amphetamine has been researched along with Bipolar Disorder in 85 studies
Amphetamine: A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.
1-phenylpropan-2-amine : A primary amine that is isopropylamine in which a hydrogen attached to one of the methyl groups has been replaced by a phenyl group.
amphetamine : A racemate comprising equimolar amounts of (R)-amphetamine (also known as levamphetamine or levoamphetamine) and (S)-amphetamine (also known as dexamfetamine or dextroamphetamine.
Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The use of traditional psychostimulants (methylphenidate and dexamphetamine) and stimulant-like drugs (modafinil and armodafinil) for the treatment of depression is a growing concern given the lack of research evidence supporting their effectiveness." | 4.93 | Stimulants for depression: On the up and up? ( Bassett, D; Boyce, P; Byrow, Y; Hopwood, M; Lyndon, W; Malhi, GS; Mulder, R; Murray, G; Porter, R; Singh, A, 2016) |
| "Lithium carbonate (LiCO) is a mainstay therapeutic for the prevention of mood-episode recurrences in bipolar disorder (BD)." | 4.31 | Different pharmacokinetics of lithium orotate inform why it is more potent, effective, and less toxic than lithium carbonate in a mouse model of mania. ( Bekar, LK; Pacholko, AG, 2023) |
| " In the context of bipolar disorder, amphetamine-induced hyperactivity (AIH) is a frequently used screening model for antimanic effects." | 3.91 | Questioning the predictive validity of the amphetamine-induced hyperactivity model for screening mood stabilizing drugs. ( Einat, H; Lan, A, 2019) |
| " Two successive generations of female rats were supplemented with soybean oil (SO, rich in n-6 FA, control group), fish oil (FO, rich in n-3 FA) and hydrogenated vegetable fat (HVF, rich in trans FA) from pregnancy, lactation to adulthood, when male rats from 2nd generation received amphetamine (AMPH-4 mg/kg-i." | 3.81 | Cross-generational trans fat intake facilitates mania-like behavior: oxidative and molecular markers in brain cortex. ( Barcelos, RC; Bürger, ME; Dias, VT; Emanuelli, T; Golombieski, R; Kuhn, FT; Pase, CS; Piccolo, J; Pochmann, D; Porciúncula, LO; Rocha, JB; Roversi, K; Trevizol, F; Veit, JC, 2015) |
| "Asenapine is indicated for the treatment of schizophrenia and manic episodes in bipolar disorder (BPD)." | 3.81 | The effects of the atypical antipsychotic asenapine in a strain-specific battery of tests for mania-like behaviors. ( Einat, H; Ene, HM; Kara, NZ, 2015) |
| " The antidepressant imipramine, which shows pro-manic properties in patients with bipolar disorder (BPD), also enhanced phospho-MARCKS in prefrontal cortex in vivo." | 3.75 | Glutamate receptors as targets of protein kinase C in the pathophysiology and treatment of animal models of mania. ( Cirelli, C; Du, J; Falke, C; Machado-Vieira, R; Manji, HK; Szabo, ST; Tononi, G; Wang, Y; Wei, Y; Yuan, P, 2009) |
| " In sight of the scarcity of studies with other neurotrophins, and the possible relevance of multiple neurotrophic signaling systems in bipolar disorder we investigated the effects of Li and VPT on NT-3 levels in rat serum and hippocampus, using an animal model of mania induced by amphetamine (AMPH)." | 3.74 | Effects of lithium and valproate on serum and hippocampal neurotrophin-3 levels in an animal model of mania. ( Andreazza, AC; Cacilhas, AA; Ceresér, KM; Frey, BN; Kapczinski, F; Quevedo, J; Valvassori, SS; Walz, JC, 2008) |
| " The present study aims to investigate the effects of the mood stabilizers lithium (Li) and valproate (VPT) in an animal model of bipolar disorder." | 3.73 | Effects of mood stabilizers on hippocampus BDNF levels in an animal model of mania. ( Andreazza, AC; Ceresér, KM; Frey, BN; Kapczinski, F; Martins, MR; Quevedo, J; Réus, GZ; Valvassori, SS, 2006) |
