Page last updated: 2024-10-25

amphetamine and Anxiety

amphetamine has been researched along with Anxiety in 138 studies

Amphetamine: A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.
1-phenylpropan-2-amine : A primary amine that is isopropylamine in which a hydrogen attached to one of the methyl groups has been replaced by a phenyl group.
amphetamine : A racemate comprising equimolar amounts of (R)-amphetamine (also known as levamphetamine or levoamphetamine) and (S)-amphetamine (also known as dexamfetamine or dextroamphetamine.

Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.

Research Excerpts

ExcerptRelevanceReference
"This study assessed behaviour, as measured by 50kHz calls related to positive affect, in rats with different fear conditioned response strengths: low-anxiety rats (LR) and high-anxiety rats (HR), after amphetamine injection in a two-injection protocol (TIPS)."7.80High-anxiety rats are less sensitive to the rewarding affects of amphetamine on 50kHz USV. ( Kaniuga, E; Lehner, MH; Płaźnik, A; Skórzewska, A; Sobolewska, A; Taracha, E; Turzyńska, D; Wisłowska-Stanek, A; Wróbel, J, 2014)
"Withdrawal from amphetamine is associated with increased anxiety and sensitivity to stressors which are thought to contribute to relapse."7.80Serotonin in the ventral hippocampus modulates anxiety-like behavior during amphetamine withdrawal. ( Cook, A; Forster, GL; Mears, M; Renner, KJ; Scholl, JL; Tu, W; Watt, MJ, 2014)
"Chronic amphetamine use results in anxiety-like states after drug cessation."7.79The influence of ionotropic and metabotropic glutamate receptor ligands on anxiety-like effect of amphetamine withdrawal in rats. ( Gibula-Bruzda, E; Koltunowska, D; Kotlinska, JH, 2013)
"Withdrawal from psychostimulants increases anxiety states, and amphetamine-treated rats show increased CRF(2) receptors in the serotonergic cell body region, the dorsal raphe nucleus (dRN)."7.76Increased anxiety-like behavior of rats during amphetamine withdrawal is reversed by CRF2 receptor antagonism. ( Forster, GL; Oliver, HA; Oliver, KM; Scholl, JL; Vuong, SM, 2010)
"Acute amphetamine administration activates monoaminergic pathways and increases systemic corticosterone, both of which influence anxiety states and adult dentate gyrus neurogenesis."7.76Withdrawal from chronic amphetamine produces persistent anxiety-like behavior but temporally-limited reductions in monoamines and neurogenesis in the adult rat dentate gyrus. ( Barr, JL; Forster, GL; Renner, KJ, 2010)
"Although we could not establish an association between the anxiety level of rats with either the onset or severity of LID, our results showed that citalopram was able to mediate a partial alleviation in LID after chronic treatment, and the extent of recovery was negatively correlated to the anxiety measures of individual animals."7.74The role of anxiety in the development of levodopa-induced dyskinesias in an animal model of Parkinson's disease, and the effect of chronic treatment with the selective serotonin reuptake inhibitor citalopram. ( Barker, RA; Kuan, WL; Zhao, JW, 2008)
"Seventy unwed pregnant patients in states of mild to moderate depression evidenced by one or more symptoms (tenseness, "nervousness," crying spells, listlessness, fatigue, nausea and vomiting, insomnia and overeating), received informal psychotherapy and a sustained-release capsule combining d-amphetamine sulfate and amobarbital."7.63Prepartum depression; a study of seventy unwed mothers treated with d-amphetamine sulfate and amobarbital. ( CALDWELL, WG; NOWERS, W, 1958)
"Amphetamine is thought to produce its stimulant effects mainly via the dopamine system, but its effects may also be influenced by other systems."6.71Interindividual variation in anxiety response to amphetamine: possible role for adenosine A2A receptor gene variants. ( Baune, BT; Cook, EH; de Wit, H; Deckert, J; Hohoff, C; McDonald, JM, 2005)
" Mice treated with PGW5 (25 and 50mg/kg/d) for 28 days did not show toxic effects in terms of weight gain and blood-chemistry analysis."5.40A novel analog of olanzapine linked to sarcosinyl moiety (PGW5) demonstrates high efficacy and good safety profile in mouse models of schizophrenia. ( Bidder, M; Gil-Ad, I; Kramer, M; Portnoy, M; Taler, M; Tarasenko, I; Weizman, A, 2014)
"Schizophrenia is believed to arise from an interaction of genetic predisposition and adverse environmental factors, with stress being a primary variable."5.39Peripubertal diazepam administration prevents the emergence of dopamine system hyperresponsivity in the MAM developmental disruption model of schizophrenia. ( Du, Y; Grace, AA, 2013)
" In rats, withdrawal from chronic amphetamine increases OCT3 expression in specific limbic brain regions involved anxiety and stress responses, including the ventral hippocampus, central nucleus of amygdala (CeA) and dorsomedial hypothalamus."4.31Chronic administration of glucocorticoid receptor ligands increases anxiety-like behavior and selectively increase serotonin transporters in the ventral hippocampus. ( Forster, GL; Renner, KJ; Scholl, JL; Solanki, RR; Watt, MJ, 2023)
"Kava extract (Piper methysticum) is a phytotherapic mainly used for the treatment of anxiety."4.02Kava decreases the stereotyped behavior induced by amphetamine in mice. ( Barbosa, CP; Boligon, AA; Chiapinotto Ceretta, AP; da Silva Córneo, E; de Moraes Reis, E; Fachinetto, R; Krum, BN; Machado-de-Ávila, RA; Molz de Freitas, C; Scussel, R, 2021)
" The primary objective of the current study was to assess differences in blood pressure and heart rate before and after induction of anesthesia between patients on chronic amphetamine or methylphenidate therapy who receive their normal dose preoperatively compared to patients in whom the prescribed medication was withheld."3.85Hemodynamic profile and behavioral characteristics during induction of anesthesia in pediatric patients with attention deficit hyperactivity disorder. ( Cartabuke, RS; Rice, J; Tobias, JD; Tumin, D, 2017)
"This study assessed behaviour, as measured by 50kHz calls related to positive affect, in rats with different fear conditioned response strengths: low-anxiety rats (LR) and high-anxiety rats (HR), after amphetamine injection in a two-injection protocol (TIPS)."3.80High-anxiety rats are less sensitive to the rewarding affects of amphetamine on 50kHz USV. ( Kaniuga, E; Lehner, MH; Płaźnik, A; Skórzewska, A; Sobolewska, A; Taracha, E; Turzyńska, D; Wisłowska-Stanek, A; Wróbel, J, 2014)
"Withdrawal from amphetamine is associated with increased anxiety and sensitivity to stressors which are thought to contribute to relapse."3.80Serotonin in the ventral hippocampus modulates anxiety-like behavior during amphetamine withdrawal. ( Cook, A; Forster, GL; Mears, M; Renner, KJ; Scholl, JL; Tu, W; Watt, MJ, 2014)
"Chronic amphetamine use results in anxiety-like states after drug cessation."3.79The influence of ionotropic and metabotropic glutamate receptor ligands on anxiety-like effect of amphetamine withdrawal in rats. ( Gibula-Bruzda, E; Koltunowska, D; Kotlinska, JH, 2013)
" GFAP-DNSynCAM1 mice also display high levels of basal activity in the dark period (the rodent's awake/active time) that are attenuated by the psychostimulant D,L-amphetamine, and reduced anxiety levels in response to both avoidable and unavoidable provoking stimuli."3.78Astrocyte-specific disruption of SynCAM1 signaling results in ADHD-like behavioral manifestations. ( Alderman, Z; Corfas, G; Ojeda, SR; Raber, J; Sandau, US, 2012)
