amphetamine has been researched along with Fever in 57 studies
Amphetamine: A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.
1-phenylpropan-2-amine : A primary amine that is isopropylamine in which a hydrogen attached to one of the methyl groups has been replaced by a phenyl group.
amphetamine : A racemate comprising equimolar amounts of (R)-amphetamine (also known as levamphetamine or levoamphetamine) and (S)-amphetamine (also known as dexamfetamine or dextroamphetamine.
Fever: An abnormal elevation of body temperature, usually as a result of a pathologic process.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The dopamine-releasing and depleting substance amphetamine (AMPH) can make cortical neurons susceptible to damage, and the prevention of hyperthermia, seizures and stroke is thought to block these effects." | 7.71 | Parvalbumin neuron circuits and microglia in three dopamine-poor cortical regions remain sensitive to amphetamine exposure in the absence of hyperthermia, seizure and stroke. ( Bowyer, JF; Jakab, RL, 2002) |
| "Amphetamine was more toxic to isolated mice subjected to foot-shock than to isolated mice housed under normal conditions." | 5.24 | Hyperpyrexia as a contributory factor in the toxicity of amphetamine to aggregated mice. ( ASKEW, BM, 1962) |
| "The dopamine-releasing and depleting substance amphetamine (AMPH) can make cortical neurons susceptible to damage, and the prevention of hyperthermia, seizures and stroke is thought to block these effects." | 3.71 | Parvalbumin neuron circuits and microglia in three dopamine-poor cortical regions remain sensitive to amphetamine exposure in the absence of hyperthermia, seizure and stroke. ( Bowyer, JF; Jakab, RL, 2002) |
| " The present work provides a comprehensive review on neurotoxic mechanisms of synthetic cathinones highlighting intoxication cases and fatalities in humans, as well as the toxic effects on animals (in particular rats, mice and zebrafish larvae)." | 3.01 | Synthetic Cathinones and Neurotoxicity Risks: A Systematic Review. ( Bambagiotti, G; Daziani, G; Giorgetti, R; Goteri, G; Lo Faro, AF; Montana, A; Montana, V; Montanari, E; Pesaresi, M, 2023) |
| "Tramadol was quantified to be 140 mg/L, approximately 470 times the therapeutic range." | 1.39 | Complicated suicide versus autoeroticism?: a case involving multiple drugs and a porta-potty. ( Dickerson, EM; Jones, P; Prahlow, JA; Regnier, J; Wilkins, D, 2013) |
| "Measures to treat seizures, hypoglycaemia, electrolyte anomalies and hyperthermia are the therapeutic goals." | 1.32 | Paramethoxyamphetamine (PMA) poisoning; a 'party drug' with lethal effects. ( Refstad, S, 2003) |
| " Rats that did not become hyperthermic when dosed with 15 mg/kg AMPH in a cold environment (10 degrees C) exhibited some hyperactivity and stereotypic behavior, but not overt convulsive behavior." | 1.31 | Seizure activity and hyperthermia potentiate the increases in dopamine and serotonin extracellular levels in the amygdala during exposure to d-amphetamine. ( Bowyer, JF; Tor-Agbidye, J; Yamamoto, B, 2001) |
