Page last updated: 2024-10-25

amphetamine and Memory Disorders

amphetamine has been researched along with Memory Disorders in 21 studies

Amphetamine: A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.
1-phenylpropan-2-amine : A primary amine that is isopropylamine in which a hydrogen attached to one of the methyl groups has been replaced by a phenyl group.
amphetamine : A racemate comprising equimolar amounts of (R)-amphetamine (also known as levamphetamine or levoamphetamine) and (S)-amphetamine (also known as dexamfetamine or dextroamphetamine.

Memory Disorders: Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions.

Research Excerpts

ExcerptRelevanceReference
"Treatment with levetiracetam dose-dependently improved memory performance of the ketamine-exposed rats."5.48Treatment with levetiracetam improves cognition in a ketamine rat model of schizophrenia. ( Gallagher, M; Koh, MT; Rosenzweig-Lipson, S; Shao, Y, 2018)
"We used the passive avoidance test and acute amphetamine administration in aging gammasynuclein knock-out mice."3.88The Dopaminergic Dysfunction and Altered Working Memory Performance of Aging Mice Lacking Gamma-synuclein Gene. ( Aliev, G; Fisenko, VP; Kokhan, TYG; Kokhan, VS; Samsonova, AN; Ustyugov, AA, 2018)
"Treatment with levetiracetam dose-dependently improved memory performance of the ketamine-exposed rats."1.48Treatment with levetiracetam improves cognition in a ketamine rat model of schizophrenia. ( Gallagher, M; Koh, MT; Rosenzweig-Lipson, S; Shao, Y, 2018)
"PWZ-029 did not affect recognition memory deficits in social novelty discrimination procedure."1.42Negative modulation of α₅ GABAA receptors in rats may partially prevent memory impairment induced by MK-801, but not amphetamine- or MK-801-elicited hyperlocomotion. ( Biawat, P; Cook, JM; Joksimović, S; Marković, B; Savić, MM; Stanković, T; Timić Stamenić, T, 2015)
"Candesartan (CDS) is an AT1 receptor antagonist with potential neuroprotective properties."1.42Antimanic-like activity of candesartan in mice: Possible involvement of antioxidant, anti-inflammatory and neurotrophic mechanisms. ( Berk, M; Budni, J; Carvalho, AF; Cavalcante, LM; de Lucena, DF; de Sousa, FC; de Souza Gomes, JA; de Souza, GC; Macêdo, D; Quevedo, J, 2015)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19902 (9.52)18.7374
1990's0 (0.00)18.2507
2000's2 (9.52)29.6817
2010's14 (66.67)24.3611
2020's3 (14.29)2.80

