amphetamine has been researched along with Aging in 115 studies
Amphetamine: A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.
1-phenylpropan-2-amine : A primary amine that is isopropylamine in which a hydrogen attached to one of the methyl groups has been replaced by a phenyl group.
amphetamine : A racemate comprising equimolar amounts of (R)-amphetamine (also known as levamphetamine or levoamphetamine) and (S)-amphetamine (also known as dexamfetamine or dextroamphetamine.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Schizophrenia is characterized by severe abnormalities in cognition, including disordered attention." | 5.32 | Phencyclidine exacerbates attentional deficits in a neurodevelopmental rat model of schizophrenia. ( Grottick, AJ; Higgins, GA; Le Pen, G; Moreau, JL, 2003) |
| "We used the passive avoidance test and acute amphetamine administration in aging gammasynuclein knock-out mice." | 3.88 | The Dopaminergic Dysfunction and Altered Working Memory Performance of Aging Mice Lacking Gamma-synuclein Gene. ( Aliev, G; Fisenko, VP; Kokhan, TYG; Kokhan, VS; Samsonova, AN; Ustyugov, AA, 2018) |
| "Attention-deficit/hyperactivity disorder (ADHD) is comorbid with cocaine abuse." | 3.83 | Adolescent D-amphetamine treatment in a rodent model of ADHD: Pro-cognitive effects in adolescence without an impact on cocaine cue reactivity in adulthood. ( Dwoskin, LP; Jordan, CJ; Kantak, KM; Taylor, DM, 2016) |
| " Amphetamine-induced disruption of LI and its potentiation by antipsychotic drugs (APDs) in the adult rat are well-established models of schizophrenia and antipsychotic drug action, respectively." | 3.72 | Latent inhibition in 35-day-old rats is not an "adult" latent inhibition: implications for neurodevelopmental models of schizophrenia. ( Rimmerman, N; Weiner, I; Zuckerman, L, 2003) |
| "Because AZT (azidothymidine, zidovudine, ZDV) has become the standard of care for preventing HIV transmission during pregnancy, we conducted a study to assess the possible neurobehavioral effects of this drug, using a rat model." | 3.70 | Neurobehavioral effects of perinatal AZT exposure in Sprague-Dawley weaning rats. ( Busidan, Y; Dow-Edwards, DL, 1999) |
| "Mice treated with nicotine during early but not late adolescence showed an increase in CPP for cocaine, morphine and amphetamine later in adulthood." | 1.43 | Early adolescent nicotine exposure affects later-life cocaine reward in mice. ( Alajaji, M; Carroll, FI; Damaj, MI; Kota, D; Lazenka, MF; Levine, A; Selley, DE; Sim-Selley, LJ; Wise, LE; Younis, RM, 2016) |
| "Modafinil is a psychostimulant approved for treating excessive sleepiness in adults; off-label uses (e." | 1.36 | Age-dependent effects of modafinil on acoustic startle and prepulse inhibition in rats. ( McFadden, SL; Morgan, RE; Zulas, AL, 2010) |
| "Schizophrenia is characterized by severe abnormalities in cognition, including disordered attention." | 1.32 | Phencyclidine exacerbates attentional deficits in a neurodevelopmental rat model of schizophrenia. ( Grottick, AJ; Higgins, GA; Le Pen, G; Moreau, JL, 2003) |
| "Consequence of the long-term use of psychostimulants as treatment for attention deficit/hyperactivity disorder (ADHD) is unknown, particularly whether treatment with psychostimulants at an early age increases an individual's potential for cross-sensitization to other stimulants exposed at a later age." | 1.32 | Chronic pretreatment with methylphenidate induces cross-sensitization with amphetamine. ( Dafny, N; Swann, AC; Yang, PB, 2003) |
| " After 1-d or 14-d withdrawal from Amph, they were challenged on day 8 (W1d) or on day 21 (W14d) with a single same dosage and then perfused." | 1.32 | Age- and region-dependent alterations in the GABAergic innervation in the brain of rats treated with amphetamine. ( Chen, CT; Lin, TY; Yin, HS, 2004) |
| " Here we demonstrate that, after chronic administration of the psychostimulants cocaine and amphetamine, the transcription factor DeltaFosB is upregulated in the nucleus accumbens of periadolescent mice but not in post-weanling or adult mice." | 1.31 | Periadolescent mice show enhanced DeltaFosB upregulation in response to cocaine and amphetamine. ( Canas, E; Ehrlich, ME; Sommer, J; Unterwald, EM, 2002) |