| "Amphetamine treatment caused an acute rise in core body temperature to 40 degrees C for at least 1 hr and increased hsp25 and hsp70i levels, as measured by Western blotting, at 6, 24, 48, and 72 hr with no apparent induction of other hsps (hsp60, hsc70, or hsp90)." | 1.30 | Protection against hepatotoxicity by a single dose of amphetamine: the potential role of heat shock protein induction. ( Roberts, SM; Salminen, WF; Voellmy, R, 1997) |
| "Brain temperature monitoring and microdialysis were performed simultaneously in the caudate/putamen (CPu) of conscious, freely moving rats dosed with d-amphetamine (AMPH)." | 1.30 | Time course of brain temperature and caudate/putamen microdialysate levels of amphetamine and dopamine in rats after multiple doses of d-amphetamine. ( Bowyer, JF; Clausing, P, 1999) |
| "Pargyline was without effect." | 1.25 | Hypothermia produced in mice by histamine acting on the central nervous system. ( Shaw, GG, 1971) |
| "Amphetamine was more toxic to isolated mice subjected to foot-shock than to isolated mice housed under normal conditions." | 1.24 | Hyperpyrexia as a contributory factor in the toxicity of amphetamine to aggregated mice. ( ASKEW, BM, 1962) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 35 (61.40) | 18.7374 |
| 1990's | 6 (10.53) | 18.2507 |
| 2000's | 8 (14.04) | 29.6817 |
| 2010's | 7 (12.28) | 24.3611 |
| 2020's | 1 (1.75) | 2.80 |
| Authors | Studies |
|---|---|
| Daziani, G | 1 |
| Lo Faro, AF | 1 |
| Montana, V | 1 |
| Goteri, G | 1 |
| Pesaresi, M | 1 |
| Bambagiotti, G | 1 |
| Montanari, E | 1 |
| Giorgetti, R | 1 |
| Montana, A | 1 |
| Camacho, L | 2 |
| Silva, CS | 1 |
| Hanig, JP | 3 |
| Schleimer, RP | 1 |
| George, NI | 4 |
| Bowyer, JF | 10 |
| Patterson, TA | 2 |
| Saini, UT | 1 |
| Thomas, M | 3 |
| Chen, JJ | 1 |
| Levi, MS | 1 |
| Patton, RE | 1 |
| Tranter, KM | 1 |
| James, LP | 1 |
| Davis, KJ | 1 |
| Bespalov, AY | 1 |
| van Gaalen, MM | 2 |
| Sukhotina, IA | 1 |
| Wicke, K | 1 |
| Mezler, M | 2 |
| Schoemaker, H | 1 |
| Gross, G | 2 |
| Schmued, LC | 1 |
| Ali, SF | 1 |
| Akahoshi, T | 1 |
| Wada, T | 1 |
| Takemoto, T | 1 |
| Okokon, JE | 1 |
| Nwafor, PA | 1 |
| Relo, AL | 1 |
| Mueller, BK | 1 |
| Angoa-Pérez, M | 1 |
| Kane, MJ | 1 |
| Briggs, DI | 1 |
| Francescutti, DM | 1 |
| Sykes, CE | 1 |
| Shah, MM | 1 |
| Thomas, DM | 1 |
| Kuhn, DM | 1 |
| Dickerson, EM | 1 |
| Jones, P | 1 |
| Wilkins, D | 1 |
| Regnier, J | 1 |
| Prahlow, JA | 1 |
| Jakab, RL | 1 |
| CHEYMOL, J | 1 |
| LEVASSORT, C | 1 |
| FROMMEL, E | 1 |
| FLEURY, C | 1 |
| VON LEDEBUR, I | 1 |
| BEGUIN, M | 1 |
| ASKEW, BM | 1 |
| JACOB, J | 1 |
| LAFILLE, C | 1 |
| WOLF, HH | 2 |
| GEORGE, DJ | 1 |
| DANDIYA, PC | 1 |
| MENON, MK | 1 |
| BAGDON, WJ | 1 |
| MANN, DE | 1 |
| LEWIS, E | 2 |
| MORPURGO, C | 1 |
| THEOBALD, W | 1 |
| JORDAN, SC | 1 |
| HAMPSON, F | 1 |
| KLISSIUNIS, MN | 1 |
| DOSI, I | 1 |
| Refstad, S | 1 |
| Wolinsky, TD | 1 |
| Swanson, CJ | 1 |
| Smith, KE | 1 |
| Zhong, H | 1 |
| Borowsky, B | 1 |
| Seeman, P | 1 |
| Branchek, T | 1 |
| Gerald, CP | 1 |
| Morrison-Bogorad, M | 1 |
| Pardue, S | 1 |
| McIntire, DD | 1 |
| Miller, EK | 1 |
| Salminen, WF | 1 |
| Voellmy, R | 1 |