"Acute amphetamine administration activates monoaminergic pathways and increases systemic corticosterone, both of which influence anxiety states and adult dentate gyrus neurogenesis."3.76Withdrawal from chronic amphetamine produces persistent anxiety-like behavior but temporally-limited reductions in monoamines and neurogenesis in the adult rat dentate gyrus. ( Barr, JL; Forster, GL; Renner, KJ, 2010)
"Withdrawal from psychostimulants increases anxiety states, and amphetamine-treated rats show increased CRF(2) receptors in the serotonergic cell body region, the dorsal raphe nucleus (dRN)."3.76Increased anxiety-like behavior of rats during amphetamine withdrawal is reversed by CRF2 receptor antagonism. ( Forster, GL; Oliver, HA; Oliver, KM; Scholl, JL; Vuong, SM, 2010)
"Although we could not establish an association between the anxiety level of rats with either the onset or severity of LID, our results showed that citalopram was able to mediate a partial alleviation in LID after chronic treatment, and the extent of recovery was negatively correlated to the anxiety measures of individual animals."3.74The role of anxiety in the development of levodopa-induced dyskinesias in an animal model of Parkinson's disease, and the effect of chronic treatment with the selective serotonin reuptake inhibitor citalopram. ( Barker, RA; Kuan, WL; Zhao, JW, 2008)
"The effects of the anxiogenic agents FG7142, caffeine, pentylenetetrazole, and amphetamine were assessed in two anxiety situations in the marmoset, first in an "anxiogenic" test based on the animal's response to a human observer standing in front of the home cage and second in a low-anxiety situation where animals behaviour was videotaped in the absence of the observer."3.68Behavioural effects of anxiogenic agents in the common marmoset. ( Carey, GJ; Costall, B; Domeney, AM; Jones, DN; Naylor, RJ, 1992)
"Seventy unwed pregnant patients in states of mild to moderate depression evidenced by one or more symptoms (tenseness, "nervousness," crying spells, listlessness, fatigue, nausea and vomiting, insomnia and overeating), received informal psychotherapy and a sustained-release capsule combining d-amphetamine sulfate and amobarbital."3.63Prepartum depression; a study of seventy unwed mothers treated with d-amphetamine sulfate and amobarbital. ( CALDWELL, WG; NOWERS, W, 1958)
" However, their chronic use is related to memory loss, emotional instability, insomnia, psychosis and paranoia."1.46Influence of physical activity on addiction parameters of rats exposed to amphetamine which were previously supplemented with hydrogenated vegetable fat. ( Antoniazzi, CTD; Barcelos, RCS; Burger, ME; Emanuelli, T; Kronbauer, M; Metz, VG; Piccolo, JC; Rosa, HZ; Roversi, K; Segat, HJ; Veit, JC; Vey, LT, 2017)
"Amphetamine (AMPH) is an addictive psychostimulant drug whose use has been related to neurotoxicity."1.42Cross-Generational trans Fat Consumption Favors Self-Administration of Amphetamine and Changes Molecular Expressions of BDNF, DAT, and D1/D2 Receptors in the Cortex and Hippocampus of Rats. ( Bürger, ME; de Freitas, DL; Dias, VT; Emanuelli, T; Kuhn, FT; Pase, CS; Roversi, K; Veit, JC; Vey, LT, 2015)
"Other PTSD symptoms, such as anxiety (elevated plus maze) and hyperarousal (acoustic startle response), were also investigated in these rats."1.40Only susceptible rats exposed to a model of PTSD exhibit reactivity to trauma-related cues and other symptoms: an effect abolished by a single amphetamine injection. ( Gisquet-Verrier, P; Toledano, D, 2014)
" Mice treated with PGW5 (25 and 50mg/kg/d) for 28 days did not show toxic effects in terms of weight gain and blood-chemistry analysis."1.40A novel analog of olanzapine linked to sarcosinyl moiety (PGW5) demonstrates high efficacy and good safety profile in mouse models of schizophrenia. ( Bidder, M; Gil-Ad, I; Kramer, M; Portnoy, M; Taler, M; Tarasenko, I; Weizman, A, 2014)
"Schizophrenia is believed to arise from an interaction of genetic predisposition and adverse environmental factors, with stress being a primary variable."1.39Peripubertal diazepam administration prevents the emergence of dopamine system hyperresponsivity in the MAM developmental disruption model of schizophrenia. ( Du, Y; Grace, AA, 2013)
"It also decreased catalepsy and weight gain induced by APDs, suggesting that it may decrease APD-induced extrapyramidal side effects (EPS) and compliance."1.37AVE1625, a cannabinoid CB1 receptor antagonist, as a co-treatment with antipsychotics for schizophrenia: improvement in cognitive function and reduction of antipsychotic-side effects in rodents. ( Arad, M; Barak, S; Black, MD; Borowsky, B; Cohen, C; De Levie, A; Featherstone, RE; Giardino, O; Griebel, G; Pichat, P; Rogacki, N; Senyah, Y; Stemmelin, J; Stevens, RJ; Varty, GB; Weiner, I, 2011)
" Amphetamine and diazepam produced an inverted U-shaped dose-response effect on different parameters of the test and demonstrate that the drug concentration which elicited a peak in mean number of entries is different from the drug concentration which elicited a peak in mean duration of entries."1.36Distinguishing anxiolysis and hyperactivity in an open space behavioral test. ( Chazot, PL; Ennaceur, A; Michalikova, S; van Rensburg, R, 2010)
"Using the rat Maximal Electroshock Seizure Threshold (MEST) test, (S)-3,4-DCPG (30 mg/kg, i."1.34Evaluation of the mGlu8 receptor as a putative therapeutic target in schizophrenia. ( Harris, AJ; Honey, A; Jones, DN; Jones, GA; Kelly, FM; Kew, JN; Maycox, PR; Melarange, RA; Murdock, PR; Robbins, MJ; Rocheville, M; Rourke, C; Rupniak, T; Soffin, EM; Starr, KR; Strum, J, 2007)
"Several psychiatric disorders are associated with white matter defects, suggesting that oligodendrocyte (OL) abnormalities underlie some aspects of these diseases."1.34Loss of erbB signaling in oligodendrocytes alters myelin and dopaminergic function, a potential mechanism for neuropsychiatric disorders. ( Benoit-Marand, M; Brunner, D; Chen, C; Corfas, G; Edgar, N; El-Khodor, BF; Hooks, BM; Moore, H; Murtie, JC; O'Donnell, P; Roy, K; Sardi, SP, 2007)
"Diazepam pre-treatment did not restore the expression of amphetamine CPP."1.31Diazepam modifies the effect of pedunculopontine lesions on morphine but not on amphetamine conditioned place preference. ( Franklin, KB; Leri, F, 2000)
"When FG 7142 (20 mg/kg) was administered during five consecutive days before behavioral testing, its anxiogenic-like effect first deepened, but waned off by the fifth session."1.30Characterization of rat exploratory behavior using the exploration box test. ( Allikmets, L; Harro, J; Matto, V; Otter, MH; Skrebuhhova, T; Sõukand, R, 1997)
" Chronic administration of chlordiazepoxide in the diet of the maternal rat also produced an increased exploratory activity in the weanlings."1.27Differential effects of benzodiazepines and amphetamine on exploratory behaviour in weanling rats: an animal model for anxiolytic activity. ( Salt, JS; Taberner, PV, 1984)
" Chronic administration dissociated the pattern of results produced by sodium phenobarbitone (35 mg/kg) from that produced by flurazepam (0."1.26A test of anxiety that distinguishes between the actions of benzodiazepines and those of other minor tranquilisers and of stimulants. ( File, SE; Hyde, JR, 1979)

