amoxicillin-potassium-clavulanate-combination and Dermatomycoses

The in vitro activity of a novel oxazolidinone, linezolid, was studied by comparing the activity of linezolid with those of amikacin, trimethoprim-sulfamethoxazole, and amoxicillin-clavulanic acid against 25 strains of Nocardia brasiliensis isolated from patients with mycetoma. All N. brasiliensis strains tested were sensitive to linezolid (MIC at which 90% of strains are inhibited [MIC(90)], 2 microg/ml; MIC(50), 1 microg/ml). This antimicrobial might constitute a good alternative for treatment of actinomycetoma.

Topics: Acetamides; Amikacin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Dermatomycoses; Drug Therapy, Combination; Humans; Linezolid; Microbial Sensitivity Tests; Nocardia; Nocardia Infections; Oxazolidinones; Trimethoprim, Sulfamethoxazole Drug Combination