| "Some evidence indicates that bipolar depression may be more responsive to dopaminergic agents, suggesting that adjunctive stimulant medication may be an effective treatment for bipolar depression as well as for medication-induced sedation." | 2.71 | Adjunctive stimulant use in patients with bipolar disorder: treatment of residual depression and sedation. ( Carlson, PJ; Merlock, MC; Suppes, T, 2004) |
| "Amphetamine was clearly superior to placebo in reducing inattention, hyperactivity, and other disruptive behavior problems and tended to lead to improved results on the Wechsler Intelligence Scale for Children--Revised." | 2.68 | Long-term stimulant treatment of children with attention-deficit hyperactivity disorder symptoms. A randomized, double-blind, placebo-controlled trial. ( Eidevall-Wallin, L; Gillberg, C; Gustafsson, P; Hägglöf, B; Janols, LO; Kopp, S; Melander, H; Thernlund, G; von Knorring, AL, 1997) |
| "d-Amphetamine was 2 to 2." | 2.64 | Attenuation of the euphoriant and activating effects of d- and l-amphetamine by lithium carbonate treatment. ( Murphy, DL; Van Kammen, DP, 1975) |
| "Amphetamine salts have been helpful in treating bipolar children with comorbid ADHD, but no data are available on treating comorbid depression in bipolar children." | 2.43 | Recognizing and managing bipolar disorder in children. ( Wozniak, J, 2005) |
| "To this aim, we subdivided juvenile rats into those emitting low (LC) and high (HC) rates of baseline 50-kHz USV and compared them across four AMPH dosage conditions: 0." | 1.48 | Mapping trait-like socio-affective phenotypes in rats through 50-kHz ultrasonic vocalizations. ( Engelhardt, K-; Schwarting, RKW; Wöhr, M, 2018) |
| "Candesartan (CDS) is an AT1 receptor antagonist with potential neuroprotective properties." | 1.42 | Antimanic-like activity of candesartan in mice: Possible involvement of antioxidant, anti-inflammatory and neurotrophic mechanisms. ( Berk, M; Budni, J; Carvalho, AF; Cavalcante, LM; de Lucena, DF; de Sousa, FC; de Souza Gomes, JA; de Souza, GC; Macêdo, D; Quevedo, J, 2015) |
| "Pretreatment with lamotrigine significantly attenuated AMPH/CDP-induced effects, but also reduced motility when tested in the presence of CDP-alone." | 1.35 | Effects of neuronal Kv7 potassium channel activators on hyperactivity in a rodent model of mania. ( Nielsen, AN; Redrobe, JP, 2009) |
| "Bipolar mania and schizophrenia are recognized as separate disorders but share many commonalities, which raises the question of whether they are the same disorder on different ends of a continuum." | 1.35 | A reverse-translational study of dysfunctional exploration in psychiatric disorders: from mice to men. ( Ferguson, EJ; Geyer, MA; Henry, BL; Kincaid, MJ; Masten, VL; Minassian, A; Paulus, MP; Perry, W; Sharp, RF; Young, JW; Zhuang, X, 2009) |
| "In amphetamine-pretreated animals, valproate administration reversed citrate synthase activity inhibition induced by amphetamine." | 1.34 | Effects of lithium and valproate on hippocampus citrate synthase activity in an animal model of mania. ( Amboni, G; Assis, LC; Corrêa, C; Kapczinski, F; Martins, MR; Quevedo, J; Streck, EL, 2007) |
| "A group of 329 hospitalized drug abusers were evaluated for a current or past diagnosis of alcoholism." | 1.27 | A comparison of alcoholic and nonalcoholic drug abusers. ( Griffin, ML; Michael, JL; Mirin, SM; Weiss, RD, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (38.82) | 18.7374 |
