amoxicillin-potassium-clavulanate-combination and Exanthema

Acute localized exanthematous pustulosis (ALEP), a localized variant of acute generalized exanthematous pustulosis, is characterized by pin-sized, non-follicular, sterile pustules that typically appear on the face, neck, and chest.. The purpose of this report is to describe a case of ALEP in an 11-year-old girl because of cefixime and the etiological factors and clinical presentation of ALEP in pediatric group.. We described a case of ALEP in an 11-year-old girl because of cefixime; a systematic review of the literature was performed to identify the etiological factors and clinical presentation of ALEP in children.. We identified eight pediatric cases with ALEP. The causative agent was an herbal product in six cases, and pustular eruption was located on the face. In two cases, responsible agents were drugs (lamotrigine and amoxicillin-clavulanic acid). The eruptions were localized on the penis and extremities, respectively.. ALEP is very rare in the pediatric age group, and topical/systemic drugs or herbal products may be involved in the etiology.

Topics: Acute Generalized Exanthematous Pustulosis; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Cefixime; Child; Exanthema; Female; Humans; Male

The aim of this study was to evaluate the difference between the effect of a 5-day and a 1-day postoperative course of antibiotics on the incidence of infection after midfacial fractures. A total of 98 patients with displaced Le Fort or zygomatic fractures that required operation were randomly assigned into 2 groups, both of which were given amoxicillin/clavulanic acid 1.2g intravenously every 8h from the time of admission until 24h postoperatively. The 5-day group was then given amoxicillin/clavulanic acid 625 mg orally 8-hourly for another 4 days. The 1-day group was given placebo orally at the same time points. Patients were followed up 1, 2, 4, 6, and 12 weeks, and 6 months, postoperatively. The development of an infection of the wound was the primary end point. Ninety-four of the 98 patients completed the study. Two of the 45 patients in the 5-day group (4%) and 2/49 in the 1-day group (4%) developed postoperative wound infections. One in each group had a purulent infection, while the others had only wound breakdown. Two patients of the 5-day group and one in the 1-day group developed rashes on the trunk. There were no significant differences in the incidence of infection or side effects between the groups. In midfacial fractures a 1-day course of antibiotics postoperatively is as effective in preventing infective complications as a 5-day regimen.

Topics: Administration, Intravenous; Administration, Oral; Adult; Amoxicillin-Potassium Clavulanate Combination; Antibiotic Prophylaxis; Double-Blind Method; Drug Administration Schedule; Exanthema; Facial Bones; Female; Follow-Up Studies; Fracture Fixation, Internal; Humans; Male; Maxillary Fractures; Middle Aged; Orbital Fractures; Pilot Projects; Placebos; Postoperative Care; Prospective Studies; Skull Fractures; Surgical Wound Dehiscence; Surgical Wound Infection; Treatment Outcome; Zygomatic Fractures

The aim of this study was to evaluate the difference between a 5-day and a 1-day postoperative course of antibiotic on the incidence of infection after mandibular fractures involving the alveolus. Sixty-two patients with fractures of the mandible involving the dentoalveolar region were randomly assigned to 2 groups, both of which were given amoxicillin/clavulanic acid 1.2 g intravenously every 8 h from admission until 24 h postoperatively. The 5-day group were then given amoxicillin/clavulanic acid 625 mg orally every 8 h for another 4 days. The 1-day group was given an oral placebo at the same intervals. Follow-up appointments were 1, 2, 4, 6, 12 weeks and 6 months postoperatively. Development of an infection was the primary end point. Fifty-nine of the 62 patients completed this study. Six of the 30 patients in the 5-day group (20%) and 6 out of the 29 in the 1-day group (21%) developed local wound infections. Three of the 6 in the 1-day group developed purulent discharge and swelling. One patient in the 5-day group developed a rash on the trunk. There were no significant differences in the incidence of infection or side effects between the groups. In fractures of the mandible involving the alveolus, a 1-day postoperative course of antibiotic is as effective in preventing infective complications as a 5-day regimen.

Topics: Administration, Intravenous; Administration, Oral; Adolescent; Adult; Aged; Alveolar Process; Amoxicillin-Potassium Clavulanate Combination; Anti-Infective Agents, Local; Antibiotic Prophylaxis; Double-Blind Method; Drainage; Exanthema; Female; Follow-Up Studies; Fracture Fixation, Internal; Humans; Male; Mandibular Fractures; Middle Aged; Pilot Projects; Placebos; Postoperative Care; Povidone-Iodine; Prospective Studies; Surgical Wound Dehiscence; Surgical Wound Infection; Young Adult

