amoxicillin-potassium-clavulanate-combination and Infections

Any antibiotic agent that improves the safety of antibiotic treatment means progress in the management of infectious diseases. A new antibiotic has to show the following properties in order to signify progress compared to the well established antibiotics: Better antibacterial activity, better pharmacokinetic and pharmacodynamic properties, which improve patient compliance. Reduction of costs for antibiotic treatment also means progress. Infections most frequently seen in outpatients who are usually treated with oral antibiotics are respiratory and urinary tract infections. Progress in the management of infectious diseases by the introduction of quinolones, combination of amoxicillin-clavulanic acid, new macrolides and new oral cephalosporins is discussed.

Topics: Administration, Oral; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Cephalosporins; Clavulanic Acids; Drug Therapy, Combination; Humans; Infections; Macrolides

Augmentin (SmithKline Beecham) was used in the treatment of 24 patients after operations on the otorhinolaryngologic organs. The drug was administered orally, intravenously or applied locally. After a radical operation on the maxillary sinus the use of augmentin resulted in a marked decrease of the wound secretion and soft tissue edema on the 6th-7th days. After tonsillectomy cleaning of the tonsil niche from the fibrin patches and the epithelialization started on the 4th-5th days. After operations on the temporal bone cleaning of the postoperative cavity and beginning of the epithelialization were observed on the 9th-10th days. On the whole, the use of augmentin accelerated the cure which was recorded 3-4 days earlier.

Topics: Adolescent; Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Combined Modality Therapy; Drug Therapy, Combination; Female; Humans; Infections; Inflammation; Male; Middle Aged; Otorhinolaryngologic Diseases; Postoperative Care; Time Factors

Topics: Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Humans; Infections; Molar, Third; Tooth Extraction; Tooth, Impacted

Topics: Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Humans; Infections; Molar, Third; Tooth Extraction; Tooth, Impacted

Topics: Amoxicillin-Potassium Clavulanate Combination; Antibiotic Prophylaxis; Humans; Infections; Molar, Third; Tooth Extraction

Topics: Amoxicillin-Potassium Clavulanate Combination; beta-Lactamase Inhibitors; Cysts; Female; Gastrointestinal Tract; Humans; Infant; Infections; Magnetic Resonance Imaging; Tomography, X-Ray Computed

Genital tract integrity is not always mantained during childbirth. No treatment protocol for post-partum perineal wounds (tears and episiotomies) existed in our Department, thus their management depends upon clinician. This study aimed to establish the role of antibiotic in the treatment of post-partum perineal wounds as well as the impact of antibioprophylaxis on wound healing and on prevention of infectious complications after repair.. The average age was 26.32 ± 6.5 years, ranging between 15 and 43 years. Primiparous women accouted for 55.9% of the study population. At day 0 post-partum the main symptom was pain, without significant predominance of a group (OR = 0.9; CI = 0.14-7.19; p = 1). Swollen wounds were the second complaint, without significant variation between the two groups (OR = 1.69; CI = 0.88-3.24; p = 0.13). At day 0, day 2 and day 9 no significant variation was observed between the two treatment protocols with regard to the indicators analyzed: pain evolution, infection, swelling and average healing time. At day 9 the healing was complete in both groups and the two treatment protocols were shown to be equivalent in their effectiveness and prevention of infections.. At the end of this study the two treatment protocols were shown to be equivalent. Antibiotics should not be prescribed for perineal wounds in order to contain the healthcare costs.

Topics: Adolescent; Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Cameroon; Cohort Studies; Delivery, Obstetric; Episiotomy; Female; Follow-Up Studies; Humans; Infections; Lacerations; Pain; Perineum; Postpartum Period; Povidone-Iodine; Pregnancy; Prospective Studies; Treatment Outcome; Wound Healing; Young Adult

Topics: Administration, Oral; Adult; Amoxicillin-Potassium Clavulanate Combination; Cross Reactions; Drug Eruptions; Female; Humans; Infections; Skin Tests

A common problem for the clinician in an outpatient clinic is to distinguish a drug eruption from a viral exanthem in a child. The aim of this study was to describe the common drug eruptions seen in children with ENT infections, suggesting an approach to this problem.. We studied the cases of ENT patients aged 15-years-old and below, with the clinical diagnosis of cutaneous adverse reactions. Main variables in the assessment of drug etiology in skin eruptions were previous experience with the drug in the general population, alternative explanation for the eruption, timing between the ingestion of the drug and the appearance of the lesions, drug levels or evidence of overdose or long-acting drug, subsequent progression of the eruption and reactions to dechallenge and rechallenge.. A total of 47 children were examined during a period of 11 months. The indications for drug prescribed were tonsillitis, pharyngitis, rhinitis, otitis and sinusitis. The most usually implicated drugs were amoxycillin-clavulanic acid, cephalosporin, clindamycin, erythromycin, clarithromycin and paracetamol. The main clinical patterns of the eruptions seen were urticaria, maculopapular rash, fixed drug eruption and erythema multiforme.. Careful clinical examination, detailed history, knowledge of the numerous clinical patterns of the eruptions and the drugs specific reaction rates, as well as oral drug rechallenge, RAST and patch tests if indicated, are essential factors in the management of patients with drug eruptions.

Topics: Acetaminophen; Adolescent; Amoxicillin-Potassium Clavulanate Combination; Cephalosporins; Child; Child, Preschool; Clarithromycin; Clindamycin; Diagnosis, Differential; Drug Eruptions; Erythromycin; Female; Humans; Infant; Infections; Male; Otitis; Otorhinolaryngologic Diseases; Pharyngitis; Prospective Studies; Rhinitis; Risk Factors; Sinusitis; Stomatognathic Diseases; Tonsillitis

Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Clavulanic Acids; Ear Diseases; Female; Humans; Infections; Male; Nose Diseases; Respiratory Tract Infections; Ticarcillin; Tonsillitis