amphetamine has been researched along with Chronic Motor and Vocal Tic Disorder in 15 studies
Amphetamine: A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.
1-phenylpropan-2-amine : A primary amine that is isopropylamine in which a hydrogen attached to one of the methyl groups has been replaced by a phenyl group.
amphetamine : A racemate comprising equimolar amounts of (R)-amphetamine (also known as levamphetamine or levoamphetamine) and (S)-amphetamine (also known as dexamfetamine or dextroamphetamine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thus, mouse strains selected for a particular trait may be leveraged to generate hypothesis-driven studies aimed at clarifying the potential role played by the environment in modulating the exhibition of the symptoms of interest." | 1.40 | A behavioural test battery to investigate tic-like symptoms, stereotypies, attentional capabilities, and spontaneous locomotion in different mouse strains. ( Ceci, C; Laviola, G; Macrì, S; Proietti Onori, M, 2014) |
| "Seven adults with Tourette's syndrome and five age-matched comparison subjects each received two positron emission tomography (PET) scans with high specific activity [11C]raclopride." | 1.31 | Elevated intrasynaptic dopamine release in Tourette's syndrome measured by PET. ( Brasic, JR; Dogan, AS; Giuliano, J; Grace, AA; Singer, HS; Szymanski, S; Wong, DF; Yokoi, F; Zhou, Y, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (60.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 4 (26.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Baldan, LC | 1 |
| Williams, KA | 1 |
| Gallezot, JD | 1 |
| Pogorelov, V | 2 |
| Rapanelli, M | 2 |
| Crowley, M | 1 |
| Anderson, GM | 1 |
| Loring, E | 1 |
| Gorczyca, R | 1 |
| Billingslea, E | 1 |
| Wasylink, S | 1 |
| Panza, KE | 1 |
| Ercan-Sencicek, AG | 1 |
| Krusong, K | 1 |
| Leventhal, BL | 1 |
| Ohtsu, H | 2 |
| Bloch, MH | 1 |
| Hughes, ZA | 1 |
| Krystal, JH | 1 |
| Mayes, L | 1 |
| de Araujo, I | 1 |
| Ding, YS | 1 |
| State, MW | 1 |
| Pittenger, C | 3 |
| Proietti Onori, M | 1 |
| Ceci, C | 1 |
| Laviola, G | 1 |
| Macrì, S | 1 |
| Frick, LR | 1 |
| Ota, KT | 1 |
| Abbasi, E | 1 |
| Xu, M | 1 |
| Li, L | 1 |
| Singer, HS | 2 |
| Szymanski, S | 1 |
| Giuliano, J | 1 |
| Yokoi, F | 1 |
| Dogan, AS | 1 |
| Brasic, JR | 2 |
| Zhou, Y | 2 |
| Grace, AA | 2 |
| Wong, DF | 2 |
| POLITES, DJ | 1 |
| KRUGER, D | 1 |
| STEVENSON, I | 1 |
| Schretlen, DJ | 1 |
| Kuwabara, H | 1 |
| Nandi, A | 1 |
| Maris, MA | 1 |
| Alexander, M | 1 |
| Ye, W | 1 |
| Rousset, O | 1 |
| Kumar, A | 1 |
| Szabo, Z | 1 |
| Gjedde, A | 1 |
| Caine, ED | 2 |
| Ludlow, CL | 2 |
| Polinsky, RJ | 2 |
| Ebert, MH | 2 |
| Kinsbourne, M | 1 |
| Nee, LE | 1 |
| Feinberg, M | 1 |
| Carroll, BJ | 1 |
| Milman, DH | 1 |
| Snyder, SH | 2 |
| Taylor, KM | 1 |
| Coyle, JT | 1 |
| Meyerhoff, JL | 2 |
| de Groot, MH | 1 |
| Bardwell, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open Label, Proof-of-Principle, Pilot Study to Evaluate Pimavanserin for the Treatment of Motor and Behavioral Symptoms of Tourette Syndrome[NCT04794413] | Early Phase 1 | 10 participants (Actual) | Interventional | 2018-11-12 | Completed | ||
| Development and Validation of a System for the Anticipation of Challenging Behaviors of People With Autism Spectrum Disorder Based on a Smart Shirt: a Mixed-method Design[NCT05340608] | 51 participants (Actual) | Observational | 2022-06-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for amphetamine and Chronic Motor and Vocal Tic Disorder
| Article | Year |
|---|---|
Mechanisms of dopaminergic and serotonergic neurotransmission in Tourette syndrome: clues from an in vivo neurochemistry study with PET.
