amphetamine and Drug Abuse, Intravenous studies

Amphetamine: A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.
1-phenylpropan-2-amine : A primary amine that is isopropylamine in which a hydrogen attached to one of the methyl groups has been replaced by a phenyl group.
amphetamine : A racemate comprising equimolar amounts of (R)-amphetamine (also known as levamphetamine or levoamphetamine) and (S)-amphetamine (also known as dexamfetamine or dextroamphetamine.

Research Excerpts

Excerpt	Relevance	Reference
"A man aged 27 years presented with an acute myocardial infarction after injecting himself intravenously with amphetamine."	7.68	Acute myocardial infarction caused by intravenous amphetamine abuse. ( Garton, MJ; Jennings, K; Packe, GE, 1990)
"Amphetamine, methamphetamine, and cocaine are suspected of being pulmonary hypertension risk factors based on a small number of case reports along with pharmacologic similarities to fenfluramine, a diet drug associated with pulmonary arterial hypertension (PAH)."	3.73	Is methamphetamine use associated with idiopathic pulmonary arterial hypertension? ( Channick, RN; Chin, KM; Rubin, LJ, 2006)
"A man aged 27 years presented with an acute myocardial infarction after injecting himself intravenously with amphetamine."	3.68	Acute myocardial infarction caused by intravenous amphetamine abuse. ( Garton, MJ; Jennings, K; Packe, GE, 1990)
"Methylphenidate is an effective treatment for reducing intravenous drug use in patients with severe amphetamine dependence."	2.73	A comparison of aripiprazole, methylphenidate, and placebo for amphetamine dependence. ( Föhr, J; Haukka, J; Kuikanmäki, O; Kuoppasalmi, K; Meririnne, E; Sokero, P; Tiihonen, J; Tuomola, P; Vorma, H, 2007)
"Amphetamine was not detected in either sample."	1.31	A case of fatal hemorrhage in the cerebral ventricles following intravenous use of methamphetamine. ( Hashimoto, Y; Moriya, F, 2002)
"Viremia was observed as early as 25 days before the onset of clinical hepatitis, and up to 30 days after."	1.30	Characterisation of an epidemic of hepatitis A virus involving intravenous drug abusers--infection by needle sharing? ( Grinde, B; Hoel, T; Jensenius, M; Sharma, B; Skaug, K; Stene-Johansen, K, 1997)
"Amphetamine was the main drug used by 115 and heroin by 85."	1.29	Preference for sex on amphetamine: a marker for HIV risk behaviour among male intravenous amphetamine users in Stockholm. ( Käll, K; Nilsonne, A, 1995)
"Drug abuse during pregnancy has attracted national attention, but most studies are from large cities."	1.29	Drug abuse in an obstetric population of a midsized city. ( Hawthorne, JL; Maier, RC, 1993)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (2.33)	18.7374
1990's	22 (51.16)	18.2507
2000's	12 (27.91)	29.6817
2010's	8 (18.60)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Åhman, A	1
Jerkeman, A	1
Blomé, MA	1
Björkman, P	1
Håkansson, A	1
McIlwraith, F	1
Betts, KS	1
Jenkinson, R	1
Hickey, S	1
Burns, L	1
Alati, R	1
Rácz, J	2
Csák, R	2
Tóth, KT	1
Tóth, E	1
Rozmán, K	1
Gyarmathy, VA	1
Hail-Jares, K	1
Choi, S	1
Duo, L	1
Luo, Z	1
Huang, ZJ	1
Kelly, PJ	1
Robinson, LD	1
Baker, AL	1
Deane, FP	1
McKetin, R	1
Hudson, S	1
Keane, C	1
Crombag, HS	1
Ferrario, CR	1
Robinson, TE	1
Häggkvist, J	1
Lindholm, S	1
Franck, J	1
Chen, CY	1
Lin, KM	1
Talu, A	1
Rajaleid, K	1
