amphetamine has been researched along with Brain Injuries in 35 studies
Amphetamine: A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.
1-phenylpropan-2-amine : A primary amine that is isopropylamine in which a hydrogen attached to one of the methyl groups has been replaced by a phenyl group.
amphetamine : A racemate comprising equimolar amounts of (R)-amphetamine (also known as levamphetamine or levoamphetamine) and (S)-amphetamine (also known as dexamfetamine or dextroamphetamine.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amphetamine usage was associated with reduced cortical thickness only in patients co-morbid for heavy alcohol use." | 5.36 | Amphetamine dependence and co-morbid alcohol abuse: associations to brain cortical thickness. ( Agartz, I; Bjerkan, PS; Franck, J; Hammarberg, A; Jayaram-Lindström, N; Lawyer, G, 2010) |
| " Amphetamine use at time of injury (n=10) was associated with quicker recovery (posttraumatic amnesia length-days: incidence rate ratio, 0." | 4.31 | The Influence of Substance Use on Traumatic Brain Injury Recovery and Rehabilitation Outcomes: The Outcome-ABI Study. ( Chen, Z; Crotty, M; Jolliff, L; Lannin, NA; Morarty, J; O'Brien, TJ; Pellegrini, M; Ratcliffe, J; Xie, E, 2023) |
| "Amphetamine usage was associated with reduced cortical thickness only in patients co-morbid for heavy alcohol use." | 1.36 | Amphetamine dependence and co-morbid alcohol abuse: associations to brain cortical thickness. ( Agartz, I; Bjerkan, PS; Franck, J; Hammarberg, A; Jayaram-Lindström, N; Lawyer, G, 2010) |
| "Diazepam pre-treatment did not restore the expression of amphetamine CPP." | 1.31 | Diazepam modifies the effect of pedunculopontine lesions on morphine but not on amphetamine conditioned place preference. ( Franklin, KB; Leri, F, 2000) |
| "Amphetamine-treated animals displayed no significant improvement in beam-walking ability either during or after drug intoxication (from days 3 to 5 after brain injury)." | 1.30 | Lack of delayed effects of amphetamine, methoxamine, and prazosin (adrenergic drugs) on behavioral outcome after lateral fluid percussion brain injury in the rat. ( Dhillon, HS; Dose, JM; Kraemer, PJ; Maki, A; Prasad, RM, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (42.86) | 18.7374 |
| 1990's | 6 (17.14) | 18.2507 |
| 2000's | 10 (28.57) | 29.6817 |
| 2010's | 3 (8.57) | 24.3611 |
| 2020's | 1 (2.86) | 2.80 |
| Authors | Studies |
|---|---|
| Xie, E | 1 |
| Pellegrini, M | 1 |
| Chen, Z | 1 |
| Jolliff, L | 1 |
| Crotty, M | 1 |
| Ratcliffe, J | 1 |
| Morarty, J | 1 |
| O'Brien, TJ | 1 |
| Lannin, NA | 1 |
| Gallo, A | 1 |
| Bouchard, C | 1 |
| Fortier, E | 1 |
| Ducrot, C | 1 |
| Rompré, PP | 1 |
| Busch, M | 1 |
| Søreide, E | 1 |
| Lawyer, G | 1 |
| Bjerkan, PS | 1 |
| Hammarberg, A | 1 |
| Jayaram-Lindström, N | 1 |
| Franck, J | 1 |
| Agartz, I | 1 |
| Richer, E | 1 |
| Tell, L | 1 |
| POPEK, K | 1 |
| Gilmour, G | 1 |
| Iversen, SD | 1 |
| O'Neill, MF | 1 |
| O'Neill, MJ | 1 |
| Ward, MA | 1 |
| Bannerman, DM | 1 |
| Bütefisch, CM | 1 |
| Ramic, M | 1 |
| Emerick, AJ | 1 |
| Bollnow, MR | 1 |
| O'Brien, TE | 1 |
| Tsai, SY | 1 |
| Kartje, GL | 1 |
| Angst, MJ | 1 |
| Macedo, CE | 1 |
| Guiberteau, T | 1 |
| Sandner, G | 1 |
| Griesbach, GS | 1 |
| Hovda, DA | 2 |
| Gomez-Pinilla, F | 1 |
| Sutton, RL | 2 |
| Promyslov, MS | 1 |
| Demchuk, ML | 1 |
| Hornstein, A | 1 |
| Lennihan, L | 1 |
| Seliger, G | 1 |
| Lichtman, S | 1 |
| Schroeder, K | 1 |
| Dose, JM | 1 |
| Dhillon, HS | 1 |