| Roberts, SM | 1 |
| Davies, DL | 1 |
| Clausing, P | 1 |
| Tor-Agbidye, J | 1 |
| Yamamoto, B | 1 |
| Rips, R | 1 |
| Desiles, M | 1 |
| Puech, AJ | 1 |
| Brick, J | 1 |
| Pohorecky, LA | 1 |
| Kalant, H | 1 |
| Kalant, OJ | 1 |
| Belknap, JK | 1 |
| Crabbe, JC | 1 |
| Nowak, TS | 1 |
| Bunce, ME | 1 |
| Scheel-Krüger, J | 2 |
| Hasselager, E | 1 |
| Greenblatt, DJ | 2 |
| Shader, RI | 2 |
| Tubaro, E | 1 |
| Banci, F | 1 |
| Shaw, GG | 1 |
| Matsumoto, C | 1 |
| Griffin, W | 1 |
| Hill, HF | 1 |
| Horita, A | 1 |
| Coper, H | 1 |
| Lison, H | 1 |
| Rommelspacher, H | 1 |
| Schulze, G | 1 |
| Strauss, S | 1 |
| Grahame-Smith, DG | 1 |
| Weihe, WH | 1 |
| Fuller, RW | 1 |
| Snoddy, HD | 1 |
| Molloy, BB | 1 |
| Bruzzi, G | 1 |
| Testa, R | 1 |
| Donzelli, MG | 1 |
| Beauvallet, M | 1 |
| Scott, JP | 1 |
| Lee, CT | 1 |
| Ho, JE | 1 |
| Ferrini, R | 1 |
| Glässer, A | 1 |
| Ginsberg, MD | 1 |
| Hertzman, M | 1 |
| Schmidt-Nowara, WW | 1 |
| Mantegazza, P | 1 |
| Naimzada, KM | 1 |
| Riva, M | 1 |
| Kriskó, I | 1 |
| Johnson, JE | 1 |
| Jonas, W | 1 |
8 reviews available for amphetamine and Fever
| Article | Year |
|---|---|
Synthetic Cathinones and Neurotoxicity Risks: A Systematic Review.
Topics: Amphetamine; Animals; Central Nervous System Stimulants; Fever; Humans; Mice; Neurotoxicity Syndrome | 2023 |
[Fever induced by various drugs].
Topics: Amphetamine; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Body Temperature Regulation; | 2009 |
Death in amphetamine users: causes and rates.
Topics: Adolescent; Adult; Amphetamine; Cerebral Hemorrhage; Drug Interactions; Endocarditis, Subacute Bacte | 1975 |
Chromosome mapping of gene loci affecting morphine and amphetamine responses in BXD recombinant inbred mice.
Topics: Amphetamine; Analgesia; Animals; Choice Behavior; Chromosome Mapping; Fever; Hypothermia; Mice; Mice | 1992 |
Drug therapy reviews: rational use of psychotropic drugs. III. Major tranquilizers.
Topics: Adrenergic alpha-Agonists; Adult; Alcoholism; Amphetamine; Antiemetics; Antipsychotic Agents; Body T | 1974 |
Rational use of psychotropic drugs. III. Major tranquilizers.
Topics: Adrenergic alpha-Antagonists; Amphetamine; Antiemetics; Antipsychotic Agents; Basal Ganglia Diseases | 1974 |
The effect of temperature on the action of drugs.
Topics: Amphetamine; Animals; Body Temperature; Body Temperature Regulation; Cannabis; Cats; Chlorpromazine; | 1973 |
[Amphetamine and monoamines of the central nervous system].
Topics: Amphetamine; Animals; Brain Chemistry; Cats; Dogs; Dopamine; Epinephrine; Fever; Horses; Hypothalamu | 1968 |
49 other studies available for amphetamine and Fever
| Article | Year |
|---|---|
Identification of whole blood mRNA and microRNA biomarkers of tissue damage and immune function resulting from amphetamine exposure or heat stroke in adult male rats.
Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Biomarkers; Fever; Heat Stroke; Male; MicroRNAs | 2019 |
Comparison of the global gene expression of choroid plexus and meninges and associated vasculature under control conditions and after pronounced hyperthermia or amphetamine toxicity.