| " As expected, regular Wean-21 animals showed an AMPH-induced hyperactivity and a profile of conditioned locomotion, whereas the same dosage failed to induce any change in Wean-15 and Wean-27 groups." | 1.31 | Spontaneous novelty seeking and amphetamine-induced conditioning and sensitization in adult mice: evidence of dissociation as a function of age at weaning. ( Adriani, W; Laviola, G, 2002) |
| " The ability of amphetamine to alter taste preference increased with dosage level and this effect interacted with age." | 1.26 | Developmental changes in amphetamine-induced taste aversions. ( Infurna, RN; Spear, LP, 1979) |
| "6 Animals withdrawn following chronic administration of a number of drugs, barbitone, barbitone/bemegride mixture, Mandrax (methaqualone: diphenhydramine; 10: 1), chlordiazepoxide, nitrazepam, chlorpromazine or ethanol, exhibited a significant tolerance to intracerebroventricularly administered pentobarbitone." | 1.25 | A study of the factors affecting the sleeping time following intracerebroventricular administration of pentobarbitone sodium: effect of prior administration of centrally active drugs. ( Stevenson, IH; Turnbull, MJ, 1974) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 35 (30.43) | 18.7374 |
| 1990's | 26 (22.61) | 18.2507 |
| 2000's | 28 (24.35) | 29.6817 |
| 2010's | 25 (21.74) | 24.3611 |
| 2020's | 1 (0.87) | 2.80 |
| Authors | Studies |
|---|---|
| Stollenwerk, TM | 1 |
| Hillard, CJ | 1 |
| Sherrill, LK | 2 |
| Gulley, JM | 3 |
| Kokhan, VS | 1 |
| Kokhan, TYG | 1 |
| Samsonova, AN | 1 |
| Fisenko, VP | 1 |
| Ustyugov, AA | 1 |
| Aliev, G | 1 |
| Yates, JR | 1 |
| Beckmann, JS | 1 |
| Meyer, AC | 1 |
| Bardo, MT | 2 |
| Hansen, C | 1 |
| Björklund, T | 1 |
| Petit, GH | 1 |
| Lundblad, M | 1 |
| Murmu, RP | 1 |
| Brundin, P | 1 |
| Li, JY | 1 |
| Hankosky, ER | 1 |
| Kofsky, NM | 1 |
| Duncan, JR | 1 |
| Gibbs, SJ | 1 |
| Lawrence, AJ | 1 |
| Hall, FS | 1 |
| Itokawa, K | 1 |
| Schmitt, A | 1 |
| Moessner, R | 1 |
| Sora, I | 1 |
| Lesch, KP | 1 |
| Uhl, GR | 1 |
| Smittkamp, S | 1 |
| Spalding, H | 1 |
| Zhang, H | 1 |
| Stanford, JA | 1 |
| Shanks, RA | 1 |
| Ross, JM | 1 |
| Doyle, HH | 1 |
| Helton, AK | 1 |
| Picou, BN | 1 |
| Schulz, J | 1 |
| Tavares, C | 1 |
| Bryant, S | 1 |
| Dawson, BL | 1 |
| Lloyd, SA | 1 |
| Collier, TJ | 2 |
| O'Malley, J | 1 |
| Rademacher, DJ | 1 |
| Stancati, JA | 1 |
| Sisson, KA | 1 |
| Sortwell, CE | 2 |
| Paumier, KL | 1 |
| Gebremedhin, KG | 1 |
| Steece-Collier, K | 1 |
| Jordan, CJ | 1 |
| Taylor, DM | 1 |
| Dwoskin, LP | 1 |
| Kantak, KM | 1 |
| Alajaji, M | 1 |
| Lazenka, MF | 1 |
| Kota, D | 1 |
| Wise, LE | 1 |
| Younis, RM | 1 |
| Carroll, FI | 1 |
| Levine, A | 1 |
| Selley, DE | 1 |
| Sim-Selley, LJ | 1 |
| Damaj, MI | 1 |
| Tendilla-Beltrán, H | 1 |
| Arroyo-García, LE | 1 |
| Diaz, A | 1 |
| Camacho-Abrego, I | 2 |
| de la Cruz, F | 2 |
| Rodríguez-Moreno, A | 1 |
| Flores, G | 2 |
| García-Cabrerizo, R | 1 |
| García-Fuster, MJ | 1 |
| Black, MD | 1 |
| Varty, GB | 1 |
| Arad, M | 2 |
| Barak, S | 1 |
| De Levie, A | 1 |
| Boulay, D | 1 |
| Pichat, P | 1 |
| Griebel, G | 1 |
| Weiner, I | 4 |
| Banerjee, PS | 1 |
| Aston, J | 1 |
| Khundakar, AA | 1 |
| Zetterström, TS | 1 |
| Bertrand, JB | 2 |
| Langlois, JB | 1 |
| Bégou, M | 2 |
| Volle, J | 1 |
| Brun, P | 2 |
| d'Amato, T | 2 |
| Saoud, M | 2 |
| Suaud-Chagny, MF | 2 |
| Solis, O | 1 |
| Vázquez-Roque, RA | 1 |
| Gamboa, C | 1 |
| Zamudio, S | 1 |
| Alexander, KS | 1 |
| Brooks, JM | 1 |
| Sarter, M | 2 |
| Bruno, JP | 1 |
| Grant, A | 1 |
| Speed, Z | 1 |
| Labelle-Dumais, C | 1 |
| Flores, C | 2 |
| McFadden, SL | 1 |
| Zulas, AL | 1 |
| Morgan, RE | 1 |
| Chen, YI | 1 |
| Choi, JK | 1 |
| Xu, H | 1 |
| Ren, J | 1 |
| Andersen, SL | 1 |
| Jenkins, BG | 1 |
| Burke, AR | 1 |
| Renner, KJ | 1 |
| Forster, GL | 1 |
| Watt, MJ | 1 |
| Pesic, V | 1 |
| Marinkovic, P | 1 |
| Janac, B | 2 |
| Ignjatovic, S | 1 |
| Popic, J | 1 |
| Kanazir, S | 1 |
| Ruzdijic, S | 1 |
| Yetnikoff, L | 1 |
| Almey, A | 1 |
| Arvanitogiannis, A | 1 |
| Brown, RW | 1 |
| Perna, MK | 1 |
| Noel, DM | 1 |
| Whittemore, JD | 1 |
| Lehmann, J | 1 |
| Smith, ML | 1 |
| Piontkewitz, Y | 1 |
| Burton, CL | 1 |
| Fletcher, PJ | 1 |
| Richetto, J | 1 |
| Feldon, J | 1 |
| Riva, MA | 1 |
| Meyer, U | 1 |
| Stanis, JJ | 1 |
| Kabbaj, M | 1 |
| Isgor, C | 1 |
| Watson, SJ | 1 |
| Akil, H | 1 |