| Maki, A | 1 |
| Kraemer, PJ | 1 |
| Prasad, RM | 1 |
| Schmanke, T | 1 |
| Barth, TM | 1 |
| Vargo, JM | 1 |
| Grachek, RA | 1 |
| Rockswold, GL | 1 |
| Chen, MJ | 1 |
| Feeney, DM | 1 |
| Leri, F | 1 |
| Franklin, KB | 1 |
| Nudo, RJ | 1 |
| Plautz, EJ | 1 |
| Frost, SB | 1 |
| Whyte, J | 1 |
| Vaccaro, M | 1 |
| Grieb-Neff, P | 1 |
| Hart, T | 1 |
| Promyslov, MSh | 4 |
| Mirzoian, RA | 1 |
| Baskaeva, TS | 1 |
| Walker, KA | 1 |
| Borshchagovskiĭ, ML | 1 |
| Dubikaitis, IuV | 1 |
| Bach-y-Rita, P | 1 |
| Bjelke, B | 1 |
| Glick, SD | 1 |
| Teuber, HL | 1 |
| Marsden, CA | 1 |
| Guldberg, HC | 1 |
| Friedlander, WJ | 1 |
| Pond, DA | 1 |
| Tigranian, RA | 2 |
| Fog, R | 1 |
| Pakkenberg, H | 1 |
| Tigranian, RH | 1 |
| DiGiacomo, JN | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Optimizing Contralaterally Controlled FES for Acute Upper Limb Hemiplegia[NCT01688856] | 67 participants (Actual) | Interventional | 2013-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The Arm Motor Abilities Test (AMAT) is an assessment of the participant's ability to do 9 standardized upper limb tasks. Each task is composed of 1 to 3 component tasks, each of which is rated on an ordinal scale of 0 to 5. The final score is the average of all component task scores across all 9 compound tasks.~Min=0; Max=5. Higher scores mean a better outcome." (NCT01688856)
Timeframe: 2 timepoints: prior to treatment, 6 months post-treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Arm+Hand CCFES | 1.0 |
| Hand CCFES | 0.8 |
| Arm+Hand Cyclic NMES | 0.9 |
The BBT counts how many blocks a participant can pick up, move over a barrier, and release in 60 seconds. Higher scores mean a better outcome. (NCT01688856)
Timeframe: 2 timepoints: prior to treatment, 6 months post-treatment
| Intervention | blocks (Least Squares Mean) |
|---|---|
| Arm+Hand CCFES | 13.5 |
| Hand CCFES | 12.6 |
| Arm+Hand Cyclic NMES | 9.6 |
Reachable Workspace (RW) is the area (cm^2) traced out when reaching for a target moving in a circular path just outside the reach of the participant. (NCT01688856)
Timeframe: 2 timepoints: prior to treatment, 6 months post-treatment
| Intervention | squared centimeters (Least Squares Mean) |
|---|---|
| Arm+Hand CCFES | 430 |
| Hand CCFES | 166 |
| Arm+Hand Cyclic NMES | 152 |
"Stroke Upper Limb Capacity Scale (SULCS) is a 10-item test in which participants are given a score of 0 or 1 on their performance of tasks requiring varying degrees of upper limb capacity.~Min=0; Max=10. Higher scores mean a better outcome." (NCT01688856)
Timeframe: 2 timepoints: prior to treatment, 6 months post-treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Arm+Hand CCFES | 2.6 |
| Hand CCFES | 1.5 |
| Arm+Hand Cyclic NMES | 1.9 |
"The Upper Extremity Fugl-Meyer (UEFM) is an assessment of motor impairment of the upper limb in which the participant is asked to make specific movements of the arm, forearm, wrist, and hand. Each movement is scored 0, 1, or 2 and the subscores are summed.~Min=0; Max=66. Higher scores mean a better outcome." (NCT01688856)
Timeframe: 2 timepoints: prior to treatment, 6 months post-treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Arm+Hand CCFES | 11.0 |
| Hand CCFES | 4.4 |
| Arm+Hand Cyclic NMES | 10.7 |
6 reviews available for amphetamine and Brain Injuries
| Article | Year |
|---|---|
[Indications, efficacy and tolerance of drug therapy in view of improving recovery of consciousness following a traumatic brain injury].