| 1990's | 2 (2.35) | 18.2507 |
| 2000's | 22 (25.88) | 29.6817 |
| 2010's | 25 (29.41) | 24.3611 |
| 2020's | 3 (3.53) | 2.80 |
| Authors | Studies |
|---|---|
| Pacholko, AG | 1 |
| Bekar, LK | 1 |
| Zhao, WN | 1 |
| Tobe, BTD | 1 |
| Udeshi, ND | 1 |
| Xuan, LL | 1 |
| Pernia, CD | 1 |
| Zolg, DP | 1 |
| Roberts, AJ | 1 |
| Mani, D | 1 |
| Blumenthal, SR | 1 |
| Kurtser, I | 1 |
| Patnaik, D | 1 |
| Gaisina, I | 1 |
| Bishop, J | 1 |
| Sheridan, SD | 1 |
| Lalonde, J | 1 |
| Carr, SA | 1 |
| Snyder, EY | 1 |
| Haggarty, SJ | 1 |
| Armstrong, C | 1 |
| Kapolowicz, MR | 1 |
| Parekh, PK | 1 |
| Sidor, MM | 1 |
| Gillman, A | 1 |
| Becker-Krail, D | 1 |
| Bettelini, L | 1 |
| Arban, R | 1 |
| Alvaro, GS | 1 |
| Zambello, E | 1 |
| Mutinelli, C | 1 |
| Huang, Y | 2 |
| Large, CH | 1 |
| McClung, CA | 1 |
| Engelhardt, K- | 1 |
| Schwarting, RKW | 1 |
| Wöhr, M | 1 |
| Pappas, AL | 1 |
| Bey, AL | 1 |
| Wang, X | 1 |
| Rossi, M | 1 |
| Kim, YH | 1 |
| Yan, H | 1 |
| Porkka, F | 1 |
| Duffney, LJ | 1 |
| Phillips, SM | 1 |
| Cao, X | 1 |
| Ding, JD | 1 |
| Rodriguiz, RM | 1 |
| Yin, HH | 1 |
| Weinberg, RJ | 1 |
| Ji, RR | 1 |
| Wetsel, WC | 1 |
| Jiang, YH | 1 |
| Hodes, A | 1 |
| Lifschytz, T | 1 |
| Rosen, H | 1 |
| Cohen Ben-Ami, H | 1 |
| Lichtstein, D | 1 |
| Han, L | 1 |
| Wang, L | 1 |
| Tang, S | 1 |
| Yuan, L | 1 |
| Wu, S | 1 |
| Du, X | 1 |
| Xiang, Y | 1 |
| Qu, X | 1 |
| Liu, H | 1 |
| Luo, H | 1 |
| Qin, X | 1 |
| Liu, C | 1 |
| Lan, A | 1 |
| Einat, H | 7 |
| Kim, W | 1 |
| Won, SY | 1 |
| Yoon, BJ | 1 |
| Castellani, G | 1 |
| Contarini, G | 1 |
| Mereu, M | 1 |
| Albanesi, E | 1 |
| Devroye, C | 1 |
| D'Amore, C | 1 |
| Ferretti, V | 1 |
| De Martin, S | 1 |
| Papaleo, F | 1 |
| Trevizol, F | 3 |
| Roversi, K | 6 |
| Dias, VT | 3 |
| Pase, CS | 3 |
| Barcelos, RC | 3 |
| Benvegnu, DM | 1 |
| Kuhn, FT | 2 |
| Dolci, GS | 1 |
| Ross, DH | 1 |
| Veit, JC | 2 |
| Piccolo, J | 2 |
| Emanuelli, T | 3 |
| Bürger, ME | 3 |
| Valvassori, SS | 10 |
| Bavaresco, DV | 1 |
| Budni, J | 2 |
| Bobsin, TS | 1 |
| Gonçalves, CL | 1 |
| de Freitas, KV | 1 |
| Streck, EL | 4 |
| Quevedo, J | 12 |
| Golombieski, R | 2 |
| Pochmann, D | 1 |
| Porciúncula, LO | 1 |
| Rocha, JB | 1 |
| Ene, HM | 2 |
| Kara, NZ | 3 |
| Fries, GR | 1 |
| Bock, H | 1 |
| Stertz, L | 2 |
| Magalhães, PV | 1 |
| Mariot, E | 1 |
| Varela, RB | 1 |
| Kauer-Sant'Anna, M | 2 |
| Kapczinski, F | 9 |
| Saraiva-Pereira, ML | 1 |
| Zhou, Z | 1 |
| Wang, Y | 2 |
| Tan, H | 2 |
| Bharti, V | 1 |
| Che, Y | 2 |
| Wang, JF | 2 |
| de Souza Gomes, JA | 1 |
| de Souza, GC | 1 |
| Berk, M | 1 |
| Cavalcante, LM | 1 |
| de Sousa, FC | 1 |
| de Lucena, DF | 1 |
| Carvalho, AF | 1 |
| Macêdo, D | 1 |
| Kunh, FT | 1 |
| Schuster, AJ | 1 |
| Flaisher-Grinberg, S | 2 |
| Malhi, GS | 1 |
| Byrow, Y | 1 |
| Bassett, D | 1 |
| Boyce, P | 1 |
| Hopwood, M | 1 |
| Lyndon, W | 1 |
| Mulder, R | 1 |
| Porter, R | 1 |
| Singh, A | 1 |
| Murray, G | 1 |
| Szabo, ST | 2 |
| Machado-Vieira, R | 1 |
| Yuan, P | 2 |
| Wei, Y | 1 |
| Falke, C | 1 |
| Cirelli, C | 1 |
| Tononi, G | 1 |
| Manji, HK | 2 |
| Du, J | 1 |
| Andreazza, AC | 4 |
| Frey, BN | 5 |
| Zanotto, C | 1 |
| Ribeiro, L | 1 |
| Giasson, K | 1 |
| Réus, GZ | 4 |
| Salvador, M | 1 |
| Gonçalves, CA | 1 |
| Redrobe, JP | 1 |
| Nielsen, AN | 1 |
| Zugno, AI | 1 |
| Scherer, EB | 1 |
| Mattos, C | 1 |
| Matté, C | 1 |
| Ferreira, CL | 1 |
| Rezin, GT | 2 |
| Wyse, AT | 1 |
| Kelly, MP | 1 |
| Logue, SF | 1 |
| Dwyer, JM | 1 |
| Beyer, CE | 1 |
| Majchrowski, H | 1 |
| Cai, Z | 1 |
| Liu, Z | 1 |
| Adedoyin, A | 1 |
| Rosenzweig-Lipson, S | 1 |
| Comery, TA | 1 |
| Perry, W | 1 |
| Minassian, A | 1 |
