amoxicillin-potassium-clavulanate-combination and Seizures

Topics: Aged; Amoxicillin-Potassium Clavulanate Combination; beta-Lactamase Inhibitors; Drug Interactions; Female; Humans; Rhabdomyolysis; Seizures; Serotonin and Noradrenaline Reuptake Inhibitors; Serotonin Syndrome; Venlafaxine Hydrochloride

Cerebral actinomycosis is rare and difficult to diagnose.. We report a case of a 45-year-old man hospitalized for seizures associated with fever and left hemiparesis. The white cell count and C-reactive protein were elevated. HIV serology was negative. Blood cultures remained sterile. The CT scan revealed hyperdense nodular lesions in the occipital area, with annular contrast uptake and peripheral edema causing a mass effect, suggestive of brain metastasis. The pathology examination of a surgical specimen disclosed cerebral actinomycosis. A dental origin of the infection was suspected. Hemiparesis remained after a 12-month antibiotic regimen associated with dental care and short-term corticosteroid therapy.. Actinomycosis should be discussed as a possible diagnosis for all cerebral lesions, particularly in patients with a potential dental infection. Histology is required for positive diagnosis. Antibiotic therapy alone is generally sufficient; surgery is often performed for diagnostic purposes.

Topics: Actinomycosis; Adrenal Cortex Hormones; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Ciprofloxacin; Combined Modality Therapy; Dental Caries; Drug Therapy, Combination; Dysarthria; Humans; Male; Metronidazole; Middle Aged; Occipital Lobe; Oral Hygiene; Paresis; Penicillin G; Periapical Abscess; Pseudotumor Cerebri; Seizures; Tomography, X-Ray Computed