Research

Studies (138)

TimeframeStudies, this research(%)All Research%
pre-199050 (36.23)18.7374
1990's10 (7.25)18.2507
2000's22 (15.94)29.6817
2010's52 (37.68)24.3611
2020's4 (2.90)2.80

Authors

AuthorsStudies
Scholl, JL6
Solanki, RR3
Watt, MJ5
Renner, KJ5
Forster, GL7
Arab, AO1
Alasmari, F1
Albaker, AB1
Alhazmi, HA1
Alameen, AA1
Alagail, NM1
Alwaeli, SA1
Rizwan Ahamad, S1
AlAsmari, AF1
AlSharari, SD1
Niedzielak, T1
Ravenelle, R1
Joseph, M1
Calhoun, C1
Plotkin, B1
Jones, R1
Herrera, M1
Tiffany Donaldson, S1
Krum, BN1
Molz de Freitas, C1
Chiapinotto Ceretta, AP1
Barbosa, CP1
de Moraes Reis, E1
Scussel, R1
da Silva Córneo, E1
Machado-de-Ávila, RA1
Boligon, AA1
Fachinetto, R1
Lehner, M2
Gryz, M3
Wisłowska-Stanek, A4
Turzyńska, D3
Sobolewska, A4
Skórzewska, A4
Płaźnik, A3
Fischer, DK1
Rice, RC1
Martinez Rivera, A1
Donohoe, M1
Rajadhyaksha, AM1
Segat, HJ2
Barcelos, RCS2
Metz, VG1
Rosa, HZ2
Roversi, K5
Antoniazzi, CTD1
Vey, LT4
Kronbauer, M2
Veit, JC2
Piccolo, JC1
Emanuelli, T2
Burger, ME4
Bananej, A1
Völkl-Kernstock, S1
Lesch, O1
Walter, H1
Skala, K1
Liu, J1
Scira, J1
Donaldson, S1
Kajiji, N1
Dash, GH1
Donaldson, ST1
Richetto, J1
Polesel, M1
Weber-Stadlbauer, U1
Rincón-Cortés, M1
Gagnon, KG1
Dollish, HK1
Grace, AA2
Giovanoli, S1
Werge, TM1
Mortensen, PB1
Didriksen, M1
Meyer, U1
Loiodice, S1
Wing Young, H1
Rion, B1
Méot, B1
Montagne, P1
Denibaud, AS1
Viel, R1
Drieu La Rochelle, C1
Lai, CW1
Chang, CH1
Dias, VT2
D'avila, LF1
Kołosowska, K1
Gawryluk, A1
Liguz-Lęcznar, M1
Hetmańczyk, K1
Ługowska, A1
Du, Y1
Koltunowska, D2
Gibula-Bruzda, E2
Kotlinska, JH2
Schmidt, MJ1
Horvath, S1
Ebert, P1
Norris, JL1
Seeley, EH1
Brown, J1
Gellert, L1
Everheart, M1
Garbett, KA1
Grice, TW1
Caprioli, RM1
Mirnics, K1
Gil-Ad, I1
Portnoy, M1
Tarasenko, I1
Bidder, M1
Kramer, M1
Taler, M1
Weizman, A1
Schuster, AJ1
Pase, CS2
Antoniazzi, CT1
Schmidt, KT1
Weinshenker, D1
Yu, Q1
Teixeira, CM1
Mahadevia, D1
Huang, Y1
Balsam, D1
Mann, JJ1
Gingrich, JA1
Ansorge, MS1
McLelland, AE1
Martin-Iverson, MT1
Beninger, RJ2
Mabrouk, OS1
Dripps, IJ1
Ramani, S1
Chang, C1
Han, JL1
Rice, KC1
Jutkiewicz, EM1
Toledano, D2
Gisquet-Verrier, P2
Reinbold, ED1
Oliver, KM2
Lehner, MH2
Taracha, E2
Kaniuga, E2
Wróbel, J1
Tu, W1
Cook, A1
Mears, M1
Lin, SH1
Chien, YC1
Chiang, WW1
Liu, YZ1
Lien, CC1
Chen, CC1
Fulde, GW1
Forster, SL1
Kuhn, FT1
de Freitas, DL1
Fukushiro, DF1
Olivera, A1
Liu, Y1
Wang, Z1
Kirkpatrick, MG1
Goldenson, NI1
Kapadia, N1
Kahler, CW1
de Wit, H2
Swift, RM1
McGeary, JE1
Sussman, S1
Leventhal, AM1
Xu, M2
Li, L1
Pittenger, C1
Gentile, A1
Fresegna, D1
Musella, A1
Sepman, H1
Bullitta, S1
De Vito, F1
Fantozzi, R1
Usiello, A1
Maccarrone, M1
Mercuri, NB1
Lutz, B1
Mandolesi, G1
Centonze, D1
Gatica, RI1
Pérez-Valenzuela, E1
Sierra-Mercado, D1
Fuentealba, JA1
Cartabuke, RS1
Tobias, JD1
Rice, J1
Tumin, D1
Gonzáles, MA1
Miranda, AP1
Orrego, H1
Silva, R1
Forray, MI1
Bespalov, AY1
van Gaalen, MM1
Sukhotina, IA1
Wicke, K1
Mezler, M1
Schoemaker, H1
Gross, G1
Barbier, E1
Pierrefiche, O1
Vaudry, D1
Vaudry, H1
Daoust, M1
Naassila, M1
Luuk, H1
Plaas, M1
Raud, S1
Innos, J1
Sütt, S1
Lasner, H1
Abramov, U1
Kurrikoff, K1
Kõks, S1
Vasar, E1
Willi, R1
Aloy, EM1
Yee, BK2
Feldon, J3
Schwab, ME1
Kelly, MP1
Logue, SF1
Dwyer, JM1
Beyer, CE1
Majchrowski, H1
Cai, Z1
Liu, Z1
Adedoyin, A1
Rosenzweig-Lipson, S1
Comery, TA1
Ennaceur, A2
Michalikova, S1
van Rensburg, R1
Chazot, PL1
Vuong, SM1
Oliver, HA1
Rotllant, D1
Márquez, C1
Nadal, R1
Armario, A1
Barr, JL1
Black, MD1
Stevens, RJ1
Rogacki, N1
Featherstone, RE1
Senyah, Y1
Giardino, O1
Borowsky, B2
Stemmelin, J1
Cohen, C1
Pichat, P1
Arad, M1
Barak, S1
De Levie, A1
Weiner, I1
Griebel, G1
Varty, GB1
Iezhitsa, IN1
Spasov, AA1
Kharitonova, MV1
Kravchenko, MS1
Bailer, UF1
Narendran, R1
Frankle, WG1
Himes, ML1
Duvvuri, V1
Mathis, CA1
Kaye, WH1
Muhammad, A1
Kolb, B1
Shabanov, PD1
Lebedev, AA1
Labonte, B1
McLaughlin, RJ1
Dominguez-Lopez, S1
Bambico, FR1
Lucchino, I1
Ochoa-Sanchez, R1
Leyton, M1
Gobbi, G1
Raoof, H1
Suder, P1
Silberring, J1
Erreger, K1
Davis, AR1
Poe, AM1
Greig, NH1
Stanwood, GD1
Galli, A1
Sandau, US1
Alderman, Z1
Corfas, G2
Ojeda, SR1
Raber, J1
Latapy, C1
Rioux, V1
Guitton, MJ1
Beaulieu, JM1
Bannerman, DM1
Grubb, M1
Deacon, RM1
Rawlins, JN1
van den Buuse, M2
LEHEW, JL1
GRAHN, HV1
COBBIN, LB1
LAWSON, PT1
MCFADYEN, R1
LANZETTA, JT1
WENDT, GR1
LANGHAM, P1
HAEFNER, D1
SCHOPBACH, RR1
SETTEL, E1
CALDWELL, WG1
NOWERS, W1
CUPARENCU, B1
GROSU, L1
DAMACUS, M1
FEIGLEY, DM1
BEECHER, HK1
SMITH, GM1
PFEIFFER, CC1
GOLDSTEIN, L1
WEITZNER, M1
Wood, GK1
Quirion, R2
Srivastava, LK2
Hohoff, C1
McDonald, JM1
Baune, BT1
Cook, EH1
Deckert, J1
Russig, H1
Murphy, CA1
Cassidy, CM1
Mällo, T1
Alttoa, A1
Kõiv, K1
Tõnissaar, M1
Eller, M1
Harro, J2
Wolinsky, TD1
Swanson, CJ1
Smith, KE1
Zhong, H1
Seeman, P1
Branchek, T1
Gerald, CP1
Robbins, MJ1
Starr, KR1
Honey, A1
Soffin, EM1
Rourke, C1
Jones, GA1
Kelly, FM1
Strum, J1
Melarange, RA1
Harris, AJ1
Rocheville, M1
Rupniak, T1
Murdock, PR1
Jones, DN2
Kew, JN1
Maycox, PR1
Roy, K1
Murtie, JC1
El-Khodor, BF1
Edgar, N1
Sardi, SP1
Hooks, BM1
Benoit-Marand, M1
Chen, C1
Moore, H1
O'Donnell, P1
Brunner, D1
Angel, C1
Murphree, OD1
DeLuca, DC1
Bilkei-Gorzó, A1
Otto, M1
Zimmer, A1
Siuciak, JA1
McCarthy, SA1
Chapin, DS1
Martin, AN1
Harms, JF1
Schmidt, CJ1
Kuan, WL1
Zhao, JW1
Barker, RA1
Featherby, T1
Lubman, DI1
Lawrence, AJ1
Seelye, EE1
Salt, JS1
Taberner, PV1
deWit, H1
Johanson, CE1
Uhlenhuth, EH1
McCracken, S1
Milkman, H2
Frosch, W1
Perry, W1
Sprock, J1
Schaible, D1
McDougall, A1
Minassian, A1
Jenkins, M1
Braff, D1
Lapin, IP1
Borisenko, SA1
Meng, QH1
Rauhala, P1
Männistö, PT1
Koeltzow, TE1
Santiago, GT1
Moratalla, R1
Cooper, DC1
Hu, XT1
White, NM1
Graybiel, AM1
White, FJ1
Tonegawa, S1
Otter, MH1
Matto, V1
Sõukand, R1
Skrebuhhova, T1
Allikmets, L1
Will, MJ1
Watkins, LR1
Maier, SF1
Lin, HQ1
Burden, PM1
Christie, MJ1
Johnston, GA1
Leri, F1
Franklin, KB1
Dringenberg, HC1
Wightman, M1
Cancela, LM1
Basso, AM1
Martijena, ID1
Capriles, NR1
Molina, VA1
File, SE1
Hyde, JR1
Woody, GE1
O'Brien, CP1
Rickels, K1
Saletu, B1
Saletu, M1
Simeon, J1
Viamontes, G1
Itil, TM1
Laviola, G1
Pick, CG1
Yanai, J1
Alleva, E1
Carey, GJ1
Costall, B1
Domeney, AM1
Naylor, RJ1
Bennett, G1
Rigby, K1
Koella, WP1
Tibilova, AU1
Alimova, RA1
Fowler, B1
Ackles, KN1
Porlier, G1
Kinsbourne, M1
Rardin, DR1
Lawson, TR1
Kruzich, DJ1
Schnee, J1
Ginet, J1
Levy, JC1
Rolland, D1
Heller, ME1
Mordkoff, AM1
Henriques, E1
Arsenian, J1
Cutter, H1
Samaraweera, AB1
Kipperman, A1
Fine, EW1
Schildkraut, JJ1
Wallace, D1
Hiner, D1
Enelow, AJ1
Kielholz, P1
Levy, RM1
Brown, AR1
Halikas, JA1
Cappell, H1
Ginsberg, R1
Webster, CD1
Arnold, LE1
Strobl, D1
Weisenberg, A1
Dow, TW1
Silver, D1
Frosch, WA1
Müller-Oswald, U1
Ruppen, R1
Baumann, U1
Angst, J1
Nail, RL1
Gunderson, EK1
Kolb, D1
Goldstein, BJ1
Brauzer, B1
Simon, P2
Howell, MC1
Rever, GW1
Scholl, ML1
Trowbridge, F1
Rutledge, A1
Juve, JL1
Boissier, JR1
Cockett, R1
Marks, V1
Jackson, B1
Reed, A1
Prokop, H1
Blackman, D1