| Ehrlich, ME | 2 |
| Sommer, J | 1 |
| Canas, E | 1 |
| Unterwald, EM | 2 |
| Bell, RL | 1 |
| Rodd, ZA | 1 |
| Hsu, CC | 1 |
| Lumeng, L | 1 |
| Murphy, JM | 1 |
| McBride, WJ | 1 |
| Le Pen, G | 1 |
| Grottick, AJ | 1 |
| Higgins, GA | 1 |
| Moreau, JL | 1 |
| Zuckerman, L | 2 |
| Rimmerman, N | 1 |
| Rehavi, M | 2 |
| Nachman, R | 1 |
| Vasilev, V | 1 |
| Veskov, R | 1 |
| Rakić, Lj | 1 |
| Stojiljković, M | 1 |
| FARNER, D | 1 |
| HEIMSTRA, NW | 1 |
| McDONALD, A | 1 |
| Yang, PB | 1 |
| Swann, AC | 1 |
| Dafny, N | 1 |
| McDonald, LM | 1 |
| Moran, PM | 1 |
| Vythelingum, GN | 1 |
| Joseph, MH | 1 |
| Stephenson, JD | 1 |
| Gray, JA | 1 |
| Yin, HS | 1 |
| Chen, CT | 1 |
| Lin, TY | 1 |
| Meissner, KK | 1 |
| Kirkham, DL | 1 |
| Doering, LC | 1 |
| Niculescu, M | 1 |
| Cassidy, CM | 1 |
| Quirion, R | 1 |
| Srivastava, LK | 1 |
| Elangbam, CS | 1 |
| Wehe, JG | 1 |
| Barton, JC | 1 |
| Krull, DL | 1 |
| Nyska, A | 1 |
| Crabbs, T | 1 |
| Kissling, GE | 1 |
| Job, D | 1 |
| Schweitzer, A | 1 |
| Andrieux, A | 1 |
| McDermott, JL | 4 |
| Dluzen, DE | 4 |
| Hershey, SC | 1 |
| Hales, RE | 1 |
| Knoll, J | 1 |
| Yen, TT | 1 |
| Dallo, J | 1 |
| Hyde, JF | 1 |
| Jerussi, TP | 1 |
| Fisher, RS | 1 |
| Levine, MS | 1 |
| Hull, CD | 1 |
| Buchwald, NA | 1 |
| Concannon, JT | 1 |
| Schechter, MD | 1 |
| Hicks, P | 1 |
| Strong, R | 1 |
| Schoolar, JC | 1 |
| Samorajski, T | 1 |
| Truex, LL | 1 |
| Schmidt, MJ | 1 |
| Thompson, JM | 1 |
| Whitaker, JR | 1 |
| Joseph, JA | 2 |
| Lewis, MJ | 1 |
| Leshem, M | 1 |
| Bauer, RH | 1 |
| Marwaha, J | 1 |
| Hoffer, B | 1 |
| Pittman, R | 1 |
| Freedman, R | 1 |
| Diaz, R | 1 |
| Ogren, SO | 1 |
| Blum, M | 1 |
| Fuxe, K | 1 |
| Bowyer, JF | 2 |
| Gordon, I | 1 |
| Weizman, R | 1 |
| Rosenne, E | 1 |
| McDougall, SA | 2 |
| Duke, MA | 1 |
| Bolanos, CA | 2 |
| Crawford, CA | 2 |
| McGaughy, J | 1 |
| Date, I | 1 |
| Furukawa, S | 1 |
| Ohmoto, T | 1 |
| Draski, LJ | 1 |
| Nash, DJ | 1 |
| Gerhardt, GA | 1 |
| Cerrito, F | 1 |
| Aloisi, G | 1 |
| Arminio, P | 1 |
| Abrous, DN | 3 |
| Torres, EM | 2 |
| Dunnett, SB | 3 |
| Exposito, I | 1 |
| Mora, F | 1 |
| Zisapel, N | 1 |
| Oaknin, S | 1 |
| Wood, GK | 1 |
| Lipska, BK | 3 |
| Weinberger, DR | 3 |
| Snyder-Keller, A | 1 |
| Keller, RW | 1 |
| Frame, LT | 1 |
| Clausing, P | 1 |
| Nagamoto-Combs, K | 1 |
| Osterhout, CA | 1 |
| Sterling, CR | 1 |
| Tank, AW | 1 |
| Glatt, SJ | 1 |
| Jackson, D | 1 |
| Daley, BF | 1 |
| Busidan, Y | 1 |
| Dow-Edwards, DL | 1 |
| Rehders, JH | 1 |
| Löscher, W | 1 |
| Richter, A | 1 |
| Sohn, EH | 1 |
| Wolden-Hanson, T | 1 |
| Matsumoto, AM | 1 |
| Laviola, G | 2 |
| Adriani, W | 2 |
| Morley-Fletcher, S | 1 |
| Terranova, ML | 1 |
| Halim, ND | 1 |
| Segal, PN | 1 |
| Richfield, EK | 1 |
| Thiruchelvam, MJ | 1 |
| Cory-Slechta, DA | 1 |
| Wuertzer, C | 1 |
| Gainetdinov, RR | 1 |
| Caron, MG | 1 |
| Di Monte, DA | 1 |
| Federoff, HJ | 1 |
| Bortolozzi, A | 1 |
| Duffard, R | 1 |
| Antonelli, M | 1 |
| Evangelista de Duffard, AM | 1 |
| Berger, RE | 1 |
| Engel, BT | 1 |
| Roth, GS | 1 |
| Infurna, RN | 1 |
| Spear, LP | 1 |
| Alpern, HP | 1 |
| Greer, CA | 1 |
| James, RC | 1 |
| Franklin, MR | 1 |
| Alhava, E | 1 |
| Rutanen, S | 1 |
| Attila, M | 1 |
| Oliverio, A | 1 |
| Castellano, C | 1 |
| Renzi, P | 1 |
| Wareham, AT | 1 |
| Buwalda, B | 1 |
| Strubbe, JH | 1 |
| Hoes, MW | 1 |
| Bohus, B | 1 |
| Reading, PJ | 1 |
| Rivet, JM | 1 |
| Le Moal, M | 1 |
| Herman, JP | 1 |
| Ramirez, VD | 2 |
| Kolta, MG | 1 |
| Scalzo, FM | 1 |
| Ali, SF | 1 |
| Holson, RR | 1 |
| Laping, NJ | 1 |
| Lun, A | 1 |
| Gross, J | 1 |
| Beyer, M | 1 |
| Fischer, HD | 1 |
| Wustmann, C | 1 |
| Schmidt, J | 1 |
| Hecht, K | 1 |
| de Wit, H | 1 |
| Uhlenhuth, EH | 1 |
| Johanson, CE | 1 |
| Barr, GA | 1 |
| Lithgow, T | 1 |
| Stevenson, IH | 1 |
| Turnbull, MJ | 1 |
| Mabry, PD | 1 |
| Campbell, BA | 2 |
| Jarvik, ME | 1 |
| Gritz, ER | 1 |
| Schneider, NG | 1 |
| Holzman, PS | 1 |
| Fineberg, SK | 1 |
| Doberauer, W | 1 |
| Gordon, P | 1 |
| Galatulas, I | 1 |
| Martini, M | 1 |
| Pomarelli, P | 1 |
| Piccinini, F | 1 |
| Vaccari, A | 1 |
| Lytle, LD | 1 |
| Fibiger, HC | 1 |
| Doty, BA | 1 |
| Doty, LA | 1 |
6 reviews available for amphetamine and Aging
| Article | Year |
|---|---|
Pharmacologic neuroimaging of the ontogeny of dopamine receptor function.
