amoxicillin-potassium-clavulanate-combination has been researched along with Peritoneal-Diseases* in 2 studies
2 other study(ies) available for amoxicillin-potassium-clavulanate-combination and Peritoneal-Diseases
Article | Year |
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Antibiotic-induced mesenteric adenopathy in an intussusception mouse model: a randomized, controlled trial.
Idiopathic intussusception is a leading cause of intestinal obstruction in young children. Although the etiology remains obscure, lymphoid hyperplasia is found in a majority of cases. Antibiotics, the most frequently prescribed medication class in the pediatric population, have been recently associated with intussusception. The authors sought to determine whether enteral antibiotic exposure influences the development of mesenteric adenopathy, bowel dilation or intussusception in an animal model.. The authors conducted a randomized, controlled animal trial using a previously described intussusception model. Mice were gavaged with normal saline, amoxicillin-clavulanate or azithromycin twice daily for 5 days to assess the influence of enteral antibiotic exposure on intussusception, mesenteric adenopathy and bowel dilation. One pediatric surgeon performed all laparotomies and was blinded to group designation. Chi2 and Fisher exact tests were used to evaluate differences between antibiotic exposed and control groups.. Mesenteric adenopathy was identified in 4.1% of the normal saline controls compared with 54.1% (P < 0.01) and 38.9% (P < 0.01) of the amoxicillin-clavulanate and azithromycin exposed animals, respectively. A total of four intussusceptions were observed in the antibiotic-exposed groups combined whereas no intussusception cases were identified in the control group (P = 0.30).. This is the first study to describe a significant association between antibiotic use and mesenteric adenopathy in any animal species. Topics: Amoxicillin-Potassium Clavulanate Combination; Animals; Anti-Bacterial Agents; Azithromycin; Disease Models, Animal; Female; Intestine, Small; Intussusception; Lymphatic Diseases; Male; Mesentery; Mice; Mice, Inbred BALB C; Peritoneal Diseases; Random Allocation | 2005 |
Orally delivered antibiotics which lower bacterial numbers decrease experimental intra-abdominal adhesions.
Postsurgical adhesion formation is a common occurrence after most surgical procedures and is still a major cause of postoperative morbidity because no satisfactory treatment or prophylaxis has yet been developed. Further elucidation of the basic mechanisms of postsurgical adhesion formation is needed. Recent studies using germfree rats have found the indigenous bowel flora to be important in the adhesive response. The present study examined whether antibiotic treatment affects intra-abdominal adhesion formation.. Using the cecal crush model to inflict adhesions, groups of rats ( n=12) were treated with placebo or amoxicillin/clavulanic acid in the drinking water. Treatment started 3 days before operation and continued until evaluation. Adhesion scores were recorded after 7 days. Bacterial counts were made from cultures of fecal samples on operation day and at termination.. Amoxicillin/clavulanic acid decreased adhesion score compared to placebo. Adhesion incidence was 50% in the treatment group and 92% in the placebo group. Bacterial numbers were lower in the treatment group.. Antibiotic treatment which lowers bacterial numbers can decrease adhesions. Topics: Abdomen; Amoxicillin-Potassium Clavulanate Combination; Animals; Drug Therapy, Combination; Female; Male; Peritoneal Diseases; Postoperative Complications; Random Allocation; Rats; Rats, Inbred Strains; Tissue Adhesions | 2003 |