Page last updated: 2024-10-25

amphetamine and Brain Ischemia

amphetamine has been researched along with Brain Ischemia in 5 studies

Amphetamine: A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.
1-phenylpropan-2-amine : A primary amine that is isopropylamine in which a hydrogen attached to one of the methyl groups has been replaced by a phenyl group.
amphetamine : A racemate comprising equimolar amounts of (R)-amphetamine (also known as levamphetamine or levoamphetamine) and (S)-amphetamine (also known as dexamfetamine or dextroamphetamine.

Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.

Research Excerpts

ExcerptRelevanceReference
"Complete cerebral ischemia was induced in artificially ventilated rats by cardiac arrest."1.26The increase in extracellular potassium concentration in the ischemic brain in relation to the preischemic functional activity and cerebral metabolic rate. ( Astrup, J; Rehncrona, S; Siesjö, BK, 1980)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19901 (20.00)18.7374
1990's1 (20.00)18.2507
2000's3 (60.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gilmour, G1
Iversen, SD1
O'Neill, MF1
O'Neill, MJ1
Ward, MA1
Bannerman, DM1
Sprigg, N1
Willmot, MR1
Gray, LJ1
Sunderland, A1
Pomeroy, V1
Walker, M1
Bath, PM1
Astrup, J1
Rehncrona, S1
Siesjö, BK1
Ueki, A1
Rosén, L1
Andbjer, B1
Agnati, LF1
Hallström, A1
Goiny, M1
Tanganelli, S1
Ungerstedt, U1
Fuxe, K1
Leviel, V1

Reviews

1 review available for amphetamine and Brain Ischemia

ArticleYear
The reverse transport of DA, what physiological significance?
    Neurochemistry international, 2001, Volume: 38, Issue:2

    Topics: Amphetamine; Animals; Biological Transport, Active; Brain Diseases; Brain Ischemia; Corpus Striatum;

2001

Trials

1 trial available for amphetamine and Brain Ischemia

ArticleYear
Amphetamine increases blood pressure and heart rate but has no effect on motor recovery or cerebral haemodynamics in ischaemic stroke: a randomized controlled trial (ISRCTN 36285333).
    Journal of human hypertension, 2007, Volume: 21, Issue:8

    Topics: Adult; Aged; Amphetamine; Blood Pressure; Brain Ischemia; Cerebrovascular Circulation; Double-Blind

2007

Other Studies

3 other studies available for amphetamine and Brain Ischemia

ArticleYear
Amphetamine promotes task-dependent recovery following focal cortical ischaemic lesions in the rat.
    Behavioural brain research, 2005, Nov-30, Volume: 165, Issue:1

    Topics: Amphetamine; Analysis of Variance; Animals; Brain Injuries; Brain Ischemia; Central Nervous System S

2005
The increase in extracellular potassium concentration in the ischemic brain in relation to the preischemic functional activity and cerebral metabolic rate.
    Brain research, 1980, Oct-13, Volume: 199, Issue:1

    Topics: Adenosine Triphosphate; Amphetamine; Animals; Bicuculline; Blood Pressure; Body Temperature; Brain I

1980
Evidence for a preventive action of the vigilance-promoting drug modafinil against striatal ischemic injury induced by endothelin-1 in the rat.
    Experimental brain research, 1993, Volume: 96, Issue:1

    Topics: Amphetamine; Animals; Arousal; Benzhydryl Compounds; Blood Pressure; Brain Ischemia; Cerebrovascular

1993