Topics: Adolescent; Adult; Aging; Amphetamine; Animals; Brain; Cerebrovascular Circulation; Cocaine; Dopamin | 2010 |
Psychopharmacologic approach to the medically ill patient.
Topics: Aged; Aging; Amphetamine; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Antipsychotic Agent | 1984 |
Peculiar response of adolescent mice to acute and chronic stress and to amphetamine: evidence of sex differences.
Topics: Acute Disease; Aging; Amphetamine; Animals; Central Nervous System Stimulants; Chronic Disease; Cort | 2002 |
Drugs and memory disorders in human aging.
Topics: Adolescent; Adult; Aged; Aging; Amphetamine; Anticonvulsants; Antidepressive Agents; Arousal; Caffei | 1972 |
Personality.
Topics: Adolescent; Adult; Aging; Alcoholism; Amphetamine; Cannabis; Child; Child Development; Child, Presch | 1974 |
Molecular approaches to the drug enhancement of deteriorated functioning in the aged.
Topics: 1-Propanol; Aging; Amino Alcohols; Amphetamine; Animals; Brain; Cognition; Deoxyribonucleases; DNA; | 1971 |
1 trial available for amphetamine and Aging
| Article | Year |
|---|---|
Drug preference in normal volunteers: effects of age and time of day.
Topics: Adult; Aging; Amphetamine; Diazepam; Drug Interactions; Emotions; Humans; Middle Aged; Reinforcement | 1985 |
108 other studies available for amphetamine and Aging
| Article | Year |
|---|---|
Adolescent THC Treatment Does Not Potentiate the Behavioral Effects in Adulthood of Maternal Immune Activation.
Topics: Aging; Amphetamine; Animals; Behavior, Animal; Conditioning, Classical; Dronabinol; Extinction, Psyc | 2021 |
Effects of amphetamine exposure during adolescence on behavior and prelimbic cortex neuron activity in adulthood.
Topics: Aging; Amphetamine; Animals; Behavior, Animal; Central Nervous System Stimulants; Dopamine Agonists; | 2018 |
The Dopaminergic Dysfunction and Altered Working Memory Performance of Aging Mice Lacking Gamma-synuclein Gene.
Topics: Aging; Amphetamine; Animals; Avoidance Learning; Disease Models, Animal; Dopamine; Dopamine Agents; | 2018 |
Concurrent choice for social interaction and amphetamine using conditioned place preference in rats: effects of age and housing condition.
Topics: Aging; Amphetamine; Animals; Choice Behavior; Conditioning, Psychological; Housing, Animal; Interper | 2013 |
A novel α-synuclein-GFP mouse model displays progressive motor impairment, olfactory dysfunction and accumulation of α-synuclein-GFP.
Topics: Aging; alpha-Synuclein; Amphetamine; Animals; Discrimination, Psychological; Dopamine; Dopamine Agen | 2013 |
Age of exposure-dependent effects of amphetamine on behavioral flexibility.
Topics: Adaptation, Physiological; Aging; Amphetamine; Analysis of Variance; Animals; Animals, Newborn; Atte | 2013 |
Chronic intermittent toluene inhalation in adolescent rats alters behavioural responses to amphetamine and MK801.
Topics: Aging; Amphetamine; Animals; Central Nervous System Stimulants; Dizocilpine Maleate; Excitatory Amin | 2014 |
Decreased vesicular monoamine transporter 2 (VMAT2) and dopamine transporter (DAT) function in knockout mice affects aging of dopaminergic systems.
Topics: Aging; Amphetamine; Animals; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; | 2014 |
Differential effects of amphetamine and GBR-12909 on orolingual motor function in young vs aged F344/BN rats.
Topics: Age Factors; Aging; Amphetamine; Animals; Behavior, Animal; Male; Motor Activity; Piperazines; Rats; | 2014 |
Adolescent exposure to cocaine, amphetamine, and methylphenidate cross-sensitizes adults to methamphetamine with drug- and sex-specific effects.
Topics: Aging; Amphetamine; Animals; Central Nervous System Stimulants; Cocaine; Dose-Response Relationship, | 2015 |
Interrogating the aged striatum: robust survival of grafted dopamine neurons in aging rats produces inferior behavioral recovery and evidence of impaired integration.
Topics: Aging; Amphetamine; Animals; Corpus Striatum; Disease Models, Animal; Dopamine and cAMP-Regulated Ph | 2015 |
Adolescent D-amphetamine treatment in a rodent model of ADHD: Pro-cognitive effects in adolescence without an impact on cocaine cue reactivity in adulthood.
Topics: Aging; Amphetamine; Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System S | 2016 |
Early adolescent nicotine exposure affects later-life cocaine reward in mice.