Abel-Ollo, K	1
Rüütel, K	1
Rahu, M	1
Rhodes, T	1
Platt, L	1
Bobrova, N	1
Uusküla, A	1
Hällgren, A	1
Lindqvist, M	1
Faragó, R	1
Vadász, V	1
Moriya, F	1
Hashimoto, Y	1
Fisher, DG	1
Fenaughty, AM	1
Cagle, HH	1
Wells, RS	1
James, D	1
Davies, G	1
Willner, P	1
Peretti-Watel, P	1
Spire, B	1
Lert, F	1
Obadia, Y	1
Kato, H	1
Maeno, Y	1
Seko-Nakamura, Y	1
Monma-Ohtaki, J	1
Sugiura, S	1
Takahashi, K	1
Zhe, LX	1
Matsumoto, T	1
Kurvanov, F	1
Mizokami, M	1
Nagao, M	1
Chuang, TY	1
Chuang, CP	1
Cheng, HH	1
Hsueh, PR	1
Chin, KM	1
Channick, RN	1
Rubin, LJ	1
Tiihonen, J	1
Kuoppasalmi, K	1
Föhr, J	1
Tuomola, P	1
Kuikanmäki, O	1
Vorma, H	1
Sokero, P	1
Haukka, J	1
Meririnne, E	1
Käll, K	2
Nilsonne, A	1
Schütz, CG	1
Rapiti, E	1
Vlahov, D	1
Anthony, JC	1
Darke, S	6
Ross, J	3
Cohen, J	2
Hando, J	4
Hall, W	6
Hawthorne, JL	1
Maier, RC	1
Ragland, AS	1
Ismail, Y	1
Arsura, EL	1
Ross, M	1
Wodak, A	1
Klee, H	2
Morris, J	1
Topp, L	1
Grinde, B	1
Stene-Johansen, K	1
Sharma, B	1
Hoel, T	1
Jensenius, M	1
Skaug, K	1
Kaye, S	1
Blaxhult, A	1
Janzon, R	1
Böttiger, M	1
Annell, A	1
Gabrielsson, G	1
Rantala, J	1
Wejderma, A	1
Käll, KI	2
Dearlove, JC	1
Betteridge, TJ	1
Henry, JA	1
Marks, JA	1
Palombella, A	1
Skretting, A	1
Olin, RG	1
Packe, GE	1
Garton, MJ	1
Jennings, K	1
Giggs, J	1
Bean, P	1
Whynes, D	1
Wilkinson, C	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
HAART Adherence Among HIV-infected Persons and the Factors Affecting Treatment Adherence[NCT01369056]				150 participants (Actual)	Interventional	2010-07-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Health consequences of illegal drug use. Current opinion in psychiatry, 2009, Volume: 22, Issue:3 Topics: Amphetamine; Depressive Disorder; Health Status; Hepatitis C; Humans; Illicit Drugs; Marijuana Abuse	2009
A new target for behavioural research--amphetamine misuse. British journal of addiction, 1992, Volume: 87, Issue:3 Topics: Amphetamine; Heroin Dependence; HIV Infections; Humans; Illicit Drugs; Needle Sharing; Risk Factors;	1992

Article	Year
Needle exchange and injection drug use frequency: a randomized clinical trial. Journal of acquired immune deficiency syndromes (1999), 2003, Jun-01, Volume: 33, Issue:2 Topics: Adult; Alaska; Algorithms; Amphetamine; Cocaine; Cohort Studies; Community Pharmacy Services; Female	2003
A comparison of aripiprazole, methylphenidate, and placebo for amphetamine dependence. The American journal of psychiatry, 2007, Volume: 164, Issue:1 Topics: Adult; Amphetamine; Amphetamine-Related Disorders; Aripiprazole; Female; Humans; Male; Methylphenida	2007

amphetamine and Drug Abuse, Intravenous

Research Excerpts

Research

Studies (43)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Article	Year
Mortality and causes of death among people who inject amphetamine: A long-term follow-up cohort study from a needle exchange program in Sweden. Drug and alcohol dependence, 2018, 07-01, Volume: 188 Topics: Adult; Aged; Aged, 80 and over; Amphetamine; Case-Control Studies; Cause of Death; Cohort Studies; F	2018
Is low BMI associated with specific drug use among injecting drug users? Substance use & misuse, 2014, Volume: 49, Issue:4 Topics: Adolescent; Adult; Amphetamine; Australia; Body Mass Index; Cross-Sectional Studies; Female; Heroin;	2014