Topics: Amphetamine; Brain Injuries; Bromocriptine; Central Nervous System Stimulants; Coma; Consciousness; | 2003 |
Neurobiological bases of rehabilitation.
Topics: Amphetamine; Brain Injuries; Central Nervous System Stimulants; Humans; Motor Cortex; Neurobiology; | 2006 |
Role of adaptive plasticity in recovery of function after damage to motor cortex.
Topics: Adaptation, Physiological; Amphetamine; Animals; Brain Injuries; Brain Mapping; Humans; Learning; Lo | 2001 |
Psychostimulant use in the rehabilitation of individuals with traumatic brain injury.
Topics: Amphetamine; Brain Injuries; Central Nervous System Stimulants; Controlled Clinical Trials as Topic; | 2002 |
Epilepsy.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Amphetamine; Anesthetics, Local; Anticonvulsants; Ba | 1967 |
Behaviour disorders in brain-damaged children.
Topics: Adolescent; Age Factors; Amphetamine; Anticonvulsants; Brain Damage, Chronic; Brain Injuries; Child; | 1967 |
29 other studies available for amphetamine and Brain Injuries
| Article | Year |
|---|---|
The Influence of Substance Use on Traumatic Brain Injury Recovery and Rehabilitation Outcomes: The Outcome-ABI Study.
Topics: Adult; Amnesia; Amphetamine; Brain Injuries; Brain Injuries, Traumatic; Humans; Longitudinal Studies | 2023 |
Cannabinoids reward sensitivity in a neurodevelopmental animal model of schizophrenia: a brain stimulation reward study.
Topics: Amphetamine; Analysis of Variance; Animals; Animals, Newborn; Benzoxazines; Brain; Brain Injuries; C | 2014 |
Successful use of therapeutic hypothermia in an opiate induced out-of-hospital cardiac arrest complicated by severe hypoglycaemia and amphetamine intoxication: a case report.
Topics: Adult; Amphetamine; Brain Injuries; Female; Heart Arrest; Heroin; Humans; Hypoglycemia; Hypothermia, | 2010 |
Amphetamine dependence and co-morbid alcohol abuse: associations to brain cortical thickness.
Topics: Adult; Alcoholism; Amphetamine; Amphetamine-Related Disorders; Brain Injuries; Central Nervous Syste | 2010 |
THE STUDY OF CHANGES IN THE SO-CALLED SUCCESSIVE CONTRAST IN NEUROLOGY.
Topics: Afterimage; Amphetamine; Arteriosclerosis; Brain Concussion; Brain Injuries; Brain Neoplasms; Bromid | 1964 |
Amphetamine promotes task-dependent recovery following focal cortical ischaemic lesions in the rat.
Topics: Amphetamine; Analysis of Variance; Animals; Brain Injuries; Brain Ischemia; Central Nervous System S | 2005 |
Axonal plasticity is associated with motor recovery following amphetamine treatment combined with rehabilitation after brain injury in the adult rat.
Topics: Amphetamine; Animals; Axons; Biotin; Brain Injuries; Central Nervous System Stimulants; Dextrans; Di | 2006 |
Alteration of conditioned emotional response and conditioned taste aversion after neonatal ventral hippocampus lesions in rats.
Topics: Amphetamine; Animals; Animals, Newborn; Avoidance Learning; Behavior, Animal; Brain Injuries; Centra | 2007 |
Voluntary exercise or amphetamine treatment, but not the combination, increases hippocampal brain-derived neurotrophic factor and synapsin I following cortical contusion injury in rats.
Topics: Amphetamine; Animals; Blotting, Western; Brain Injuries; Brain-Derived Neurotrophic Factor; Central | 2008 |
Interrelationship between the functional state of the central nervous system and lipid peroxidation level in brain following craniocerebral trauma.
Topics: Amphetamine; Animals; Antioxidants; Behavior, Animal; Brain Chemistry; Brain Injuries; Central Nervo | 1995 |
Amphetamine in recovery from brain injury.
Topics: Adolescent; Adult; Aged; Amphetamine; Brain Injuries; Central Nervous System Stimulants; Humans; Mid | 1996 |
Lack of delayed effects of amphetamine, methoxamine, and prazosin (adrenergic drugs) on behavioral outcome after lateral fluid percussion brain injury in the rat.
