amphetamine has been researched along with Encephalopathy, Toxic in 18 studies
Amphetamine: A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.
1-phenylpropan-2-amine : A primary amine that is isopropylamine in which a hydrogen attached to one of the methyl groups has been replaced by a phenyl group.
amphetamine : A racemate comprising equimolar amounts of (R)-amphetamine (also known as levamphetamine or levoamphetamine) and (S)-amphetamine (also known as dexamfetamine or dextroamphetamine.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In conclusion, the current study revealed that the S-100β serum level could be used as an outcome predictor in hospital admission cases due to toxic amphetamine exposure and offers an idea about the cardiac and neuronal involvement." | 5.62 | Potential Role of Serum S-100β Protein as a Predictor of Cardiotoxicity and Clinical Poor Outcome in Acute Amphetamine Intoxication. ( Al-Asmari, AZ; Elsheikh, E; Gameel, DE; Sharif, AF, 2021) |
| " A young alcohol abuser was referred to the Acute Poisonings Unit at Wrocław with a presumptive diagnosis of methanol poisoning." | 3.73 | Poisoning or primary nervous system disease?--difficulties of the differential diagnosis exemplified by four different clinical cases. ( Antończyk, A; Kochman, K; Magdalan, J; Porebska, B, 2005) |
| "Methamphetamine (METH) is an amphetamine-type stimulant that is highly toxic to the central nervous system (CNS)." | 3.01 | The Role of Non-coding RNAs in Methamphetamine-Induced Neurotoxicity. ( Chen, Q; Chen, X; Huang, Y; Li, L; Qiao, D; Xu, L, 2023) |
| " The present work provides a comprehensive review on neurotoxic mechanisms of synthetic cathinones highlighting intoxication cases and fatalities in humans, as well as the toxic effects on animals (in particular rats, mice and zebrafish larvae)." | 3.01 | Synthetic Cathinones and Neurotoxicity Risks: A Systematic Review. ( Bambagiotti, G; Daziani, G; Giorgetti, R; Goteri, G; Lo Faro, AF; Montana, A; Montana, V; Montanari, E; Pesaresi, M, 2023) |
| "Amphetamine stimulants have been used medically since early in the twentieth century, but they have a high abuse potential and can be neurotoxic." | 2.45 | Potential adverse effects of amphetamine treatment on brain and behavior: a review. ( Berman, SM; Kuczenski, R; London, ED; McCracken, JT, 2009) |
| "Drug addiction is now considered a brain disease, because the abuse of drugs affects several brain functions." | 2.44 | Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs. ( Cunha-Oliveira, T; Oliveira, CR; Rego, AC, 2008) |
| " In conclusion, the current study revealed that the S-100β serum level could be used as an outcome predictor in hospital admission cases due to toxic amphetamine exposure and offers an idea about the cardiac and neuronal involvement." | 1.62 | Potential Role of Serum S-100β Protein as a Predictor of Cardiotoxicity and Clinical Poor Outcome in Acute Amphetamine Intoxication. ( Al-Asmari, AZ; Elsheikh, E; Gameel, DE; Sharif, AF, 2021) |
| "Amphetamine (AMPH) is a commonly abused psychostimulant that induces neuronal cell death/degeneration in humans and experimental animals." | 1.46 | The neurotoxic mechanisms of amphetamine: Step by step for striatal dopamine depletion. ( Chang, ST; Huang, CL; Huang, NK; Tung, CS, 2017) |
