amoxicillin-potassium-clavulanate-combination and Brain-Abscess

Metronidazole is a commonly used antimicrobial worldwide. The most common side effects that have been reported are nausea, vomiting and hypersensitivity reactions. However, neurotoxicity has been reported with the use of metronidazole but rather rare. The most common neurological manifestation is peripheral neuropathy involvement in the form of sensory loss. It is worth mentioning that central neurotoxicity is a rare side effect of metronidazole use but reversible. The manifestations vary from a headache, altered mental status to focal neurological deficits. The diagnosis is mainly by neuroimaging in the setting of acute neurological change in the patient status. Here, we report a case of metronidazole-induced neurotoxicity in a 38-year-old male patient who was admitted with a brain abscess and was started on metronidazole for more than 10 weeks.

Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Infective Agents; beta-Lactamase Inhibitors; Brain Abscess; Diagnosis, Differential; Headache; Humans; Magnetic Resonance Imaging; Male; Metronidazole; Neurotoxicity Syndromes; Peripheral Nervous System Diseases; Treatment Outcome

Topics: Aged, 80 and over; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Brain Abscess; C-Reactive Protein; Carcinoma, Squamous Cell; Debridement; Drainage; Humans; Male; Negative-Pressure Wound Therapy; Scalp; Silicones; Skin Neoplasms; Surgical Wound Dehiscence

Brain abscess is a serious life-threatening infection of the brain parenchyma. We are reporting a rare case of brain abscess caused by Group G Streptococcus in a 12 year-old female child who presented with neurological symptoms. She was diagnosed with congenital anomalies of the heart at birth. She was treated with amoxyclav and ciprofloxacin. The child recovered and was discharged uneventfully.

Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Brain; Brain Abscess; Child; Ciprofloxacin; Female; Humans; Magnetic Resonance Imaging; Radiography; Streptococcal Infections; Streptococcus; Treatment Outcome

Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Ampicillin; Anti-Bacterial Agents; Brain Abscess; Frontal Bone; Frontal Sinusitis; Humans; Magnetic Resonance Imaging; Male; Osteomyelitis; Sulbactam

Recently published guidance from NICE highlights that antibiotic prophylaxis is no longer required for patients with structural heart disease at risk of infective endocarditis. The American Heart Association has published similarly less interventive guidance. Individuals with pulmonary arteriovenous malformations and hereditary haemorrhagic telangiectasia are at risk of brain abscess from dental bacteraemias. In this article we explore why these patients do not fall into the groups considered by NICE and provide recommendations to reduce their risks of dental bacteraemias, including optimising dental hygiene and use of antibiotic prophylaxis prior to dental procedures.

Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Antibiotic Prophylaxis; Arteriovenous Malformations; Bacteremia; Brain Abscess; Dental Care for Chronically Ill; Drug Combinations; Humans; Practice Guidelines as Topic; Pulmonary Artery; Pulmonary Veins; Telangiectasia, Hereditary Hemorrhagic

A rare case of brain abscess due to Gemella morbillorum, a normal inhabitant of the oral cavity, is presented. The aim of this report is to draw the attention of radiology literature readers to this little known pathogen, which caused a potentially life-threatening condition in an immunocompetent young man, and to emphasise the usefulness of a combined stereotactic, medical, and imaging approach to deep-located brain abscesses.

Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Brain Abscess; Clindamycin; Combined Modality Therapy; Humans; Male; Staphylococcaceae; Stereotaxic Techniques; Tomography, X-Ray Computed