amphetamine has been researched along with Ache in 56 studies
Amphetamine: A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.
1-phenylpropan-2-amine : A primary amine that is isopropylamine in which a hydrogen attached to one of the methyl groups has been replaced by a phenyl group.
amphetamine : A racemate comprising equimolar amounts of (R)-amphetamine (also known as levamphetamine or levoamphetamine) and (S)-amphetamine (also known as dexamfetamine or dextroamphetamine.
Excerpt | Relevance | Reference |
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" In the current mouse model, following the repeated amphetamine (Amph) treatment, a reduction of reactivity to thermal pain stimulus was noticed." | 7.80 | Repeated amphetamine treatment alters spinal magnetic resonance signals and pain sensitivity in mice. ( Chen, JH; Lei, BH; Yin, HS, 2014) |
"Pain is a complex and subjective experience that involves not only the transduction of noxious stimuli by nociceptive fibers, but also the cognitive and emotional processing by the brain." | 5.36 | Dopamine D3 receptor regulates basal but not amphetamine-induced changes in pain sensitivity in mice. ( Chen, T; Chen, Y; Dang, Y; Lai, J; Xu, M; Yan, C; Zhu, J, 2010) |
" In the current mouse model, following the repeated amphetamine (Amph) treatment, a reduction of reactivity to thermal pain stimulus was noticed." | 3.80 | Repeated amphetamine treatment alters spinal magnetic resonance signals and pain sensitivity in mice. ( Chen, JH; Lei, BH; Yin, HS, 2014) |
" These diabetic animals had a higher level of the spontaneous pain threshold, but displayed a reduced sensitivity of analgesic responses to morphine injection." | 3.67 | Alterations in physiologic functions and in brain monoamine content in streptozocin-diabetic rats. ( Chu, PC; Leu, SY; Lin, MT; Shian, LR, 1986) |
"Infective endocarditis is associated with significant morbidity and mortality, despite advances in diagnosis and treatment strategies." | 1.51 | No Fever, No Murmur, No Problem? A Concealed Case of Infective Endocarditis. ( Gorman, M; McCann, M; McKeown, B, 2019) |
"Pain is a complex and subjective experience that involves not only the transduction of noxious stimuli by nociceptive fibers, but also the cognitive and emotional processing by the brain." | 1.36 | Dopamine D3 receptor regulates basal but not amphetamine-induced changes in pain sensitivity in mice. ( Chen, T; Chen, Y; Dang, Y; Lai, J; Xu, M; Yan, C; Zhu, J, 2010) |
"Decreased pain was correlated with increased motor activity for morphine and amphetamine, and with decreased activity for xylazine and acepromazine; dipyrone and indomethacin did not alter activity levels." | 1.31 | The formalin test in the mouse: a parametric analysis of scoring properties. ( Abbott, FV; Saddi, GM, 2000) |
" To examine the properties of various pain rating methods we established dose-response relations for formalin injected in the plantar surface of one hind paw, and the analgesic effects of morphine and amphetamine using the most frequently reported behavioural measures of pain (favouring, lifting, licking and flinching/shaking of the injured paw) and combinations of these." | 1.29 | The formalin test: scoring properties of the first and second phases of the pain response in rats. ( Abbott, FV; Franklin, KBJ; Westbrook, FR, 1995) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 35 (62.50) | 18.7374 |