Veni, vidi, vici: The appearance and dominance of new psychoactive substances among new participants at the largest needle exchange program in Hungary between 2006 and 2014. Drug and alcohol dependence, 2016, Jan-01, Volume: 158 Topics: Adolescent; Adult; Amphetamine; Female; Heroin; Humans; Hungary; Male; Needle-Exchange Programs; Pre	2016
Occupational and demographic factors associated with drug use among female sex workers at the China-Myanmar border. Drug and alcohol dependence, 2016, Apr-01, Volume: 161 Topics: Adolescent; Adult; Amphetamine; China; Demography; Female; HIV Infections; Humans; Myanmar; Risk-Tak	2016
Polysubstance use in treatment seekers who inject amphetamine: Drug use profiles, injecting practices and quality of life. Addictive behaviors, 2017, Volume: 71 Topics: Adult; Amphetamine; Amphetamine-Related Disorders; Central Nervous System Stimulants; Comorbidity; F	2017
The rate of intravenous cocaine or amphetamine delivery does not influence drug-taking and drug-seeking behavior in rats. Pharmacology, biochemistry, and behavior, 2008, Volume: 90, Issue:4 Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Body Temperature; Cocaine; Cocaine-Related Diso	2008
The opioid receptor antagonist naltrexone attenuates reinstatement of amphetamine drug-seeking in the rat. Behavioural brain research, 2009, Jan-30, Volume: 197, Issue:1 Topics: Amphetamine; Animals; Appetitive Behavior; Behavior, Addictive; Behavior, Animal; Conditioning, Oper	2009
HIV infection and risk behaviour of primary fentanyl and amphetamine injectors in Tallinn, Estonia: implications for intervention. The International journal on drug policy, 2010, Volume: 21, Issue:1 Topics: Adult; Amphetamine; Cross-Sectional Studies; Drug Overdose; Estonia; Female; Fentanyl; HIV Infection	2010
Enterococcal endocarditis among intravenous drug users: report of a cluster of cases, possibly caused by contaminated amphetamine. Scandinavian journal of infectious diseases, 2011, Volume: 43, Issue:5 Topics: Adult; Amphetamine; Animals; Drug Contamination; Endocarditis, Bacterial; Enterococcus faecalis; Fat	2011
[The phenomenon of drug change in the interviews with injecting drug users]. Psychiatria Hungarica : A Magyar Pszichiatriai Tarsasag tudomanyos folyoirata, 2012, Volume: 27, Issue:1 Topics: Adolescent; Adult; Amphetamine; Cocaine; Cocaine-Related Disorders; Designer Drugs; Dopamine Uptake	2012
A case of fatal hemorrhage in the cerebral ventricles following intravenous use of methamphetamine. Forensic science international, 2002, Sep-26, Volume: 129, Issue:2 Topics: Acetic Anhydrides; Adult; Amphetamine; Central Nervous System Stimulants; Cerebral Hemorrhage; Cereb	2002
The development and initial validation of a questionnaire to measure craving for amphetamine. Addiction (Abingdon, England), 2004, Volume: 99, Issue:9 Topics: Adolescent; Adult; Amphetamine; Amphetamine-Related Disorders; Female; Humans; Intention; Male; Midd	2004
Drug use patterns and adherence to treatment among HIV-positive patients: evidence from a large sample of French outpatients (ANRS-EN12-VESPA 2003). Drug and alcohol dependence, 2006, Volume: 82 Suppl 1 Topics: Adult; Amphetamine; Antiretroviral Therapy, Highly Active; Cluster Analysis; Cocaine-Related Disorde	2006