Reviews

7 reviews available for amphetamine and Anxiety

ArticleYear
Adrenaline rush: the role of adrenergic receptors in stimulant-induced behaviors.
    Molecular pharmacology, 2014, Volume: 85, Issue:4

    Topics: Amphetamine; Animals; Anxiety; Avoidance Learning; Behavior, Addictive; Behavior, Animal; Central Ne

2014
The impact of amphetamine-type stimulants on emergency services.
    Current opinion in psychiatry, 2015, Volume: 28, Issue:4

    Topics: Acute Disease; Aggression; Amphetamine; Amphetamine-Related Disorders; Anxiety; Central Nervous Syst

2015
CNS-related (side-)effects of beta-blockers with special reference to mechanisms of action.
    European journal of clinical pharmacology, 1985, Volume: 28 Suppl

    Topics: Adrenergic beta-Antagonists; Amphetamine; Animals; Anxiety; Blood-Brain Barrier; Central Nervous Sys

1985
The use and abuse of the psychotropic drugs.
    The Journal of the Oklahoma State Medical Association, 1973, Volume: 66, Issue:8

    Topics: Adult; Amphetamine; Antidepressive Agents; Anxiety; Chlorpromazine; Depression; Drug Utilization; Fe

1973
[Psychopharmacologic drugs in dentistry and drug dependency].
    Schweizerische Monatsschrift fur Zahnheilkunde = Revue mensuelle suisse d'odonto-stomatologie, 1974, Volume: 84, Issue:9

    Topics: Amphetamine; Amphetamines; Antidepressive Agents; Anxiety; Humans; Hypnotics and Sedatives; Phenacet

1974
Pharmacologic considerations in the treatment of anxiety and depression in medical practice.
    The Medical clinics of North America, 1971, Volume: 55, Issue:2

    Topics: Adult; Amphetamine; Antidepressive Agents; Anxiety; Autonomic Nervous System; Cardiovascular System;

1971
[Tranquilizing agents. Possibilities for animal studies].
    Actualites pharmacologiques, 1970, Volume: 23

    Topics: Aggression; Amphetamine; Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Brain; Conflict,

1970

Trials

5 trials available for amphetamine and Anxiety

ArticleYear
Interindividual variation in anxiety response to amphetamine: possible role for adenosine A2A receptor gene variants.
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2005, Nov-05, Volume: 139B, Issue:1

    Topics: Adolescent; Adult; Amphetamine; Anxiety; Central Nervous System Stimulants; Dose-Response Relationsh

2005
Amphetamine on Rorschach measures in normal subjects.
    Journal of personality assessment, 1995, Volume: 64, Issue:3

    Topics: Adult; Amphetamine; Anxiety; Blood Pressure; Double-Blind Method; Humans; Male; Placebos; Rorschach

1995
Depression and anxiety in heroin addicts: a placebo-controlled study of doxepin in combination with methadone.
    The American journal of psychiatry, 1975, Volume: 132, Issue:4

    Topics: Administration, Oral; Adult; Alcoholic Intoxication; Amphetamine; Anxiety; Barbiturates; Capsules; C

1975
Comparative symptomatological and evoked potential studies with d-amphetamine, thioridazine, and placebo in hyperkinetic children.
    Biological psychiatry, 1975, Volume: 10, Issue:3

    Topics: Administration, Oral; Adolescent; Amphetamine; Anxiety; Child; Child Behavior; Clinical Trials as To

1975
Hyperkinetic adult. Study of the "paradoxical" amphetamine response.
    JAMA, 1972, Nov-06, Volume: 222, Issue:6

    Topics: Adult; Age Factors; Amphetamine; Anxiety; Depression; Dextroamphetamine; Humans; Hyperkinesis; Male;

1972

Other Studies

126 other studies available for amphetamine and Anxiety

ArticleYear
Chronic administration of glucocorticoid receptor ligands increases anxiety-like behavior and selectively increase serotonin transporters in the ventral hippocampus.
    Brain research, 2023, 02-01, Volume: 1800

    Topics: Amphetamine; Animals; Anxiety; Corticosterone; Hippocampus; Hypothalamo-Hypophyseal System; Male; Mi

2023
Chronic administration of glucocorticoid receptor ligands increases anxiety-like behavior and selectively increase serotonin transporters in the ventral hippocampus.
    Brain research, 2023, 02-01, Volume: 1800

    Topics: Amphetamine; Animals; Anxiety; Corticosterone; Hippocampus; Hypothalamo-Hypophyseal System; Male; Mi

2023
Chronic administration of glucocorticoid receptor ligands increases anxiety-like behavior and selectively increase serotonin transporters in the ventral hippocampus.
    Brain research, 2023, 02-01, Volume: 1800

    Topics: Amphetamine; Animals; Anxiety; Corticosterone; Hippocampus; Hypothalamo-Hypophyseal System; Male; Mi

2023
Chronic administration of glucocorticoid receptor ligands increases anxiety-like behavior and selectively increase serotonin transporters in the ventral hippocampus.
    Brain research, 2023, 02-01, Volume: 1800

    Topics: Amphetamine; Animals; Anxiety; Corticosterone; Hippocampus; Hypothalamo-Hypophyseal System; Male; Mi

2023
Clavulanic Acid Improves Memory Dysfunction and Anxiety Behaviors through Upregulating Glutamatergic Transporters in the Nucleus Accumbens of Mice Repeatedly Exposed to Khat Extract.
    International journal of molecular sciences, 2023, Oct-27, Volume: 24, Issue:21

    Topics: Amphetamine; Animals; Anxiety; Catha; Clavulanic Acid; Memory Disorders; Mice; Nucleus Accumbens; Ra

2023
5-HT1A and α2 adrenergic receptor levels are associated with high anxiety-like patterns and impulsivity in selectively bred Long Evans rats.
    Behavioural brain research, 2020, 04-06, Volume: 383

    Topics: Adrenergic Agents; Amphetamine; Animals; Anxiety; Behavior, Animal; Brain; Conditioning, Operant; El

2020
Kava decreases the stereotyped behavior induced by amphetamine in mice.
    Journal of ethnopharmacology, 2021, Jan-30, Volume: 265

    Topics: Amphetamine; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Kava; Locomotion; Male; Maze L

2021
The amphetamine-associated context exerts a stronger motivational effect in low-anxiety rats than in high-anxiety rats.
    Behavioural brain research, 2017, 07-14, Volume: 330

    Topics: Amphetamine; Amphetamines; Amygdala; Animals; Anxiety; Anxiety Disorders; Behavior, Animal; Conditio

2017
Altered reward sensitivity in female offspring of cocaine-exposed fathers.
    Behavioural brain research, 2017, 08-14, Volume: 332

    Topics: Amphetamine; Animals; Anxiety; Central Nervous System Stimulants; Cocaine; Dopamine Uptake Inhibitor

2017
Influence of physical activity on addiction parameters of rats exposed to amphetamine which were previously supplemented with hydrogenated vegetable fat.
    Brain research bulletin, 2017, Volume: 135

    Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Anxiety; Behavior, Animal; Brain; Cerebral Cort

2017
No evidence of subgroups found in amphetamine consumers in Iran.
    Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater, 2018, Volume: 32, Issue:2

    Topics: Amphetamine; Anxiety; Depression; Drug Users; Humans; Iran; Substance-Related Disorders

2018
Sex and Trait Anxiety Differences in Psychological Stress are Modified by Environment.
    Neuroscience, 2018, 07-15, Volume: 383

    Topics: Amphetamine; Animals; Anxiety; Central Nervous System Stimulants; Female; Habituation, Psychophysiol

2018
Effects of light and dark phase testing on the investigation of behavioural paradigms in mice: Relevance for behavioural neuroscience.
    Pharmacology, biochemistry, and behavior, 2019, Volume: 178

    Topics: Amphetamine; Animals; Anxiety; Behavior, Animal; Circadian Rhythm; Cohort Studies; Dopamine Plasma M

