Page last updated: 2024-10-25

amphetamine and Gambling

amphetamine has been researched along with Gambling in 17 studies

Amphetamine: A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.
1-phenylpropan-2-amine : A primary amine that is isopropylamine in which a hydrogen attached to one of the methyl groups has been replaced by a phenyl group.
amphetamine : A racemate comprising equimolar amounts of (R)-amphetamine (also known as levamphetamine or levoamphetamine) and (S)-amphetamine (also known as dexamfetamine or dextroamphetamine.

Gambling: An activity distinguished primarily by an element of risk in trying to obtain a desired goal, e.g., playing a game of chance for money.

Research Excerpts

ExcerptRelevanceReference
"To investigate effects of slot machine gambling (Slots) and d-amphetamine (AMPH; 20 mg) on risk-taking in people with GD and healthy controls (HCs) (n = 30/group)."8.31Priming effects of a slot machine game and amphetamine on probabilistic risk-taking in people with gambling disorder and healthy controls. ( Biback, C; Digiacomo, D; Fang, T; Kalia, A; Kennedy, JL; Lobo, D; Smart, K; Tatone, D; Zack, M, 2023)
" To compare gambling and drug effects, subjects received the prototypic psychostimulant drug d-amphetamine (AMPH; 20 mg) in a multi-session, placebo-controlled design."7.85Parallel role for the dopamine D1 receptor in gambling and amphetamine reinforcement in healthy volunteers. ( Biback, C; Digiacomo, D; Fang, T; Kalia, A; Kennedy, JL; Lobo, DS; Smart, K; Tatone, D; Zack, MH, 2017)
" Further studies looking at chronic administration of anticonvulsants may help us understand the impact of this medication class on decision-making and impulsivity in healthy rats and disease models."5.43Anticonvulsant medications attenuate amphetamine-induced deficits in behavioral inhibition but not decision making under risk on a rat gambling task. ( Tremblay, M; Winstanley, CA, 2016)
"To investigate effects of slot machine gambling (Slots) and d-amphetamine (AMPH; 20 mg) on risk-taking in people with GD and healthy controls (HCs) (n = 30/group)."4.31Priming effects of a slot machine game and amphetamine on probabilistic risk-taking in people with gambling disorder and healthy controls. ( Biback, C; Digiacomo, D; Fang, T; Kalia, A; Kennedy, JL; Lobo, D; Smart, K; Tatone, D; Zack, M, 2023)
" To compare gambling and drug effects, subjects received the prototypic psychostimulant drug d-amphetamine (AMPH; 20 mg) in a multi-session, placebo-controlled design."3.85Parallel role for the dopamine D1 receptor in gambling and amphetamine reinforcement in healthy volunteers. ( Biback, C; Digiacomo, D; Fang, T; Kalia, A; Kennedy, JL; Lobo, DS; Smart, K; Tatone, D; Zack, MH, 2017)
"Pathological gambling is a psychiatric disorder and the first recognized behavioral addiction, with similarities to substance use disorders but without the confounding effects of drug-related brain changes."1.43Blunted Endogenous Opioid Release Following an Oral Amphetamine Challenge in Pathological Gamblers. ( Bowden-Jones, H; Brailsford, AD; Clark, L; Colasanti, A; Erritzoe, D; Galduróz, JC; Gunn, RN; Lingford-Hughes, AR; Mick, I; Myers, J; Nutt, DJ; Parkin, MC; Rabiner, EA; Ramos, AC; Searle, GE; Stokes, PR; Waldman, AD, 2016)
" Further studies looking at chronic administration of anticonvulsants may help us understand the impact of this medication class on decision-making and impulsivity in healthy rats and disease models."1.43Anticonvulsant medications attenuate amphetamine-induced deficits in behavioral inhibition but not decision making under risk on a rat gambling task. ( Tremblay, M; Winstanley, CA, 2016)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.88)18.7374
1990's0 (0.00)18.2507
2000's1 (5.88)29.6817
2010's14 (82.35)24.3611
2020's1 (5.88)2.80

Authors

AuthorsStudies
Zack, M5
Lobo, D2
Biback, C3
Fang, T3
Smart, K3
Tatone, D3
Kalia, A3
Digiacomo, D3
Kennedy, JL3
Zeeb, FD2
Li, Z1
Fisher, DC1
Zack, MH2
Fletcher, PJ1
Robinson, MJF1
Clibanoff, C1
Freeland, CM1
Knes, AS1
Cote, JR1
Russell, TI1
Boileau, I2
Payer, D2
Chugani, B2
Lobo, DS3
Houle, S2
Wilson, AA2
Warsh, J1
Kish, SJ2
Silveira, MM2
Malcolm, E1
Shoaib, M1
Winstanley, CA5
Oswald, LM1
Wand, GS1
Wong, DF1
Brown, CH1
Kuwabara, H1
Brašić, JR1
Warsh, JJ1
Mick, I1
Myers, J1
Ramos, AC1
Stokes, PR1
Erritzoe, D1
Colasanti, A1
Gunn, RN1
Rabiner, EA1
Searle, GE1
Waldman, AD1
Parkin, MC1
Brailsford, AD1
Galduróz, JC1
Bowden-Jones, H1
Clark, L2
Nutt, DJ1
Lingford-Hughes, AR1
Murch, WS1
Tremblay, M1
Wong, AC1
van Enkhuizen, J1
Geyer, MA1
Young, JW1
Cocker, PJ1
Dinelle, K1
Kornelson, R1
Sossi, V1
Poulos, CX1
Rouse, BA1
Ewing, JA1