| Paulus, MP | 1 |
| Young, JW | 2 |
| Kincaid, MJ | 1 |
| Ferguson, EJ | 1 |
| Henry, BL | 1 |
| Zhuang, X | 1 |
| Masten, VL | 1 |
| Sharp, RF | 1 |
| Geyer, MA | 2 |
| Dencker, D | 2 |
| Husum, H | 2 |
| Elias, G | 1 |
| de Souza, B | 1 |
| Petronilho, F | 1 |
| Dal-Pizzol, F | 2 |
| Trzesniak, C | 1 |
| Tumas, V | 1 |
| Dursun, S | 1 |
| Chagas, MH | 1 |
| Hallak, JE | 1 |
| Zuardi, AW | 1 |
| Crippa, JA | 1 |
| Kalinichev, M | 1 |
| Dawson, LA | 1 |
| Hannah-Poquette, C | 1 |
| Anderson, GW | 1 |
| Wang, J | 1 |
| Meinerding, TM | 1 |
| Young, LT | 1 |
| Shao, L | 1 |
| Honer, WG | 1 |
| van Enkhuizen, J | 1 |
| ALLIEZ, J | 1 |
| SAVY, A | 1 |
| GIBERTI, F | 1 |
| ROSSI, R | 1 |
| CLANCY, J | 1 |
| Carlson, PJ | 1 |
| Merlock, MC | 1 |
| Suppes, T | 1 |
| DELAY, J | 1 |
| PICHOT, P | 1 |
| DENIKER, P | 1 |
| Wozniak, J | 1 |
| Ceresér, KM | 2 |
| Martins, MR | 4 |
| Petronilho, FC | 1 |
| Bardini, K | 1 |
| Rosa, AR | 1 |
| Hatch, JP | 1 |
| Corrêa, C | 1 |
| Amboni, G | 2 |
| Assis, LC | 1 |
| Walz, JC | 1 |
| Cacilhas, AA | 1 |
| Kozikowski, AP | 1 |
| Gaisina, IN | 1 |
| Yuan, H | 1 |
| Petukhov, PA | 1 |
| Blond, SY | 1 |
| Fedolak, A | 1 |
| Caldarone, B | 1 |
| McGonigle, P | 1 |
| McNamara, RK | 1 |
| Sullivan, J | 1 |
| Richtand, NM | 1 |
| Dogra, S | 1 |
| Dias, R | 1 |
| Pedersen, ML | 1 |
| Scaini, G | 1 |
| Di-Pietro, PB | 1 |
| Luz, G | 1 |
| Maas, JW | 1 |
| Kalix, P | 1 |
| Saratikov, AS | 1 |
| Zamoshchina, TA | 1 |
| Alekseeva, LP | 1 |
| Agarkova, VP | 1 |
| Silverstone, T | 1 |
| Feinberg, M | 1 |
| Carroll, BJ | 1 |
| Post, RM | 1 |
| Uhde, TW | 1 |
| Putnam, FW | 1 |
| Ballenger, JC | 1 |
| Berrettini, WH | 1 |
| Antelman, SM | 2 |
| Chiodo, LA | 1 |
| DeGiovanni, LA | 1 |
| Gillberg, C | 1 |
| Melander, H | 1 |
| von Knorring, AL | 1 |
| Janols, LO | 1 |
| Thernlund, G | 1 |
| Hägglöf, B | 1 |
| Eidevall-Wallin, L | 1 |
| Gustafsson, P | 1 |
| Kopp, S | 1 |
| Caggiula, AR | 1 |
| Kucinski, BJ | 1 |
| Fowler, H | 1 |
| Gershon, S | 2 |
| Edwards, DJ | 1 |
| Austin, MC | 1 |
| Stiller, R | 1 |
| Kiss, S | 1 |
| Kocan, D | 1 |
| Anand, A | 1 |
| Verhoeff, P | 1 |
| Seneca, N | 1 |
| Zoghbi, SS | 1 |
| Seibyl, JP | 1 |
| Charney, DS | 1 |
| Innis, RB | 1 |
| Weintraub, D | 1 |
| Linder, MW | 1 |
| Shaldivin, A | 1 |
| Kaptsan, A | 1 |
| Belmaker, RH | 1 |
| Grisaru, N | 1 |
| Niculescu, AB | 1 |
| Kelsoe, JR | 1 |
| Van Kammen, DP | 1 |
| Murphy, DL | 1 |
| Poitou, P | 1 |
| Boulu, R | 1 |
| Bohuon, C | 1 |
| Sachar, EJ | 2 |
| Mamelak, M | 1 |
| Gold, MS | 1 |
| Byck, R | 1 |
| Baron, M | 1 |
| Mandell, AJ | 1 |
| Knapp, S | 1 |
| Mikhalenko, IN | 1 |
| Kiseleva, LP | 1 |
| Lapin, IP | 1 |
| Weiss, RD | 1 |
| Mirin, SM | 1 |
| Griffin, ML | 1 |
| Michael, JL | 1 |
| Schmidt, CW | 1 |
| Randrup, A | 1 |
| Munkvad, I | 1 |
| Schnee, J | 1 |
| Johnson, G | 1 |
| Schildkraut, JJ | 1 |
| Davis, JM | 2 |
| Stone, MH | 1 |
| Dalai, O | 1 |
| Stone, WN | 1 |
| Hofling, CK | 1 |
| Winslow, WW | 1 |
| Chien, CP | 1 |
| Kaplan, RM | 1 |
| Medvecký, J | 1 |
| Niskac, M | 1 |
| Klimo, Z | 1 |
| Mashkovskii, MD | 1 |
| Polezhaeva, AI | 1 |
| Avrutskii, GIa | 1 |
| Vertozgadova, OP | 1 |
| Smulevich, AB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| PET Imaging of Dopamine D2 Receptors and Extracellular Dopamine With (18F)Fallypride, D-amphetamine, and Alpha-Methyl-Para-Tyrosine in Healthy Subjects[NCT00062946] | Phase 2 | 45 participants | Interventional | 2003-06-17 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
14 reviews available for amphetamine and Bipolar Disorder
| Article | Year |
|---|---|
Stimulants for depression: On the up and up?