2019
Diazepam reverses increased anxiety-like behavior, social behavior deficit, and dopamine dysregulation following withdrawal from acute amphetamine.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018, Volume: 43, Issue:12

    Topics: Amphetamine; Animals; Anti-Anxiety Agents; Anxiety; Central Nervous System Stimulants; Diazepam; Dop

2018
Interactive effects between hemizygous 15q13.3 microdeletion and peripubertal stress on adult behavioral functions.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2019, Volume: 44, Issue:4

    Topics: Age Factors; Amphetamine; Anhedonia; Animals; Anxiety; Behavior, Animal; Central Nervous System Stim

2019
Implication of nigral dopaminergic lesion and repeated L-dopa exposure in neuropsychiatric symptoms of Parkinson's disease.
    Behavioural brain research, 2019, 03-15, Volume: 360

    Topics: Amphetamine; Animals; Antiparkinson Agents; Anxiety; Benserazide; Disease Models, Animal; Dopamine;

2019
Adaptive anxious states and down-regulation of dopamine activity under amygdala activation in rats.
    Behavioural brain research, 2019, 04-01, Volume: 361

    Topics: Amphetamine; Amygdala; Animals; Anxiety; Dopamine; Dopaminergic Neurons; Down-Regulation; Male; Moto

2019
Modafinil reduces amphetamine preference and prevents anxiety-like symptoms during drug withdrawal in young rats: Involvement of dopaminergic targets in VTA and striatum.
    Progress in neuro-psychopharmacology & biological psychiatry, 2019, 06-08, Volume: 92

    Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Anxiety; Central Nervous System Stimulants; Cor

2019
Stress changes amphetamine response, D2 receptor expression and epigenetic regulation in low-anxiety rats.
    Progress in neuro-psychopharmacology & biological psychiatry, 2019, 07-13, Volume: 93

    Topics: Amphetamine; Animals; Anxiety; Dentate Gyrus; Disease Models, Animal; Epigenesis, Genetic; Fear; Hip

2019
Peripubertal diazepam administration prevents the emergence of dopamine system hyperresponsivity in the MAM developmental disruption model of schizophrenia.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2013, Volume: 38, Issue:10

    Topics: Amphetamine; Animals; Anxiety; Central Nervous System Sensitization; Diazepam; Dopaminergic Neurons;

2013
The influence of ionotropic and metabotropic glutamate receptor ligands on anxiety-like effect of amphetamine withdrawal in rats.
    Progress in neuro-psychopharmacology & biological psychiatry, 2013, Aug-01, Volume: 45

    Topics: Acamprosate; Amphetamine; Animals; Anxiety; Bridged Bicyclo Compounds; Dose-Response Relationship, D

2013
Modulation of behavioral networks by selective interneuronal inactivation.
    Molecular psychiatry, 2014, Volume: 19, Issue:5

    Topics: Amphetamine; Animals; Anxiety; Behavior; Brain; Central Nervous System Stimulants; Cholecystokinin;

2014
A novel analog of olanzapine linked to sarcosinyl moiety (PGW5) demonstrates high efficacy and good safety profile in mouse models of schizophrenia.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2014, Volume: 24, Issue:3

    Topics: Alanine; Amphetamine; Animals; Antipsychotic Agents; Anxiety; Benzodiazepines; Brain; Central Nervou

2014
Exercise modifies amphetamine relapse: behavioral and oxidative markers in rats.
    Behavioural brain research, 2014, Apr-01, Volume: 262

    Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Anxiety; Biomarkers; Catalase; Conditioning, Ps

2014
Dopamine and serotonin signaling during two sensitive developmental periods differentially impact adult aggressive and affective behaviors in mice.
    Molecular psychiatry, 2014, Volume: 19, Issue:6

    Topics: 3,4-Dihydroxyphenylacetic Acid; Affect; Aggression; Amphetamine; Animals; Anxiety; Brain; Central Ne

2014
The effect of quetiapine (Seroquel™) on conditioned place preference and elevated plus maze tests in rats when administered alone and in combination with (+)-amphetamine.
    Psychopharmacology, 2014, Volume: 231, Issue:22

    Topics: Amphetamine; Animals; Antipsychotic Agents; Anxiety; Behavior, Animal; Central Nervous System Stimul

2014
Automated touch screen device for recording complex rodent behaviors.
    Journal of neuroscience methods, 2014, Aug-15, Volume: 233

    Topics: Actigraphy; Amphetamine; Analgesics, Opioid; Animals; Anxiety; Behavior, Animal; Benzamides; Biomech

2014
Only susceptible rats exposed to a model of PTSD exhibit reactivity to trauma-related cues and other symptoms: an effect abolished by a single amphetamine injection.
    Behavioural brain research, 2014, Oct-01, Volume: 272

    Topics: Amphetamine; Animals; Anxiety; Cues; Disease Models, Animal; Genetic Predisposition to Disease; Indi

2014
Central CRF2 receptor antagonism reduces anxiety states during amphetamine withdrawal.
    Neuroscience research, 2014, Volume: 89

    Topics: Amphetamine; Animals; Anxiety; Infusions, Intraventricular; Male; Motor Activity; Peptide Fragments;

2014
High-anxiety rats are less sensitive to the rewarding affects of amphetamine on 50kHz USV.
    Behavioural brain research, 2014, Dec-15, Volume: 275

    Topics: Amphetamine; Analysis of Variance; Animals; Anxiety; Central Nervous System Stimulants; Conditioning

2014
Serotonin in the ventral hippocampus modulates anxiety-like behavior during amphetamine withdrawal.
    Neuroscience, 2014, Dec-05, Volume: 281

    Topics: 5,7-Dihydroxytryptamine; Amphetamine; Amphetamine-Related Disorders; Animals; Anxiety; Central Nervo

2014
Genetic mapping of ASIC4 and contrasting phenotype to ASIC1a in modulating innate fear and anxiety.
    The European journal of neuroscience, 2015, Volume: 41, Issue:12

    Topics: Acid Sensing Ion Channels; Amphetamine; Animals; Anxiety; Body Composition; Eating; Estrogen Antagon

2015
Cross-Generational trans Fat Consumption Favors Self-Administration of Amphetamine and Changes Molecular Expressions of BDNF, DAT, and D1/D2 Receptors in the Cortex and Hippocampus of Rats.
    Neurotoxicity research, 2015, Volume: 28, Issue:4

    Topics: Amphetamine; Animals; Anxiety; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Dopamine Plasma M

2015
Neonatal exposure to amphetamine alters social affiliation and central dopamine activity in adult male prairie voles.
    Neuroscience, 2015, Oct-29, Volume: 307

    Topics: Amphetamine; Analysis of Variance; Animals; Animals, Newborn; Anxiety; Arvicolinae; Body Weight; Cen

2015
Emotional traits predict individual differences in amphetamine-induced positive mood in healthy volunteers.
    Psychopharmacology, 2016, Volume: 233, Issue:1

    Topics: Adult; Affect; Amphetamine; Anxiety; Arousal; Central Nervous System Stimulants; Dextroamphetamine;

2016
Repeated amphetamine injections alter behavior and induce a delayed behavioral sensitization modulated by reactivity to novelty: Similarities and differences with trauma consequences.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2016, Volume: 26, Issue:3

    Topics: Adaptation, Ocular; Amphetamine; Analysis of Variance; Animals; Anxiety; Avoidance Learning; Central

2016
Ablation of fast-spiking interneurons in the dorsal striatum, recapitulating abnormalities seen post-mortem in Tourette syndrome, produces anxiety and elevated grooming.
    Neuroscience, 2016, Jun-02, Volume: 324

    Topics: Amphetamine; Animals; Anxiety; Central Nervous System Stimulants; Conditioning, Psychological; Corpu

2016
Interaction between interleukin-1β and type-1 cannabinoid receptor is involved in anxiety-like behavior in experimental autoimmune encephalomyelitis.
    Journal of neuroinflammation, 2016, 09-02, Volume: 13, Issue:1

    Topics: Amphetamine; Animals; Antirheumatic Agents; Anxiety; Central Nervous System Stimulants; Cerebral Cor

2016
Low-anxiety rats are more sensitive to amphetamine in comparison to high-anxiety rats.
    Journal of psychopharmacology (Oxford, England), 2017, Volume: 31, Issue:1

    Topics: Amphetamine; Animals; Anxiety; Anxiety Disorders; Behavior, Animal; Conditioning, Classical; Conditi

2017
The expression of amphetamine sensitization is dissociable from anxiety and aversive memory: Effect of an acute injection of amphetamine.
    Neuroscience letters, 2017, 01-18, Volume: 638

    Topics: Amphetamine; Animals; Anxiety; Avoidance Learning; Central Nervous System Stimulants; Male; Memory;

2017
Hemodynamic profile and behavioral characteristics during induction of anesthesia in pediatric patients with attention deficit hyperactivity disorder.
    Paediatric anaesthesia, 2017, Volume: 27, Issue:4