Topics: Amphetamine; Arachnoid; Blood-Brain Barrier; Brain; Cerebrospinal Fluid; Choroid Plexus; Environment | 2013 |
Serum myoglobin, but not lipopolysaccharides, is predictive of AMPH-induced striatal neurotoxicity.
Topics: Amphetamine; Animals; Basal Ganglia; Biomarkers; Body Temperature Regulation; Disease Models, Animal | 2013 |
Behavioral characterization of the mGlu group II/III receptor antagonist, LY-341495, in animal models of anxiety and depression.
Topics: Amino Acids; Amphetamine; Animals; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; An | 2008 |
Brain region-specific neurodegenerative profiles showing the relative importance of amphetamine dose, hyperthermia, seizures, and the blood-brain barrier.
Topics: Amphetamine; Animals; Blood-Brain Barrier; Central Nervous System Stimulants; Fever; Hippocampus; Hu | 2008 |
Amphetamine and environmentally induced hyperthermia differentially alter the expression of genes regulating vascular tone and angiogenesis in the meninges and associated vasculature.
Topics: Amphetamine; Animals; Blood Vessels; Body Temperature; Brain; Central Nervous System Stimulants; Con | 2009 |
Antiinflammatory, analgesic and antipyretic activities of ethanolic root extract of Croton zambesicus.
Topics: Acetic Acid; Amphetamine; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal | 2010 |
NOGO-66 receptor deficient mice show slow acquisition of spatial memory task performance.
Topics: Alzheimer Disease; Amphetamine; Animals; Eating; Female; Fever; Hyperkinesis; Male; Maze Learning; M | 2012 |
Mephedrone does not damage dopamine nerve endings of the striatum, but enhances the neurotoxicity of methamphetamine, amphetamine, and MDMA.
Topics: Amphetamine; Animals; Corpus Striatum; Dopamine; Drug Synergism; Female; Fever; Methamphetamine; Mic | 2013 |
Complicated suicide versus autoeroticism?: a case involving multiple drugs and a porta-potty.
Topics: Adult; Amphetamine; Analgesics, Opioid; Asphyxia; Central Nervous System Stimulants; Disinfectants; | 2013 |
Parvalbumin neuron circuits and microglia in three dopamine-poor cortical regions remain sensitive to amphetamine exposure in the absence of hyperthermia, seizure and stroke.
Topics: Amphetamine; Animals; Astrocytes; Cerebral Cortex; Dopamine; Drug Residues; Fever; Glial Fibrillary | 2002 |
[Amphetamine hyperthermia & curarization by d-tubocurarine].
Topics: Amphetamine; Amphetamines; Body Temperature; Curare; Fever; Tubocurarine | 1957 |
[Deviations in the pharmacodynamic action of various drugs by hypo- and hyperthermia. 2].
Topics: Acetylcholine; Aminobutyrates; Amphetamine; Amphetamines; Atropine; Chlordiazepoxide; Chlorpromazine | 1962 |
Hyperpyrexia as a contributory factor in the toxicity of amphetamine to aggregated mice.
Topics: Amphetamine; Animals; Fever; Mice; Temperature; Thyroxine | 1962 |
[PHARMACOLOGICAL CHARACTERIZATION AND DETECTION OF HALLUCINOGENIC SUBSTANCES. I. HYPERTHERMIC ACTION IN THE RABBIT].
Topics: Amphetamine; Amphetamines; Animals; Body Temperature; Fever; Hallucinogens; Lagomorpha; Nalorphine; | 1963 |
DRUG-INDUCED HYPERTHERMIA AND AMPHETAMINE TOXICITY.
Topics: Amphetamine; Amphetamines; Aspirin; Chlorpromazine; Fever; Hyperthermia, Induced; Mice; Pharmacology | 1964 |
ACTIONS OF ASARONE ON BEHAVIOR, STRESS, AND HYPERPYREXIA, AND ITS INTERACTION WITH CENTRAL STIMULANTS.
