amoxicillin-potassium-clavulanate-combination and Menorrhagia

To study the effect of prophylactic antibiotics on the incidence of bacteraemia following hysteroscopic surgery.. Prospective randomized study.. Aberdeen Royal Infirmary.. One hundred and sixteen women about to undergo either endometrial laser ablation (ELA) or transcervical resection of the endometrium (TCRE).. Fifty-five women were randomised to receive 1.2 g of Augmentin (co-amoxiclav) i.v. at induction of anaesthesia. Sixty-one women received no antibiotic prophylaxis. Blood cultures were obtained at the end of the surgical procedure.. Incidence of bacteraemia in the non-antibiotic group (16%) was significantly higher than that in the antibiotic group (2%) (95% confidence interval for difference from 5% to 25%). The majority of organisms were of dubious clinical significance and contamination could not be excluded in 7 cases out of 10.. There is no convincing evidence that antibiotics are of value in this clinical setting.

Topics: Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Antibiotic Prophylaxis; Bacteremia; Clavulanic Acids; Drug Therapy, Combination; Endometrium; Female; Humans; Hysteroscopy; Laser Therapy; Menorrhagia; Prospective Studies

To assess medium-term efficacy of rollerball endometrial ablation in a district general hospital.. From March 1992 to June 1997, 91 women underwent rollerball endometrial ablation for uncontrolled menorrhagia unresponsive to medical treatment. Each was sent a detailed questionnaire after at least 18 months (range 18-55). There was an overall response rate of 88% (80/91). Case notes were reviewed to collect additional data related to pre-operative management and actual operative procedure. The main outcome measures included treatment satisfaction, relief of symptoms, improvement in health related quality of life, at least 18 months after surgery.. Thirty-five of the 80 women (44%) had achieved amenorrhea. Ten women required further treatment; of these seven had a hysterectomy (9%). None of the non-responders had a hysterectomy. Following rollerball endometrial ablation, many women reported improvement in cyclical pelvic pain (73%), pre-menstrual symptoms (65%), ability to do housework (85%), and an improved sexual life (96%). Seventy-nine (99%) women were able to return to normal work within 4 weeks following surgery. The majority of them remained satisfied with treatment (79%) and they would recommend it to a friend (91%).. Rollerball endometrial ablation is a simple, effective, and acceptable procedure for the treatment of menorrhagia in selected cases. Longer-term follow up is still needed to establish the ultimate effectiveness of the procedure.

Topics: Adolescent; Adult; Amoxicillin-Potassium Clavulanate Combination; Antineoplastic Agents, Hormonal; Danazol; Endometrium; Estrogen Antagonists; Female; Follow-Up Studies; Goserelin; Humans; Menorrhagia; Middle Aged; Patient Satisfaction; Quality of Life; Surveys and Questionnaires