Authors

AuthorsStudies
Di Capua, A1
Reale, A1
Paolino, M1
Chemi, G1
Brogi, S1
Cappelli, A1
Giorgi, G1
Grande, F1
Di Cesare Mannelli, L1
Ghelardini, C1
Matucci, R1
Garofalo, A1
Anzini, M1
Arab, AO1
Alasmari, F1
Albaker, AB1
Alhazmi, HA1
Alameen, AA1
Alagail, NM1
Alwaeli, SA1
Rizwan Ahamad, S1
AlAsmari, AF1
AlSharari, SD1
Tufvesson-Alm, M1
Imbeault, S1
Liu, XC1
Zheng, Y1
Faka, A1
Choi, DS1
Schwieler, L1
Engberg, G1
Erhardt, S1
Koh, MT2
Shao, Y2
Rosenzweig-Lipson, S1
Gallagher, M1
Mishra, A1
Mishra, AK1
Jha, S1
Kokhan, VS1
Kokhan, TYG1
Samsonova, AN1
Fisenko, VP1
Ustyugov, AA1
Aliev, G1
Loiodice, S1
Wing Young, H1
Rion, B1
Méot, B1
Montagne, P1
Denibaud, AS1
Viel, R1
Drieu La Rochelle, C1
Timić Stamenić, T1
Joksimović, S1
Biawat, P1
Stanković, T1
Marković, B1
Cook, JM1
Savić, MM1
de Souza Gomes, JA1
de Souza, GC1
Berk, M1
Cavalcante, LM1
de Sousa, FC1
Budni, J1
de Lucena, DF1
Quevedo, J1
Carvalho, AF1
Macêdo, D1
Sherwood, A1
Smith, DR1
Marszalek-Grabska, M1
Gibula-Bruzda, E1
Jenda, M1
Gawel, K1
Kotlinska, JH1
Woolley, ML1
Waters, KA1
Reavill, C1
Bull, S1
Lacroix, LP1
Martyn, AJ1
Hutcheson, DM1
Valerio, E1
Bate, S1
Jones, DN1
Dawson, LA1
Moeller, FG1
Steinberg, JL1
Schmitz, JM1
Ma, L1
Liu, S1
Kjome, KL1
Rathnayaka, N1
Kramer, LA1
Narayana, PA1
López-Téllez, JF1
López-Aranda, MF1
Navarro-Lobato, I1
Masmudi-Martín, M1
Montañez, EM1
Calvo, EB1
Khan, ZU1
Papaleo, F1
Yang, F1
Garcia, S1
Chen, J1
Lu, B1
Crawley, JN1
Weinberger, DR1
Won, H1
Mah, W1
Kim, E2
Kim, JW1
Hahm, EK1
Kim, MH1
Cho, S1
Kim, J1
Jang, H1
Cho, SC1
Kim, BN1
Shin, MS1
Seo, J1
Jeong, J1
Choi, SY1
Kim, D1
Kang, C1
Sumowski, JF1
Chiaravalloti, N1
Erlanger, D1
Kaushik, T1
Benedict, RH1
DeLuca, J1
Sanday, L1
Patti, CL1
Zanin, KA1
Tufik, S1
Frussa-Filho, R1
Daumann, J1
Fischermann, T1
Heekeren, K1
Henke, K1
Thron, A1
Gouzoulis-Mayfrank, E1
Jarvik, ME1
Gritz, ER1
Schneider, NG1
Jones, HB1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Dysbindin-antipsychotics Psychophamarcogenetics: a Mouse-human Translational Study Towards Personalized Healthcare in Bipolar Disorders[NCT06167577]150 participants (Actual)Observational2018-11-08Completed
Candidate Gene Screening for 6-14 Year Old Patients With ADHD (Attention Deficit/ Hyperactivity Disorder)[NCT03018574]100 participants (Actual)Observational2016-05-31Completed
Stimulation of Parieto-hippocampal Connectivity in Patients With Major Depressive Disorder[NCT04081519]53 participants (Actual)Interventional2016-08-02Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for amphetamine and Memory Disorders

ArticleYear
Drugs and memory disorders in human aging.
    Behavioral biology, 1972, Volume: 7, Issue:5

    Topics: Adolescent; Adult; Aged; Aging; Amphetamine; Anticonvulsants; Antidepressive Agents; Arousal; Caffei

1972

Trials

2 trials available for amphetamine and Memory Disorders

ArticleYear
Working memory fMRI activation in cocaine-dependent subjects: association with treatment response.
    Psychiatry research, 2010, Mar-30, Volume: 181, Issue:3

    Topics: Adult; Amphetamine; Analysis of Variance; Benzhydryl Compounds; Brain; Brain Mapping; Carbidopa; Cen

2010
L-amphetamine improves memory in MS patients with objective memory impairment.
    Multiple sclerosis (Houndmills, Basingstoke, England), 2011, Volume: 17, Issue:9

    Topics: Adult; Amphetamine; Double-Blind Method; Female; Humans; Male; Memory; Memory Disorders; Middle Aged

2011

Other Studies

18 other studies available for amphetamine and Memory Disorders

ArticleYear
Design, synthesis and biological evaluation of 7-substituted 4-phenyl-6H-imidazo[1,5-a]thieno[3,2-f] [1,4]diazepines as safe anxiolytic agents.
    European journal of medicinal chemistry, 2020, Aug-15, Volume: 200

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Binding Sites; Drug Design; Locomoti

2020
Clavulanic Acid Improves Memory Dysfunction and Anxiety Behaviors through Upregulating Glutamatergic Transporters in the Nucleus Accumbens of Mice Repeatedly Exposed to Khat Extract.
    International journal of molecular sciences, 2023, Oct-27, Volume: 24, Issue:21

    Topics: Amphetamine; Animals; Anxiety; Catha; Clavulanic Acid; Memory Disorders; Mice; Nucleus Accumbens; Ra

2023
Repeated administration of LPS exaggerates amphetamine-induced locomotor response and causes learning deficits in mice.
    Journal of neuroimmunology, 2020, 12-15, Volume: 349

    Topics: Amphetamine; Animals; Central Nervous System Stimulants; Drug Administration Schedule; Drug Synergis

2020
Treatment with levetiracetam improves cognition in a ketamine rat model of schizophrenia.
    Schizophrenia research, 2018, Volume: 193

    Topics: Amphetamine; Animals; Central Nervous System Stimulants; Cognition Disorders; Disease Models, Animal