Topics: Amphetamine; Antidepressive Agents; Benzhydryl Compounds; Bipolar Disorder; Central Nervous System S | 2016 |
Recognizing and managing bipolar disorder in children.
Topics: Adolescent; Age Factors; Amphetamine; Anticonvulsants; Antipsychotic Agents; Attention Deficit Disor | 2005 |
Noradrenergic function and depression, too much or too little?
Topics: Amphetamine; Bipolar Disorder; Brain; Brain Chemistry; Desipramine; Electroconvulsive Therapy; Human | 1980 |
The clinical pharmacology of appetite--its relevance to psychiatry.
Topics: Amphetamine; Anorexia; Appetite; Bipolar Disorder; Brain Chemistry; Depressive Disorder; Dopamine; F | 1983 |
Kindling and carbamazepine in affective illness.
Topics: Affective Disorders, Psychotic; Amphetamine; Amygdala; Animals; Bipolar Disorder; Carbamazepine; Coc | 1982 |
Convergent functional genomics: application to bipolar disorder.
Topics: Amphetamine; Animals; Bipolar Disorder; Cloning, Molecular; Gene Expression Profiling; Genetic Linka | 2001 |
Evidence for neuroendocrine abnormalities in the major mental illnesses.
Topics: Adrenocorticotropic Hormone; Aged; Amphetamine; Bipolar Disorder; Chlorpromazine; Circadian Rhythm; | 1975 |
An amphetamine model of manic depressive illness.
Topics: Adaptation, Psychological; Amphetamine; Antidepressive Agents; Bipolar Disorder; Brain; Humans; Lith | 1978 |
The biology of affective disorders.
Topics: Adrenocorticotropic Hormone; Amphetamine; Antidepressive Agents, Tricyclic; Biogenic Amines; Bipolar | 1979 |
Pharmacology and physiology of stereotyped behavior.
Topics: Amphetamine; Animals; Apomorphine; Avoidance Learning; Behavior; Behavior, Animal; Bipolar Disorder; | 1974 |
Differential response to psychotropic drugs.
Topics: Adult; Affective Symptoms; Amphetamine; Antidepressive Agents; Bipolar Disorder; Central Nervous Sys | 1971 |
Drug-related schizophrenic syndromes.
Topics: Amphetamine; Bipolar Disorder; Cannabis; Diagnosis, Differential; Female; Humans; Lysergic Acid Diet | 1973 |
Drug therapy.
Topics: Amphetamine; Animals; Antidepressive Agents; Bipolar Disorder; Butyrophenones; Chlorprothixene; Clin | 1968 |
Theories of biological etiology of affective disorders.
Topics: Adrenal Cortex Hormones; Affective Symptoms; Amines; Amphetamine; Antidepressive Agents; Bipolar Dis | 1970 |
5 trials available for amphetamine and Bipolar Disorder
| Article | Year |
|---|---|
Adjunctive stimulant use in patients with bipolar disorder: treatment of residual depression and sedation.
Topics: Adult; Aged; Amphetamine; Antipsychotic Agents; Bipolar Disorder; Central Nervous System Stimulants; | 2004 |
Long-term stimulant treatment of children with attention-deficit hyperactivity disorder symptoms. A randomized, double-blind, placebo-controlled trial.
Topics: Abdominal Pain; Amphetamine; Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Centra | 1997 |
Attenuation of the euphoriant and activating effects of d- and l-amphetamine by lithium carbonate treatment.
Topics: Adult; Amphetamine; Bipolar Disorder; Depression; Dextroamphetamine; Euphoria; Female; Humans; Hydro | 1975 |
Drug therapy.
Topics: Amphetamine; Animals; Antidepressive Agents; Bipolar Disorder; Butyrophenones; Chlorprothixene; Clin | 1968 |
Clinical trial of imidazoline (DH-524) as an antidepressant. I. Browsing phase.
Topics: Adult; Amphetamine; Antidepressive Agents; Bipolar Disorder; Clinical Trials as Topic; Female; Human | 1969 |
67 other studies available for amphetamine and Bipolar Disorder
| Article | Year |
|---|---|
Different pharmacokinetics of lithium orotate inform why it is more potent, effective, and less toxic than lithium carbonate in a mouse model of mania.
Topics: Amphetamine; Animals; Antimanic Agents; Bipolar Disorder; Disease Models, Animal; Female; Lithium; L | 2023 |
Discovery of suppressors of CRMP2 phosphorylation reveals compounds that mimic the behavioral effects of lithium on amphetamine-induced hyperlocomotion.
Topics: Amphetamine; Animals; Bipolar Disorder; Humans; Induced Pluripotent Stem Cells; Lithium; Lithium Com | 2020 |
Mixed Amphetamine Salts Without a Mood Stabilizer for Treating Comorbid Attention-Deficit Hyperactivity Disorder and Bipolar Disorder: Two Case Reports.
Topics: Amphetamine; Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; | 2023 |
Antimanic Efficacy of a Novel Kv3 Potassium Channel Modulator.