Topics: Aging; Amphetamine; Animals; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; | 2016 |
The effects of amphetamine exposure on juvenile rats on the neuronal morphology of the limbic system at prepubertal, pubertal and postpubertal ages.
Topics: Aging; Amphetamine; Animals; Central Nervous System Stimulants; Dendritic Spines; Female; Limbic Sys | 2016 |
Comparative effects of amphetamine-like psychostimulants on rat hippocampal cell genesis at different developmental ages.
Topics: Age Factors; Aging; Amphetamine; Animals; Brain-Derived Neurotrophic Factor; Bromodeoxyuridine; Cent | 2016 |
Procognitive and antipsychotic efficacy of glycine transport 1 inhibitors (GlyT1) in acute and neurodevelopmental models of schizophrenia: latent inhibition studies in the rat.
Topics: Aging; Amphetamine; Animals; Animals, Newborn; Antipsychotic Agents; Benzamides; Central Nervous Sys | 2009 |
Differential regulation of psychostimulant-induced gene expression of brain derived neurotrophic factor and the immediate-early gene Arc in the juvenile and adult brain.
Topics: Aging; Amphetamine; Animals; Brain; Brain-Derived Neurotrophic Factor; Central Nervous System Stimul | 2009 |
Longitudinal MRI monitoring of brain damage in the neonatal ventral hippocampal lesion rat model of schizophrenia.
Topics: Aging; Amphetamine; Animals; Animals, Newborn; Brain; Central Nervous System Stimulants; Disease Mod | 2010 |
Decreased dendritic spine density of neurons of the prefrontal cortex and nucleus accumbens and enhanced amphetamine sensitivity in postpubertal rats after a neonatal amygdala lesion.
Topics: Aging; Amphetamine; Amygdala; Animals; Animals, Newborn; Apomorphine; Central Nervous System Stimula | 2009 |
Disruption of mesolimbic regulation of prefrontal cholinergic transmission in an animal model of schizophrenia and normalization by chronic clozapine treatment.
Topics: Acetylcholine; Aging; Amphetamine; Animals; Animals, Newborn; Clozapine; Disease Models, Animal; Hip | 2009 |
Post-pubertal emergence of a dopamine phenotype in netrin-1 receptor-deficient mice.
Topics: Aging; Amphetamine; Animals; Behavior, Animal; Brain; Central Nervous System Stimulants; DCC Recepto | 2009 |
Age-dependent effects of modafinil on acoustic startle and prepulse inhibition in rats.
Topics: Acoustic Stimulation; Aging; Amphetamine; Analysis of Variance; Animals; Behavior, Animal; Benzhydry | 2010 |
Adolescent social defeat alters neural, endocrine and behavioral responses to amphetamine in adult male rats.
Topics: Adolescent; Aging; Amphetamine; Animals; Behavior, Animal; Biogenic Monoamines; Corticosterone; Dopa | 2010 |
Changes of behavioral parameters during long-term food restriction in middle-aged Wistar rats.
Topics: Aging; Amphetamine; Analysis of Variance; Animals; Behavior, Animal; Blood Glucose; Central Nervous | 2010 |
Abolition of the behavioral phenotype of adult netrin-1 receptor deficient mice by exposure to amphetamine during the juvenile period.
Topics: Aging; Amphetamine; Amphetamine-Related Disorders; Animals; Behavior, Animal; Blotting, Western; DCC | 2011 |
Amphetamine locomotor sensitization and conditioned place preference in adolescent male and female rats neonatally treated with quinpirole.
Topics: Aging; Amphetamine; Animals; Animals, Newborn; Central Nervous System Stimulants; Conditioning, Oper | 2011 |
Abnormal trajectories of neurodevelopment and behavior following in utero insult in the rat.
Topics: Aging; Amphetamine; Animals; Behavior, Animal; Central Nervous System; Corpus Striatum; Data Interpr | 2011 |
Age and sex differences in impulsive action in rats: the role of dopamine and glutamate.
Topics: Aging; Amphetamine; Analysis of Variance; Animals; Animals, Newborn; Choice Behavior; Conditioning, | 2012 |
Comparison of the long-term consequences of withdrawal from repeated amphetamine exposure in adolescence and adulthood on information processing and locomotor sensitization in mice.
Topics: Age Factors; Aging; Amphetamine; Animals; Association Learning; Central Nervous System Sensitization | 2013 |
Age-dependent effects of repeated amphetamine exposure on working memory in rats.
Topics: Aging; Amphetamine; Analysis of Variance; Animals; Central Nervous System Stimulants; Conditioning, | 2013 |
Stress during adolescence alters behavioral sensitization to amphetamine.
Topics: Aging; Amphetamine; Animals; Animals, Newborn; Behavior, Animal; Central Nervous System Stimulants; | 2002 |
Periadolescent mice show enhanced DeltaFosB upregulation in response to cocaine and amphetamine.
Topics: Age Factors; Aging; Amphetamine; Amphetamine-Related Disorders; Animals; Caudate Nucleus; Cocaine; C | 2002 |
Amphetamine-modified acoustic startle responding and prepulse inhibition in adult and adolescent alcohol-preferring and -nonpreferring rats.
Topics: Acoustic Stimulation; Aging; Alcohol Drinking; Amphetamine; Animals; Central Nervous System Stimulan | 2003 |
Phencyclidine exacerbates attentional deficits in a neurodevelopmental rat model of schizophrenia.
Topics: Aging; Amphetamine; Animals; Animals, Newborn; Attention; Attention Deficit Disorder with Hyperactiv | 2003 |
Latent inhibition in 35-day-old rats is not an "adult" latent inhibition: implications for neurodevelopmental models of schizophrenia.
Topics: Aging; Amphetamine; Animals; Antipsychotic Agents; Behavior, Animal; Central Nervous System Stimulan | 2003 |
Immune activation during pregnancy in rats leads to a postpubertal emergence of disrupted latent inhibition, dopaminergic hyperfunction, and altered limbic morphology in the offspring: a novel neurodevelopmental model of schizophrenia.