2018
Effect of traditional medicine brahmi vati and bacoside A-rich fraction of Bacopa monnieri on acute pentylenetetrzole-induced seizures, amphetamine-induced model of schizophrenia, and scopolamine-induced memory loss in laboratory animals.
    Epilepsy & behavior : E&B, 2018, Volume: 80

    Topics: Acetylcholinesterase; Amnesia; Amphetamine; Animals; Animals, Laboratory; Antioxidants; Bacopa; Brai

2018
The Dopaminergic Dysfunction and Altered Working Memory Performance of Aging Mice Lacking Gamma-synuclein Gene.
    CNS & neurological disorders drug targets, 2018, Volume: 17, Issue:8

    Topics: Aging; Amphetamine; Animals; Avoidance Learning; Disease Models, Animal; Dopamine; Dopamine Agents;

2018
Implication of nigral dopaminergic lesion and repeated L-dopa exposure in neuropsychiatric symptoms of Parkinson's disease.
    Behavioural brain research, 2019, 03-15, Volume: 360

    Topics: Amphetamine; Animals; Antiparkinson Agents; Anxiety; Benserazide; Disease Models, Animal; Dopamine;

2019
Negative modulation of α₅ GABAA receptors in rats may partially prevent memory impairment induced by MK-801, but not amphetamine- or MK-801-elicited hyperlocomotion.
    Journal of psychopharmacology (Oxford, England), 2015, Volume: 29, Issue:9

    Topics: Amphetamine; Animals; Behavior, Animal; Benzodiazepines; Cognition Disorders; Dizocilpine Maleate; H

2015
Antimanic-like activity of candesartan in mice: Possible involvement of antioxidant, anti-inflammatory and neurotrophic mechanisms.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2015, Volume: 25, Issue:11

    Topics: Amphetamine; Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Inflammatory Agents; Antimanic A

2015
Impaired hippocampal-dependent memory and reduced parvalbumin-positive interneurons in a ketamine mouse model of schizophrenia.
    Schizophrenia research, 2016, Volume: 171, Issue:1-3

    Topics: Amphetamine; Animals; Conditioning, Classical; Disease Models, Animal; Fear; Hippocampus; Interneuro

2016
Memantine improves memory impairment and depressive-like behavior induced by amphetamine withdrawal in rats.
    Brain research, 2016, 07-01, Volume: 1642

    Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Antidepressive Agents; Central Nervous System S

2016
Selective dopamine D4 receptor agonist (A-412997) improves cognitive performance and stimulates motor activity without influencing reward-related behaviour in rat.
    Behavioural pharmacology, 2008, Volume: 19, Issue:8

    Topics: Acetamides; Acetylcholine; Amphetamine; Animals; Behavior, Animal; Cognition; Disease Models, Animal

2008
Prefrontal inositol triphosphate is molecular correlate of working memory in nonhuman primates.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, Feb-24, Volume: 30, Issue:8

    Topics: Amphetamine; Animals; Antipsychotic Agents; Calcium; Calcium Signaling; Central Nervous System Stimu

2010
Dysbindin-1 modulates prefrontal cortical activity and schizophrenia-like behaviors via dopamine/D2 pathways.
    Molecular psychiatry, 2012, Volume: 17, Issue:1

    Topics: Action Potentials; Amphetamine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Carrier

2012
GIT1 is associated with ADHD in humans and ADHD-like behaviors in mice.
    Nature medicine, 2011, Volume: 17, Issue:5

    Topics: Adaptor Proteins, Signal Transducing; Amphetamine; Animals; Attention Deficit Disorder with Hyperact

2011
Amphetamine-induced memory impairment in a discriminative avoidance task is state-dependent in mice.
    The international journal of neuropsychopharmacology, 2013, Volume: 16, Issue:3

    Topics: Amphetamine; Animals; Avoidance Learning; Discrimination Learning; Male; Memory Disorders; Mice

2013
Memory-related hippocampal dysfunction in poly-drug ecstasy (3,4-methylenedioxymethamphetamine) users.
    Psychopharmacology, 2005, Volume: 180, Issue:4

    Topics: Adult; Amphetamine; Brain Mapping; Cannabis; Female; Hallucinogens; Hippocampus; Humans; Magnetic Re

2005
The effects of sensual drugs on behavior: clues to the function of the brain.
    Advances in psychobiology, 1974, Volume: 2

    Topics: Alcoholic Intoxication; Amphetamine; Barbiturates; Brain; Cannabis; Cocaine; Emotions; Female; Hallu

1974