Page last updated: 2024-10-25

amphetamine and Inflammation

amphetamine has been researched along with Inflammation in 16 studies

Amphetamine: A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.
1-phenylpropan-2-amine : A primary amine that is isopropylamine in which a hydrogen attached to one of the methyl groups has been replaced by a phenyl group.
amphetamine : A racemate comprising equimolar amounts of (R)-amphetamine (also known as levamphetamine or levoamphetamine) and (S)-amphetamine (also known as dexamfetamine or dextroamphetamine.

Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.

Research Excerpts

ExcerptRelevanceReference
" In a double-blind, randomly stratified clinical trial investigating whether add-on dextromethorphan (60-120 mg/day) attenuated inflammation and the combined use of opioids in heroin-dependent patients undergoing methadone maintenance treatment, we evaluated whether inflammation is related to the progression of opioid dependence."9.16Dextromethorphan attenuated inflammation and combined opioid use in humans undergoing methadone maintenance treatment. ( Chang, YH; Chen, PS; Chen, SH; Chen, SL; Chu, CH; Hong, JS; Lee, IH; Lee, SY; Lu, RB; Tao, PL; Yang, YK; Yeh, TL, 2012)
"Amphetamine (AMPH) is a highly abused drug that presents potent stimulating effects on the CNS and has been shown to induce behavioral, biochemical and immunological effects."5.37Amphetamine modulates cellular recruitment and airway reactivity in a rat model of allergic lung inflammation. ( Damazo, AS; de Oliveira, AP; Farsky, SH; Hamasato, EK; Hebeda, CB; Lino-Dos-Santos-Franco, A; Palermo-Neto, J; Quinteiro-Filho, W; Tavares-de-Lima, W, 2011)
" In a double-blind, randomly stratified clinical trial investigating whether add-on dextromethorphan (60-120 mg/day) attenuated inflammation and the combined use of opioids in heroin-dependent patients undergoing methadone maintenance treatment, we evaluated whether inflammation is related to the progression of opioid dependence."5.16Dextromethorphan attenuated inflammation and combined opioid use in humans undergoing methadone maintenance treatment. ( Chang, YH; Chen, PS; Chen, SH; Chen, SL; Chu, CH; Hong, JS; Lee, IH; Lee, SY; Lu, RB; Tao, PL; Yang, YK; Yeh, TL, 2012)
"Infective endocarditis is associated with significant morbidity and mortality, despite advances in diagnosis and treatment strategies."1.51No Fever, No Murmur, No Problem? A Concealed Case of Infective Endocarditis. ( Gorman, M; McCann, M; McKeown, B, 2019)
"Amphetamine (AMPH) is a highly abused drug that presents potent stimulating effects on the CNS and has been shown to induce behavioral, biochemical and immunological effects."1.37Amphetamine modulates cellular recruitment and airway reactivity in a rat model of allergic lung inflammation. ( Damazo, AS; de Oliveira, AP; Farsky, SH; Hamasato, EK; Hebeda, CB; Lino-Dos-Santos-Franco, A; Palermo-Neto, J; Quinteiro-Filho, W; Tavares-de-Lima, W, 2011)
" Inflammation following glial cell activation contributes to cell death in Parkinson's disease and we now report on the effects of acute or chronic administration of pramipexole on lipopolysaccharide (LPS) induced inflammation and nigral dopaminergic cell death in the rat."1.35Continuous subcutaneous infusion of pramipexole protects against lipopolysaccharide-induced dopaminergic cell death without affecting the inflammatory response. ( Iravani, MM; Jenner, P; Leung, CC; Rose, S; Sadeghian, M; Schapira, AH; Tel, BC, 2008)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19902 (12.50)18.7374
1990's1 (6.25)18.2507
2000's1 (6.25)29.6817
2010's9 (56.25)24.3611
2020's3 (18.75)2.80