Topics: Adult; Amphetamine; Brain Mapping; Dopamine; Dopamine Agents; Dopamine Plasma Membrane Transport Pro | 2008 |
Effects of dopamine agonists and antagonists in Tourette's disease.
Topics: Adolescent; Adult; Amphetamine; Apomorphine; Child; Clinical Trials as Topic; Dextroamphetamine; Dop | 1979 |
13 other studies available for amphetamine and Chronic Motor and Vocal Tic Disorder
| Article | Year |
|---|---|
Histidine decarboxylase deficiency causes tourette syndrome: parallel findings in humans and mice.
Topics: Adolescent; Adult; Amphetamine; Animals; Brain; Child; Dopamine Agonists; Dopamine Antagonists; Expl | 2014 |
A behavioural test battery to investigate tic-like symptoms, stereotypies, attentional capabilities, and spontaneous locomotion in different mouse strains.
Topics: Amphetamine; Amphetamines; Animals; Attention; Central Nervous System Stimulants; Circadian Rhythm; | 2014 |
Dysregulated intracellular signaling in the striatum in a pathophysiologically grounded model of Tourette syndrome.
Topics: Amphetamine; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Glycogen Synthase Kinase 3; | 2014 |
Ablation of fast-spiking interneurons in the dorsal striatum, recapitulating abnormalities seen post-mortem in Tourette syndrome, produces anxiety and elevated grooming.
Topics: Amphetamine; Animals; Anxiety; Central Nervous System Stimulants; Conditioning, Psychological; Corpu | 2016 |
Elevated intrasynaptic dopamine release in Tourette's syndrome measured by PET.
Topics: Adult; Amphetamine; Corpus Striatum; Dopamine; Dopamine Antagonists; Humans; Injections, Intravenous | 2002 |
SEQUENTIAL TREATMENTS IN A CASE OF GILLES DE LA TOURETTE'S SYNDROME.
Topics: Amobarbital; Amphetamine; Amphetamines; Carbon Dioxide; Drug Therapy; Humans; Hypnosis; Mental Disor | 1965 |
Provocative drug testing in Tourette's syndrome: d- and l-amphetamine and haloperidol.
Topics: Adolescent; Adult; Amphetamine; Child; Dextroamphetamine; Female; Haloperidol; Humans; Male; Tic Dis | 1984 |
Do repetitive movement patterns in children and animals serve a dearousing function?
Topics: Amphetamine; Animals; Arousal; Autistic Disorder; Displacement, Psychological; Humans; Intellectual | 1980 |
Heterogeneity and variability in Tourette syndrome.
Topics: Adult; Aged; Amphetamine; Child; Dextroamphetamine; Female; Haloperidol; Humans; Male; Phosphatidylc | 1982 |
Gilles de la Tourette syndrome; extended follow-up.
Topics: Adolescent; Amphetamine; Child; Female; Follow-Up Studies; Haloperidol; Humans; Jews; Male; Psychoth | 1975 |
The role of brain dopamine in behavioral regulation and the actions of psychotropic drugs.
Topics: Amphetamine; Animals; Behavior; Brain; Brain Chemistry; Compulsive Behavior; Dopamine; Haloperidol; | 1970 |
Gilles de la Tourette's disease and minimal brain dysfunction: amphetamine isomers reveal catecholamine correlates in an affected patient.
Topics: Amphetamine; Attention Deficit Disorder with Hyperactivity; Brain; Child; Dextroamphetamine; Dopamin | 1973 |
A case of Gilles de la Tourette's syndrome occurring in New Zealand.
Topics: Adolescent; Amphetamine; Barbiturates; Humans; Male; Mental Disorders; New Zealand; Schizophrenia; S | 1970 |