Page last updated: 2024-10-25

amphetamine and Learning Disabilities

amphetamine has been researched along with Learning Disabilities in 24 studies

Amphetamine: A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.
1-phenylpropan-2-amine : A primary amine that is isopropylamine in which a hydrogen attached to one of the methyl groups has been replaced by a phenyl group.
amphetamine : A racemate comprising equimolar amounts of (R)-amphetamine (also known as levamphetamine or levoamphetamine) and (S)-amphetamine (also known as dexamfetamine or dextroamphetamine.

Learning Disabilities: Conditions characterized by a significant discrepancy between an individual's perceived level of intellect and their ability to acquire new language and other cognitive skills. These may result from organic or psychological conditions. Relatively common subtypes include DYSLEXIA, DYSCALCULIA, and DYSGRAPHIA.

Research Excerpts

ExcerptRelevanceReference
"The methylazoxymethanol acetate (MAM) rodent neurodevelopmental model of schizophrenia exhibits aberrant dopamine system activation attributed to hippocampal dysfunction."3.88Impaired contextual fear-conditioning in MAM rodent model of schizophrenia. ( Gill, KM; Grace, AA; Miller, SA, 2018)
"A benzodiazepine (oxazepam) was given to nulliparous mice on days 12-16 of pregnancy, and the development and young adult behaviour of the offspring were studied."3.67Short-, medium-, and long-term effects of prenatal oxazepam on neurobehavioural development of mice. ( Alleva, E; Bignami, G; Laviola, G; Tirelli, E, 1985)
"Psychosis is linked to dysregulation of the neuromodulator dopamine and antipsychotic drugs (APDs) work by blocking dopamine receptors."1.34Linking animal models of psychosis to computational models of dopamine function. ( Becker, S; Kapur, S; Li, M; Smith, AJ, 2007)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-199015 (62.50)18.7374
1990's0 (0.00)18.2507
2000's4 (16.67)29.6817
2010's5 (20.83)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gill, KM1
Miller, SA1
Grace, AA1
Eldred, KC1
Palmiter, RD1
Connolly, NP1
Gomez-Serrano, M1
Mazitov, T1
Bregin, A1
Philips, MA1
Innos, J1
Vasar, E1
Eckart, MT1
Huelse-Matia, MC1
McDonald, RS1
Schwarting, RK1
FORRESTER, RM1
STEIN, Z1
SUSSER, MW1
Quinn, PO1
Smith, AJ1
Li, M1
Becker, S1
Kapur, S1
Garner, B1
Wood, SJ1
Pantelis, C1
van den Buuse, M1
Yee, BK1
Singer, P1
Chen, JF1
Feldon, J1
Boison, D1
Bakwin, H1
Alleva, E1
Laviola, G1
Tirelli, E1
Bignami, G1
Kinsbourne, M1
Sroufe, LA1
Stewart, MA1
Millichap, JG2
Sobotka, TJ1
Cook, MP1
Erenberg, G1
Wender, PH1
Peters, JE1
Fowler, GW1
Pond, DA1
McCabe, ER1
McCabe, L1
Conners, CK1
Oettinger, L1

Reviews

5 reviews available for amphetamine and Learning Disabilities

ArticleYear
Treating problem children with stimulant drugs.
    The New England journal of medicine, 1973, Aug-23, Volume: 289, Issue:8

    Topics: Adult; Amphetamine; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants

1973
Drug therapy in minimal brain dysfunction: a commentary.
    The Journal of pediatrics, 1972, Volume: 81, Issue:2

    Topics: Amphetamine; Anticonvulsants; Antidepressive Agents; Attention Deficit Disorder with Hyperactivity;

1972
Minimal brain dysfunction in children. Diagnosis and management.
    Pediatric clinics of North America, 1973, Volume: 20, Issue:1

    Topics: Abnormalities, Multiple; Affective Symptoms; Age Factors; Amphetamine; Attention; Attention Deficit

1973
Treatment of "minimal brain dysfunction" syndromes. Selection of drugs for children with hyperactivity and learning disabilities.
    Pediatric clinics of North America, 1967, Volume: 14, Issue:4

    Topics: Amphetamine; Anticonvulsants; Brain Damage, Chronic; Child; Chlordiazepoxide; Chlorpromazine; Clinic

1967
Behaviour disorders in brain-damaged children.
    Modern trends in neurology, 1967, Volume: 4, Issue:0

    Topics: Adolescent; Age Factors; Amphetamine; Anticonvulsants; Brain Damage, Chronic; Brain Injuries; Child;

1967

Trials

1 trial available for amphetamine and Learning Disabilities

ArticleYear
Treatment of "minimal brain dysfunction" syndromes. Selection of drugs for children with hyperactivity and learning disabilities.
    Pediatric clinics of North America, 1967, Volume: 14, Issue:4

    Topics: Amphetamine; Anticonvulsants; Brain Damage, Chronic; Child; Chlordiazepoxide; Chlorpromazine; Clinic

1967

Other Studies

19 other studies available for amphetamine and Learning Disabilities

ArticleYear
Impaired contextual fear-conditioning in MAM rodent model of schizophrenia.
    Schizophrenia research, 2018, Volume: 195