Authors

AuthorsStudies
Wang, TY1
Lu, RB2
Lee, SY2
Chang, YH2
Chen, SL2
Tsai, TY1
Tseng, HH1
Chen, PS2
Chen, KC1
Yang, YK2
Hong, JS2
Lima, VB1
Viana, AR1
Santos, D1
Felipetto, N1
Mezzomo, NF1
Zago, AM1
Flores, EMM1
Machado, AK1
Krause, A1
Peroza, LR1
Schaffer, LF1
Krause, LMF1
Hurley, SW1
Beltz, TG1
Guo, F1
Xue, B1
Johnson, AK1
Gutiérrez-Martos, M1
Girard, B1
Mendonça-Netto, S1
Perroy, J1
Valjent, E1
Maldonado, R1
Martin, M1
McCann, M1
Gorman, M1
McKeown, B1
Choi, JK1
Zhu, A1
Jenkins, BG1
Hattori, S1
Kil, KE1
Takagi, T1
Ishii, S1
Miyakawa, T1
Brownell, AL1
Vicente-Rodríguez, M1
Rojo Gonzalez, L1
Gramage, E1
Fernández-Calle, R1
Chen, Y1
Pérez-García, C1
Ferrer-Alcón, M1
Uribarri, M1
Bailey, A1
Herradón, G1
Iravani, MM1
Sadeghian, M1
Leung, CC1
Tel, BC1
Rose, S1
Schapira, AH1
Jenner, P1
Matson, DJ1
Broom, DC1
Cortright, DN1
Okokon, JE1
Nwafor, PA1
de Oliveira, AP1
Lino-Dos-Santos-Franco, A2
Hamasato, EK2
Quinteiro-Filho, W1
Hebeda, CB1
Damazo, AS2
Farsky, SH2
Tavares-de-Lima, W2
Palermo-Neto, J2
Tao, PL1
Chen, SH1
Chu, CH1
Lee, IH1
Yeh, TL1
Ligeiro de Oliveira, AP1
Acceturi, BG1
Machado, ID1
Gimenes Júnior, JA1
Vieira, RP1
Hore, SK1
Dumka, VK1
Kumar, D1
Tripathi, HC1
Tandan, SK1
Min, KW1
Gyorkey, F1
Cain, GD1
Sugar, HS1
Mandell, GH1
Shalev, J1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Pomegranate Juice Consumption by Patients Under Medication for Addiction Treatment as a Regulator of Craving and Blood Redox Status: The Study Protocol of a Randomized Control Trial (the NUTRIDOPE Study)[NCT05861544]58 participants (Anticipated)Interventional2023-03-23Enrolling by invitation
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for amphetamine and Inflammation

ArticleYear
Dextromethorphan attenuated inflammation and combined opioid use in humans undergoing methadone maintenance treatment.
    Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2012, Volume: 7, Issue:4

    Topics: Adult; Amphetamine; Amphetamine-Related Disorders; Analgesics, Opioid; Central Nervous System Stimul

2012

Other Studies

15 other studies available for amphetamine and Inflammation

ArticleYear
Association Between Inflammatory Cytokines, Executive Function, and Substance Use in Patients With Opioid Use Disorder and Amphetamine-Type Stimulants Use Disorder.
    The international journal of neuropsychopharmacology, 2023, 01-19, Volume: 26, Issue:1

    Topics: Amphetamine; Biomarkers; Brain-Derived Neurotrophic Factor; C-Reactive Protein; Central Nervous Syst

2023
Ethyl Acetate Fraction of Harpagophytum procumbens Prevents Oxidative Stress In Vitro and Amphetamine-Induced Alterations in Mice Behavior.
    Neurochemical research, 2023, Volume: 48, Issue:6

    Topics: Amphetamine; Animals; Harpagophytum; Inflammation; Mice; Oxidative Stress; Plant Extracts

2023
Amphetamine-induced sensitization of hypertension and lamina terminalis neuroinflammation.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2020, 03-01, Volume: 318, Issue:3

