amoxicillin-potassium-clavulanate-combination and Lacrimal-Apparatus-Diseases

Topics: Abscess; Adolescent; Amoxicillin-Potassium Clavulanate Combination; Anti-Infective Agents; beta-Lactamase Inhibitors; Choroid Diseases; Diagnosis, Differential; Drug Therapy, Combination; Fluorescein Angiography; Humans; Lacrimal Apparatus Diseases; Male; Metronidazole; Staphylococcal Infections; Staphylococcus epidermidis; Tomography, X-Ray Computed; Ultrasonography

Topics: Acute Disease; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Cutaneous Fistula; Dacryocystitis; Disease Susceptibility; Female; Fistula; Humans; Infant; Infectious Mononucleosis; Lacrimal Apparatus Diseases; Streptococcal Infections; Streptococcus pneumoniae

Cystic dilatation within the lacrimal gland is thought to be related to chronic inflammation and scarring of the lacrimal gland ductules. We review the literature and discuss a case and of lacrimal duct cyst suppuration presenting with visual loss, external ophthalmoplegia, proptosis and ptosis. To our knowledge, only one other report of a lacrimal ductal cyst abscess has been reported in the literature so far.

Topics: Abscess; Administration, Oral; Administration, Topical; Aged; Amoxicillin-Potassium Clavulanate Combination; beta-Lactamase Inhibitors; Blepharoptosis; Chloramphenicol; Cysts; Drug Therapy, Combination; Exophthalmos; Female; Humans; Hyaluronic Acid; Lacrimal Apparatus Diseases; Ophthalmoplegia; Tomography, X-Ray Computed; Vision Disorders

A 68-year-old woman presented with a painless inflammation of the right superior eyelid that had started several weeks before. The clinical diagnosis concluded in canaliculitis and the solid concretions were surgically extracted from the superior canalicula. The anaerobic bacteria Fusobacterium nucleatum sp. nucleatum was isolated. Signs dramatically regressed two weeks after surgery followed by one course of oral amoxicillin and clavulanic acid associated with topical tobramycin. The clinical signs had disappeared two months later.

Topics: Aged; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Canaliculitis; Combined Modality Therapy; Corneal Ulcer; Dacryocystitis; Dacryocystorhinostomy; Drug Therapy, Combination; Emergencies; Female; Fusobacterium Infections; Fusobacterium nucleatum; Humans; Lacrimal Apparatus Diseases; Lacrimal Duct Obstruction; Tobramycin

We report eight cases of liver injury related to amoxycillin-clavulanate. Liver biopsy performed in seven patients revealed varying degrees of injury to interlobular bile ducts in all cases. Lesions included irregularity of the nuclei, vacuolization of the cytoplasm, lymphocytic infiltration, destruction and endothelialization of the bile duct epithelium. Ductopenia was not observed. In two patients liver injury was accompanied by prominent extrahepatic manifestations (acute interstitial nephritis in one and acute lacrimal gland inflammation and sialadenitis with prolonged xerostomia in the other). We conclude that interlobular bile-duct lesions of varying severity are a common feature in liver injury related to amoxycillin-clavulanate. Side effects of the drug include acute interstitial nephritis and sialadenitis.

Topics: Aged; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Bile Ducts, Intrahepatic; Chemical and Drug Induced Liver Injury; Clavulanic Acids; Drug Therapy, Combination; Female; Humans; Inflammation; Lacrimal Apparatus Diseases; Male; Middle Aged; Nephritis, Interstitial; Sialadenitis; Xerostomia