Topics: Allylbenzene Derivatives; Amphetamine; Amphetamines; Animals; Anisoles; Behavior, Animal; Central Ne | 1964 |
FACTORS MODIFYING CHLORPROMAZINE HYPERTHERMIA IN YOUNG ALBINO MICE.
Topics: Amphetamine; Amphetamines; Animals; Chlorpromazine; Cocaine; Cyanides; Fever; Insulin; Iproniazid; L | 1965 |
HYPERPYREXIA WITH ANTIDEPRESSANT DRUGS.
Topics: Amphetamine; Amphetamines; Antidepressive Agents; Depression; Depressive Disorder; Drug Therapy; Fev | 1965 |
INFLUENCE OF IMPIRAMINE-LIKE COMPOUNDS AND CHLORPROMAZINE ON THE RESERPINE-HYPOTHERMIA IN MICE AND THE AMPHETAMINE-HYPERTHERMIA IN RATS.
Topics: Amphetamine; Amphetamines; Animals; Chlorpromazine; Fever; Hypothermia; Hypothermia, Induced; Imipra | 1965 |
Amphetamine poisoning associated with hyperpyrexia.
Topics: Amphetamine; Amphetamines; Central Nervous System Agents; Fever; Humans | 1960 |
[The action of promethazine on fever induced in rabbits by phenylisopropylamine].
Topics: Amphetamine; Amphetamines; Animals; Fever; Promethazine; Rabbits | 1959 |
Paramethoxyamphetamine (PMA) poisoning; a 'party drug' with lethal effects.
Topics: Adolescent; Amphetamine; Amphetamines; Fever; Humans; Male; Seizures; Substance-Related Disorders | 2003 |
The Trace Amine 1 receptor knockout mouse: an animal model with relevance to schizophrenia.
Topics: Amphetamine; Animals; Anxiety; Behavior, Animal; Catecholamines; Central Nervous System Stimulants; | 2007 |
The role of hyperthermia in amphetamine's interactions with NMDA receptors, nitric oxide, and age to produce neurotoxicity.
Topics: Aging; Amphetamine; Animals; Arginine; Brain; Dizocilpine Maleate; Fever; Glutamic Acid; Haloperidol | 1995 |
Cell size and the heat-shock response in rat brain.
Topics: Amphetamine; Animals; Brain; Cerebellum; Fever; Gene Expression; Heat-Shock Proteins; Hippocampus; H | 1994 |
Protection against hepatotoxicity by a single dose of amphetamine: the potential role of heat shock protein induction.
Topics: Acetaminophen; Amphetamine; Animals; Bromobenzenes; Carbon Tetrachloride; Chemical and Drug Induced | 1997 |
Changes in mRNA levels for heat-shock/stress proteins (Hsp) and a secretory vesicle associated cysteine-string protein (Csp1) after amphetamine (AMPH) exposure.
Topics: Amphetamine; Animals; Cells, Cultured; Cerebral Cortex; Corpus Striatum; Dopamine Agents; Fever; Hea | 1999 |
Time course of brain temperature and caudate/putamen microdialysate levels of amphetamine and dopamine in rats after multiple doses of d-amphetamine.
Topics: Amphetamine; Animals; Body Temperature; Caudate Nucleus; Dopamine; Dopamine Agents; Fever; Male; Put | 1999 |
Seizure activity and hyperthermia potentiate the increases in dopamine and serotonin extracellular levels in the amygdala during exposure to d-amphetamine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamine; Amygdala; Animals; Behavior, Animal; Chromatography, Hi | 2001 |
Is a dopaminergic system involved in thyrotropin releasing hormone induced hyperthermia and in its potentiation by amphetamine?
Topics: alpha-Methyltyrosine; Amphetamine; Animals; Apomorphine; Chlorpromazine; Dopamine; Dopamine Agents; | 1979 |
Ethanol withdrawal: altered ambient temperature selection in rats.
Topics: Amphetamine; Animals; Behavior, Animal; Body Temperature; Choice Behavior; Decision Making; Ethanol; | 1977 |
Effects of amphetamine on protein synthesis and energy metabolism in mouse brain: role of drug-induced hyperthermia.