    Topics: Amphetamine; Angiotensin II; Animals; Blood Pressure; Central Nervous System Stimulants; Diet, High-

2020
Cafeteria diet induces neuroplastic modifications in the nucleus accumbens mediated by microglia activation.
    Addiction biology, 2018, Volume: 23, Issue:2

    Topics: Amphetamine; Animals; Central Nervous System Stimulants; Chocolate; Corpus Striatum; Cytokines; Dend

2018
No Fever, No Murmur, No Problem? A Concealed Case of Infective Endocarditis.
    The Journal of emergency medicine, 2019, Volume: 57, Issue:2

    Topics: Adult; Amphetamine; Analgesics, Opioid; Anti-Bacterial Agents; C-Reactive Protein; Endocarditis; Eno

2019
Combined behavioral studies and in vivo imaging of inflammatory response and expression of mGlu5 receptors in schnurri-2 knockout mice.
    Neuroscience letters, 2015, Nov-16, Volume: 609

    Topics: Acetamides; Amphetamine; Animals; Brain; Carbon Radioisotopes; Central Nervous System Stimulants; Ce

2015
Pleiotrophin overexpression regulates amphetamine-induced reward and striatal dopaminergic denervation without changing the expression of dopamine D1 and D2 receptors: Implications for neuroinflammation.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2016, Volume: 26, Issue:11

    Topics: Amphetamine; Animals; Astrocytes; Autoradiography; Carrier Proteins; Central Nervous System Stimulan

2016
Continuous subcutaneous infusion of pramipexole protects against lipopolysaccharide-induced dopaminergic cell death without affecting the inflammatory response.
    Experimental neurology, 2008, Volume: 212, Issue:2

    Topics: Amphetamine; Animals; Behavior, Animal; Benzothiazoles; Cell Count; Cell Death; Dopamine; Dopamine A

2008
Locomotor activity in a novel environment as a test of inflammatory pain in rats.
    Methods in molecular biology (Clifton, N.J.), 2010, Volume: 617

    Topics: Amphetamine; Analgesics, Opioid; Animals; Arthritis, Experimental; Behavior, Animal; Central Nervous

2010
Antiinflammatory, analgesic and antipyretic activities of ethanolic root extract of Croton zambesicus.
    Pakistan journal of pharmaceutical sciences, 2010, Volume: 23, Issue:4

    Topics: Acetic Acid; Amphetamine; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal

2010
Amphetamine modulates cellular recruitment and airway reactivity in a rat model of allergic lung inflammation.
    Toxicology letters, 2011, Jan-15, Volume: 200, Issue:1-2

    Topics: Amphetamine; Animals; Bronchoalveolar Lavage Fluid; Capillary Permeability; Disease Models, Animal;

2011
Long-term amphetamine treatment exacerbates inflammatory lung reaction while decreases airway hyper-responsiveness after allergic stimulus in rats.
    International immunopharmacology, 2012, Volume: 14, Issue:4

    Topics: Amphetamine; Animals; Bronchial Spasm; Bronchoalveolar Lavage Fluid; Cytokines; Drug Administration

2012
Central noradrenergic & dopaminergic modulation of brewer's yeast-induced inflammation & nociception in rats.
    The Indian journal of medical research, 1997, Volume: 105

    Topics: Amphetamine; Animals; Dopamine; Inflammation; Male; Norepinephrine; Pain; Rats; Rats, Sprague-Dawley

1997
Talc granulomata in liver disease in narcotic addicts.
    Archives of pathology, 1974, Volume: 98, Issue:5

    Topics: Adult; Amphetamine; Barbiturates; Biopsy; Cannabis; Chemical and Drug Induced Liver Injury; Granulom

1974
Metastatic endophthalmitis associated with injection of addictive drugs.
    American journal of ophthalmology, 1971, Volume: 71, Issue:5

    Topics: Adult; Amphetamine; Aspergillosis; Cannabis; Eye Diseases; Heroin; Humans; Inflammation; Injections,

1971