    Topics: Action Potentials; Amphetamine; Animals; Central Nervous System Stimulants; Conditioning, Classical;

2018
Amphetamine-induced sensitization has little effect on multiple learning paradigms and fails to rescue mice with a striatal learning defect.
    PloS one, 2013, Volume: 8, Issue:4

    Topics: Amphetamine; Animals; Central Nervous System Sensitization; Central Nervous System Stimulants; Condi

2013
D4 dopamine receptor-specific antagonist improves reversal learning impairment in amphetamine-treated male rats.
    Experimental and clinical psychopharmacology, 2014, Volume: 22, Issue:6

    Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Attention; Behavior, Animal; Central Nervous Sy

2014
Deficit in emotional learning in neurotrimin knockout mice.
    Behavioural brain research, 2017, 01-15, Volume: 317

    Topics: Amphetamine; Animals; Avoidance Learning; Body Weight; Cell Adhesion Molecules, Neuronal; Central Ne

2017
6-hydroxydopamine lesions in the rat neostriatum impair sequential learning in a serial reaction time task.
    Neurotoxicity research, 2010, Volume: 17, Issue:3

    Topics: Amphetamine; Analysis of Variance; Animals; Brain Chemistry; Disease Models, Animal; Freezing Reacti

2010
A TRIAL OF CONDITIONING THERAPY IN NOCTURNAL ENURESIS.
    Developmental medicine and child neurology, 1964, Volume: 6

    Topics: Adaptation, Psychological; Adolescent; Amphetamine; Amphetamines; Behavior Therapy; Child; Child Beh

1964
Treating adolescent girls and women with ADHD: gender-specific issues.
    Journal of clinical psychology, 2005, Volume: 61, Issue:5

    Topics: Adolescent; Adult; Age Factors; Amphetamine; Anxiety Disorders; Attention Deficit Disorder with Hype

2005
Linking animal models of psychosis to computational models of dopamine function.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007, Volume: 32, Issue:1

    Topics: Action Potentials; Amphetamine; Animals; Computer Simulation; Conditioning, Classical; Disease Model

2007
Early maternal deprivation reduces prepulse inhibition and impairs spatial learning ability in adulthood: no further effect of post-pubertal chronic corticosterone treatment.
    Behavioural brain research, 2007, Jan-25, Volume: 176, Issue:2

    Topics: Acoustic Stimulation; Amphetamine; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal

2007
Transgenic overexpression of adenosine kinase in brain leads to multiple learning impairments and altered sensitivity to psychomimetic drugs.
    The European journal of neuroscience, 2007, Volume: 26, Issue:11

    Topics: Adenosine Kinase; Amphetamine; Animals; Behavior, Animal; Brain; Central Nervous System Stimulants;

2007
Developmental hyperactivity.
    Acta paediatrica Scandinavica, 1967

    Topics: Adolescent; Amphetamine; Autistic Disorder; Child; Child Behavior Disorders; Child Guidance; Chlorpr

1967
Short-, medium-, and long-term effects of prenatal oxazepam on neurobehavioural development of mice.
    Psychopharmacology, 1985, Volume: 87, Issue:4

    Topics: Amphetamine; Animals; Avoidance Learning; Behavior, Animal; Female; Growth Disorders; Learning Disab

1985
School problems: diagnosis and treatment.
    Pediatrics, 1973, Volume: 52, Issue:5

    Topics: Agnosia; Amphetamine; Anxiety; Child; Child, Preschool; Cognition Disorders; Developmental Disabilit

1973
Drugs in the management of learning and behavior disorders in school children.
    IMJ. Illinois medical journal, 1974, Volume: 145, Issue:4

    Topics: Amphetamine; Anticonvulsants; Child; Child Behavior Disorders; Humans; Learning Disabilities; Methyl

1974
Postnatal lead acetate exposure in rats: possible relationship to minimal brain dysfunction.
    American journal of mental deficiency, 1974, Volume: 79, Issue:1

    Topics: Amphetamine; Animals; Animals, Newborn; Attention Deficit Disorder with Hyperactivity; Disease Model

1974
Minimal brain dysfunctions in children.
    American family physician, 1974, Volume: 10, Issue:1

    Topics: Amphetamine; Attention; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; Comm

1974
Dissociation of learning on stimulant-drug therapy.
    The New England journal of medicine, 1972, Oct-19, Volume: 287, Issue:16

    Topics: Amphetamine; Animals; Antidepressive Agents; Child; Dextroamphetamine; Humans; Hyperkinesis; Learnin

1972
Review of stimulant drugs in learning and behavior disorders.
    Psychopharmacology bulletin, 1971, Volume: 7, Issue:3

    Topics: Aggression; Amphetamine; Child; Child Behavior Disorders; Dextroamphetamine; Humans; Hyperkinesis; L

1971
Learning disorders, hyperkinesis, and the use of drugs in children.
    Rehabilitation literature, 1971, Volume: 32, Issue:6

    Topics: Amphetamine; Child; Humans; Hyperkinesis; Learning Disabilities; Methylphenidate; Psychological Test

1971