1990's | 8 (14.29) | 18.2507 |
2000's | 4 (7.14) | 29.6817 |
2010's | 8 (14.29) | 24.3611 |
2020's | 1 (1.79) | 2.80 |
Authors | Studies |
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Diester, CM | 1 |
Santos, EJ | 1 |
Moerke, MJ | 1 |
Negus, SS | 1 |
Wood, MW | 1 |
Martino, G | 1 |
Coupal, M | 1 |
Lindberg, M | 1 |
Schroeder, P | 1 |
Santhakumar, V | 1 |
Valiquette, M | 1 |
Sandin, J | 1 |
Widzowski, D | 1 |
Laird, J | 1 |
McCann, M | 1 |
Gorman, M | 1 |
McKeown, B | 1 |
Lei, BH | 1 |
Chen, JH | 1 |
Yin, HS | 1 |
Matson, DJ | 1 |
Broom, DC | 1 |
Cortright, DN | 1 |
NICKERSON, M | 1 |
GOODMAN, LS | 1 |
Zhu, J | 1 |
Chen, Y | 1 |
Lai, J | 1 |
Dang, Y | 1 |
Yan, C | 1 |
Xu, M | 1 |
Chen, T | 1 |
Okokon, JE | 1 |
Nwafor, PA | 1 |
Aladeokin, AC | 1 |
Umukoro, S | 1 |
Gonzales, E | 1 |
Ng, G | 1 |
Pesce, A | 1 |
West, C | 1 |
West, R | 1 |
Mikel, C | 1 |
Latyshev, S | 1 |
Almazan, P | 1 |
Jain, S | 1 |
Sharma, R | 2 |
TAYLOR, RG | 1 |
DOKU, HC | 1 |
CHARPENTIER, J | 2 |
FROMMEL, E | 3 |
SEYDOUX, J | 2 |
WHITTLE, BA | 1 |
FLEURY, C | 1 |
LEDEBUR, IV | 1 |
BEGUIN, M | 1 |
FAMILY, S | 1 |
LIM, RK | 2 |
GUZMAN, F | 2 |
RODGERS, DW | 2 |
GOTO, K | 1 |
BRAUN, C | 1 |
DICKERSON, GD | 2 |
ENGLE, RJ | 2 |
Trepanier, DL | 1 |
Richman, JE | 1 |
Rudzik, AD | 1 |
Spector, R | 1 |
Weissman, A | 1 |
Milne, GM | 1 |
Melvin, LS | 1 |
Moreau, JL | 1 |
Cohen, E | 1 |
Lieblich, I | 1 |
Crabbe, JC | 1 |
Jarvik, LF | 1 |
Liston, EH | 1 |
Jenden, DJ | 1 |
Abbott, FV | 3 |
Franklin, KBJ | 1 |
Westbrook, FR | 1 |
Annett, LE | 1 |
Reading, PJ | 1 |
Tharumaratnam, D | 1 |
Abrous, DN | 2 |
Torres, EM | 1 |
Dunnett, SB | 1 |
Guy, ER | 1 |
Simon, H | 1 |
Le Moal, M | 1 |
Hore, SK | 1 |
Dumka, VK | 1 |
Kumar, D | 1 |
Tripathi, HC | 1 |
Tandan, SK | 1 |
Antelman, SM | 1 |
Caggiula, AR | 1 |
Kucinski, BJ | 1 |
Fowler, H | 1 |
Gershon, S | 1 |
Edwards, DJ | 1 |
Austin, MC | 1 |
Stiller, R | 1 |
Kiss, S | 1 |
Kocan, D | 1 |
Rosario, LA | 1 |
Abercrombie, ED | 1 |
Malinka, W | 1 |
Sieklucka-Dziuba, M | 1 |
Rajtar, G | 1 |
Rejdak, R | 1 |
Rejdak, K | 1 |
Kleinrok, Z | 1 |
Connor, J | 1 |
Makonnen, E | 1 |
Rostom, A | 1 |
Saddi, GM | 1 |
Webb, SS | 1 |
Smith, GM | 1 |
Evans, WO | 1 |
Webb, NC | 1 |
Kraft, U | 1 |
Kraft, H | 1 |
Andreas, K | 1 |
Arushanian, EB | 1 |
Belozertsev, IuA | 1 |
Kuzuna, S | 1 |
Kawai, K | 1 |
Manchanda, SK | 1 |
Nayar, U | 1 |
Yehuda, S | 2 |
Youdim, MB | 1 |
Izenwasser, S | 1 |
Kornetsky, C | 1 |
Chu, PC | 1 |
Lin, MT | 1 |
Shian, LR | 1 |
Leu, SY | 1 |
Leprohon-Greenwood, CE | 1 |
Dixon, LM | 1 |
Coscina, DV | 1 |
Silverstrini, B | 1 |
Lisciani, R | 1 |
Little, HJ | 1 |
Rees, JM | 1 |
Shogam, II | 1 |
Burov, IuV | 1 |
Speranskaia, NP | 1 |
Sproule, BC | 1 |
Berger, BD | 1 |
Shanbhag, SM | 1 |
Kulkarni, HJ | 1 |
Gaitonde, BB | 1 |
von Ledebur, I | 1 |
Chmouliovsky, M | 1 |
Prasad, CR | 1 |
Nakanishi, M | 1 |
Imamura, H | 1 |
Maruyama, Y | 1 |
