amoxicillin-potassium-clavulanate-combination and Liver-Neoplasms

Liver cancers in children are primitive (hepatoblastoma, fibrolamellar hepatocarcinoma, sarcomas), or arise on a genetic or viral disease. Their treatment is a combination of chemotherapy (hepatoblastoma) and surgery. Neonatal hemangioendotheliomas may induce heart failure. They are now successfully treated with propranolol. Focal nodular hyperplasia is the most frequent benign tumour in older children and adolescents. Drug hepatotoxicity is not very frequent. Antipyretic drugs may induce severe side effects. Liver failure due to valproic acid is diagnostic of a respiratory chain disorder. The liver side effects of antituberculous and antiretroviral drugs should be monitored. Intestinal failure-associated liver disease is common and can be prevented or treated. Early referral to a specialized centre is important for the prognosis.

Topics: Acetaminophen; Amoxicillin-Potassium Clavulanate Combination; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Retroviral Agents; Anticonvulsants; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Child; Humans; Intestinal Diseases; Liver Diseases; Liver Neoplasms; Mushroom Poisoning

Septic arthritis in the elderly carries a high mortality. Underlying risk factors, such as diabetes, malignancy, chronic renal failure, rheumatoid arthritis, hepatobiliary disease and AIDS, should be assessed. Rare causative organisms are occasionally encountered. Here, we describe a case of an 80-year-old diabetic patient with liver cirrhosis who developed Klebsiella pneumoniae septic arthritis, which is a rare cause of joint infection. We postulate that this case supports the notion that the patient's knee effusion seeded during a primary K pneumoniae bacteraemia of intestinal origin and related to liver cirrhosis.

Topics: Abdominal Pain; Aged, 80 and over; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Arthritis, Infectious; Carcinoma, Hepatocellular; Clavulanic Acids; Fatal Outcome; Humans; Klebsiella Infections; Klebsiella pneumoniae; Knee Joint; Liver Cirrhosis; Liver Neoplasms; Male; Ticarcillin

Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Ascites; Bacteremia; Carcinoma, Hepatocellular; Comorbidity; Drug Combinations; Drug Therapy, Combination; Female; Gonorrhea; Hepatitis C, Chronic; HIV Infections; Humans; Ileus; Liver Neoplasms; Multiple Organ Failure; Ofloxacin; Pelvic Infection; Peritonitis