciences, 2020, Apr-18, Volume: 21, Issue:8

    Topics: Adenosine Triphosphate; Amphetamine; Amphetamines; Apoptosis; Cell Differentiation; Cell Line, Tumor

2020
Boosting chaperone-mediated autophagy in vivo mitigates α-synuclein-induced neurodegeneration.
    Brain : a journal of neurology, 2013, Volume: 136, Issue:Pt 7

    Topics: alpha-Synuclein; Amphetamine; Analysis of Variance; Animals; Apomorphine; Autophagy; Cells, Cultured

2013
Long-term protective effects of AAV9-mesencephalic astrocyte-derived neurotrophic factor gene transfer in parkinsonian rats.
    Experimental neurology, 2017, Volume: 291

    Topics: Adenoviridae; Adrenergic Agents; Amphetamine; Animals; Cells, Cultured; Disease Models, Animal; Dopa

2017
Impact of drugs approved for treating ADHD on the cell survival and energy metabolism: an in-vitro study in human neuronal and immune cells.
    Journal of psychopharmacology (Oxford, England), 2010, Volume: 24, Issue:12

    Topics: Adenosine Triphosphate; Adrenergic Uptake Inhibitors; Amphetamine; Atomoxetine Hydrochloride; Cell L

2010
Impact of psychostimulants and atomoxetine on the expression of 8-hydroxyguanine glycosylase 1 in human cells.
    Journal of neural transmission (Vienna, Austria : 1996), 2010, Volume: 117, Issue:6

    Topics: Adrenergic Uptake Inhibitors; Amphetamine; Atomoxetine Hydrochloride; Cell Line; Central Nervous Sys

2010
Expression studies of naturally occurring human dopamine transporter variants identifies a novel state of transporter inactivation associated with Val382Ala.
    Neuropharmacology, 2005, Volume: 49, Issue:6

    Topics: Alanine; Amphetamine; Animals; Biotinylation; Cattle; Cell Line; Chlorocebus aethiops; Cocaine; COS

2005
Lack of robust protective effect of quercetin in two types of 6-hydroxydopamine-induced parkinsonian models in rats and dopaminergic cell cultures.
    Brain research, 2008, Apr-08, Volume: 1203

    Topics: Amphetamine; Animals; Antioxidants; Apomorphine; Behavior, Animal; Cell Line, Tumor; Corpus Striatum

2008
Melatonin inhibits amphetamine-induced increase in alpha-synuclein and decrease in phosphorylated tyrosine hydroxylase in SK-N-SH cells.
    Neuroscience letters, 2008, May-16, Volume: 436, Issue:3

    Topics: alpha-Synuclein; Amphetamine; Antioxidants; Cell Line, Tumor; Central Nervous System Stimulants; Dos

2008
Uptake of noradrenaline by an adrenergic clone of neuroblastoma cells.
    Nature, 1975, Apr-03, Volume: 254, Issue:5499

    Topics: Amphetamine; Clone Cells; Desipramine; Imipramine; Kinetics; Neuroblastoma; Norepinephrine; Ouabain

1975