amoxicillin-potassium-clavulanate-combination and Vaginosis--Bacterial

Therapeutic options for the treatment of accurately diagnosed bacterial vaginosis are reviewed on the basis of current concepts for treatment of bacterial vaginosis. The importance for screening for bacterial vaginosis is pointed out especially before intrauterine procedures and in pregnant women at risk for premature deliveries. Treatment regimens for pregnant women are discussed as well. Emphasis is given to treatment modalities for recurrent bacterial vaginosis.

Topics: Administration, Oral; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Anti-Infective Agents; Clindamycin; Female; Humans; Metronidazole; Pregnancy; Pregnancy Complications, Infectious; Secondary Prevention; Time Factors; Vaginal Creams, Foams, and Jellies; Vaginosis, Bacterial

Gardnerella vaginalis is one of the dominant etiological factors related to bacterial vaginosis. Literature offers a growing number of reports revealing there appear Gardnerella vaginalis strains increasingly resistant to metronidazole.. The aim of this study was to determine the susceptibility of Gardnerella vaginalis strains isolated from women with bacterial vaginosis to metronidazole, clindamycin and amoxicillin/clavulanic acid.. The investigation was performed on collection of 67 Gardnerella vaginalis strains isolated from the group of 604 women participating in the study Antibiotic sensitivity of strains was verified by E-test method (BioMerieux). Interpretation of results was performed in accordance with EUCAST criteria.. All tested strains, apart from one, were sensitive to clindamycin and amoxicillin/clavulanic acid. The results of susceptibility test to metronidazole indicated that 68.7% (46 out of 67 strains) were resistant to this antibiotic, while all of them were sensitive to both clindamycin and amoxicillin/clavulanic acid.. Near future may bring the need to change the treatment regimen of bacterial vaginosis.

Topics: Administration, Intravaginal; Administration, Oral; Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Infective Agents; Bacterial Typing Techniques; Clindamycin; Drug Resistance, Bacterial; Female; Gardnerella vaginalis; Humans; Metronidazole; Microbial Sensitivity Tests; Middle Aged; Poland; Vagina; Vaginosis, Bacterial; Young Adult