Topics: Akathisia, Drug-Induced; Amphetamine; Animals; Behavior, Animal; Bipolar Disorder; Central Nervous S | 2018 |
Mapping trait-like socio-affective phenotypes in rats through 50-kHz ultrasonic vocalizations.
Topics: Affect; Amphetamine; Animals; Bipolar Disorder; Central Nervous System Stimulants; Dose-Response Rel | 2018 |
Deficiency of Shank2 causes mania-like behavior that responds to mood stabilizers.
Topics: Amphetamine; Anhedonia; Animals; Antimanic Agents; Behavior, Animal; Bipolar Disorder; Central Nervo | 2017 |
Reduction in endogenous cardiac steroids protects the brain from oxidative stress in a mouse model of mania induced by amphetamine.
Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Antibodies; Antioxidants; Bipolar Disorder; Bra | 2018 |
ITGB4 deficiency in bronchial epithelial cells directs airway inflammation and bipolar disorder-related behavior.
Topics: Amphetamine; Animals; Anti-Bacterial Agents; Bipolar Disorder; Bronchitis; Disease Models, Animal; D | 2018 |
Questioning the predictive validity of the amphetamine-induced hyperactivity model for screening mood stabilizing drugs.
Topics: Amphetamine; Animals; Anticonvulsants; Antimanic Agents; Behavior, Animal; Bipolar Disorder; Central | 2019 |
CRMP2 mediates GSK3β actions in the striatum on regulating neuronal structure and mania-like behavior.
Topics: Amphetamine; Animals; Bipolar Disorder; Cells, Cultured; Corpus Striatum; Dendrites; Depression; Dis | 2019 |
Dopamine-mediated immunomodulation affects choroid plexus function.
Topics: Amphetamine; Animals; Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Central Nervo | 2019 |
Influence of lifelong dietary fats on the brain fatty acids and amphetamine-induced behavioral responses in adult rat.
Topics: Amphetamine; Animals; Bipolar Disorder; Brain; Cerebral Cortex; Corpus Striatum; Dietary Fats; Explo | 2013 |
Effects of tamoxifen on tricarboxylic acid cycle enzymes in the brain of rats submitted to an animal model of mania induced by amphetamine.
Topics: Amphetamine; Animals; Antimanic Agents; Bipolar Disorder; Brain; Citric Acid Cycle; Disease Models, | 2014 |
Cross-generational trans fat intake facilitates mania-like behavior: oxidative and molecular markers in brain cortex.
Topics: Age Factors; Amphetamine; Animals; Bipolar Disorder; Brain Chemistry; Brain-Derived Neurotrophic Fac | 2015 |
The effects of the atypical antipsychotic asenapine in a strain-specific battery of tests for mania-like behaviors.
Topics: Akathisia, Drug-Induced; Amphetamine; Anhedonia; Animals; Antimanic Agents; Antipsychotic Agents; Ap | 2015 |
Introducing Female Black Swiss Mice: Minimal Effects of Sex in a Strain-Specific Battery of Tests for Mania-Like Behavior and Response to Lithium.
Topics: Amphetamine; Animals; Antipsychotic Agents; Behavior, Animal; Bipolar Disorder; Disease Models, Anim | 2015 |
Memory and brain-derived neurotrophic factor after subchronic or chronic amphetamine treatment in an animal model of mania.
Topics: Amphetamine; Amygdala; Animals; Avoidance Learning; Behavior, Animal; Bipolar Disorder; Brain-Derive | 2015 |
Chronic treatment with mood stabilizer lithium inhibits amphetamine-induced risk-taking manic-like behaviors.
Topics: Amphetamine; Animals; Antimanic Agents; Bipolar Disorder; Lithium Compounds; Male; Motor Activity; R | 2015 |
Antimanic-like activity of candesartan in mice: Possible involvement of antioxidant, anti-inflammatory and neurotrophic mechanisms.
Topics: Amphetamine; Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Inflammatory Agents; Antimanic A | 2015 |
Lifelong consumption of trans fatty acids promotes striatal impairments on Na(+)/K(+) ATPase activity and BDNF mRNA expression in an animal model of mania.
Topics: Amphetamine; Animals; Bipolar Disorder; Brain; Brain-Derived Neurotrophic Factor; Corpus Striatum; D | 2015 |
Partial effects of the AMPAkine CX717 in a strain specific battery of tests for manic-like behavior in black Swiss mice.
Topics: Aggression; Amphetamine; Animals; Antimanic Agents; Behavior, Animal; Bipolar Disorder; Central Nerv | 2015 |
Glutamate receptors as targets of protein kinase C in the pathophysiology and treatment of animal models of mania.
Topics: Amphetamine; Animals; Antidepressive Agents, Tricyclic; Bipolar Disorder; Cell Membrane; Central Ner | 2009 |
Effects of mood stabilizers on DNA damage in an animal model of mania.
Topics: Amphetamine; Animals; Antimanic Agents; Antioxidants; Bipolar Disorder; Central Nervous System Stimu | 2008 |
Effects of neuronal Kv7 potassium channel activators on hyperactivity in a rodent model of mania.