Topics: Aging; Amphetamine; Animals; Central Nervous System Stimulants; Clozapine; Corpus Striatum; Disease | 2003 |
Age-related differences in MK-801- and amphetamine-induced locomotor and stereotypic activities of rats.
Topics: Aging; Amphetamine; Animals; Animals, Newborn; Central Nervous System Stimulants; Dizocilpine Maleat | 2003 |
[Studies on the effect of pharmacological agents on animals of different age. III. Modification of appetite by amphetamine (Benzedrine) and Preludin in rats of different age].
Topics: Aging; Amphetamine; Amphetamines; Animals; Appetite; Phenmetrazine; Rats | 1961 |
Social influence on the response to drugs. III. Response to amphetamine sulfate as a function of age.
Topics: Aging; Amphetamine; Amphetamines; Behavior; Humans | 1962 |
Chronic pretreatment with methylphenidate induces cross-sensitization with amphetamine.
Topics: Aging; Amphetamine; Animals; Central Nervous System Stimulants; Dose-Response Relationship, Drug; In | 2003 |
Enhancement of latent inhibition by two 5-HT2A receptor antagonists only when given at both pre-exposure and conditioning.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Amphetamine; Analysis of Varianc | 2003 |
Age- and region-dependent alterations in the GABAergic innervation in the brain of rats treated with amphetamine.
Topics: Aging; Amphetamine; Animals; Behavior, Animal; Brain; Central Nervous System Stimulants; gamma-Amino | 2004 |
Transplants of neurosphere cell suspensions from aged mice are functional in the mouse model of Parkinson's.
Topics: Aging; Amphetamine; Animals; Apomorphine; Astrocytes; Behavior, Animal; Behavioral Symptoms; Corpus | 2005 |
Age-specific behavioral responses to psychostimulants in mice.
Topics: Aging; Amphetamine; Animals; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Male; Met | 2005 |
Blockade of presynaptic voltage-gated calcium channels in the medial prefrontal cortex of neonatal rats leads to post-pubertal alterations in locomotor behavior.
Topics: Aging; Amphetamine; Animals; Animals, Newborn; Anxiety; Behavior, Animal; Calcium Channel Blockers; | 2006 |
Evaluation of glycosaminoglycans content and 5-hydroxytryptamine 2B receptor in the heart valves of Sprague-Dawley rats with spontaneous mitral valvulopathy--a possible exacerbation by dl-amphetamine sulfate in Fischer 344 rats?
Topics: Aging; Amphetamine; Animals; Female; Glycosaminoglycans; Male; Mitral Valve; Rats; Rats, Inbred F344 | 2006 |
Post-pubertal emergence of alterations in locomotor activity in stop null mice.
Topics: Aging; Amphetamine; Analysis of Variance; Animals; Behavior, Animal; Central Nervous System Stimulan | 2007 |
Aging and sex differences in striatal dopaminergic function.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Amphetamine; Animals; Dopamine; Dopamine Uptake Inhibitors; F | 2007 |
Long-lasting, true aphrodisiac effect of (-)-deprenyl in sexually sluggish old male rats.
Topics: Aging; Amphetamine; Animals; Aphrodisiacs; Castration; Clorgyline; Copulation; Male; Phenethylamines | 1983 |
Intersex difference in striatal amphetamine concentration is independent of age.
Topics: Aging; Amphetamine; Animals; Corpus Striatum; Female; Male; Rats; Rats, Inbred Strains; Sex Factors | 1983 |
Amphetamine alters evoked responses of nigral neurons in kittens and adult cats.
Topics: Afferent Pathways; Aging; Amphetamine; Animals; Cats; Evoked Potentials; Neurons; Substantia Nigra | 1982 |
Failure of amphetamine isomers to decrease hyperactivity in developing rats.
Topics: Aging; Amphetamine; Animals; Brain Chemistry; Dextroamphetamine; Dopamine; Dose-Response Relationshi | 1982 |
Aging alters amphetamine-induced stereotyped gnawing and neostriatal elimination of amphetamine in mice.
Topics: Aging; Amphetamine; Animals; Brain Chemistry; Corpus Striatum; Dopamine; Humans; Male; Metabolic Cle | 1980 |
3H-amphetamine concentrations in the brains of young and aged rats: implications for assessment of drug effects in aged animals.
Topics: Adipose Tissue; Aging; Amphetamine; Animals; Brain; Dextroamphetamine; Humans; Liver; Male; Motor Ac | 1980 |
[3H]Dopamine accumulation and release from striatal slices in young, mature and senescent rats.
Topics: Aging; Amphetamine; Animals; Corpus Striatum; Dopamine; In Vitro Techniques; Kinetics; Male; Potassi | 1981 |
Age-related decline in brain stimulation reward: rejuvenation by amphetamine.
Topics: Aging; Amphetamine; Animals; Behavior, Animal; Brain; Electric Stimulation; Male; Motivation; Rats; | 1981 |
Ontogeny of fenfluramine and amphetamine anorexia compared in rat pups.
Topics: Aging; Amphetamine; Animals; Body Weight; Dose-Response Relationship, Drug; Eating; Fenfluramine; Mu | 1981 |
The effects of l-, d-, and parahydroxy-amphetamine on locomotor activity and wall climbing in rats of different ages.
Topics: Aging; Amphetamine; Amphetamines; Animals; Catecholamines; Dextroamphetamine; Dose-Response Relation | 1980 |
Age-related electrophysiological changes in rat cerebellum.
Topics: Aging; Amphetamine; Animals; Cerebellum; Fluphenazine; gamma-Aminobutyric Acid; Haloperidol; Locus C | 1980 |
Prenatal corticosterone increases spontaneous and d-amphetamine induced locomotor activity and brain dopamine metabolism in prepubertal male and female rats.