| "Nicotine pre-treatment attenuated behavioral deficits and lessened lesion-induced losses of the striatal dopamine transporter, and alpha6beta2* and alpha4beta2* nicotinic receptors (nAChRs)." | 1.35 | Nicotine is neuroprotective when administered before but not after nigrostriatal damage in rats and monkeys. ( Bordia, T; Huang, LZ; Michael McIntosh, J; Parameswaran, N; Quik, M, 2009) |
| "Neurotoxicity may be defined as any adverse effect on the structure or function of the central and/or peripheral nervous system by a biological, chemical, or physical agent." | 1.33 | Biomarkers of adult and developmental neurotoxicity. ( Bowyer, JF; Slikker, W, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (38.89) | 29.6817 |
| 2010's | 7 (38.89) | 24.3611 |
| 2020's | 4 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Bojsen, JA | 1 |
| Lunau, L | 1 |
| Nguyen, NT | 1 |
| Rasmussen, BSB | 1 |
| Xu, L | 1 |
| Li, L | 1 |
| Chen, Q | 1 |
| Huang, Y | 1 |
| Chen, X | 1 |
| Qiao, D | 1 |
| Daziani, G | 1 |
| Lo Faro, AF | 1 |
| Montana, V | 1 |
| Goteri, G | 1 |
| Pesaresi, M | 1 |
| Bambagiotti, G | 1 |
| Montanari, E | 1 |
| Giorgetti, R | 1 |
| Montana, A | 1 |
| Sharif, AF | 1 |
| Elsheikh, E | 1 |
| Al-Asmari, AZ | 1 |
| Gameel, DE | 1 |
| Gramage, E | 1 |
| Herradón, G | 1 |
| Martín, YB | 1 |
| Vicente-Rodríguez, M | 1 |
| Rojo, L | 1 |
| Gnekow, H | 1 |
| Barbero, A | 1 |
| Pérez-García, C | 1 |
| Levi, MS | 1 |
| Patton, RE | 1 |
| Hanig, JP | 1 |
| Tranter, KM | 1 |
| George, NI | 1 |
| James, LP | 1 |
| Davis, KJ | 1 |
| Bowyer, JF | 2 |
| Courtney, KE | 1 |
| Ray, LA | 1 |
| Tung, CS | 1 |
| Chang, ST | 1 |
| Huang, CL | 1 |
| Huang, NK | 1 |
| Berman, SM | 1 |
| Kuczenski, R | 1 |
| McCracken, JT | 1 |
| London, ED | 1 |
| Huang, LZ | 1 |
| Parameswaran, N | 1 |
| Bordia, T | 1 |
| Michael McIntosh, J | 1 |
| Quik, M | 1 |
| Drouin-Ouellet, J | 1 |
| Brownell, AL | 1 |
| Saint-Pierre, M | 1 |
| Fasano, C | 1 |
| Emond, V | 1 |
| Trudeau, LE | 1 |
| Lévesque, D | 1 |
| Cicchetti, F | 1 |
| Carvalho, M | 1 |
| Carmo, H | 1 |
| Costa, VM | 1 |
| Capela, JP | 1 |
| Pontes, H | 1 |
| Remião, F | 1 |
| Carvalho, F | 1 |
| Bastos, Mde L | 1 |
| Healy-Stoffel, M | 1 |
| Ahmad, SO | 1 |
| Stanford, JA | 1 |
| Levant, B | 1 |
| Slikker, W | 1 |
| Magdalan, J | 1 |
| Antończyk, A | 1 |
| Kochman, K | 1 |
| Porebska, B | 1 |
| Paquette, MA | 1 |
| Brudney, EG | 1 |
| Putterman, DB | 1 |
| Meshul, CK | 1 |
| Johnson, SW | 1 |
| Berger, SP | 1 |
| Cunha-Oliveira, T | 1 |
| Rego, AC | 1 |
| Oliveira, CR | 1 |
| Ladenheim, B | 1 |
| Krasnova, IN | 1 |
| Deng, X | 1 |
| Oyler, JM | 1 |
| Polettini, A | 1 |
| Moran, TH | 1 |
| Huestis, MA | 1 |
| Cadet, JL | 1 |
6 reviews available for amphetamine and Encephalopathy, Toxic
| Article | Year |
|---|---|
The Role of Non-coding RNAs in Methamphetamine-Induced Neurotoxicity.
Topics: Amphetamine; Behavior, Addictive; Humans; Methamphetamine; MicroRNAs; Neurotoxicity Syndromes | 2023 |
Synthetic Cathinones and Neurotoxicity Risks: A Systematic Review.