    Topics: Adolescent; Amphetamine; Anesthesia; Anti-Anxiety Agents; Anxiety; Attention Deficit Disorder with H

2017
Enduring attenuation of norepinephrine synaptic availability and augmentation of the pharmacological and behavioral effects of desipramine by repeated immobilization stress.
    Neuropharmacology, 2017, 05-01, Volume: 117

    Topics: Amphetamine; Animals; Antidepressive Agents, Tricyclic; Anxiety; Central Nervous System Stimulants;

2017
Behavioral characterization of the mGlu group II/III receptor antagonist, LY-341495, in animal models of anxiety and depression.
    European journal of pharmacology, 2008, Sep-11, Volume: 592, Issue:1-3

    Topics: Amino Acids; Amphetamine; Animals; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; An

2008
Long-term alterations in vulnerability to addiction to drugs of abuse and in brain gene expression after early life ethanol exposure.
    Neuropharmacology, 2008, Volume: 55, Issue:7

    Topics: Amphetamine; Animals; Anxiety; Avoidance Learning; Brain Chemistry; Central Nervous System Depressan

2008
Wfs1-deficient mice display impaired behavioural adaptation in stressful environment.
    Behavioural brain research, 2009, Mar-17, Volume: 198, Issue:2

    Topics: Adaptation, Psychological; Amphetamine; Animals; Anxiety; Apomorphine; Central Nervous System Stimul

2009
Behavioral characterization of mice lacking the neurite outgrowth inhibitor Nogo-A.
    Genes, brain, and behavior, 2009, Volume: 8, Issue:2

    Topics: Amphetamine; Animals; Anxiety; Association Learning; Avoidance Learning; Behavior, Animal; Central N

2009
The supra-additive hyperactivity caused by an amphetamine-chlordiazepoxide mixture exhibits an inverted-U dose response: negative implications for the use of a model in screening for mood stabilizers.
    Pharmacology, biochemistry, and behavior, 2009, Volume: 92, Issue:4

    Topics: Affect; Amphetamine; Animals; Antimanic Agents; Anxiety; Bipolar Disorder; Chlordiazepoxide; Disease

2009
Distinguishing anxiolysis and hyperactivity in an open space behavioral test.
    Behavioural brain research, 2010, Feb-11, Volume: 207, Issue:1

    Topics: Amphetamine; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Central

2010
Increased anxiety-like behavior of rats during amphetamine withdrawal is reversed by CRF2 receptor antagonism.
    Behavioural brain research, 2010, Mar-17, Volume: 208, Issue:1

    Topics: Amphetamine; Animals; Anxiety; Behavior, Animal; Central Nervous System Stimulants; Male; Maze Learn

2010
The brain pattern of c-fos induction by two doses of amphetamine suggests different brain processing pathways and minor contribution of behavioural traits.
    Neuroscience, 2010, Jul-14, Volume: 168, Issue:3

    Topics: Amphetamine; Animals; Anxiety; Brain; Central Nervous System Stimulants; Exploratory Behavior; Facto

2010
Withdrawal from chronic amphetamine produces persistent anxiety-like behavior but temporally-limited reductions in monoamines and neurogenesis in the adult rat dentate gyrus.
    Neuropharmacology, 2010, Volume: 59, Issue:6

    Topics: Amphetamine; Analysis of Variance; Animals; Anxiety; Cell Count; Cell Death; Corticosterone; Dentate

2010
AVE1625, a cannabinoid CB1 receptor antagonist, as a co-treatment with antipsychotics for schizophrenia: improvement in cognitive function and reduction of antipsychotic-side effects in rodents.
    Psychopharmacology, 2011, Volume: 215, Issue:1

    Topics: Acoustic Stimulation; Amphetamine; Animals; Antipsychotic Agents; Anxiety; Behavior, Animal; Catalep

2011
Effect of magnesium chloride on psychomotor activity, emotional status, and acute behavioural responses to clonidine, d-amphetamine, arecoline, nicotine, apomorphine, and L-5-hydroxytryptophan.
    Nutritional neuroscience, 2011, Volume: 14, Issue:1

    Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Anxiety; Apomorphine; Arecoline; Clonidine; Depression; D

2011
Amphetamine induced dopamine release increases anxiety in individuals recovered from anorexia nervosa.
    The International journal of eating disorders, 2012, Volume: 45, Issue:2

    Topics: Adult; Amphetamine; Anorexia Nervosa; Anxiety; Corpus Striatum; Dopamine; Dopamine Agents; Euphoria;

2012
Mild prenatal stress-modulated behavior and neuronal spine density without affecting amphetamine sensitization.
    Developmental neuroscience, 2011, Volume: 33, Issue:2

    Topics: Amphetamine; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Dendritic Spines; Disease Mod

2011
[Behavioral correlations of gradual forced administration of psychoactive drugs].
    Eksperimental'naia i klinicheskaia farmakologiia, 2011, Volume: 74, Issue:6

    Topics: Amphetamine; Animals; Anxiety; Behavior, Animal; Dexamethasone; Dose-Response Relationship, Drug; Dr

2011
Adolescent amphetamine exposure elicits dose-specific effects on monoaminergic neurotransmission and behaviour in adulthood.
    The international journal of neuropsychopharmacology, 2012, Volume: 15, Issue:9

    Topics: Amphetamine; Animals; Anxiety; Behavior, Animal; Biogenic Monoamines; Central Nervous System Stimula

2012
Modulation of neuropeptide FF (NPFF) receptors influences the expression of amphetamine-induced conditioned place preference and amphetamine withdrawal anxiety-like behavior in rats.
    Peptides, 2012, Volume: 33, Issue:1

    Topics: Adamantane; Amphetamine; Animals; Anxiety; Behavior, Animal; Conditioning, Psychological; Dipeptides

2012
Open space anxiety test in rodents: the elevated platform with steep slopes.
    Methods in molecular biology (Clifton, N.J.), 2012, Volume: 829

    Topics: Altitude; Amphetamine; Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Behavior, Animal;

2012
Exendin-4 decreases amphetamine-induced locomotor activity.
    Physiology & behavior, 2012, Jun-25, Volume: 106, Issue:4

    Topics: Amphetamine; Animals; Antimanic Agents; Anxiety; Central Nervous System Stimulants; Conditioning, Op

2012
Astrocyte-specific disruption of SynCAM1 signaling results in ADHD-like behavioral manifestations.
    PloS one, 2012, Volume: 7, Issue:4

    Topics: Amphetamine; Animals; Anxiety; Astrocytes; Attention Deficit Disorder with Hyperactivity; Behavior,

2012
Selective deletion of forebrain glycogen synthase kinase 3β reveals a central role in serotonin-sensitive anxiety and social behaviour.
    Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2012, Sep-05, Volume: 367, Issue:1601

    Topics: Amphetamine; Animals; Anti-Anxiety Agents; Anxiety; Enzyme Activation; Female; Gene Deletion; Gene S

2012
Ventral hippocampal lesions affect anxiety but not spatial learning.
    Behavioural brain research, 2003, Feb-17, Volume: 139, Issue:1-2

    Topics: Amphetamine; Analysis of Variance; Animals; Anxiety; Discrimination Learning; Fear; Feeding Behavior

2003
Deficient prepulse inhibition of acoustic startle in Hooded-Wistar rats compared with Sprague-Dawley rats.
    Clinical and experimental pharmacology & physiology, 2003, Volume: 30, Issue:4

    Topics: Acoustic Stimulation; Amphetamine; Animals; Anxiety; Apomorphine; Disease Models, Animal; Dizocilpin

2003
Evaluation of an amphetamine-barbiturate combination in the supportive treatment of the aged.
    Journal of the American Geriatrics Society, 1954, Volume: 2, Issue:2

    Topics: Aged; Amphetamine; Amphetamines; Anxiety; Barbiturates; Depression; Depressive Disorder; Humans

1954
Use of a d-amphetamine-amobarbital combination as an adjunct to the treatment of carcinoma.
    Journal of the American Geriatrics Society, 1954, Volume: 2, Issue:9

    Topics: Amobarbital; Amphetamine; Amphetamines; Anxiety; Barbiturates; Depression; Depressive Disorder; Dext

1954
An apparatus for the study of the effects of central nervous stimulants on the spontaneous activity of small laboratory animals.
    The Australian journal of experimental biology and medical science, 1955, Volume: 33, Issue:5

    Topics: Amphetamine; Amphetamines; Animals; Animals, Laboratory; Anxiety; Central Nervous System; Central Ne

1955
The effects of an anxiety-reducing medication on group behavior under threat.
    Journal of abnormal psychology, 1956, Volume: 52, Issue:1

    Topics: Amphetamine; Amphetamines; Anxiety; Anxiety Disorders; Barbiturates; Behavior; Humans

1956
Anxiety and its pharmacologic control.
    Henry Ford Hospital medical bulletin, 1957, Volume: 5, Issue:2

    Topics: Amphetamine; Amphetamines; Anxiety; Anxiety Disorders; Humans; Tranquilizing Agents