Topics: Adenosine Triphosphate; Amphetamine; Animals; Body Temperature; Brain; Energy Metabolism; Fever; Gly | 1988 |
Hyperthermia and the amphetamine aggregation phenomenon: absence of a causal relation.
Topics: Amphetamine; Animals; Body Temperature; Fever; Hydroxydopamines; Isomerism; Male; Mice; Mice, Inbred | 1973 |
Studies of various amphetamines, apomorphine and clonidine on body temperature and brain 5-hydroxytryptamine metabolism in rats.
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Body Temperature; Brain; Brain Chemistry; Carbo | 1974 |
Pharmacology of a nicotinamido-methylaminopyrazolone (Ra 101).
Topics: Aminopyrine; Amphetamine; Analgesics; Animals; Anti-Inflammatory Agents; Anticonvulsants; Carrageena | 1970 |
Hypothermia produced in mice by histamine acting on the central nervous system.
Topics: Amphetamine; Animals; Atropine; Body Temperature; Body Temperature Regulation; Central Nervous Syste | 1971 |
Antagonism of (+)-amphetamine-induced hyperthermia in rats by pimozide.
Topics: Amphetamine; Animals; Benzimidazoles; Body Temperature; Fever; Male; Rats; Time Factors; Tranquilizi | 1971 |
Inhibition of (+)-amphetamine hyperthermia by blockade of dopamine receptors in rabbits.
Topics: Amphetamine; Animals; Benzimidazoles; Body Temperature; Dopamine; Fever; Male; Rabbits; Receptors, D | 1971 |
The influence of adrenergic receptor-blocking agents, amphetamine, and 6-aminonicotinamide on thermoregulation.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Amines; Amphetamine; Animals; Body Temper | 1971 |
The prevention by inhibitors of brain proptein synthesis of the hyperactivity and hyperpyrexia produced in rats by monoamine oxidase inhibition and the administration of L-tryptophan or 5-methoxy-N,N-dimethyltryptamine.
Topics: Amphetamine; Animals; Brain; Carbon Isotopes; Cycloheximide; Emetine; Fever; Hallucinogens; Humans; | 1972 |
Effect of , -difluoro substitution on the disposition and pharmacological effects of 4-chloroamphetamine in rats.
Topics: Amphetamine; Animals; Body Temperature; Brain Chemistry; Chemical Phenomena; Chemistry; Chlorine; Fe | 1973 |
[Changes caused by uridine amphetamine induced hyperthermia in mice and rats].
Topics: Amphetamine; Animals; Body Temperature Regulation; Disease Models, Animal; Female; Fever; Male; Mice | 1973 |
Effects of fighting, genotype, and amphetamine sulfate on body temperature of mice.
Topics: Aggression; Amphetamine; Animals; Behavior, Animal; Body Temperature; Fever; Genetics, Behavioral; G | 1971 |
Antagonism of central effects of tryptamine and 5-hydroxytryptophan by 1,6-dimethyl-8beta-carbobenzyloxy-aminomethyl-10alpha-ergoline. Interference with amphetamine and DOPA.
Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Central Nervous System; Dihydroxyphenylalanine; Fever; Mi | 1965 |
Amphetamine intoxication with coagulopathy, hyperthermia, and reversible renal failure. A syndrome resembling heatstroke.
Topics: Acute Kidney Injury; Adult; Amphetamine; Diagnosis, Differential; Fever; Fibrinolysis; Heat Exhausti | 1970 |
Activity of amphetamine in hypothyroid rats.
Topics: Amphetamine; Animals; Appetite; Blood Glucose; Body Temperature; Fatty Acids, Nonesterified; Fever; | 1968 |
Severe hyperpyrexia due to tranylcypromine-amphetamine toxicity.
Topics: Amphetamine; Coma; Drug Synergism; Female; Fever; Humans; Middle Aged; Movement Disorders; Seizures; | 1969 |
Amphetamine induced stereotyped behaviour correlated with the accumulation of O-methylated dopamine.
Topics: Amphetamine; Animals; Behavior, Animal; Brain; Depression, Chemical; Fever; Male; Nialamide; Norepin | 1969 |