Trials

1 trial available for amphetamine and Gambling

ArticleYear
Amphetamine primes motivation to gamble and gambling-related semantic networks in problem gamblers.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2004, Volume: 29, Issue:1

    Topics: Adult; Affect; Alcohol Drinking; Amphetamine; Behavior, Addictive; Blood Pressure; Central Nervous S

2004

Other Studies

16 other studies available for amphetamine and Gambling

ArticleYear
Priming effects of a slot machine game and amphetamine on probabilistic risk-taking in people with gambling disorder and healthy controls.
    Journal of clinical and experimental neuropsychology, 2023, Volume: 45, Issue:1

    Topics: Amphetamine; Dextroamphetamine; Dopamine; Fluphenazine; Gambling; Haloperidol; Humans; Risk-Taking

2023
Uncertainty exposure causes behavioural sensitization and increases risky decision-making in male rats: toward modelling gambling disorder.
    Journal of psychiatry & neuroscience : JPN, 2017, Volume: 42, Issue:6

    Topics: Amphetamine; Animals; Central Nervous System Stimulants; Decision Making; Disease Models, Animal; Ga

2017
Distinguishing between predictive and incentive value of uncertain gambling-like cues in a Pavlovian autoshaping task.
    Behavioural brain research, 2019, 10-03, Volume: 371

    Topics: Amphetamine; Animals; Conditioning, Classical; Conditioning, Operant; Cues; Female; Gambling; Models

2019
Impulsivity moderates the effects of dopamine D2 and mixed D1-D2 antagonists in individuals with gambling disorder.
    Journal of psychopharmacology (Oxford, England), 2019, Volume: 33, Issue:8

    Topics: Adult; Amphetamine; Central Nervous System Stimulants; Dopamine D2 Receptor Antagonists; Double-Blin

2019
In vivo evidence for greater amphetamine-induced dopamine release in pathological gambling: a positron emission tomography study with [(11)C]-(+)-PHNO.
    Molecular psychiatry, 2014, Volume: 19, Issue:12

    Topics: Adult; Amphetamine; Brain; Dopamine; Dopamine Agents; Dopamine Agonists; Gambling; Humans; Male; Mod

2014
Scopolamine and amphetamine produce similar decision-making deficits on a rat gambling task via independent pathways.
    Behavioural brain research, 2015, Mar-15, Volume: 281

    Topics: Amphetamine; Animals; Behavior, Animal; Choice Behavior; Decision Making; Gambling; Male; Mecamylami

2015
Risky decision-making and ventral striatal dopamine responses to amphetamine: a positron emission tomography [(11)C]raclopride study in healthy adults.
    NeuroImage, 2015, Volume: 113

    Topics: Adolescent; Adult; Amphetamine; Central Nervous System Stimulants; Decision Making; Dopamine; Dopami

2015
Differential cardiovascular and hypothalamic pituitary response to amphetamine in male pathological gamblers versus healthy controls.
    Journal of psychopharmacology (Oxford, England), 2015, Volume: 29, Issue:9

    Topics: Adult; Amphetamine; Blood Pressure; Cardiovascular System; Case-Control Studies; Central Nervous Sys

2015
Blunted Endogenous Opioid Release Following an Oral Amphetamine Challenge in Pathological Gamblers.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016, Volume: 41, Issue:7

    Topics: Administration, Oral; Adult; Amphetamine; Analgesics, Opioid; Analysis of Variance; Carbon Isotopes;

2016
Chronic atomoxetine treatment during adolescence does not influence decision-making on a rodent gambling task, but does modulate amphetamine's effect on impulsive action in adulthood.
    Behavioural pharmacology, 2016, Volume: 27, Issue:4

    Topics: Adrenergic Uptake Inhibitors; Amphetamine; Animals; Atomoxetine Hydrochloride; Decision Making; Dose

2016
Anticonvulsant medications attenuate amphetamine-induced deficits in behavioral inhibition but not decision making under risk on a rat gambling task.
    Behavioural brain research, 2016, 11-01, Volume: 314

    Topics: Amphetamine; Animals; Anticonvulsants; Carbamazepine; Central Nervous System Stimulants; Choice Beha

2016
Parallel role for the dopamine D1 receptor in gambling and amphetamine reinforcement in healthy volunteers.
    Journal of psychopharmacology (Oxford, England), 2017, Volume: 31, Issue:1

    Topics: Adult; Amphetamine; Behavior, Addictive; Central Nervous System Stimulants; Dextroamphetamine; Dopam

2017
Differential effects of environmental enrichment, social-housing, and isolation-rearing on a rat gambling task: dissociations between impulsive action and risky decision-making.
    Psychopharmacology, 2013, Volume: 225, Issue:2

    Topics: Amphetamine; Animals; Choice Behavior; Decision Making; Dopamine Antagonists; Dopamine D2 Receptor A

2013
Differential effects of dopamine transporter inhibitors in the rodent Iowa gambling task: relevance to mania.
    Psychopharmacology, 2013, Volume: 225, Issue:3

    Topics: Amphetamine; Animals; Behavior, Animal; Benzhydryl Compounds; Bipolar Disorder; Choice Behavior; Con

2013
Irrational choice under uncertainty correlates with lower striatal D(2/3) receptor binding in rats.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Oct-31, Volume: 32, Issue:44

    Topics: Amphetamine; Animals; Autoradiography; Benzazepines; Choice Behavior; Conditioning, Operant; Dopamin

2012
Marijuana and other drug use by graduate and professional students.
    The American journal of psychiatry, 1972, Volume: 129, Issue:4

    Topics: Adult; Alcohol Drinking; Amphetamine; Attitude to Health; Cannabis; Education, Graduate; Female; Gam

1972