Topics: Amphetamine; Animals; Anticonvulsants; Antimanic Agents; Benzamides; Bipolar Disorder; Carbamates; C | 2009 |
Na+,K+-ATPase activity in an animal model of mania.
Topics: Amphetamine; Analysis of Variance; Animals; Antimanic Agents; Bipolar Disorder; Disease Models, Anim | 2009 |
The supra-additive hyperactivity caused by an amphetamine-chlordiazepoxide mixture exhibits an inverted-U dose response: negative implications for the use of a model in screening for mood stabilizers.
Topics: Affect; Amphetamine; Animals; Antimanic Agents; Anxiety; Bipolar Disorder; Chlordiazepoxide; Disease | 2009 |
A reverse-translational study of dysfunctional exploration in psychiatric disorders: from mice to men.
Topics: Adolescent; Adult; Amphetamine; Animals; Bipolar Disorder; Disease Models, Animal; Dopamine Plasma M | 2009 |
Antimanic efficacy of retigabine in a proposed mouse model of bipolar disorder.
Topics: Amphetamine; Analysis of Variance; Animals; Anticonvulsants; Antimanic Agents; Behavior, Animal; Bip | 2010 |
Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of mania.
Topics: Amphetamine; Animals; Antimanic Agents; Bipolar Disorder; Brain-Derived Neurotrophic Factor; Cannabi | 2011 |
Evidence for antimanic efficacy of glycogen synthase kinase-3 (GSK3) inhibitors in a strain-specific model of acute mania.
Topics: Amphetamine; Animals; Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Blood-Brain Barrier; | 2011 |
Modeling mania: Further validation for Black Swiss mice as model animals.
Topics: Amphetamine; Animals; Animals, Outbred Strains; Behavior, Animal; beta Catenin; Bipolar Disorder; Br | 2011 |
Mood stabilizer lithium inhibits amphetamine-increased 4-hydroxynonenal-protein adducts in rat frontal cortex.
Topics: Aldehydes; Amphetamine; Animals; Antimanic Agents; Bipolar Disorder; Blotting, Western; Central Nerv | 2012 |
Differential effects of dopamine transporter inhibitors in the rodent Iowa gambling task: relevance to mania.
Topics: Amphetamine; Animals; Behavior, Animal; Benzhydryl Compounds; Bipolar Disorder; Choice Behavior; Con | 2013 |
[Symptomatic manias and recent therapies].
Topics: Adrenocorticotropic Hormone; Amphetamine; Amphetamines; Bipolar Disorder; Cortisone; Humans; Mental | 1954 |
Proposal of a psychopharmacological test ("stimulation threshold") for differentiating neurotic from psychotic depressions. Preliminary report.
Topics: Amphetamine; Amphetamines; Bipolar Disorder; Depression; Depressive Disorder; Humans; Psychotic Diso | 1962 |
OTHER ASPECTS OF DEPRESSION.
Topics: Alcoholism; Amphetamine; Antidepressive Agents; Barbiturates; Bipolar Disorder; Brain Diseases; Depr | 1965 |
[Action of amphetamines in states of manic excitation; some paradoxical effects].
Topics: Amphetamine; Amphetamines; Bipolar Disorder; Humans; Psychotic Disorders | 1950 |
Effects of mood stabilizers on hippocampus BDNF levels in an animal model of mania.
Topics: Affect; Amphetamine; Animals; Antimanic Agents; Bipolar Disorder; Brain-Derived Neurotrophic Factor; | 2006 |
Changes in antioxidant defense enzymes after d-amphetamine exposure: implications as an animal model of mania.
Topics: Amphetamine; Animals; Antioxidants; Bipolar Disorder; Brain; Catalase; Dopamine Agents; Male; Rats; | 2006 |
Lithium increases nerve growth factor levels in the rat hippocampus in an animal model of mania.
Topics: Amphetamine; Animals; Antimanic Agents; Bipolar Disorder; Central Nervous System Stimulants; Hippoca | 2006 |
Effects of lithium and valproate on hippocampus citrate synthase activity in an animal model of mania.
Topics: Amphetamine; Analysis of Variance; Animals; Antimanic Agents; Bipolar Disorder; Citrate (si)-Synthas | 2007 |
Effects of lithium and valproate on serum and hippocampal neurotrophin-3 levels in an animal model of mania.
Topics: Amphetamine; Animals; Antimanic Agents; Bipolar Disorder; Disease Models, Animal; Hippocampus; Lithi | 2008 |
Structure-based design leads to the identification of lithium mimetics that block mania-like effects in rodents. possible new GSK-3beta therapies for bipolar disorders.
Topics: Amphetamine; Animals; Antimanic Agents; Bipolar Disorder; Chlordiazepoxide; Drug Design; Glycogen Sy | 2007 |
Omega-3 fatty acid deficiency augments amphetamine-induced behavioral sensitization in adult mice: prevention by chronic lithium treatment.
Topics: Amphetamine; Animals; Antimanic Agents; Bipolar Disorder; Central Nervous System Stimulants; Disease | 2008 |
Protein kinase C inhibition by tamoxifen antagonizes manic-like behavior in rats: implications for the development of novel therapeutics for bipolar disorder.
