amoxicillin-potassium-clavulanate-combination and Skin-Ulcer

In this study, we evaluated the treatment of feline eosinophilic plaques and lip ulcers with amoxicillin trihydrate-potassium clavulanate (Clavamox(®); Pfizer Animal Health). Nineteen cats with clinical and cytological findings consistent with eosinophilic plaques and/or lip ulcers were enrolled. Lesions were photographed and their areas measured in square centimetres before and after 21 days of therapy with either flavoured amoxicillin-clavulanate suspension or flavoured placebo suspension. Sixteen cats completed the study, with nine plaque lesions (four treatment and five placebo) and eight lip ulcer lesions (four treatment and four placebo) included in the analysis. All lesions were shown to have infection, with bacterial phagocytosis present on cytological examination. Coagulase-positive staphylococci were the most commonly isolated bacteria. The amoxicillin-clavulanate-treated eosinophilic plaque group had a statistically significant 96.2% reduction in mean lesion size (-7.60 cm(2), P = 0.0078) and an 80% reduction in mean percentage of microscopic fields demonstrating evidence of bacterial infection (P < 0.0001), whereas the placebo group did not. The amoxicillin-clavulanate-treated lip ulcer group had a 42.6% decrease in mean lesion size (-0.25 cm(2), P = 0.4125) and the placebo group a 36.6% increase (+0.49 cm(2), P = 0.1575), although neither change was statistically significant. The amoxicillin-clavulanate-treated lip ulcer group had a statistically significant 65.0% reduction in mean percentage of microscopic fields demonstrating evidence of bacterial infection (P < 0.0001), while no significant reduction was observed in the placebo group. A suspension of amoxicillin trihydrate-potassium clavulanate is an effective monotherapy for the treatment of feline eosinophilic plaques.

Topics: Amoxicillin-Potassium Clavulanate Combination; Animals; Anti-Bacterial Agents; Cat Diseases; Cats; Double-Blind Method; Drug Administration Schedule; Eosinophilic Granuloma; Female; Male; Skin Ulcer

Topics: Administration, Cutaneous; Administration, Oral; Amoxicillin-Potassium Clavulanate Combination; Bandages; Collagenases; Debridement; Face; Female; Humans; Italy; Middle Aged; Necrosis; Ointments; Skin; Skin Ulcer; Spider Bites; Treatment Outcome; Wound Healing

Topics: Amikacin; Amoxicillin-Potassium Clavulanate Combination; Collagenases; Drug Therapy, Combination; Ecthyma; Female; Gels; Humans; Hyaluronic Acid; Infant; Necrosis; Pharyngitis; Skin Ulcer; Vulvar Diseases

Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Antiviral Agents; Debridement; Drug Eruptions; Drug Therapy, Combination; Female; Hepatitis C, Chronic; Humans; Injections, Subcutaneous; Interferon alpha-2; Interferon-alpha; Middle Aged; Necrosis; Polyethylene Glycols; Recombinant Proteins; Ribavirin; Skin Ulcer

Human bite on genitalia is a rare cause of penile ulceration, but is increasingly being reported, probably due to the increasing frequency of orogenital sex. The great morbidity associated with it brings it under the category of high-risk bite wounds, similar to those on hands, feet and joints. We report a case and review the literature on human bite-induced penile ulceration.

Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Bites, Human; Drug Therapy, Combination; Humans; Male; Penile Diseases; Sexual Behavior; Skin Ulcer