Lal, H | 1 |
DeFeo, JJ | 1 |
Thut, P | 1 |
Moormann, J | 1 |
Opitz, K | 1 |
Deffenu, G | 1 |
Thuránszky, K | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
An Open-label, Single-dose, Pharmacokinetic Study of Acetaminophen/Naproxen Sodium Fixed Combination Tablets in Adolescents 12 to <17 Years of Age With Orthodontic Pain[NCT05844995] | Phase 1 | 30 participants (Anticipated) | Interventional | 2023-09-13 | Recruiting | ||
A Full-Factorial, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Single-Dose Efficacy and Safety Study of an Acetaminophen/Naproxen Sodium Fixed Combination, Acetaminophen, and Naproxen Sodium in Postoperative Dental Pain[NCT05761574] | Phase 3 | 440 participants (Anticipated) | Interventional | 2023-05-22 | Recruiting | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
3 trials available for amphetamine and Ache
Article | Year |
---|---|
Behavioral responses to amphetamines in identical twins.
Topics: Adult; Amphetamine; Amphetamines; Behavior; Cognition; Dextroamphetamine; Emotions; Female; Genetics | 1983 |
Toward the development of a potent, nonsedating, oral analgesic.
Topics: Administration, Oral; Adult; Amphetamine; Analgesics; Clinical Trials as Topic; Double-Blind Method; | 1978 |
Double-blind trial of anorectic agents.
Topics: Adolescent; Adult; Aged; Amphetamine; Appetite Depressants; Clinical Trials as Topic; Dextroamphetam | 1969 |
53 other studies available for amphetamine and Ache
Article | Year |
---|---|
Behavioral Battery for Testing Candidate Analgesics in Mice. I. Validation with Positive and Negative Controls.
Topics: Amphetamine; Analgesics; Animals; Behavior, Animal; Diazepam; Drug Evaluation, Preclinical; False Ne | 2021 |
Broad analgesic activity of a novel, selective M1 agonist.
Topics: Amphetamine; Analgesics; Animals; Benzimidazoles; Brain; Central Nervous System Stimulants; CHO Cell | 2017 |
No Fever, No Murmur, No Problem? A Concealed Case of Infective Endocarditis.
Topics: Adult; Amphetamine; Analgesics, Opioid; Anti-Bacterial Agents; C-Reactive Protein; Endocarditis; Eno | 2019 |
Repeated amphetamine treatment alters spinal magnetic resonance signals and pain sensitivity in mice.
Topics: Amphetamine; Analgesics; Animals; Central Nervous System Stimulants; Hot Temperature; Lumbosacral Re | 2014 |
Locomotor activity in a novel environment as a test of inflammatory pain in rats.
Topics: Amphetamine; Analgesics, Opioid; Animals; Arthritis, Experimental; Behavior, Animal; Central Nervous | 2010 |
Synergistic isonipecaine-amphetamine analgesia.
Topics: Amphetamine; Amphetamines; Analgesia; Analgesics; Humans; Pain | 1947 |
Dopamine D3 receptor regulates basal but not amphetamine-induced changes in pain sensitivity in mice.
Topics: Amphetamine; Animals; Central Nervous System Stimulants; Male; Mice; Mice, Knockout; Pain; Pain Thre | 2010 |
Antiinflammatory, analgesic and antipyretic activities of ethanolic root extract of Croton zambesicus.
Topics: Acetic Acid; Amphetamine; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal | 2010 |
Psychopharmacological properties of an aqueous extract of Tetracarpidium conophorum Hutch. & Dalziel in mice.
