amoxicillin-potassium-clavulanate-combination and Pleural-Effusion

Staphylococcus lugdunensis, a strain of coagulase-negative staphylococci, is part of the normal flora of human skin but can cause multiple infections at various sites. This microorganism has emerged as a major human pathogen. However, no study has reported primary lung abscess caused by S. lugdunensis. A 54-year-old alcoholic man without relevant past medical history was admitted because of primary lung abscesses. Empirical amoxicillin/clavulanate therapy was initially administered; however, the patient had persistent pleuritic chest pain and fever. He subsequently underwent resection of the lung abscess and removal of exudative pleural effusion on the fourth hospital day. Histopathologic examination confirmed the diagnosis of lung abscess, and colonies of gram-positive bacteria were identified. The culture specimen from the abscess was positive for S. lugdunensis, which was susceptible to amoxicillin/clavulanate, cefazolin, ciprofloxacin, clindamycin, erythromycin, oxacillin, teicoplanin, tetracycline, and vancomycin. Following resection and 3 weeks of amoxicillin/clavulanate therapy, the patient eventually recovered well without relapse. This case report is the first to describe S. lugdunensis as a cause of primary lung abscess; this microorganism should be considered a potential monomicrobial pathogen in primary lung abscess.

Topics: Alcoholics; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Chest Pain; Humans; Lung Abscess; Male; Middle Aged; Pleural Effusion; Pneumonectomy; Radiography; Staphylococcal Infections; Staphylococcus lugdunensis

Topics: Actinomyces; Actinomycosis; Aged; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Cholecystectomy, Laparoscopic; Coinfection; Cutaneous Fistula; Escherichia coli; Escherichia coli Infections; Humans; Male; Penicillins; Pleural Effusion; Postoperative Complications; Respiratory Tract Fistula; Thoracic Wall; Tomography, X-Ray Computed

Topics: Aged; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Diagnosis, Differential; Echocardiography; Electrocardiography; Humans; Male; Pleural Effusion; Pneumonia; Pulmonary Edema; Radiography; Thrombosis

The results of treatment of pyothorax using systemic antibiotics, drainage, and lavage of the pleural space, are reported for 9 dogs. All 9 dogs recovered completely. In 8 of the 9 dogs the follow-up period was at least 6 months and in none was there a relapse. The results obtained with this treatment are excellent in comparison with the results that have been reported for treatment with systemic antibiotics and drainage of the pleural space but without lavage. Apart from the addition of pleural lavage to the treatment protocol, the better result might be because migrating plant related foreign bodies did not seem to play an important role in the pathogenesis of pyothorax in this group of dogs.

Topics: Amoxicillin-Potassium Clavulanate Combination; Animals; Anti-Infective Agents; Dog Diseases; Dogs; Drainage; Drug Therapy, Combination; Empyema, Pleural; Female; Male; Metronidazole; Pleura; Pleural Effusion; Radiography, Thoracic; Therapeutic Irrigation