1957
Dextro-amphetamine sulfate in mild depression and anxiety.
    International record of medicine and general practice clinics, 1957, Volume: 170, Issue:9

    Topics: Amphetamine; Amphetamines; Anxiety; Anxiety Disorders; Depression; Depressive Disorder; Dextroamphet

1957
Prepartum depression; a study of seventy unwed mothers treated with d-amphetamine sulfate and amobarbital.
    California medicine, 1958, Volume: 88, Issue:5

    Topics: Amobarbital; Amphetamine; Amphetamines; Anxiety; Apathy; Depression; Depressive Disorder; Dextroamph

1958
The influence of certain drugs with a predominant central nervous action on protein assimilation and disassimilation.
    Rumanian medical review, 1961, Volume: 5

    Topics: Amphetamine; Amphetamines; Anxiety; Barbiturates; Chlorpromazine; Humans; Picrotoxin; Proteins

1961
Office care of mild emotional distress.
    Diseases of the nervous system, 1962, Volume: 23

    Topics: Amobarbital; Amphetamine; Amphetamines; Anxiety; Anxiety Disorders; Atropa belladonna; Depression; D

1962
THE FUTURE OF TRANQUILIZER RESEARCH AND THE THERAPY OF ANXIETY. THE NEED FOR A QUANTITATIVE APPROACH TO THE STUDY OF "DEPRESSANT TRANQUILIZERS".
    Journal of neuropsychiatry, 1964, Volume: 5

    Topics: Amphetamine; Amphetamines; Anxiety; Anxiety Disorders; Drug Therapy; Hypnotics and Sedatives; Morphi

1964
PANEL DISCUSSION. 3. THE FUTURE OF TRANQUILIZER RESEARCH AND THE THERAPY OF ANXIETY. ASSAY OF ANTI-ANXIETY DRUGS BY QUANTITATIVE ELECTROENCEPHALOGRAPHY.
    Journal of neuropsychiatry, 1964, Volume: 5

    Topics: Alcohols; Amphetamine; Anti-Anxiety Agents; Anxiety; Anxiety Disorders; Biomedical Research; Chlordi

1964
MANIFEST ANXIETY, AMPHETAMINE, AND PERFORMANCE.
    The Journal of psychology, 1965, Volume: 60

    Topics: Amphetamine; Amphetamines; Anxiety; Anxiety Disorders; Humans; Motor Skills; Paired-Associate Learni

1965
Early environment contributes to developmental disruption of MPFC after neonatal ventral hippocampal lesions in rats.
    Synapse (New York, N.Y.), 2003, Dec-01, Volume: 50, Issue:3

    Topics: Amphetamine; Animals; Animals, Newborn; Anxiety; Behavior, Animal; Dopamine Agents; Environment; Hip

2003
Behavioural consequences of withdrawal from three different administration schedules of amphetamine.
    Behavioural brain research, 2005, Nov-30, Volume: 165, Issue:1

    Topics: Amphetamine; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Central Nervous System Stimul

2005
Blockade of presynaptic voltage-gated calcium channels in the medial prefrontal cortex of neonatal rats leads to post-pubertal alterations in locomotor behavior.
    Brain research, 2006, Apr-14, Volume: 1083, Issue:1

    Topics: Aging; Amphetamine; Animals; Animals, Newborn; Anxiety; Behavior, Animal; Calcium Channel Blockers;

2006
Rats with persistently low or high exploratory activity: behaviour in tests of anxiety and depression, and extracellular levels of dopamine.
    Behavioural brain research, 2007, Feb-27, Volume: 177, Issue:2

    Topics: Amphetamine; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Central Nervous System Stimul

2007
The Trace Amine 1 receptor knockout mouse: an animal model with relevance to schizophrenia.
    Genes, brain, and behavior, 2007, Volume: 6, Issue:7

    Topics: Amphetamine; Animals; Anxiety; Behavior, Animal; Catecholamines; Central Nervous System Stimulants;

2007
Evaluation of the mGlu8 receptor as a putative therapeutic target in schizophrenia.
    Brain research, 2007, Jun-04, Volume: 1152

    Topics: Amphetamine; Animals; Anticonvulsants; Anxiety; Autoreceptors; Benzoates; Brain; Central Nervous Sys

2007
Loss of erbB signaling in oligodendrocytes alters myelin and dopaminergic function, a potential mechanism for neuropsychiatric disorders.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, May-08, Volume: 104, Issue:19

    Topics: Amphetamine; Animals; Anxiety; Cyclic Nucleotide Phosphodiesterases, Type 1; Dopamine; ErbB Receptor

2007
The effects of chlordiazepoxide, amphetamine and cocaine on bar-press behavior in normal and genetically nervous dogs.
    Diseases of the nervous system, 1974, Volume: 35, Issue:5

    Topics: Amphetamine; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Chlordiazepoxide; Cocaine; Con

1974
Environmental modulation of anxiety-related neuronal activity and behaviors.
    Behavioural brain research, 2008, Jan-25, Volume: 186, Issue:2

    Topics: Amphetamine; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Central Nervous System Stimul

2008
Behavioral characterization of mice deficient in the phosphodiesterase-10A (PDE10A) enzyme on a C57/Bl6N congenic background.
    Neuropharmacology, 2008, Volume: 54, Issue:2

    Topics: Amphetamine; Animals; Anxiety; Avoidance Learning; Behavior, Animal; Biogenic Monoamines; Brain Chem

2008
The role of anxiety in the development of levodopa-induced dyskinesias in an animal model of Parkinson's disease, and the effect of chronic treatment with the selective serotonin reuptake inhibitor citalopram.
    Psychopharmacology, 2008, Volume: 197, Issue:2

    Topics: Adrenal Cortex Hormones; Amphetamine; Animals; Anxiety; Blotting, Western; Body Weight; Central Nerv

2008
Persistent downregulation of hippocampal CREB mRNA parallels a Y-maze deficit in adolescent rats following semi-chronic amphetamine administration.
    British journal of pharmacology, 2008, Volume: 154, Issue:2

    Topics: Age Factors; Amphetamine; Animals; Anxiety; Behavior, Animal; Central Nervous System Stimulants; Cyc

2008
Successful treatment of amphetamine addiction in a schizophrenic woman.
    American journal of psychotherapy, 1967, Volume: 21, Issue:2

    Topics: Adult; Amphetamine; Anticonvulsants; Anxiety; Depression; Electroconvulsive Therapy; Female; Humans;

1967
Differential effects of benzodiazepines and amphetamine on exploratory behaviour in weanling rats: an animal model for anxiolytic activity.
    Progress in neuro-psychopharmacology & biological psychiatry, 1984, Volume: 8, Issue:1

    Topics: Amphetamine; Animals; Animals, Suckling; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Desipramine;

1984
The effects of two nonpharmacological variables on drug preference in humans.
    NIDA research monograph, 1983, Volume: 43

    Topics: Adult; Amphetamine; Anxiety; Diazepam; Dose-Response Relationship, Drug; Emotions; Humans; Psycholog

1983
Theory of drug use.
    NIDA research monograph, 1980, Volume: 30

    Topics: Adaptation, Psychological; Adult; Aggression; Amphetamine; Anxiety; Child; Child Development; Confli

1980
Anxiogenic effect of phenylethylamine and amphetamine in the elevated plus-maze in mice and its attenuation by ethanol.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 44, Issue:1

    Topics: Amphetamine; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Dose-Response Relationship, Dr

1993
Neurochemical mediators of anxiety have inconsistent effects on hypothalamic self-stimulation in rats.
    Pharmacology & toxicology, 1996, Volume: 78, Issue:5

    Topics: Amphetamine; Animals; Antipsychotic Agents; Anxiety; Arousal; Central Nervous System Stimulants; Cer

1996
Dopamine D3 receptor mutant mice exhibit increased behavioral sensitivity to concurrent stimulation of D1 and D2 receptors.
    Neuron, 1997, Volume: 19, Issue:4

    Topics: Amphetamine; Animals; Anxiety; Chimera; Cocaine; Conditioning, Operant; Crosses, Genetic; Cues; Dopa

1997
Characterization of rat exploratory behavior using the exploration box test.
    Methods and findings in experimental and clinical pharmacology, 1997, Volume: 19, Issue:10

    Topics: Amphetamine; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Buspirone; Carbolines; Diazepa

1997
Uncontrollable stress potentiates morphine's rewarding properties.
    Pharmacology, biochemistry, and behavior, 1998, Volume: 60, Issue:3

    Topics: Amphetamine; Animals; Anxiety; Carbolines; Central Nervous System Stimulants; Conditioning, Operant;

1998
The anxiogenic-like and anxiolytic-like effects of MDMA on mice in the elevated plus-maze: a comparison with amphetamine.
    Pharmacology, biochemistry, and behavior, 1999, Volume: 62, Issue:3