Topics: Amphetamine; Animals; Behavior, Animal; Bipolar Disorder; Disease Models, Animal; Drug Administratio | 2007 |
Effect of the new antiepileptic drug retigabine in a rodent model of mania.
Topics: Amphetamine; Animals; Anticonvulsants; Behavior, Animal; Bipolar Disorder; Carbamates; Chlordiazepox | 2008 |
Brain creatine kinase activity in an animal model of mania.
Topics: Amphetamine; Animals; Antimanic Agents; Bipolar Disorder; Brain; Central Nervous System Stimulants; | 2008 |
Amphetamine psychosis due to khat leaves.
Topics: Amphetamine; Bipolar Disorder; Catha; Humans; Plant Extracts | 1984 |
[Influence of lithium hydroxybutyrate on the electroencephalographic effects of fenamin].
Topics: Amphetamine; Animals; Bipolar Disorder; Cerebral Cortex; Chlorides; Disease Models, Animal; Drug Int | 1982 |
Biological markers for endogenous depression in series and parallel.
Topics: Amphetamine; Bipolar Disorder; Depressive Disorder; Dexamethasone; Electroencephalography; Growth Ho | 1984 |
Antidepressants and dopamine autoreceptors: implications for both a novel means of treating depression and understanding bipolar illness.
Topics: Amphetamine; Animals; Antidepressive Agents; Bipolar Disorder; Depression; Electrophysiology; Humans | 1982 |
The effects of lithium on a potential cycling model of bipolar disorder.
Topics: Amphetamine; Animals; Antipsychotic Agents; Bipolar Disorder; Cocaine; Corpus Striatum; Disease Mode | 1998 |
Brain SPECT imaging of amphetamine-induced dopamine release in euthymic bipolar disorder patients.
Topics: Adult; Amphetamine; Benzamides; Bipolar Disorder; Blood Pressure; Brain; Corpus Striatum; Dopamine; | 2000 |
Amphetamine positive toxicology screen secondary to bupropion.
Topics: Aged; Amphetamine; Antidepressive Agents, Second-Generation; Bipolar Disorder; Bupropion; Chromatogr | 2000 |
Transcranial magnetic stimulation in an amphetamine hyperactivity model of mania.
Topics: Amphetamine; Animals; Bipolar Disorder; Disease Models, Animal; Electromagnetic Phenomena; Hyperkine | 2001 |
Effect of lithium and other drugs on the amphetamine chlordiazeposice hyperactivity in mice.
Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Bipolar Disorder; Brain Chemistry; Chlordiazepoxide; Dise | 1975 |
Endorphins, lithium, and naloxone: their relationship to pathological and drug-induced manic-euphoric states.
Topics: Adult; Amphetamine; Bipolar Disorder; Cocaine; Dopamine; Endorphins; Euphoria; Heroin Dependence; Hu | 1978 |
Asymmetry and mood, emergent properties of serotonin regulation.
Topics: Affect; Amphetamine; Animals; Bipolar Disorder; Brain; Calcium; Cocaine; Dominance, Cerebral; Humans | 1979 |
[Absecence of the antidepressant action of lithium under clinical and experimental conditions].
Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Antidepressive Agents; Bipolar Disorder; Drug Interaction | 1976 |
A comparison of alcoholic and nonalcoholic drug abusers.
Topics: Adult; Alcoholism; Amphetamine; Bipolar Disorder; Cocaine; Depressive Disorder; Female; Humans; Hypn | 1988 |
Psychiatric problems of the aged.
Topics: Adjustment Disorders; Aged; Amphetamine; Antidepressive Agents; Antipsychotic Agents; Attitude of He | 1974 |
Pharmacological and dynamic factors in psychotropic drug therapy.
Topics: Adult; Amphetamine; Antidepressive Agents; Antitubercular Agents; Anxiety; Bipolar Disorder; Chlorpr | 1970 |
Biochemical criteria for classifying depressive disorders and predicting responses to pharmacotherapy: preliminary findings from studies of norepinephrine metabolism. Contributions to biochemistry.
Topics: Adolescent; Adult; Aged; Amitriptyline; Amphetamine; Anxiety; Bipolar Disorder; Brain; Depression; F | 1974 |
A two factor theory of schizophrenia.
Topics: Acetylcholine; Amphetamine; Animals; Bipolar Disorder; Brain; Dextroamphetamine; Dopamine; Dose-Resp | 1974 |
[Genetic factors in the recurrent confusional psychoses].
Topics: Amphetamine; Bipolar Disorder; Cognition Disorders; Humans; Lysergic Acid Diethylamide; Mental Proce | 1972 |
[Further experience with therapy of depressive states by a combination of psychotone and electric shock therapy].
Topics: Amphetamine; Bipolar Disorder; Electroconvulsive Therapy; Humans; Methods; Middle Aged; Premedicatio | 1971 |
[The pharmacologic properties and therapeutic effectiveness of the new antidepressant preparation Azaphen].
Topics: Adult; Aged; Amphetamine; Animals; Antidepressive Agents; Bipolar Disorder; Cats; Depression; Depres | 1969 |