Compounds > amoxicillin-potassium-clavulanate-combination

amoxicillin-potassium-clavulanate-combination and Intervertebral-Disc-Displacement

amoxicillin-potassium-clavulanate-combination has been researched along with Intervertebral-Disc-Displacement* in 18 studies

Trials

1 trial(s) available for amoxicillin-potassium-clavulanate-combination and Intervertebral-Disc-Displacement

Article	Year
Antibiotic treatment in patients with chronic low back pain and vertebral bone edema (Modic type 1 changes): a double-blind randomized clinical controlled trial of efficacy. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2013, Volume: 22, Issue:4 Modic type 1 changes/bone edema in the vertebrae are present in 6 % of the general population and 35-40 % of the low back pain population. It is strongly associated with low back pain. The aim was to test the efficacy of antibiotic treatment in patients with chronic low back pain (>6 months) and Modic type 1 changes (bone edema).. The study was a double-blind RCT with 162 patients whose only known illness was chronic LBP of greater than 6 months duration occurring after a previous disc herniation and who also had bone edema demonstrated as Modic type 1 changes in the vertebrae adjacent to the previous herniation. Patients were randomized to either 100 days of antibiotic treatment (Bioclavid) or placebo and were blindly evaluated at baseline, end of treatment and at 1-year follow-up.. Primary outcome, disease-specific disability, lumbar pain. Secondary outcome leg pain, number of hours with pain last 4 weeks, global perceived health, EQ-5D thermometer, days with sick leave, bothersomeness, constant pain, magnetic resonance image (MRI).. 144 of the 162 original patients were evaluated at 1-year follow-up. The two groups were similar at baseline. The antibiotic group improved highly statistically significantly on all outcome measures and improvement continued from 100 days follow-up until 1-year follow-up. At baseline, 100 days follow-up, 1-year follow-up the disease-specific disability-RMDQ changed: antibiotic 15, 11, 5.7; placebo 15, 14, 14. Leg pain: antibiotics 5.3, 3.0, 1.4; placebo 4.0, 4.3, 4.3. Lumbar pain: antibiotics 6.7, 5.0, 3.7; placebo 6.3, 6.3, 6.3. For the outcome measures, where a clinically important effect size was defined, improvements exceeded the thresholds, and a trend towards a dose-response relationship with double dose antibiotics being more efficacious.. The antibiotic protocol in this study was significantly more effective for this group of patients (CLBP associated with Modic I) than placebo in all the primary and secondary outcomes. Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Bone Diseases; Disability Evaluation; Dose-Response Relationship, Drug; Double-Blind Method; Edema; Female; Follow-Up Studies; Humans; Intervertebral Disc Displacement; Low Back Pain; Lumbar Vertebrae; Male; Middle Aged; Outcome Assessment, Health Care; Pain Measurement; Surveys and Questionnaires; Treatment Outcome	2013

Article

Year

Antibiotic treatment in patients with chronic low back pain and vertebral bone edema (Modic type 1 changes): a double-blind randomized clinical controlled trial of efficacy.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2013, Volume: 22, Issue:4

Modic type 1 changes/bone edema in the vertebrae are present in 6 % of the general population and 35-40 % of the low back pain population. It is strongly associated with low back pain. The aim was to test the efficacy of antibiotic treatment in patients with chronic low back pain (>6 months) and Modic type 1 changes (bone edema).. The study was a double-blind RCT with 162 patients whose only known illness was chronic LBP of greater than 6 months duration occurring after a previous disc herniation and who also had bone edema demonstrated as Modic type 1 changes in the vertebrae adjacent to the previous herniation. Patients were randomized to either 100 days of antibiotic treatment (Bioclavid) or placebo and were blindly evaluated at baseline, end of treatment and at 1-year follow-up.. Primary outcome, disease-specific disability, lumbar pain. Secondary outcome leg pain, number of hours with pain last 4 weeks, global perceived health, EQ-5D thermometer, days with sick leave, bothersomeness, constant pain, magnetic resonance image (MRI).. 144 of the 162 original patients were evaluated at 1-year follow-up. The two groups were similar at baseline. The antibiotic group improved highly statistically significantly on all outcome measures and improvement continued from 100 days follow-up until 1-year follow-up. At baseline, 100 days follow-up, 1-year follow-up the disease-specific disability-RMDQ changed: antibiotic 15, 11, 5.7; placebo 15, 14, 14. Leg pain: antibiotics 5.3, 3.0, 1.4; placebo 4.0, 4.3, 4.3. Lumbar pain: antibiotics 6.7, 5.0, 3.7; placebo 6.3, 6.3, 6.3. For the outcome measures, where a clinically important effect size was defined, improvements exceeded the thresholds, and a trend towards a dose-response relationship with double dose antibiotics being more efficacious.. The antibiotic protocol in this study was significantly more effective for this group of patients (CLBP associated with Modic I) than placebo in all the primary and secondary outcomes.

Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Bone Diseases; Disability Evaluation; Dose-Response Relationship, Drug; Double-Blind Method; Edema; Female; Follow-Up Studies; Humans; Intervertebral Disc Displacement; Low Back Pain; Lumbar Vertebrae; Male; Middle Aged; Outcome Assessment, Health Care; Pain Measurement; Surveys and Questionnaires; Treatment Outcome

2013

Other Studies

17 other study(ies) available for amoxicillin-potassium-clavulanate-combination and Intervertebral-Disc-Displacement

Article	Year
Antibiotics for low back pain? European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2014, Volume: 23, Issue:2 Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Bone Diseases; Edema; Female; Gram-Positive Bacterial Infections; Humans; Intervertebral Disc; Intervertebral Disc Displacement; Low Back Pain; Lumbar Vertebrae; Male; Propionibacterium acnes	2014
Answer to the letter to the editor of Svend Lings entitled "antibiotics for low back pain?" concerning "antibiotic treatment in patients with chronic low back pain and vertebral bone edema (Modic type 1 changes): a double-blind randomized controlled trial European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2014, Volume: 23, Issue:2 Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Bone Diseases; Edema; Female; Humans; Intervertebral Disc Displacement; Low Back Pain; Lumbar Vertebrae; Male	2014
Antibiotics a cure for back pain, a false dawn or a new era? European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2013, Volume: 22, Issue:8 Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Bone Diseases; Edema; Female; Gram-Positive Bacterial Infections; Humans; Intervertebral Disc; Intervertebral Disc Displacement; Low Back Pain; Lumbar Vertebrae; Male; Propionibacterium acnes	2013
Do these results apply to the 'intervention naive' patient? European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2013, Volume: 22, Issue:8 Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Bone Diseases; Edema; Female; Humans; Intervertebral Disc Displacement; Low Back Pain; Lumbar Vertebrae; Male	2013
Letter to the editor concerning: "Antibiotic treatment in patients with chronic low back pain and vertebral bone edema (Modic type 1 changes): a double-blind randomized controlled trial of efficacy" by Albert HB et al. Eur Spine J (2013) 22:697-707. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2013, Volume: 22, Issue:8 Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Bone Diseases; Edema; Female; Humans; Intervertebral Disc Displacement; Low Back Pain; Lumbar Vertebrae; Male	2013
No conflict of interest? European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2013, Volume: 22, Issue:8 Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Bone Diseases; Edema; Female; Gram-Positive Bacterial Infections; Humans; Intervertebral Disc; Intervertebral Disc Displacement; Low Back Pain; Lumbar Vertebrae; Male; Propionibacterium acnes	2013
Answer to the letter to the editor of A. Sotto et al. concerning "Antibiotic treatment in patients with chronic low back pain and vertebral bone edema (Modic type 1 changes): a double-blind randomized controlled trial of efficacy" by Albert HB et al., Eur European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2013, Volume: 22, Issue:8 Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Bone Diseases; Edema; Female; Humans; Intervertebral Disc Displacement; Low Back Pain; Lumbar Vertebrae; Male	2013
Answer to the Letter to the Editor of Benjamin John Floyd Dean et al. entitled "No conflict of interest?" concerning "Antibiotic treatment in patients with chronic low back pain and vertebral bone edema (Modic type 1 changes): a double-blind randomized co European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2013, Volume: 22, Issue:8 Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Bone Diseases; Edema; Female; Gram-Positive Bacterial Infections; Humans; Intervertebral Disc; Intervertebral Disc Displacement; Low Back Pain; Lumbar Vertebrae; Male; Propionibacterium acnes	2013
Answer to the Letter to the Editor of Benjamin John Floyd Dean entitled "Do these results apply to the 'intervention naive' patient?" concerning "Antibiotic treatment in patients with chronic low back pain and vertebral bone edema (Modic type 1 changes): European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2013, Volume: 22, Issue:8 Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Bone Diseases; Edema; Female; Humans; Intervertebral Disc Displacement; Low Back Pain; Lumbar Vertebrae; Male	2013