Topics: Aging; Amphetamine; Animals; Behavior, Animal; Corticosterone; Dopamine; Female; Fetus; Locomotion; | 1995 |
The role of hyperthermia in amphetamine's interactions with NMDA receptors, nitric oxide, and age to produce neurotoxicity.
Topics: Aging; Amphetamine; Animals; Arginine; Brain; Dizocilpine Maleate; Fever; Glutamic Acid; Haloperidol | 1995 |
Developmental and age-related alterations in rat brain presynaptic dopaminergic mechanisms.
Topics: Age Factors; Aging; Amphetamine; Animals; Binding, Competitive; Brain; Carrier Proteins; Corpus Stri | 1995 |
Ontogeny of behavioral sensitization in the rat: effects of direct and indirect dopamine agonists.
Topics: Aging; Amphetamine; Animals; Apomorphine; Behavior, Animal; Dopamine Agonists; Female; Male; Motor A | 1994 |
Behavioral vigilance in rats: task validation and effects of age, amphetamine, and benzodiazepine receptor ligands.
Topics: Aging; Amphetamine; Animals; Arousal; Attention; Behavior, Animal; Carbolines; Chlordiazepoxide; Con | 1995 |
Increased nerve growth factor level in the distal stump of transected sciatic nerve in relation to aging and its application for neural grafting.
Topics: Adrenal Medulla; Aging; Amphetamine; Animals; Denervation; Disease Models, Animal; Male; Mice; Mice, | 1994 |
Ontogenetic effects of EEDQ on amphetamine-induced behaviors of rats: role of presynaptic processes.
Topics: Aging; Amphetamine; Animals; Behavior, Animal; Conditioning, Operant; Dopamine Antagonists; Dopamine | 1994 |
CNS monoamine levels and motoric behaviors in the hotfoot ataxic mutant.
Topics: Aging; Amphetamine; Animals; Ataxia; Biogenic Monoamines; Body Temperature; Body Weight; Central Ner | 1994 |
Age-related changes in rat brain monoamines release: peculiarity of dopamine release.
Topics: Aging; Amphetamine; Animals; Biogenic Monoamines; Brain Chemistry; Calcimycin; Caudate Nucleus; Cere | 1993 |
Dopaminergic grafts implanted into the neonatal or adult striatum: comparative effects on rotation and paw reaching deficits induced by subsequent unilateral nigrostriatal lesions in adulthood.
Topics: Aging; Amphetamine; Animals; Animals, Newborn; Apomorphine; Behavior, Animal; Brain Tissue Transplan | 1993 |
Effects of estrogen upon dopamine release from the corpus striatum of young and aged female rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Amphetamine; Animals; Corpus Striatum; Dopamine; Estrogens; F | 1993 |
The modulatory effect of melatonin on the dopamine-glutamate interaction in the anterior hypothalamus during ageing.
Topics: Aging; Amphetamine; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Dopamine; Dopamine | 1995 |
Behavioral changes in rats with early ventral hippocampal damage vary with age at damage.
Topics: Aging; Amphetamine; Animals; Apomorphine; Behavior, Animal; Dopamine Agonists; Dopamine Uptake Inhib | 1997 |
Prefrontal cortical and hippocampal modulation of dopamine-mediated effects.
Topics: Aging; Amphetamine; Animals; Animals, Newborn; Apomorphine; Disease Models, Animal; Dopamine; Halope | 1998 |
Stimulant-mediated c-fos induction in striatum as a function of age, sex, and prenatal cocaine exposure.
Topics: Aging; Amphetamine; Animals; Benzazepines; Cocaine; Corpus Striatum; Dopamine Antagonists; Dopamine | 1998 |
Long-term effects of amphetamine neurotoxicity on tyrosine hydroxylase mRNA and protein in aged rats.
Topics: Aging; Amphetamine; Animals; Blotting, Western; Dopamine; Dopamine Uptake Inhibitors; Glyceraldehyde | 1998 |
Subsensitivity to dopaminergic drugs in periadolescent rats: a behavioral and neurochemical analysis.
Topics: Acetylcholine; Aging; Amphetamine; Animals; Apomorphine; Behavior, Animal; Cocaine; Corpus Striatum; | 1998 |
Diminished viability, growth, and behavioral efficacy of fetal dopamine neuron grafts in aging rats with long-term dopamine depletion: an argument for neurotrophic supplementation.
Topics: Aging; Amphetamine; Animals; Behavior, Animal; Cell Division; Cell Size; Cell Survival; Dopamine; Ma | 1999 |
Neurobehavioral effects of perinatal AZT exposure in Sprague-Dawley weaning rats.
Topics: Aging; Amphetamine; Animals; Animals, Newborn; Animals, Suckling; Anti-HIV Agents; Behavior, Animal; | 1999 |
Evidence for striatal dopaminergic overactivity in paroxysmal dystonia indicated by microinjections in a genetic rodent model.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Amphetamine; Animals; Benzazepine | 2000 |
Testosterone (T)-induced changes in arcuate nucleus cocaine-amphetamine-regulated transcript and NPY mRNA are attenuated in old compared to young male brown Norway rats: contribution of T to age-related changes in cocaine-amphetamine-regulated transcript
Topics: Aging; Amphetamine; Animals; Arcuate Nucleus of Hypothalamus; Body Composition; Body Weight; Cocaine | 2002 |
Effects of reversible inactivation of the neonatal ventral hippocampus on behavior in the adult rat.
Topics: Age Factors; Aging; Amphetamine; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; | 2002 |
Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aging; alpha-Synuclein; Amphetamine; Animals; Behavior | 2002 |
Spontaneous novelty seeking and amphetamine-induced conditioning and sensitization in adult mice: evidence of dissociation as a function of age at weaning.
Topics: Aging; Amphetamine; Amphetamine-Related Disorders; Animals; Animals, Newborn; Behavior, Animal; Cond | 2002 |
Increased sensitivity in dopamine D(2)-like brain receptors from 2,4-dichlorophenoxyacetic acid (2,4-D)-exposed and amphetamine-challenged rats.
