amoxicillin-potassium-clavulanate-combination and Genital-Neoplasms--Female

Frequency of postoperation complications at oncological patients deviates in the range from 10 to 70 per cent. The highest frequency of infectious complications is registered after extended and complex operations (cervical carcinoma, cancer of vulva, ovarian cancer). The most frequent aerobic pathogens in oncology are enterococci, staphylococci and streptococci, in the case of urinary tract operations--enterococci and Erscherichia coli. Perioperation prophylaxis with amoxycillin/clavulanate (Augmentin) effective against this microorganisms and also against anaerobic bacteria (usual pathogens of post operation infections in oncogynecology) resulted with lower frequency of wound infections. Demonstrated prophylaxy efficacy was more potent than that of cefotaxime (p < 0.05) or when compared to results of other antibiotics administration after operations only.

Topics: Adult; Aged; Amoxicillin-Potassium Clavulanate Combination; Antibiotic Prophylaxis; Female; Genital Neoplasms, Female; Humans; Middle Aged; Postoperative Complications; Surgical Wound Infection

Hysterectomies are arbitrarily pure operations and thus require antibiotic prevention. A great risk for postoperative infections is particularly high after Wertheim's operation. This study evaluated the efficiency of infection prevention in 19 cancer gynecological patients by using the antibiotic augmentin (amoxicillin/clavulanic acid). The first dose was administered 30 minutes before surgery in order to achieve the maximum drug concentration in blood and tissue at surgery. There was no wound suppuration. One patient (5.3%) undergone Werthein's operation was diagnosed to have retroperitoneal hematoma suppuration. One more patient (5.3%) had fever of unknown genesis. Urinary infections that are not considered to be a sign of inefficiency of antibiotic prevention and that were due to long-term catheter placement developed in 4 (21.1%) of the 19 patients. The postoperative period was smooth in 14 (73.7%) of the 19 patients. The perioperative Augumentin administration regimen used by the authors was easy-to-use and beneficial and the drug shows a low toxicity so it may be used for antibiotic prevention in cancer gynecological patients.

Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Female; Genital Neoplasms, Female; Humans; Surgical Wound Infection