Identification and phylogenetic analysis of hepatitis C virus in forensic blood samples obtained from injecting drug users. Forensic science international, 2007, May-03, Volume: 168, Issue:1 Topics: Adult; Amphetamine; Base Sequence; Central Nervous System Stimulants; DNA, Viral; Female; Forensic M	2007
Aortic valve infective endocarditis caused by Serratia liquefaciens. The Journal of infection, 2007, Volume: 54, Issue:3 Topics: Adult; Amphetamine; Aortic Valve; Endocarditis, Bacterial; Fatal Outcome; Humans; Male; Multiple Org	2007
Is methamphetamine use associated with idiopathic pulmonary arterial hypertension? Chest, 2006, Volume: 130, Issue:6 Topics: Adult; Amphetamine; California; Central Nervous System Stimulants; Chronic Disease; Cocaine; Drug In	2006
Preference for sex on amphetamine: a marker for HIV risk behaviour among male intravenous amphetamine users in Stockholm. AIDS care, 1995, Volume: 7, Issue:2 Topics: Adult; Amphetamine; Female; HIV Seronegativity; HIV Seropositivity; Humans; Male; Predictive Value o	1995
Suspected determinants of enrollment into detoxification and methadone maintenance treatment among injecting drug users. Drug and alcohol dependence, 1994, Volume: 36, Issue:2 Topics: Adolescent; Adult; Amphetamine; Baltimore; Cocaine; Cross-Sectional Studies; Female; Follow-Up Studi	1994
The use of benzodiazepines among regular amphetamine users. Addiction (Abingdon, England), 1994, Volume: 89, Issue:12 Topics: Adolescent; Adult; Amphetamine; Anti-Anxiety Agents; Benzodiazepines; Comorbidity; Female; HIV Infec	1994
The risk of HIV infection for noninjecting sex partners of injecting drug users in Stockholm. AIDS education and prevention : official publication of the International Society for AIDS Education, 1994, Volume: 6, Issue:4 Topics: Adult; Amphetamine; Female; Health Knowledge, Attitudes, Practice; Heroin Dependence; HIV Infections	1994
Transitions between routes of administration of regular amphetamine users. Addiction (Abingdon, England), 1994, Volume: 89, Issue:9 Topics: Adolescent; Adult; Age of Onset; Amphetamine; Australia; Drug Administration Routes; Female; Humans;	1994
HIV risk-taking behaviour among amphetamine users in Sydney, Australia. Addiction (Abingdon, England), 1994, Volume: 89, Issue:1 Topics: Adult; Amphetamine; Female; HIV Infections; Humans; Male; Needle Sharing; New South Wales; Risk-Taki	1994
Drug abuse in an obstetric population of a midsized city. Southern medical journal, 1993, Volume: 86, Issue:12 Topics: Adult; Amphetamine; Barbiturates; Benzodiazepines; Cannabis; Cocaine; Female; Georgia; Humans; Illic	1993
Myocardial infarction after amphetamine use. American heart journal, 1993, Volume: 125, Issue:1 Topics: Adult; Amphetamine; Coronary Angiography; Echocardiography; Electrocardiography; Female; Humans; Myo	1993
Patterns of drug use and risk-taking among injecting amphetamine and opioid drug users in Sydney, Australia. Addiction (Abingdon, England), 1993, Volume: 88, Issue:4 Topics: Adolescent; Adult; Amphetamine; Cross-Sectional Studies; Female; HIV Infections; Humans; Incidence;	1993
The role of needle exchanges in modifying sharing behaviour: cross-study comparisons 1989-1993. Addiction (Abingdon, England), 1995, Volume: 90, Issue:12 Topics: Adult; Amphetamine; England; Female; Health Knowledge, Attitudes, Practice; Heroin Dependence; HIV I	1995