Topics: Acetic Acid; Alkaloids; Amphetamine; Animals; Antidepressive Agents; Euphorbiaceae; Female; Formalde | 2011 |
Stability of pain-related medications, metabolites, and illicit substances in urine.
Topics: Amphetamine; Analgesics; Chromatography, Liquid; Drug Stability; Heroin; Humans; Illicit Drugs; Morp | 2013 |
Analgesia in phasic and tonic pain tests in a pharmacological model of autotomy.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Amphetamine; Analgesia; Animals; Behavio | 2002 |
USE OF A 'SOMA' COMPOUND IN PAIN CONTROL AFTER ORAL SURGERY.
Topics: Acetaminophen; Amphetamine; Analgesics; Analgesics, Non-Narcotic; Anesthesia; Anesthesia, Dental; An | 1963 |
[EFFECTS OF IMIPRAMINE ON THE REACTION TO PAIN IN THE RAT].
Topics: Amphetamine; Amphetamines; Animals; Behavior, Animal; Imipramine; Pain; Pharmacology; Physostigmine; | 1963 |
[ON THE EFFECT OF ETHANOL ON THE BRAIN. RESULTS OF SO-CALLED NEUROPHARMACOLOGIC TESTS IN ANIMALS].
Topics: Alcoholic Intoxication; Amphetamine; Amphetamines; Body Temperature Regulation; Brain; Electroconvul | 1964 |
THE USE OF CHANGES IN CAPILLARY PERMEABILITY IN MICE TO DISTINGUISH BETWEEN NARCOTIC AND NONNARCOTIC ALALGESICS.
Topics: Acetates; Amphetamine; Analgesics, Non-Narcotic; Animals; Antipyretics; Aspirin; Capillary Permeabil | 1964 |
THE PLACE OF ACETYLSALICYLIC ACID IN PSYCHOPHARMACOLOGY. AN EXPERIMENTAL STUDY.
Topics: Amphetamine; Amphetamines; Animals; Aspirin; Body Temperature Regulation; Chlordiazepoxide; Chlorpro | 1963 |
SITE OF ACTION OF NARCOTIC AND NON-NARCOTIC ANALGESICS DETERMINED BY BLOCKING BRADYKININ-EVOKED VISCERAL PAIN.
Topics: Amphetamine; Analgesics; Analgesics, Non-Narcotic; Animals; Antipyretics; Aspirin; Azepines; Bradyki | 1964 |
SITE OF ACTION OF NARCOTIC AND NON-NARCOTIC ANALGESICS DETERMINED BY BLOCKING BRADYKININ-EVOKED VISCERAL PAIN.
Topics: Amphetamine; Analgesics; Analgesics, Non-Narcotic; Animals; Antipyretics; Aspirin; Azepines; Bradyki | 1964 |
SITE OF ACTION OF NARCOTIC AND NON-NARCOTIC ANALGESICS DETERMINED BY BLOCKING BRADYKININ-EVOKED VISCERAL PAIN.
Topics: Amphetamine; Analgesics; Analgesics, Non-Narcotic; Animals; Antipyretics; Aspirin; Azepines; Bradyki | 1964 |
SITE OF ACTION OF NARCOTIC AND NON-NARCOTIC ANALGESICS DETERMINED BY BLOCKING BRADYKININ-EVOKED VISCERAL PAIN.
Topics: Amphetamine; Analgesics; Analgesics, Non-Narcotic; Animals; Antipyretics; Aspirin; Azepines; Bradyki | 1964 |
1,4,5,6-tetrahydro-as-triazines. II. Condensation of beta-aminoalkylhydrazines with iminoesters and orthoesters.
Topics: Amphetamine; Animals; Chemistry, Organic; Drug Synergism; Electric Stimulation; Electrophysiology; H | 1967 |
Treatment of moderate & severe chronic pain syndromes with morphine & adjunctive drugs.
Topics: Amphetamine; Chronic Disease; Cocaine; Doxapram; Histamine H1 Antagonists; Humans; Morphine; Narcoti | 1981 |
Cannabimimetic activity from CP-47,497, a derivative of 3-phenylcyclohexanol.
