amoxicillin-potassium-clavulanate-combination and Bordetella-Infections

Topics: Amoxicillin-Potassium Clavulanate Combination; Anemia, Sickle Cell; Anti-Bacterial Agents; Bacteremia; Bordetella; Bordetella Infections; Child; Disease Susceptibility; DNA, Bacterial; Drug Resistance, Multiple, Bacterial; Female; Fever; Humans; Ribotyping; Sequence Homology, Nucleic Acid

We describe the first clinical isolate of Bordetella petrii from a patient with mandibular osteomyelitis. The only previously documented isolation of B. petrii occurred after the initial culture of a single strain from an environmental source.

Topics: Aged; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Bordetella; Bordetella Infections; Drug Resistance, Multiple, Bacterial; Humans; Male; Osteomyelitis

The antimicrobial sensitivities of 78 recent (1995-1998) canine isolates of Bordetella bronchiseptica from 13 separate sources were determined. Minimum inhibitory concentrations were assessed using the E-test method or by agar dilution. All 78 isolates were sensitive to tetracycline, doxycycline, enrofloxacin, and amoxycillin/clavulanic acid; the majority were sensitive to ampicillin (63/78; 81%), trimethoprim (57/78; 73%), and sulphadiazine (63/78; 81%). Plasmids were detected in 14 out of the 24 isolates tested. There was no correlation between the presence of plasmids and antibiotic resistance, but there was some correlation between the presence of plasmids and the origin of the isolates. Three sizes of plasmid were found: 20, 14, and 5.5 kb. Eight of the isolates contained all three plasmids, the remainder one or two, Thirteen isolates demonstrated beta-haemolysis, of which six produced a soluble haemolysin. Except for one isolate, haemolysin production correlated with plasmid carriage. Pulsed-field gel electrophoresis showed that all except one isolate could be grouped in the same genotype. Within this genotype isolates could be divided into three subtypes, generally corresponding to their place of origin.

Topics: Amoxicillin-Potassium Clavulanate Combination; Ampicillin; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Urinary; Bordetella bronchiseptica; Bordetella Infections; DNA, Bacterial; Dog Diseases; Dogs; Doxycycline; Drug Resistance, Microbial; Drug Therapy, Combination; Electrophoresis, Gel, Pulsed-Field; Enrofloxacin; Fluoroquinolones; Microbial Sensitivity Tests; Penicillins; Quinolones; R Factors; Sulfadiazine; Tetracycline; Trimethoprim