Levels and correlates of polydrug use among heroin users and regular amphetamine users. Drug and alcohol dependence, 1995, Volume: 39, Issue:3 Topics: Adolescent; Adult; Amphetamine; Comorbidity; Female; Heroin Dependence; Humans; Illicit Drugs; Male;	1995
Psychological morbidity and route of administration among amphetamine users in Sydney, Australia. Addiction (Abingdon, England), 1996, Volume: 91, Issue:1 Topics: Adult; Amphetamine; Cross-Sectional Studies; Female; Humans; Incidence; Male; New South Wales; Psych	1996
Amphetamine-related harms and treatment preferences of regular amphetamine users in Sydney, Australia. Drug and alcohol dependence, 1997, Jun-06, Volume: 46, Issue:1-2 Topics: Adolescent; Adult; Amphetamine; Comorbidity; Cross-Sectional Studies; Female; Humans; Incidence; Mal	1997
Characterisation of an epidemic of hepatitis A virus involving intravenous drug abusers--infection by needle sharing? Journal of medical virology, 1997, Volume: 53, Issue:1 Topics: Amphetamine; Base Sequence; Cross Infection; Disease Outbreaks; DNA Primers; Drug Contamination; Hep	1997
A comparison of the harms associated with the injection of heroin and amphetamines. Drug and alcohol dependence, 2000, Feb-01, Volume: 58, Issue:1-2 Topics: Adolescent; Adult; Amphetamine; Chi-Square Distribution; Crime; Female; Heroin; Humans; Interviews a	2000
A six-year follow-up of HIV seroprevalence among 300 intravenous drug users in Stockholm. Scandinavian journal of infectious diseases, 1992, Volume: 24, Issue:6 Topics: Adolescent; Adult; Amphetamine; Female; Follow-Up Studies; Heroin; HIV Seroprevalence; Humans; Male;	1992
Effects of amphetamine on sexual behavior of male i.v. drug users in Stockholm--a pilot study. AIDS education and prevention : official publication of the International Society for AIDS Education, 1992,Spring, Volume: 4, Issue:1 Topics: Acquired Immunodeficiency Syndrome; Adult; Amphetamine; Attitude to Health; Humans; Libido; Male; Mi	1992
Stillbirth due to intravenous amphetamine. BMJ (Clinical research ed.), 1992, Feb-29, Volume: 304, Issue:6826 Topics: Adult; Amphetamine; Female; Fetal Death; Humans; Pregnancy; Substance Abuse, Intravenous	1992
Prescribing smokable drugs. Lancet (London, England), 1990, Apr-07, Volume: 335, Issue:8693 Topics: Administration, Inhalation; Amphetamine; Cocaine; Heroin; Humans; Methadone; Substance Abuse, Intrav	1990
[Intravenous drug users and contact with the health care system]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1990, Aug-20, Volume: 110, Issue:19 Topics: Adult; Amphetamine; Delivery of Health Care; Female; Heroin Dependence; Humans; Male; Norway; Patien	1990
HIV status and changes in risk behaviour among intravenous drug users in Stockholm 1987-1988. AIDS (London, England), 1990, Volume: 4, Issue:2 Topics: Acquired Immunodeficiency Syndrome; Adult; Amphetamine; Behavior; Female; Heroin; HIV Seroprevalence	1990
Acute myocardial infarction caused by intravenous amphetamine abuse. British heart journal, 1990, Volume: 64, Issue:1 Topics: Acute Disease; Adult; Amphetamine; Electric Countershock; Electrocardiography; Humans; Male; Myocard	1990
Class A drug users: prevalence and characteristics in greater Nottingham. British journal of addiction, 1989, Volume: 84, Issue:12 Topics: Adolescent; Adult; Amphetamine; Cross-Sectional Studies; England; Female; Humans; Incidence; Lysergi	1989