Topics: Amphetamine; Analgesia; Animals; Anticonvulsants; Apomorphine; Behavior, Animal; Body Temperature; C | 1982 |
Ventral tegmental analgesia in two strains of rats: effects of amphetamine, naloxone and parachlorophenylalanine.
Topics: Amphetamine; Animals; Dopamine; Endorphins; Fenclonine; Male; Naloxone; Pain; Rats; Rats, Inbred Str | 1984 |
The formalin test: scoring properties of the first and second phases of the pain response in rats.
Topics: Amphetamine; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Formaldehyde; Male; Morphi | 1995 |
Conditioning versus priming of dopaminergic grafts by amphetamine.
Topics: Amphetamine; Animals; Brain; Brain Tissue Transplantation; Conditioning, Psychological; Dopamine; Fe | 1993 |
Effects of morphine, pentobarbital and amphetamine on formalin-induced behaviours in infant rats: sedation versus specific suppression of pain.
Topics: Amphetamine; Animals; Animals, Newborn; Behavior, Animal; Female; Formaldehyde; Hypnotics and Sedati | 1995 |
Administration of amphetamine does not increase the functional efficacy of dopaminergic grafts made in infancy.
Topics: Amphetamine; Analysis of Variance; Animals; Apomorphine; Brain Tissue Transplantation; Conditioning, | 1996 |
Central noradrenergic & dopaminergic modulation of brewer's yeast-induced inflammation & nociception in rats.
Topics: Amphetamine; Animals; Dopamine; Inflammation; Male; Norepinephrine; Pain; Rats; Rats, Sprague-Dawley | 1997 |
The effects of lithium on a potential cycling model of bipolar disorder.
Topics: Amphetamine; Animals; Antipsychotic Agents; Bipolar Disorder; Cocaine; Corpus Striatum; Disease Mode | 1998 |
Individual differences in behavioral reactivity: correlation with stress-induced norepinephrine efflux in the hippocampus of Sprague-Dawley rats.
Topics: Amphetamine; Animals; Behavior, Animal; Circadian Rhythm; Exploratory Behavior; Hippocampus; Individ | 1999 |
Synthesis of some N-substituted 3,4-pyrroledicarboximides as potential CNS depressive agents.
Topics: Amphetamine; Analgesics, Non-Narcotic; Animals; Anticonvulsants; Behavior, Animal; Blood Pressure; C | 2000 |
Comparison of analgesic effects of khat (Catha edulis Forsk) extract, D-amphetamine and ibuprofen in mice.
Topics: Acetic Acid; Amphetamine; Analgesia; Analgesics; Animals; Catha; Central Nervous System Stimulants; | 2000 |
The formalin test in the mouse: a parametric analysis of scoring properties.
Topics: Acepromazine; Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Amphetamine; Analgesics, Opioid; Ani | 2000 |
[Effect of dopaminergic substances on the antinocifensive action of arecoline].
Topics: Amphetamine; Animals; Apomorphine; Arecoline; Chlorpromazine; Dopamine; Dose-Response Relationship, | 1979 |
[Neurophysiologic analysis of the effect of phenamine and caffeine or cortical neurons].
Topics: Amphetamine; Animals; Auditory Perception; Caffeine; Cats; Caudate Nucleus; Cerebral Cortex; Electri | 1976 |
Evaluation of analgesic agents in rats with adjuvant arthritis.
Topics: Amphetamine; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Na | 1975 |
Role of opioid receptors in self-aggression in rats.
Topics: Aggression; Amphetamine; Animals; Behavior, Animal; Male; Naloxone; Norepinephrine; Pain; Phenoxyben | 1991 |
Brain iron: a lesson from animal models.
Topics: Amphetamine; Anemia, Hypochromic; Animals; Antipsychotic Agents; Apomorphine; beta-Endorphin; Body T | 1989 |
Potentiation of morphine analgesia by D-amphetamine is mediated by norepinephrine and not dopamine.
