amphetamine has been researched along with Astrocytosis in 9 studies
Amphetamine: A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.
1-phenylpropan-2-amine : A primary amine that is isopropylamine in which a hydrogen attached to one of the methyl groups has been replaced by a phenyl group.
amphetamine : A racemate comprising equimolar amounts of (R)-amphetamine (also known as levamphetamine or levoamphetamine) and (S)-amphetamine (also known as dexamfetamine or dextroamphetamine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Astrocytosis, a process in which astrocytes undergo proliferation and enhancement of glial fibrillary acidic protein (GFAP) expression, has been suggested to play important roles in the maintenance of dependence to amphetamine and its derivatives." | 7.79 | Maintenance of amphetamine-induced place preference does not correlate with astrocytosis. ( Gramage, E; Herradón, G; Martín, YB, 2013) |
| "The dopamine-releasing and depleting substance amphetamine (AMPH) can make cortical neurons susceptible to damage, and the prevention of hyperthermia, seizures and stroke is thought to block these effects." | 7.71 | Parvalbumin neuron circuits and microglia in three dopamine-poor cortical regions remain sensitive to amphetamine exposure in the absence of hyperthermia, seizure and stroke. ( Bowyer, JF; Jakab, RL, 2002) |
| "The dopamine-releasing and depleting substance amphetamine (AMPH) can make cortical neurons susceptible to damage, and the prevention of hyperthermia, seizures and stroke is thought to block these effects." | 3.71 | Parvalbumin neuron circuits and microglia in three dopamine-poor cortical regions remain sensitive to amphetamine exposure in the absence of hyperthermia, seizure and stroke. ( Bowyer, JF; Jakab, RL, 2002) |
| " These results suggest that the chronic administration of clobenzorex may decrease motor function in a manner similar to amphetamine, via the neuroadaptive and non-neurotoxic changes caused to the striatum under this administration scheme." | 1.62 | The Chronic Oral Administration of Clobenzorex or Amphetamine Decreases Motor Behavior and Induces Glial Activation in the Striatum Without Dopaminergic Degeneration. ( Apóstol Del Rosal, GD; Limón, ID; Martínez, I; Patricio-Martínez, A, 2021) |
| "Amphetamine (AMPH) is a psychostimulant whose chronic abuse may cause impairments in attention and memory in humans." | 1.33 | Amphetamine induces apoptosis of medium spiny striatal projection neurons via the mitochondria-dependent pathway. ( Cadet, JL; Krasnova, IN; Ladenheim, B, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Apóstol Del Rosal, GD | 1 |
| Limón, ID | 1 |
| Martínez, I | 1 |
| Patricio-Martínez, A | 1 |
| Tripathy, D | 1 |
| Haobam, R | 1 |
| Nair, R | 1 |
| Mohanakumar, KP | 1 |
| Gramage, E | 3 |
| Putelli, A | 1 |
| Polanco, MJ | 1 |
| González-Martín, C | 1 |
| Ezquerra, L | 1 |
| Alguacil, LF | 1 |
| Pérez-Pinera, P | 1 |
| Deuel, TF | 1 |
| Herradón, G | 3 |
| Martín, YB | 2 |
| Ramanah, P | 1 |
| Pérez-García, C | 1 |
| Jakab, RL | 1 |
| Bowyer, JF | 1 |
| Krasnova, IN | 1 |
| Ladenheim, B | 1 |
| Cadet, JL | 1 |
| McCoy, MK | 1 |
| Martinez, TN | 1 |
| Ruhn, KA | 1 |
| Szymkowski, DE | 1 |
| Smith, CG | 1 |
| Botterman, BR | 1 |
| Tansey, KE | 1 |
| Tansey, MG | 1 |
| Silva-Araújo, AL | 1 |
| Tavares, MA | 1 |
9 other studies available for amphetamine and Astrocytosis
| Article | Year |
|---|---|
The Chronic Oral Administration of Clobenzorex or Amphetamine Decreases Motor Behavior and Induces Glial Activation in the Striatum Without Dopaminergic Degeneration.
Topics: Administration, Oral; Amphetamine; Amphetamines; Animals; Corpus Striatum; Dopamine Uptake Inhibitor | 2021 |
Engraftment of mouse embryonic stem cells differentiated by default leads to neuroprotection, behaviour revival and astrogliosis in parkinsonian rats.
Topics: Amphetamine; Animals; Cell Differentiation; Embryonic Stem Cells; Gliosis; Immunohistochemistry; Mal | 2013 |
The neurotrophic factor pleiotrophin modulates amphetamine-seeking behaviour and amphetamine-induced neurotoxic effects: evidence from pleiotrophin knockout mice.
Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Carrier Proteins; Cell Survival; Conditioning, | 2010 |
Midkine regulates amphetamine-induced astrocytosis in striatum but has no effects on amphetamine-induced striatal dopaminergic denervation and addictive effects: functional differences between pleiotrophin and midkine.
Topics: Amphetamine; Animals; Astrocytes; Carrier Proteins; Central Nervous System Stimulants; Conditioning, | 2011 |
Maintenance of amphetamine-induced place preference does not correlate with astrocytosis.
Topics: Amphetamine; Animals; Astrocytes; Carrier Proteins; Caudate Nucleus; Conditioning, Psychological; Cy | 2013 |
Parvalbumin neuron circuits and microglia in three dopamine-poor cortical regions remain sensitive to amphetamine exposure in the absence of hyperthermia, seizure and stroke.
Topics: Amphetamine; Animals; Astrocytes; Cerebral Cortex; Dopamine; Drug Residues; Fever; Glial Fibrillary | 2002 |
Amphetamine induces apoptosis of medium spiny striatal projection neurons via the mitochondria-dependent pathway.
Topics: Amphetamine; Animals; Apoptosis; bcl-2-Associated X Protein; Calbindins; Caspase 3; Caspases; Corpus | 2005 |
Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's disease.
Topics: Amphetamine; Animals; Cell Death; Cells, Cultured; Coculture Techniques; Disease Models, Animal; Dop | 2006 |
Expression of glial fibrillary acidic protein in the rat retina after exposure to psychostimulants.
Topics: Amphetamine; Animals; Animals, Newborn; Astrocytes; Central Nervous System Stimulants; Cocaine; Fema | 1995 |