Topics: Amphetamine; Animals; Central Nervous System Stimulants; Fever; Humans; Mice; Neurotoxicity Syndrome | 2023 |
Clinical neuroscience of amphetamine-type stimulants: From basic science to treatment development.
Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Central Nervous System Stimulants; Humans; Neur | 2016 |
Potential adverse effects of amphetamine treatment on brain and behavior: a review.
Topics: Amphetamine; Animals; Attention Deficit Disorder with Hyperactivity; Behavior; Brain; Central Nervou | 2009 |
Toxicity of amphetamines: an update.
Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Central Nervous System Stimulants; Chemical and | 2012 |
Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs.
Topics: Amphetamine; Analgesics, Opioid; Animals; Brain; Central Nervous System Stimulants; Cocaine; Humans; | 2008 |
12 other studies available for amphetamine and Encephalopathy, Toxic
| Article | Year |
|---|---|
[Amphetamine-induced toxic encephalopathy].
Topics: Adult; Amphetamine; Female; Humans; Magnetic Resonance Imaging; Neurotoxicity Syndromes; Tomography, | 2022 |
Potential Role of Serum S-100β Protein as a Predictor of Cardiotoxicity and Clinical Poor Outcome in Acute Amphetamine Intoxication.
Topics: Adolescent; Adult; Amphetamine; Biomarkers; Cardiotoxicity; Central Nervous System Stimulants; Cross | 2021 |
Differential phosphoproteome of the striatum from pleiotrophin knockout and midkine knockout mice treated with amphetamine: correlations with amphetamine-induced neurotoxicity.
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Amphetamine; Animals; Annexin A7; Blotting, | 2013 |
Serum myoglobin, but not lipopolysaccharides, is predictive of AMPH-induced striatal neurotoxicity.
Topics: Amphetamine; Animals; Basal Ganglia; Biomarkers; Body Temperature Regulation; Disease Models, Animal | 2013 |
The neurotoxic mechanisms of amphetamine: Step by step for striatal dopamine depletion.
Topics: Amphetamine; Animals; Central Nervous System Stimulants; Corpus Striatum; Dextroamphetamine; Dizocil | 2017 |
Nicotine is neuroprotective when administered before but not after nigrostriatal damage in rats and monkeys.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amphetamine; Analysis of Variance; Animals; Autoradiog | 2009 |
Neuroinflammation is associated with changes in glial mGluR5 expression and the development of neonatal excitotoxic lesions.
Topics: Amphetamine; Animals; Animals, Newborn; Anti-Inflammatory Agents; Behavior, Animal; Cells, Cultured; | 2011 |
A novel use of combined tyrosine hydroxylase and silver nucleolar staining to determine the effects of a unilateral intrastriatal 6-hydroxydopamine lesion in the substantia nigra: a stereological study.
Topics: Adrenergic Agents; Amphetamine; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Function | 2012 |
Biomarkers of adult and developmental neurotoxicity.
Topics: Amphetamine; Biomarkers; Gene Expression; Humans; Insulin-Like Growth Factor Binding Protein 1; Neur | 2005 |
Poisoning or primary nervous system disease?--difficulties of the differential diagnosis exemplified by four different clinical cases.
Topics: Acute Disease; Adolescent; Adult; Amphetamine; Antipsychotic Agents; Central Nervous System Stimulan | 2005 |
Sigma ligands, but not N-methyl-D-aspartate antagonists, reduce levodopa-induced dyskinesias.
Topics: Adrenergic Agents; Amphetamine; Animals; Anti-Anxiety Agents; Behavior, Animal; Dextromethorphan; Di | 2008 |
Methamphetamine-induced neurotoxicity is attenuated in transgenic mice with a null mutation for interleukin-6.
Topics: Amphetamine; Animals; Benzodiazepines; Carrier Proteins; Chromatography, High Pressure Liquid; Dopam | 2000 |