Topics: Amphetamine; Animals; Behavior, Animal; Brain Injuries; Male; Methoxamine; Prazosin; Rats; Rats, Spr | 1997 |
Amphetamine and task-specific practice augment recovery of vibrissae-evoked forelimb placing after unilateral sensorimotor cortical injury in the rat.
Topics: Amphetamine; Animals; Behavior, Animal; Brain Injuries; Central Nervous System Stimulants; Disease M | 1997 |
Light deprivation soon after frontal brain trauma accelerates recovery from attentional deficits and promotes functional normalization of basal ganglia.
Topics: Amphetamine; Analysis of Variance; Animals; Attention; Basal Ganglia; Behavior, Animal; Brain Injuri | 1999 |
Alleviation of brain injury-induced cerebral metabolic depression by amphetamine: a cytochrome oxidase histochemistry study.
Topics: Amphetamine; Animals; Brain; Brain Injuries; Electron Transport Complex IV; Histocytochemistry; Male | 2000 |
Diazepam modifies the effect of pedunculopontine lesions on morphine but not on amphetamine conditioned place preference.
Topics: Amphetamine; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Brain Injuries; Central Ne | 2000 |
[Homocarnosine metabolism in brain tissue].
Topics: Amphetamine; Animals; Brain; Brain Injuries; Brain Neoplasms; Brain Stem; Carnosine; Dipeptides; Hum | 1976 |
[Regulation of mitochondrial monoamine oxidase activity in the brain in experimental closed cranio-cerebral trauma].
Topics: Acute Disease; Amphetamine; Animals; Brain; Brain Injuries; Brain Stem; Cerebellum; Craniocerebral T | 1975 |
Motor-racing.
Topics: Airway Obstruction; Alcohol Drinking; Amphetamine; Athletic Injuries; Automobile Driver Examination; | 1975 |
[Clinico-electroencephalographic characteristics of the condition of brain stem systems following surgical and non-surgical brain injury].
Topics: Adult; Amphetamine; Anesthesia, General; Autonomic Nervous System; Brain Injuries; Brain Neoplasms; | 1976 |
Lasting recovery of motor function, following brain damage, with a single dose of amphetamine combined with physical therapy; changes in gene expression?
Topics: Amphetamine; Animals; Brain Injuries; Genes, fos; Humans; Psychomotor Performance | 1991 |
Functional recovery after lesions of the nervous system. IV. Structural correlates of recovery in adult subjects. Changes in drug sensitivity during recovery of function after brain damage.
Topics: Amphetamine; Animals; Apomorphine; Brain; Brain Injuries; Brain Mapping; Corpus Striatum; Frontal Lo | 1974 |
Functional recovery after lesions of the nervous system. II. Recovery of function after lesions of the central nervous system: history and prospects.
Topics: Age Factors; Amphetamine; Anesthesia, General; Animals; Aphasia; Brain Injuries; Brain Mapping; Cats | 1974 |
The role of monoamines in rotation induced or potentiated by amphetamine after nigral, raphe and mesencephalic reticular lesions in the rat brain.
Topics: Amines; Amphetamine; Animals; Behavior, Animal; Brain; Brain Injuries; Catalepsy; Cerebral Cortex; C | 1973 |
[Characteristics of brain energy metabolism in craniocerebral trauma].
Topics: Adenine Nucleotides; Adenosine Diphosphate; Adenosine Triphosphate; Amphetamine; Animals; Brain; Bra | 1971 |
Intracerebral lesions causing stereotyped behaviour in rats.
Topics: Amphetamine; Animals; Basal Ganglia; Behavior, Animal; Brain Injuries; Catalepsy; Catheterization; D | 1971 |
[Peculiarities of oxidative phosphorylation in brain mitochondria with craniocerebral trauma].
Topics: Amphetamine; Animals; Brain; Brain Injuries; Brain Stem; Cerebellum; Cerebral Cortex; Male; Mitochon | 1969 |
[Effect of brain injury on carbohydrate metabolism in the brain].
Topics: Amphetamine; Animals; Barbiturates; Brain; Brain Injuries; Glycolysis; Hexokinase; Male; Rabbits; Ur | 1970 |
Toxic effect of stramonium simulating LSD trip.
Topics: Adolescent; Amphetamine; Atropa belladonna; Body Temperature; Brain Injuries; Datura stramonium; Dia | 1968 |