Page last updated: 2024-10-25

amphetamine and Dystonia

amphetamine has been researched along with Dystonia in 8 studies

Amphetamine: A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.
1-phenylpropan-2-amine : A primary amine that is isopropylamine in which a hydrogen attached to one of the methyl groups has been replaced by a phenyl group.
amphetamine : A racemate comprising equimolar amounts of (R)-amphetamine (also known as levamphetamine or levoamphetamine) and (S)-amphetamine (also known as dexamfetamine or dextroamphetamine.

Dystonia: An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often affects the large axial muscles of the trunk and limb girdles. Conditions which feature persistent or recurrent episodes of dystonia as a primary manifestation of disease are referred to as DYSTONIC DISORDERS. (Adams et al., Principles of Neurology, 6th ed, p77)

Research Excerpts

ExcerptRelevanceReference
"Excepting clozapine and DOD 647, all drugs induced dystonia."3.70New and old antipsychotics versus clozapine in a monkey model: adverse effects and antiamphetamine effects. ( Gerlach, J; Peacock, L, 1999)
"Early onset torsion dystonia (DYT1), the most common form of hereditary primary dystonia, is caused by a mutation in the TOR1A gene, which codes for the protein, torsinA."1.36Function of dopamine transporter is compromised in DYT1 transgenic animal model in vivo. ( Balcioglu, A; Hewett, J; Johanson, P; Sharma, N; Standaert, D, 2010)
"Neither (-)-3-PPP nor SND 919 produced dystonia, but had observable dopamine D2 receptor agonistic effects, (-)-3-PPP producing emesis at 1-4 mg/kg and SND 919 producing motoric unrest and stereotypy at 0."1.29Effects of several partial dopamine D2 receptor agonists in Cebus apella monkeys previously treated with haloperidol. ( Gerlach, J; Peacock, L, 1993)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19901 (12.50)18.7374
1990's4 (50.00)18.2507
2000's2 (25.00)29.6817
2010's1 (12.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Shen, YC1
Hewett, J1
Johanson, P1
Sharma, N1
Standaert, D1
Balcioglu, A1
Capstick, C1
Checkley, S1
Gray, J1
Dawe, S1
Peacock, L3
Gerlach, J3
Hansen, L1
Mørkeberg, F1
Rehders, JH1
Löscher, W1
Richter, A1
McKeon, TW1
Lorden, JF1
Beales, M1
Oltmans, GA1

Other Studies

8 other studies available for amphetamine and Dystonia

ArticleYear
Amphetamine as a risk factor for aripiprazole-induced acute dystonia.
    Progress in neuro-psychopharmacology & biological psychiatry, 2008, Oct-01, Volume: 32, Issue:7

    Topics: Acute Disease; Adult; Amphetamine; Aripiprazole; Dystonia; Humans; Male; Piperazines; Quinolones; Ri

2008
Function of dopamine transporter is compromised in DYT1 transgenic animal model in vivo.
    Journal of neurochemistry, 2010, Volume: 113, Issue:1

    Topics: Amphetamine; Analysis of Variance; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; D

2010
Dystonia induced by amphetamine and haloperidol.
    The British journal of psychiatry : the journal of mental science, 1994, Volume: 165, Issue:2

    Topics: Adult; Amphetamine; Dose-Response Relationship, Drug; Drug Synergism; Dystonia; Female; Haloperidol;

1994
Effects of several partial dopamine D2 receptor agonists in Cebus apella monkeys previously treated with haloperidol.
    European journal of pharmacology, 1993, Jun-24, Volume: 237, Issue:2-3

    Topics: Administration, Oral; Amphetamine; Animals; Antipsychotic Agents; Behavior, Animal; Benzothiazoles;

1993
Chronic dopamine D1, dopamine D2 and combined dopamine D1 and D2 antagonist treatment in Cebus apella monkeys: antiamphetamine effects and extrapyramidal side effects.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1999, Volume: 20, Issue:1

    Topics: Amphetamine; Animals; Arousal; Basal Ganglia Diseases; Benzazepines; Benzofurans; Cebus; Dopamine Ag

1999
New and old antipsychotics versus clozapine in a monkey model: adverse effects and antiamphetamine effects.
    Psychopharmacology, 1999, Volume: 144, Issue:3

    Topics: Amphetamine; Animals; Antipsychotic Agents; Cebus; Clozapine; Dextroamphetamine; Disease Models, Ani

1999
Evidence for striatal dopaminergic overactivity in paroxysmal dystonia indicated by microinjections in a genetic rodent model.
    Neuroscience, 2000, Volume: 97, Issue:2

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Amphetamine; Animals; Benzazepine

2000
Alterations in the noradrenergic projection to the cerebellum of the dystonic (dt) rat.
    Brain research, 1986, Feb-26, Volume: 366, Issue:1-2

    Topics: alpha-Methyltyrosine; Amphetamine; Animals; Cerebellum; Dystonia; Female; Male; Methoxyhydroxyphenyl

1986