Answer to the Editorial of J. O'Dowd and A. Casey. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2013, Volume: 22, Issue:8 Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Bone Diseases; Edema; Female; Gram-Positive Bacterial Infections; Humans; Intervertebral Disc; Intervertebral Disc Displacement; Low Back Pain; Lumbar Vertebrae; Male; Propionibacterium acnes	2013
The two papers of Hanne Albert et al. about Modic I changes of the vertebra published in the European Spine Journal of April 2013. Editorial. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2013, Volume: 22, Issue:8 Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Bone Diseases; Edema; Female; Gram-Positive Bacterial Infections; Humans; Intervertebral Disc; Intervertebral Disc Displacement; Low Back Pain; Lumbar Vertebrae; Male; Propionibacterium acnes	2013
Backache and infection. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2013, Volume: 22, Issue:10 Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Bone Diseases; Edema; Female; Gram-Positive Bacterial Infections; Humans; Intervertebral Disc; Intervertebral Disc Displacement; Low Back Pain; Lumbar Vertebrae; Male; Propionibacterium acnes	2013
Letter to the editor concerning: "Antibiotic treatment in patients with chronic low back pain and vertebral bone edema (Modic type 1 changes): a double-blind randomized controlled trial of efficacy" by Albert HB et al. Eur Spine J (2013) 22:697-707. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2013, Volume: 22, Issue:10 Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Bone Diseases; Edema; Female; Humans; Intervertebral Disc Displacement; Low Back Pain; Lumbar Vertebrae; Male	2013
Answer to the Letter to the Editor of K. Shubhakaran et al. entitled "Backache and infection" concerning "Antibiotic treatment in patients with chronic low back pain and vertebral bone edema (Modic type 1 changes): a double-blind randomized controlled tri European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2013, Volume: 22, Issue:10 Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Bone Diseases; Edema; Female; Humans; Intervertebral Disc Displacement; Low Back Pain; Lumbar Vertebrae; Male	2013
Answer to the Letter to the Editor of Zafar Ahmad et al. concerning "Antibiotic treatment in patients with chronic low back pain and vertebral bone edema (Modic type 1 changes): a double-blind randomized controlled trial of efficacy" by Albert HB et al., European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2013, Volume: 22, Issue:10 Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Bone Diseases; Edema; Female; Humans; Intervertebral Disc Displacement; Low Back Pain; Lumbar Vertebrae; Male	2013
From narcotics to antibiotics: evolving concepts in the treatment of lower back pain. World neurosurgery, 2013, Volume: 80, Issue:5 Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Bone Diseases; Edema; Female; Gram-Positive Bacterial Infections; Humans; Intervertebral Disc; Intervertebral Disc Displacement; Low Back Pain; Lumbar Vertebrae; Male; Propionibacterium acnes	2013
Antibiotic treatment in patients with low-back pain associated with Modic changes Type 1 (bone oedema): a pilot study. British journal of sports medicine, 2008, Volume: 42, Issue:12 The aim of this study was to assess the clinical effect of antibiotic treatment in a cohort of patients with low-back pain (LBP) and Modic changes Type 1 (bone oedema) following a lumbar herniated disc.. This was a prospective uncontrolled trial of 32 LBP patients who had Modic changes and were treated with Amoxicillin-clavulanate (500 mg/125 mg) 3 x day for 90 days. All patients had previously participated in a randomised controlled trial (RCT) that investigated active conservative treatment for a lumbar herniated disc (n = 166). All patients in that RCT who had Modic changes and LBP at 14 months follow-up (n = 37) were invited to participate in this subsequent antibiotic trial but five did not meet the inclusion criteria.. 29 patients completed the treatment, as three patients dropped out due to severe diarrhoea. At the end of treatment and at long-term follow-up (mean 10.8 months) there was both clinically important and statistically significant (p Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Bacterial Infections; Bone Marrow Diseases; Edema; Female; Humans; Intervertebral Disc Displacement; Low Back Pain; Male; Middle Aged; Pilot Projects; Prospective Studies; Treatment Outcome	2008