    Topics: Amphetamine; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Dopamine Uptake Inhi

1999
Diazepam modifies the effect of pedunculopontine lesions on morphine but not on amphetamine conditioned place preference.
    Behavioural brain research, 2000, Dec-20, Volume: 117, Issue:1-2

    Topics: Amphetamine; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Brain Injuries; Central Ne

2000
The effects of amphetamine and raclopride on food transport: possible relation to defensive behavior in rats.
    Behavioural pharmacology, 2000, Volume: 11, Issue:6

    Topics: Amphetamine; Animals; Anxiety; Behavior, Animal; Central Nervous System Stimulants; Dopamine Antagon

2000
A dopaminergic mechanism is involved in the 'anxiogenic-like' response induced by chronic amphetamine treatment: a behavioral and neurochemical study.
    Brain research, 2001, Aug-03, Volume: 909, Issue:1-2

    Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Anxiety; Behavior, Animal; Benzazepines; Brain;

2001
A test of anxiety that distinguishes between the actions of benzodiazepines and those of other minor tranquilisers and of stimulants.
    Pharmacology, biochemistry, and behavior, 1979, Volume: 11, Issue:1

    Topics: Amphetamine; Animals; Anti-Anxiety Agents; Anxiety; Caffeine; Central Nervous System Stimulants; Flu

1979
Eight-arm maze performance, neophobia, and hippocampal cholinergic alterations after prenatal oxazepam in mice.
    Brain research bulletin, 1992, Volume: 29, Issue:5

    Topics: Amphetamine; Animals; Anxiety; Behavior, Animal; Dose-Response Relationship, Drug; Exploratory Behav

1992
Behavioural effects of anxiogenic agents in the common marmoset.
    Pharmacology, biochemistry, and behavior, 1992, Volume: 42, Issue:1

    Topics: Amphetamine; Animals; Anxiety; Behavior, Animal; Caffeine; Callithrix; Carbolines; Diazepam; Motor A

1992
Psychological change during residence in a rehabilitation centre for female drug misusers. Part I. Drug misusers.
    Drug and alcohol dependence, 1991, Volume: 27, Issue:2

    Topics: Adolescent; Adult; Amphetamine; Anxiety; Depression; Female; Heroin Dependence; Humans; Opioid-Relat

1991
[Problem of transient dementias of old age (clinico-diagnostic aspect)].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1985, Volume: 85, Issue:9

    Topics: Aged; Amphetamine; Anxiety; Central Nervous System Stimulants; Dementia; Depressive Disorder; Diagno

1985
Effects of inert gas narcosis on behavior--a critical review.
    Undersea biomedical research, 1985, Volume: 12, Issue:4

    Topics: Amphetamine; Animals; Anxiety; Arousal; Attention; Behavior; Blood Gas Analysis; Conditioning, Opera

1985
School problems: diagnosis and treatment.
    Pediatrics, 1973, Volume: 52, Issue:5

    Topics: Agnosia; Amphetamine; Anxiety; Child; Child, Preschool; Cognition Disorders; Developmental Disabilit

1973
Opiates, amphetamines, alcohol: a comparative study of American soldiers.
    The International journal of the addictions, 1974, Volume: 9, Issue:6

    Topics: Adult; Alcoholism; Amphetamine; Anxiety; Authoritarianism; Boredom; Family Characteristics; Humans;

1974
Pharmacological and dynamic factors in psychotropic drug therapy.
    American journal of psychoanalysis, 1970, Volume: 30, Issue:2

    Topics: Adult; Amphetamine; Antidepressive Agents; Antitubercular Agents; Anxiety; Bipolar Disorder; Chlorpr

1970
[Psychotropic activity under the influence of fenpentadiol].
    Arzneimittel-Forschung, 1971, Volume: 21, Issue:1

    Topics: Amphetamine; Animals; Anticonvulsants; Antidepressive Agents; Anxiety; Barbiturates; Cats; Central N

1971
Personality attributes of the young, nonaddicted drug abuser.
    The International journal of the addictions, 1972, Volume: 7, Issue:1

    Topics: Adolescent; Adult; Age Factors; Amphetamine; Antisocial Personality Disorder; Anxiety; Barbiturates;

1972
Personality characteristics and drug of choice.
    The International journal of the addictions, 1972, Volume: 7, Issue:1

    Topics: Amphetamine; Analysis of Variance; Anxiety; Barbiturates; Depression; Diagnosis, Differential; Femal

1972
The combined abuse of alcohol and amphetamines.
    The American journal of psychiatry, 1974, Volume: 131, Issue:11

    Topics: Adult; Alcohol Drinking; Alcoholism; Amphetamine; Anxiety; Depression; Drug Interactions; Employment

1974
Biochemical criteria for classifying depressive disorders and predicting responses to pharmacotherapy: preliminary findings from studies of norepinephrine metabolism. Contributions to biochemistry.
    Pharmakopsychiatrie, Neuro-Psychopharmakologie, 1974, Volume: 7, Issue:2

    Topics: Adolescent; Adult; Aged; Amitriptyline; Amphetamine; Anxiety; Bipolar Disorder; Brain; Depression; F

1974
Some descriptive measures on 100 consecutive VA hospital drug abuse admissions.
    The International journal of the addictions, 1974, Volume: 9, Issue:3

    Topics: Adolescent; Adult; Amphetamine; Antisocial Personality Disorder; Anxiety; Barbiturates; Depression;

1974
Illicit pentazocine (Talwin) use: a report of thirteen cases.
    The International journal of the addictions, 1972, Volume: 7, Issue:4

    Topics: Adolescent; Adult; Amphetamine; Anxiety; Cannabis; Ethanol; Euphoria; Female; Heroin; Humans; Lyserg

1972
Amphetamine and conditioned 'anxiety'.
    British journal of pharmacology, 1972, Volume: 45, Issue:3

    Topics: Amphetamine; Animals; Anxiety; Conditioning, Psychological; Electroshock; Humans; Injections, Intrap

1972
A drug induced koro syndrome.
    JFMA, the Journal of the Florida Medical Association. Florida Medical Association, 1973, Volume: 60, Issue:4

    Topics: Adult; Amphetamine; Anxiety; Depersonalization; Humans; Male

1973
On the preferential abuse of heroin and amphetamine.
    The Journal of nervous and mental disease, 1973, Volume: 156, Issue:4

    Topics: Adaptation, Psychological; Amphetamine; Anxiety; Defense Mechanisms; Ego; Heroin; Humans; Personalit

1973
[Personality aspects of drug abuse by 19-year-old males (author's transl)].
    Archiv fur Psychiatrie und Nervenkrankheiten, 1973, Jul-20, Volume: 217, Issue:3

    Topics: Adult; Affective Symptoms; Amphetamine; Anxiety; Cannabis; Character; Depression; Hallucinogens; Hum

1973
Motives for drug use among light and heavy users.
    The Journal of nervous and mental disease, 1974, Volume: 159, Issue:2

    Topics: Adult; Amphetamine; Anxiety; Barbiturates; Cannabis; Cocaine; Creativity; Depression; Exploratory Be

1974
Hyperactivity in children: types, diagosis, drug therapy, approaches to management.
    Clinical pediatrics, 1972, Volume: 11, Issue:1

    Topics: Amphetamine; Anxiety; Attention; Attention Deficit Disorder with Hyperactivity; Brain Damage, Chroni

1972
Bad drug trips and flashbacks.
    Child welfare, 1972, Volume: 51, Issue:1

    Topics: Adolescent; Adult; Amphetamine; Anxiety; Depersonalization; Hallucinogens; Humans; Hysteria; Lysergi

1972
Evaluation of experimental techniques in the psychopharmacology of emotion.
    Annals of the New York Academy of Sciences, 1969, Jul-30, Volume: 159, Issue:3

    Topics: Amphetamine; Animals; Anxiety; Autonomic Nervous System; Avoidance Learning; Barbiturates; Behavior,

1969
Amphetamine taking among young offenders.
    The British journal of psychiatry : the journal of mental science, 1969, Volume: 115, Issue:527

    Topics: Adolescent; Adult; Amphetamine; Anxiety; Chromatography, Thin Layer; Guilt; Humans; Introversion, Ps

1969
Another abusable amphetamine.
    JAMA, 1970, Feb-02, Volume: 211, Issue:5

    Topics: Amphetamine; Anxiety; Fatigue; Humans; Substance-Related Disorders; Wisconsin

1970
[Hallucinosis in ephedrine addiction].
    Der Nervenarzt, 1968, Volume: 39, Issue:2

    Topics: Adult; Amphetamine; Anxiety; Ephedrine; Euphoria; Female; Hallucinations; Humans; Mental Disorders;

1968
Effects of drugs on conditioned "anxiety".
    Nature, 1968, Feb-24, Volume: 217, Issue:5130

    Topics: Amphetamine; Animals; Anxiety; Behavior, Animal; Conditioning, Psychological; Electroshock; Humans;

1968