Topics: Amphetamine; Analgesics; Animals; Dopamine; Dopamine Antagonists; Drug Synergism; Electric Stimulati | 1988 |
Alterations in physiologic functions and in brain monoamine content in streptozocin-diabetic rats.
Topics: Amphetamine; Animals; Body Temperature Regulation; Brain; Brain Chemistry; Brain Stem; Corpus Striat | 1986 |
Effects of dietary fat on pain threshold, thermoregulation and motor activity in rats.
Topics: Amphetamine; Animals; Body Temperature Regulation; Dietary Fats; Male; Motor Activity; Oils; Pain; R | 1986 |
Pharmacology of trazodone.
Topics: Amphetamine; Animals; Anticonvulsants; Antidepressive Agents; Avoidance Learning; Biogenic Amines; C | 1973 |
Tolerance development to the antinociceptive actions of morphine, amphetamine, physostigmine and 2-aminoindane in the mouse.
Topics: Amphetamine; Analgesia; Analgesics; Animals; Drug Tolerance; Female; Indans; Indenes; Mice; Morphine | 1974 |
[A study of sensation by the double simultaneous stimulation method].
Topics: Adult; Amphetamine; Brain Diseases; Caffeine; Epinephrine; Female; Humans; Hypesthesia; Methods; Pai | 1974 |
[Effect of psychotropic agents on development of an avoidance reaction in albino rats during painful electric stimulation of another rat].
Topics: Amphetamine; Animals; Antidepressive Agents; Droperidol; Electric Stimulation; Escape Reaction; Fear | 1973 |
Conditioning of food aversions by injections of psychoactive drugs.
Topics: Amphetamine; Animals; Avoidance Learning; Benzazepines; Chlorpromazine; Conditioning, Classical; Con | 1972 |
Pharmacological actions of berberine on the central nervous system.
Topics: Alkaloids; Amphetamine; Analgesics; Animals; Anticonvulsants; Cats; Central Nervous System; Drug Syn | 1970 |
Neuropharmacological study of central reactions to intense muscular exertion, sensorial fatigue, sexual excitation, hunger, and thirst.
Topics: Amphetamine; Animals; Brain; Electric Stimulation; Electroshock; Fatigue; Female; Guinea Pigs; Hunge | 1966 |
[Studies on anti-inflammatory agents. II. Analgesic and anti-edematous activities of 2-amino-3-ethoxycarbonyl-6-benzyl-4,5,6, 7-tetrahydrothieno (2,3-c)pyridine (Y-3642)].
Topics: Aminopyrine; Amphetamine; Analgesics; Animals; Anti-Inflammatory Agents; Edema; Imipramine; Male; Mi | 1970 |
Prevention of pain-induced aggression by parachloroamphetamine.
Topics: Aggression; Amphetamine; Animals; Chlorine; Humans; Injections, Intraperitoneal; Male; Pain; Rats | 1970 |
[On the analgesic effect of anorectic substances].
Topics: Amphetamine; Animals; Appetite Depressants; Codeine; Diethylpropion; Drug Synergism; Fenfluramine; M | 1967 |
[Correlation between the chemical structure and algogenic activity of some vasoactive substances].
Topics: Amphetamine; Animals; Nicotine; Pain; Peptides; Rats; Vasoconstrictor Agents; Vasodilator Agents | 1968 |
The intraperitoneal bradykinin-evoked pain test for analgesia.
Topics: Amphetamine; Animals; Aspirin; Bradykinin; Cats; Dogs; Guinea Pigs; Mice; Morphine; Pain; Peritoneum | 1965 |
The effect of psychopharmaca on exteroceptive blood pressure reflexes in non-anaesthetized cats.
Topics: Amphetamine; Animals; Autonomic Nervous System; Behavior, Animal; Blood Pressure; Capsicum; Cats; Ch | 1966 |
[Recent studies on the action mechanism of some central nervous system analgesics. Acetylsalicylic acid, imipramine, iminostilbene].
Topics: Amphetamine; Animals; Aspirin; Atropine; Behavior, Animal; Central Nervous System; Dibenzylchloretha | 1966 |