Breast-feeding is considered the gold standard for infant nutrition. In spite of statements about the safe use of drugs in lactation by the American Academy of Pediatrics, medical professionals remain confused regarding the management of drug therapy in nursing mothers, and this can lead to suboptimal prescribing and poor compliance. The aim of our study was to evaluate the safety of 2 of the newer antibiotics, amoxicillin/clavulanic acid and cefuroxime, during lactation. Breast-feeding women who called a drug consultation center to obtain information about the potential risks of amoxicillin/clavulanic acid (67 women) and cefuroxime (38 women) were prospectively recruited. As a control group, women who were treated with antibiotics known to be safe during lactation were recruited: amoxicillin (n = 40) for the amoxicillin/clavulanic acid group and cephalexin (n = 11) for the cefuroxime group. Women in the control group were matched for indication for antibiotic therapy, duration of treatment, and maternal age. Participants were interviewed after treatment termination regarding adverse reactions during therapy. In the amoxicillin/clavulanic acid group, 15 infants (22.3%) had adverse effects, and the rate increased with dosage (P = 0.0139). This was significantly higher than the amoxicillin group, where 3 infants (7.5%) had adverse effects (P = 0.046, relative risk (RR) = 2.99, 95% confidence interval (CI) 0.92-9.68). However, there were no significant differences between rates of specific events. The rate of adverse effects in the cefuroxime group (2.6%) was not significantly different from that in controls (9%) (P = 0.58, OR = 0.92, 95% CI 0.94-1.06). All adverse effects were minor, self-limiting, and did not necessitate interruption of breast-feeding. Our data suggest that amoxicillin/clavulanic acid and cefuroxime may be safe during lactation. Larger studies are needed to confirm these findings.

Topics: Adult; Alanine Transaminase; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Aspartate Aminotransferases; Breast Feeding; Cefuroxime; Clavulanic Acid; Diarrhea, Infantile; Dose-Response Relationship, Drug; Exanthema; Female; Humans; Infant; Lactation; Mastitis; Maternal Age; Middle Aged; Prospective Studies; Respiratory Tract Infections

Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; beta-Lactamase Inhibitors; Drug Combinations; Drug Eruptions; Exanthema; Humans; Infectious Mononucleosis; Male

Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Animals; Animals, Domestic; Anti-Bacterial Agents; Arthritis, Infectious; Diagnosis, Differential; Exanthema; Humans; Male; Rat-Bite Fever; Rats; Treatment Outcome

Topics: Acquired Immunodeficiency Syndrome; Amoxicillin-Potassium Clavulanate Combination; Diagnostic Errors; Drug Eruptions; Eosinophilia; Exanthema; Humans; Hypergammaglobulinemia; Leukopenia; Lung Diseases, Interstitial; Male; Middle Aged

Topics: Acute Disease; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Etanercept; Exanthema; Female; Humans; Immunoglobulin G; Immunosuppressive Agents; Middle Aged; Receptors, Tumor Necrosis Factor; Stevens-Johnson Syndrome

A 40-year-old woman was admitted to the hospital for an acute outbreak of multiple pustular lesions with an underlying erythematous base affecting cheeks and chin. These lesions were referred to as "aching". The patient had been taking amoxicillin-clavulanic acid (3 g a day) over the past three days for oral prophylaxis for dental treatment. Given the possible allergic reaction to the drug administered and the extension of the pustular lesions over all face and neck during the following four days, we replaced the amoxicillin-clavulanic acid with another antibiotic with wide range (ciprofloxacin). Resolution of the pustular lesions occurred within ten days and was accompanied by light scarring and pigmentation. On the basis of the close relationship between the administration of amoxicillin-clavulanic acid and the development of the disease, in combination with a rapid, acute resolution as soon as this treatment was interrupted, and all the histologic findings, we consider this to be an unusual type of acute generalized pustular eruption (AGEP) recently defined as acute localized pustular eruption (ALEP) due to amoxicillin-clavulanic acid.

Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Drug Eruptions; Exanthema; Facial Dermatoses; Female; Humans; Skin

Topics: Acute Disease; Adult; Amoxicillin-Potassium Clavulanate Combination; Biopsy; Diagnosis, Differential; Drug Eruptions; Exanthema; Humans; Male; Skin Diseases, Vesiculobullous

Topics: Acute Disease; Adolescent; Amoxicillin-Potassium Clavulanate Combination; Animals; Anti-Bacterial Agents; Bites and Stings; Dogs; Exanthema; Female; Humans; Skin Diseases, Vesiculobullous

Reported here is the first case of human acute infection with Tula virus, which occurred in a 12-year-old boy in Switzerland. This hantavirus had been considered apathogenic to humans, and in Switzerland only TULV-genome sequences have been demonstrated in wild rodents to date. In this case, paronychia, fever and exanthema occurred after the patient was bitten by a wild rodent, indicating an unusual route of hantavirus transmission. Thus, Tula virus infection should be taken into account in patients with appropriate clinical symptoms and contact with rodents.

Topics: Amoxicillin-Potassium Clavulanate Combination; Animals; Animals, Wild; Bites and Stings; Child; Exanthema; Fever; Hantavirus Infections; Humans; Male; Orthohantavirus; Rodentia; Switzerland

Topics: Acute Disease; Adult; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Drug Hypersensitivity; Drug Therapy, Combination; Exanthema; Humans; Male; Patch Tests