amoxicillin-potassium-clavulanate-combination and Cholangitis

Topics: Africa; Albendazole; Amoxicillin-Potassium Clavulanate Combination; Animals; Anthelmintics; Ascaris lumbricoides; Cholangiopancreatography, Endoscopic Retrograde; Cholangitis; Common Bile Duct; Decompression, Surgical; Drainage; Female; Humans; Klebsiella pneumoniae; Liver; Liver Abscess; Liver Diseases, Parasitic; Middle Aged; Shock, Septic; Travel-Related Illness; Treatment Outcome

A nine-month-old miniature doberman was referred for the evaluation of chronic icterus. History and clinical and histopathological findings were supportive of a diagnosis of drug-induced destructive cholangitis. The main histopathological findings were canalicular, centrilobular cholestasis and ductopenia with moderate inflammatory infiltrate. The dog had received three types of treatment for demodicosis before the onset of jaundice. Amoxicillin-clavulanate, amitraz, milbemycin oxime or an interaction between two of the three drugs may have been responsible for the destructive cholangitis.

Topics: Amoxicillin-Potassium Clavulanate Combination; Animals; Anthelmintics; Anti-Bacterial Agents; Blood Chemical Analysis; Cholangitis; Diagnosis, Differential; Dog Diseases; Dogs; Drug Interactions; Female; Insecticides; Macrolides; Skin Diseases, Bacterial; Toluidines

Topics: Acute Disease; Aged; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Biopsy; Chemical and Drug Induced Liver Injury; Cholangitis; Drug Therapy, Combination; Humans; Liver; Male