Topics: 2,4-Dichlorophenoxyacetic Acid; Aging; Amphetamine; Animals; Benzamides; Brain; Dopamine Antagonists | 2002 |
Age-related changes in the nigrostriatum: a behavioral and biochemical analysis.
Topics: Aging; Amphetamine; Animals; Apomorphine; Female; Haloperidol; Male; Rats; Rats, Inbred Strains; Rec | 1978 |
Developmental changes in amphetamine-induced taste aversions.
Topics: Aging; Amphetamine; Animals; Avoidance Learning; Conditioning, Operant; Dose-Response Relationship, | 1979 |
A dopaminergic basis for the effects of amphetamine on a mouse "preadolescent hyperkinetic" model.
Topics: Adolescent; Aging; Amphetamine; Animals; Apomorphine; Clonidine; Disease Models, Animal; Humans; Hyp | 1977 |
The triphasic amphetamine lethal dose curve in mice and its possible relationship to drug metabolism.
Topics: Aging; Amphetamine; Animals; Anticonvulsants; Dextroamphetamine; Hexobarbital; In Vitro Techniques; | 1978 |
Toxicity and temperature responses induced by d-amphetamine and cocaine in developing mice.
Topics: Aging; Amphetamine; Animals; Body Temperature; Cocaine; Drug Interactions; Mice | 1976 |
Genotype or prenatal drug experience affect brain maturation in the mouse.
Topics: Abnormalities, Drug-Induced; Aging; Amphetamine; Animals; Brain; Cerebral Cortex; Electroencephalogr | 1975 |
Unilateral dopamine lesions in neonatal, weanling and adult rats: comparison of rotation and reaching deficits.
Topics: Aging; Amphetamine; Animals; Animals, Newborn; Apomorphine; Behavior, Animal; Dopamine; Feeding Beha | 1992 |
Reduced preabsorptive insulin response in aged rats: differential effects of amphetamine and arginine-vasopressin.
Topics: Aging; Amphetamine; Analysis of Variance; Animals; Arginine Vasopressin; Blood Glucose; Eating; Insu | 1991 |
Response disinhibition on a delayed matching to position task induced by amphetamine, nicotine and age.
Topics: Aging; Amphetamine; Animals; Nicotine; Psychomotor Performance; Rats | 1991 |
The effect of long-term treatment with deprenyl on basal and L-dopa evoked dopamine release in vitro from the corpus striatum of aged rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Amphetamine; Animals; Corpus Striatum; Dopamine; In Vitro Tec | 1991 |
Similar post-lesion receptor readjustments following the unilateral 6-hydroxydopamine lesion of the dopaminergic mesotelencephalic system in neonatal and adult rats.
Topics: Aging; Amphetamine; Animals; Animals, Newborn; Behavior, Animal; Dopamine Agents; Hydroxydopamines; | 1990 |
Changes in dopamine release in vitro from the corpus striatum of young versus aged rats as a function of infusion modes of L-dopa, potassium, and amphetamine.
Topics: Aging; Amphetamine; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Infusi | 1991 |
Ontogeny of the enhanced behavioral response to amphetamine in amphetamine-pretreated rats.
Topics: Aging; Amphetamine; Animals; Behavior, Animal; Female; Male; Motor Activity; Rats; Rats, Inbred Stra | 1990 |
The importance of striatal interneurons in age-related effects upon potassium- and amphetamine-stimulated dopamine release.
Topics: Aging; Amphetamine; Animals; Corpus Striatum; Dopamine; Interneurons; Kinetics; Male; Potassium; Rat | 1988 |
The vulnerable period of perinatal hypoxia with regard to dopamine release and behaviour in adult rats.
Topics: Aging; Amphetamine; Animals; Animals, Newborn; Avoidance Learning; Circadian Rhythm; Conditioning, P | 1986 |
Pharmaco-ontogeny of reward: enhancement of self-stimulation by D-amphetamine and cocaine in 3- and 10-day-old rats.
Topics: Aging; Amphetamine; Animals; Animals, Newborn; Brain; Cocaine; Electric Stimulation; Female; Male; R | 1986 |
A study of the factors affecting the sleeping time following intracerebroventricular administration of pentobarbitone sodium: effect of prior administration of centrally active drugs.
Topics: Aging; Amphetamine; Animals; Anti-Anxiety Agents; Barbiturates; Body Weight; Carbon Radioisotopes; C | 1974 |
Ontogeny of serotonergic inhibition of behavioral arousal in the rat.
Topics: Aging; Amphetamine; Animals; Animals, Newborn; Arousal; Behavior, Animal; Brain; Brain Chemistry; Do | 1974 |
An appraisal of anorexiants in the treatment of obesity.
Topics: Adult; Aging; Amphetamine; Appetite Depressants; Evaluation Studies as Topic; Female; Humans; Middle | 1972 |
Age, ether narcosis and 'Weck'-amines.
Topics: Aging; Amphetamine; Anesthesia; Animals; Ethyl Ethers; Male; Rats; Time Factors | 1974 |
Effect of drugs on the calcium exchangeability in the pineal gland.
Topics: Aging; Amphetamine; Animals; Biological Clocks; Calcium; Calcium Isotopes; Male; Pentobarbital; Pine | 1972 |
Hyposensitivity ot 5-hydroxytryptamine in the isolated stomach fundus of the newborn rat. II. Amphetamine and receptor deficit.
Topics: Aging; Amphetamine; Animals; Animals, Newborn; Dextroamphetamine; Female; Male; Muscle, Smooth; Rats | 1968 |
Ontogeny of adrenergic arousal and cholinergic inhibitory mechanisms in the rat.
Topics: Aging; Amphetamine; Animals; Animals, Newborn; Motor Activity; Rats; Scopolamine; Stimulation, Chemi | 1969 |
Facilitative effects of amphetamine on avoidance conditioning in relation to age and problem difficulty.
Topics: Aging; Amphetamine; Animals; Avoidance Learning; Female; Rats | 1966 |